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Teresita Bellido

TitleDepartment Chairperson
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentDepartment Chairs, College of Medicine
Address200 South Cedar
Mail Slot # 505
Little Rock AR 72202
Phone501-686-5442
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentInternal Medicine, College of Medicine
    DivisionEndocrinology

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentOrthopaedics, College of Medicine


    Collapse Research 
    Collapse research activities and funding
    R13AR083263     (BILEZIKIAN, JOHN P)Jul 1, 2023 - Jun 30, 2025
    NIH
    Eighteenth Forum on Osteoporosis and Metabolic Bone Diseases for Fellows in Training
    Role: Co-Principal Investigator
    2326724     (BELLIDO, TERESITA M)Jul 1, 2023 - Jun 30, 2024
    National Science Foundation
    2023 Orthopedic Research Society Musculoskeletal Biology Workshop
    Role: Principal Investigator
    Award ID 2217231     (BELLIDO, TERESITA M)Jul 1, 2022 - Jun 30, 2023
    National Science Foundation
    2022 Musculoskeletal Biology Workshop
    Role: Principal Investigator
    AwardID2217231     (BELLIDO, TERESITA M)Jul 1, 2022 - Jun 30, 2023
    National Science Foundation
    2022 Musculoskeletal Biology Workshop
    Role: Principal Investigator
    R13AR081110     (BELLIDO, TERESITA M.)Jun 1, 2022 - May 31, 2025
    NIH
    ASBMR Three Year Pre-Meeting Symposia
    Role: Principal Investigator
    R01AG071332     (BELLIDO, TERESITA M)Sep 30, 2021 - May 31, 2026
    NIH/Nat. Inst. on Aging - Pass Through: University of Toledo
    PPARG regulates osteocyte function during aging
    Role: Principal Investigator
    IK6BX004596     (BELLIDO, TERESITA M.)Apr 1, 2019 - Mar 31, 2029
    NIH
    BLRD Research Career Scientist Award Application
    Role: Principal Investigator
    R01CA209882     (DELGADO-CALLE, JESUS)Mar 15, 2017 - Jun 30, 2028
    NIH
    Contribution of osteocytes to the musculoskeletal effects of Multiple Myeloma
    Role: Principal Investigator
    I01BX002104     (BELLIDO, TERESITA M.)Oct 1, 2013 - Sep 30, 2023
    NIH
    PTH receptor Signaling and Diabetes-induced Bone Disease
    Role: Principal Investigator
    R01AR059357     (BELLIDO, TERESITA M.)Sep 1, 2011 - Jun 30, 2024
    NIH
    Glucocorticoid-induced Atrophy in Bone and Muscle
    Role: Principal Investigator
    R01DK076007     (BELLIDO, TERESITA M)Aug 5, 2007 - Jun 30, 2013
    NIH
    Osteocyte control of bone formation via Sost
    Role: Principal Investigator
    R03TW006919     (BELLIDO, TERESITA M)Sep 1, 2005 - Aug 31, 2009
    NIH
    Bisphosphonate binding to connexin43-expressing cells
    Role: Principal Investigator
    K02AR002127     (BELLIDO, TERESITA M)Sep 15, 2000 - Aug 31, 2005
    NIH
    CYTOKINE SIGNAL TRANSDUCTION IN OSTEOBLASTIC CELLS
    Role: Principal Investigator
    K02AR02127     (BELLIDO, TERESITA M)Sep 15, 2000 - Aug 31, 2005
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases
    Cytokine Signal Transduction in Osteoblastic Cells
    Role: Principal Investigator
    5R29AR43453-05     (BELLIDO, TERESITA M)Dec 15, 1996 - Nov 30, 2001
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases
    Cytokine Signal Transduction in Osteoblastic Cells
    Role: Principal Investigator
    R29AR043453     (BELLIDO, TERESITA M)Dec 15, 1996 - Nov 30, 2001
    NIH
    CYTOKINE SIGNAL TRANSDUCTION IN OSTEOBLASTIC CELLS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Anloague A, Sabol HM, Kaur J, Khan S, Ashby C, Schinke C, Barnes CL, Alturkmani F, Ambrogini E, Gundesen MT, Lund T, Amstrup AK, Andersen TL, Diaz-delCastillo M, Roodman GD, Bellido T, Delgado-Calle J. Novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma. Haematologica. 2024 Nov 28. PMID: 39605211.
      View in: PubMed
    2. Lanzolla G, Sabini E, Beigel K, Khan MP, Sherry Liu X, Wang D, Laslow B, Taylor D, Bellido T, Giaccia A, Schipani E. Pharmacological inhibition of HIF2 protects against bone loss in an experimental model of estrogen deficiency. Proc Natl Acad Sci U S A. 2024 Dec 03; 121(49):e2416004121. PMID: 39602268.
      View in: PubMed
    3. Wang X, Sato AY, Marino S, Akel N, Boysen G, Basnakian AG, Bellido TM, Li HY. Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective via Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss. J Med Chem. 2024 Nov 28; 67(22):20708-20720. PMID: 39540576.
      View in: PubMed
    4. Sato AY, Cregor M, McAndrews K, Schurman CA, Schaible E, Shutter J, Vyas P, Adhikari B, Willis MS, Boerma M, Alliston T, Bellido T. Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease. JCI Insight. 2024 Nov 08; 9(21). PMID: 39405125.
      View in: PubMed
    5. Turkkahraman H, Flanagan S, Zhu T, Akel N, Marino S, Ortega-Gonzalez D, Yuan X, Bellido T. Sclerostin antibody corrects periodontal disease in type 2 diabetic mice. JCI Insight. 2024 Jul 18; 9(16). PMID: 39171525.
      View in: PubMed
    6. Marino S, Bellido T. PTH receptor signalling, osteocytes and bone disease induced by diabetes mellitus. Nat Rev Endocrinol. 2024 Nov; 20(11):661-672. PMID: 39020007.
      View in: PubMed
    7. Bellido T. Bisphosphonates for osteoporosis: from bench to clinic. J Clin Invest. 2024 Mar 15; 134(6). PMID: 38488010.
      View in: PubMed
    8. Marino S, Ozgurel SU, McAndrews K, Cregor M, Villase?or A, Mamani-Huanca M, Barbas C, Gortazar A, Sato AY, Bellido T. Abaloparatide is more potent than teriparatide in restoring bone mass and strength in type 1 diabetic male mice. Bone. 2024 Apr; 181:117042. PMID: 38360197.
      View in: PubMed
    9. Lewiecki EM, Bellido T, Bilezikian JP, Brown JP, Farooki A, Kovacs CS, Lee B, Leslie WD, McClung MR, Prasarn ML, Sellmeyer DE. Proceedings of the 2023 Santa Fe Bone Symposium: Progress and Controversies in the Management of Patients with Skeletal Diseases. J Clin Densitom. 2023 Oct-Dec; 26(4):101432. PMID: 37944445.
      View in: PubMed
    10. Korff C, Adaway M, Atkinson EG, Horan DJ, Klunk A, Silva BS, Bellido T, Plotkin LI, Robling AG, Bidwell JP. Loss of Nmp4 enhances bone gain from sclerostin antibody administration. Bone. 2023 Dec; 177:116891. PMID: 37660938.
      View in: PubMed
    11. Marino S, Akel N, Li S, Cregor M, Jones M, Perez B, Troncoso G, Meeks J, Stewart S, Sato AY, Nookaew I, Bellido T. Author Correction: Reversal of the diabetic bone signature with anabolic therapies in mice. Bone Res. 2023 Jun 13; 11(1):32. PMID: 37311786.
      View in: PubMed
    12. Marino S, Akel N, Li S, Cregor M, Jones M, Perez B, Troncoso G, Meeks J, Stuart S, Sato AY, Nookaew I, Bellido T. Author Correction: Reversal of the diabetic bone signature with anabolic therapies in mice. Bone Res. 2023 May 06; 11(1):23. PMID: 37147286.
      View in: PubMed
    13. Turkkahraman H, Flanagan S, Zhu T, Bellido TM, Yuan X. The LRP5 high-bone-mass mutation causes alveolar bone accrual with minor craniofacial alteration. J Periodontal Res. 2023 Aug; 58(4):723-732. PMID: 37128744.
      View in: PubMed
    14. Marino S, Akel N, Li S, Cregor M, Jones M, Perez B, Troncoso G, Meeks J, Stewart S, Sato AY, Nookaew I, Bellido T. Reversal of the diabetic bone signature with anabolic therapies in mice. Bone Res. 2023 Apr 19; 11(1):19. PMID: 37076478.
      View in: PubMed
    15. Williams JN, Irwin M, Li Y, Kambrath AV, Mattingly BT, Patel S, Kittaka M, Collins RN, Clough NA, Doud EH, Mosley AL, Bellido T, Bruzzaniti A, Plotkin LI, Trinidad JC, Thompson WR, Bonewald LF, Sankar U. Osteocyte-Derived CaMKK2 Regulates Osteoclasts and Bone Mass in a Sex-Dependent Manner through Secreted Calpastatin. Int J Mol Sci. 2023 Mar 01; 24(5). PMID: 36902150.
      View in: PubMed
    16. Yuan X, Amin V, Zhu T, Kittaka M, Ueki Y, Bellido TM, Turkkahraman H. Type 1 diabetes mellitus leads to gingivitis and an early compensatory increase in bone remodeling. J Periodontol. 2023 02; 94(2):277-289. PMID: 35869905.
      View in: PubMed
    17. Ghassib I, Zhang H, Qi S, Moshen R, Mishina Y, Bellido T, Liu F. Off-target activity of the 8?kb Dmp1-Cre results in the deletion of?Tsc1?gene in mouse intestinal mesenchyme. Transgenic Res. 2023 04; 32(1-2):135-141. PMID: 36547785.
      View in: PubMed
    18. Xu X, Yang H, Bullock WA, Gallant MA, Ohlsson C, Bellido TM, Main RP. Osteocyte Estrogen Receptor ? (Ot-ER?) Regulates Bone Turnover and Skeletal Adaptive Response to Mechanical Loading Differently in Male and Female Growing and Adult Mice. J Bone Miner Res. 2023 01; 38(1):186-197. PMID: 36321245.
      View in: PubMed
    19. Atkinson EG, Adaway M, Horan DJ, Korff C, Klunk A, Orr AL, Ratz K, Bellido T, Plotkin LI, Robling AG, Bidwell JP. Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation. J Bone Miner Res. 2023 01; 38(1):70-85. PMID: 36321253.
      View in: PubMed
    20. Clark A, Ghatak S, Guda PR, El Masry MS, Xuan Y, Sato AY, Bellido T, Sen CK. Myogenic tissue nanotransfection improves muscle torque recovery following volumetric muscle loss. NPJ Regen Med. 2022 Oct 20; 7(1):63. PMID: 36266362.
      View in: PubMed
    21. Wang X, Ma Y, Chen J, Liu Y, Liu G, Wang P, Wang B, Taketo MM, Bellido T, Tu X. A novel decellularized matrix of Wnt signaling-activated osteocytes accelerates the repair of critical-sized parietal bone defects with osteoclastogenesis, angiogenesis, and neurogenesis. Bioact Mater. 2023 Mar; 21:110-128. PMID: 36093329.
      View in: PubMed
    22. Sabol HM, Amorim T, Ashby C, Halladay D, Anderson J, Cregor M, Sweet M, Nookaew I, Kurihara N, Roodman GD, Bellido T, Delgado-Calle J. Notch3 signaling between myeloma cells and osteocytes in the tumor niche promotes tumor growth and bone destruction. Neoplasia. 2022 06; 28:100785. PMID: 35390742.
      View in: PubMed
    23. Delgado-Calle J, McAndrews K, Wu G, Orr AL, Ferrari A, Tu X, Srinivasan V, Roodman GD, Ebetino FH, Boeckman RK, Bellido T. The Notch pathway regulates the bone gain induced by PTH anabolic signaling. FASEB J. 2022 03; 36(3):e22196. PMID: 35137455.
      View in: PubMed
    24. Chen J, Cuevas PL, Dworan JS, Dawid I, Turkkahraman H, Tran K, Delgado-Calle J, Bellido T, Gorski JP, Liu B, Brunski JB, Helms JA. Wnt/?-catenin Signaling Controls Maxillofacial Hyperostosis. J Dent Res. 2022 07; 101(7):793-801. PMID: 35114849.
      View in: PubMed
    25. Sabol HM, Ferrari AJ, Adhikari M, Amorim T, McAndrews K, Anderson J, Vigolo M, Lehal R, Cregor M, Khan S, Cuevas PL, Helms JA, Kurihara N, Srinivasan V, Ebetino FH, Boeckman RK, Roodman GD, Bellido T, Delgado-Calle J. Targeting Notch Inhibitors to the Myeloma Bone Marrow Niche Decreases Tumor Growth and Bone Destruction without Gut Toxicity. Cancer Res. 2021 10 01; 81(19):5102-5114. PMID: 34348968.
      View in: PubMed
    26. Delgado-Calle J, Bellido T. The osteocyte as a signaling cell. Physiol Rev. 2022 01 01; 102(1):379-410. PMID: 34337974.
      View in: PubMed
    27. Sato AY, Pellegrini GG, Cregor M, McAndrews K, Choi RB, Maiz M, Johnson O, McCabe LD, McCabe GP, Ferruzzi MG, Lila MA, Peacock M, Burr DB, Nakatsu CH, Weaver CM, Bellido T. Skeletal Protection and Promotion of Microbiome Diversity by Dietary Boosting of the Endogenous Antioxidant Response. J Bone Miner Res. 2021 04; 36(4):768-778. PMID: 33316081.
      View in: PubMed
    28. Chen J, Yuan X, Pilawski I, Liu X, Delgado-Calle J, Bellido T, Turkkahraman H, Helms JA. Molecular Basis for Craniofacial Phenotypes Caused by Sclerostin Deletion. J Dent Res. 2021 03; 100(3):310-317. PMID: 33078679.
      View in: PubMed
    29. Bellido T, Delgado-Calle J. Ex Vivo Organ Cultures as Models to Study Bone Biology. JBMR Plus. 2020 Mar; 4(3). PMID: 32161838.
      View in: PubMed
    30. Kegelman CD, Coulombe JC, Jordan KM, Horan DJ, Qin L, Robling AG, Ferguson VL, Bellido TM, Boerckel JD. YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling. J Bone Miner Res. 2020 01; 35(1):196-210. PMID: 31610061.
      View in: PubMed
    31. Davis HM, Deosthale PJ, Pacheco-Costa R, Essex AL, Atkinson EG, Aref MW, Dilley JE, Bellido T, Ivan M, Allen MR, Plotkin LI. Osteocytic miR21 deficiency improves bone strength independent of sex despite having sex divergent effects on osteocyte viability and bone turnover. FEBS J. 2020 03; 287(5):941-963. PMID: 31532878.
      View in: PubMed
    32. Bullock WA, Hoggatt AM, Horan DJ, Elmendorf AJ, Sato AY, Bellido T, Loots GG, Pavalko FM, Robling AG. Lrp4 Mediates Bone Homeostasis and Mechanotransduction through Interaction with Sclerostin In?Vivo. iScience. 2019 Oct 25; 20:205-215. PMID: 31585407.
      View in: PubMed
    33. Zhao Y, Yuan X, Bellido T, Helms JA. A Correlation between Wnt/Beta-catenin Signaling and the Rate of Dentin Secretion. J Endod. 2019 Nov; 45(11):1357-1364.e1. PMID: 31522810.
      View in: PubMed
    34. Corry KA, Zhou H, Brustovetsky T, Himes ER, Bivi N, Horn MR, Kitase Y, Wallace JM, Bellido T, Brustovetsky N, Li J. Stat3 in osteocytes mediates osteogenic response to loading. Bone Rep. 2019 Dec; 11:100218. PMID: 31440530.
      View in: PubMed
    35. Sato AY, Cregor M, McAndrews K, Li T, Condon KW, Plotkin LI, Bellido T. Glucocorticoid-Induced Bone Fragility Is Prevented in Female Mice by Blocking Pyk2/Anoikis Signaling. Endocrinology. 2019 07 01; 160(7):1659-1673. PMID: 31081900.
      View in: PubMed
    36. Rauner M, Baschant U, Roetto A, Pellegrino RM, Rother S, Salbach-Hirsch J, Weidner H, Hintze V, Campbell G, Petzold A, Lemaitre R, Henry I, Bellido T, Theurl I, Altamura S, Colucci S, Muckenthaler MU, Schett G, Komla-Ebri DSK, Bassett JHD, Williams GR, Platzbecker U, Hofbauer LC. Author Correction: Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling. Nat Metab. 2019 May; 1(5):584. PMID: 32694850.
      View in: PubMed
    37. Delgado-Calle J, Kurihara N, Atkinson EG, Nelson J, Miyagawa K, Galmarini CM, Roodman GD, Bellido T. Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts. Oncotarget. 2019 Apr 12; 10(28):2709-2721. PMID: 31105871.
      View in: PubMed
    38. Saito H, Gasser A, Bolamperti S, Maeda M, Matthies L, J?hn K, Long CL, Schl?ter H, Kwiatkowski M, Saini V, Pajevic PD, Bellido T, van Wijnen AJ, Mohammad KS, Guise TA, Taipaleenm?ki H, Hesse E. TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone. Nat Commun. 2019 03 22; 10(1):1354. PMID: 30902975.
      View in: PubMed
    39. Rauner M, Baschant U, Roetto A, Pellegrino RM, Rother S, Salbach-Hirsch J, Weidner H, Hintze V, Campbell G, Petzold A, Lemaitre R, Henry I, Bellido T, Theurl I, Altamura S, Colucci S, Muckenthaler MU, Schett G, Komla Ebri D, Bassett JHD, Williams GR, Platzbecker U, Hofbauer LC. Transferrin receptor 2 controls bone mass and pathological bone formation via BMP and Wnt signaling. Nat Metab. 2019 01; 1(1):111-124. PMID: 30886999.
      View in: PubMed
    40. Li JY, Yu M, Tyagi AM, Vaccaro C, Hsu E, Adams J, Bellido T, Weitzmann MN, Pacifici R. IL-17 Receptor Signaling in Osteoblasts/Osteocytes Mediates PTH-Induced Bone Loss and Enhances Osteocytic RANKL Production. J Bone Miner Res. 2019 02; 34(2):349-360. PMID: 30399207.
      View in: PubMed
    41. Wu Y, Yuan X, Perez KC, Hyman S, Wang L, Pellegrini G, Salmon B, Bellido T, Helms JA. Aberrantly elevated Wnt signaling is responsible for cementum overgrowth and dental ankylosis. Bone. 2019 05; 122:176-183. PMID: 30408613.
      View in: PubMed
    42. Alam I, Oakes DK, Reilly AM, Billingsley C, Sbeta S, Gerard-O'Riley RL, Acton D, Sato A, Bellido T, Econs MJ. Overexpression of WNT16 Does Not Prevent Cortical Bone Loss Due to Glucocorticoid Treatment in Mice. JBMR Plus. 2019 Apr; 3(4):e10084. PMID: 31044183.
      View in: PubMed
    43. Pacheco-Costa R, Davis HM, Atkinson EG, Dilley JE, Byiringiro I, Aref MW, Allen MR, Bellido T, Plotkin LI. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 09; 114:22-31. PMID: 29879544.
      View in: PubMed
    44. Sato AY, Peacock M, Bellido T. GLUCOCORTICOID EXCESS IN BONE AND MUSCLE. Clin Rev Bone Miner Metab. 2018 Mar; 16(1):33-47. PMID: 29962904.
      View in: PubMed
    45. Davis HM, Aref MW, Aguilar-Perez A, Pacheco-Costa R, Allen K, Valdez S, Herrera C, Atkinson EG, Mohammad A, Lopez D, Harris MA, Harris SE, Allen M, Bellido T, Plotkin LI. Cx43 overexpression in osteocytes prevents osteocyte apoptosis and preserves cortical bone quality in aging mice. JBMR Plus. 2018 Jul; 2(4):206-216. PMID: 29978155.
      View in: PubMed
    46. Delgado-Calle J, Hancock B, Likine EF, Sato AY, McAndrews K, Sanudo C, Bruzzaniti A, Riancho JA, Tonra JR, Bellido T. MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production. FASEB J. 2018 05; 32(5):2878-2890. PMID: 29401593.
      View in: PubMed
    47. Kegelman CD, Mason DE, Dawahare JH, Horan DJ, Vigil GD, Howard SS, Robling AG, Bellido TM, Boerckel JD. Skeletal cell YAP and TAZ combinatorially promote bone development. FASEB J. 2018 05; 32(5):2706-2721. PMID: 29401582.
      View in: PubMed
    48. He G, Shi Y, Lim J, Bellido T, Ni J, Long F. Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth. Bone Res. 2017; 5:17016. PMID: 28607813.
      View in: PubMed
    49. Delgado-Calle J, Anderson J, Cregor MD, Condon KW, Kuhstoss SA, Plotkin LI, Bellido T, Roodman GD. Genetic deletion of Sost or pharmacological inhibition of sclerostin prevent multiple myeloma-induced bone disease without affecting tumor growth. Leukemia. 2017 12; 31(12):2686-2694. PMID: 28529307.
      View in: PubMed
    50. Komaba H, Kaludjerovic J, Hu DZ, Nagano K, Amano K, Ide N, Sato T, Densmore MJ, Hanai JI, Olauson H, Bellido T, Larsson TE, Baron R, Lanske B. Klotho expression in osteocytes regulates bone metabolism and controls bone formation. Kidney Int. 2017 09; 92(3):599-611. PMID: 28396120.
      View in: PubMed
    51. Delgado-Calle J, Bellido T. New Insights Into the Local and Systemic Functions of Sclerostin: Regulation of Quiescent Bone Lining Cells and Beige Adipogenesis in Peripheral Fat Depots. J Bone Miner Res. 2017 05; 32(5):889-891. PMID: 28370281.
      View in: PubMed
    52. Davis HM, Pacheco-Costa R, Atkinson EG, Brun LR, Gortazar AR, Harris J, Hiasa M, Bolarinwa SA, Yoneda T, Ivan M, Bruzzaniti A, Bellido T, Plotkin LI. Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging. Aging Cell. 2017 06; 16(3):551-563. PMID: 28317237.
      View in: PubMed
    53. Sato AY, Richardson D, Cregor M, Davis HM, Au ED, McAndrews K, Zimmers TA, Organ JM, Peacock M, Plotkin LI, Bellido T. Glucocorticoids Induce Bone and Muscle Atrophy by Tissue-Specific Mechanisms Upstream of E3 Ubiquitin Ligases. Endocrinology. 2017 03 01; 158(3):664-677. PMID: 28359087.
      View in: PubMed
    54. Pellegrini GG, Cregor M, McAndrews K, Morales CC, McCabe LD, McCabe GP, Peacock M, Burr D, Weaver C, Bellido T. Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age. PLoS One. 2017; 12(2):e0171161. PMID: 28152064.
      View in: PubMed
    55. Ayus JC, Bellido T, Negri AL. Hyponatremia and fractures: should hyponatremia be further studied as a potential biochemical risk factor to be included in FRAX algorithms? Osteoporos Int. 2017 05; 28(5):1543-1548. PMID: 28074251.
      View in: PubMed
    56. Delgado-Calle J, Tu X, Pacheco-Costa R, McAndrews K, Edwards R, Pellegrini GG, Kuhlenschmidt K, Olivos N, Robling A, Peacock M, Plotkin LI, Bellido T. Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor. J Bone Miner Res. 2017 Mar; 32(3):522-535. PMID: 27704638.
      View in: PubMed
    57. Maycas M, McAndrews KA, Sato AY, Pellegrini GG, Brown DM, Allen MR, Plotkin LI, Gortazar AR, Esbrit P, Bellido T. PTHrP-Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading. J Bone Miner Res. 2017 Mar; 32(3):486-497. PMID: 27683064.
      View in: PubMed
    58. Delgado-Calle J, Sato AY, Bellido T. Role and mechanism of action of sclerostin in bone. Bone. 2017 03; 96:29-37. PMID: 27742498.
      View in: PubMed
    59. Plotkin LI, Bellido T. Erratum: Osteocytic signalling pathways as therapeutic targets for bone fragility. Nat Rev Endocrinol. 2016 Jul 29. PMID: 27469347.
      View in: PubMed
    60. Pellegrini GG, Morales CC, Wallace TC, Plotkin LI, Bellido T. Avenanthramides Prevent Osteoblast and Osteocyte Apoptosis and Induce Osteoclast Apoptosis in Vitro in an Nrf2-Independent Manner. Nutrients. 2016 Jul 11; 8(7). PMID: 27409635.
      View in: PubMed
    61. Sato AY, Cregor M, Delgado-Calle J, Condon KW, Allen MR, Peacock M, Plotkin LI, Bellido T. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin. J Bone Miner Res. 2016 10; 31(10):1791-1802. PMID: 27163932.
      View in: PubMed
    62. Plotkin LI, Bellido T. Osteocytic signalling pathways as therapeutic targets for bone fragility. Nat Rev Endocrinol. 2016 Oct; 12(10):593-605. PMID: 27230951.
      View in: PubMed
    63. Clinkenbeard EL, Cass TA, Ni P, Hum JM, Bellido T, Allen MR, White KE. Conditional Deletion of Murine Fgf23: Interruption of the Normal Skeletal Responses to Phosphate Challenge and Rescue of Genetic Hypophosphatemia. J Bone Miner Res. 2016 06; 31(6):1247-57. PMID: 26792657.
      View in: PubMed
    64. Delgado-Calle J, Anderson J, Cregor MD, Hiasa M, Chirgwin JM, Carlesso N, Yoneda T, Mohammad KS, Plotkin LI, Roodman GD, Bellido T. Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma. Cancer Res. 2016 Mar 01; 76(5):1089-100. PMID: 26833121.
      View in: PubMed
    65. Delgado-Calle J, Bellido T. Osteocytes and Skeletal Pathophysiology. Curr Mol Biol Rep. 2015 Dec; 1(4):157-167. PMID: 26693137.
      View in: PubMed
    66. Niziolek PJ, MacDonald BT, Kedlaya R, Zhang M, Bellido T, He X, Warman ML, Robling AG. High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo. J Bone Miner Res. 2015 Oct; 30(10):1822-30. PMID: 25808845.
      View in: PubMed
    67. Pacheco-Costa R, Davis HM, Sorenson C, Hon MC, Hassan I, Reginato RD, Allen MR, Bellido T, Plotkin LI. Defective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain. Bone. 2015 Dec; 81:632-643. PMID: 26409319.
      View in: PubMed
    68. Plotkin LI, Gortazar AR, Davis HM, Condon KW, Gabilondo H, Maycas M, Allen MR, Bellido T. Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor ?B ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading. J Biol Chem. 2015 Jul 31; 290(31):18934-42. PMID: 26085098.
      View in: PubMed
    69. Wright LE, Buijs JT, Kim HS, Coats LE, Scheidler AM, John SK, She Y, Murthy S, Ma N, Chin-Sinex HJ, Bellido TM, Bateman TA, Mendonca MS, Mohammad KS, Guise TA. Single-Limb Irradiation Induces Local and Systemic Bone Loss in a Murine Model. J Bone Miner Res. 2015 Jul; 30(7):1268-79. PMID: 25588731.
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    70. Tu X, Delgado-Calle J, Condon KW, Maycas M, Zhang H, Carlesso N, Taketo MM, Burr DB, Plotkin LI, Bellido T. Osteocytes mediate the anabolic actions of canonical Wnt/?-catenin signaling in bone. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):E478-86. PMID: 25605937.
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    71. Sato AY, Tu X, McAndrews KA, Plotkin LI, Bellido T. Prevention of glucocorticoid induced-apoptosis of osteoblasts and osteocytes by protecting against endoplasmic reticulum (ER) stress in vitro and in vivo in female mice. Bone. 2015 Apr; 73:60-8. PMID: 25532480.
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    72. Delgado-Calle J, Bellido T, Roodman GD. Role of osteocytes in multiple myeloma bone disease. Curr Opin Support Palliat Care. 2014 Dec; 8(4):407-13. PMID: 25289928.
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    73. Plotkin LI, Bellido T. Comment on Osteocytes: masters orchestrators of bone. Calcif Tissue Int. 2014 Oct; 95(4):382-3. PMID: 25116738.
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    74. Wang L, Zhang H, Rodriguez S, Cao L, Parish J, Mumaw C, Zollman A, Kamoka MM, Mu J, Chen DZ, Srour EF, Chitteti BR, HogenEsch H, Tu X, Bellido TM, Boswell HS, Manshouri T, Verstovsek S, Yoder MC, Kapur R, Cardoso AA, Carlesso N. Notch-dependent repression of miR-155 in the bone marrow niche regulates hematopoiesis in an NF-?B-dependent manner. Cell Stem Cell. 2014 Jul 03; 15(1):51-65. PMID: 24996169.
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    75. Artsi H, Cohen-Kfir E, Gurt I, Shahar R, Bajayo A, Kalish N, Bellido TM, Gabet Y, Dresner-Pollak R. The Sirtuin1 activator SRT3025 down-regulates sclerostin and rescues ovariectomy-induced bone loss and biomechanical deterioration in female mice. Endocrinology. 2014 Sep; 155(9):3508-15. PMID: 24949665.
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    76. Ben-awadh AN, Delgado-Calle J, Tu X, Kuhlenschmidt K, Allen MR, Plotkin LI, Bellido T. Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes. Endocrinology. 2014 Aug; 155(8):2797-809. PMID: 24877630.
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    77. Lezcano V, Bellido T, Plotkin LI, Boland R, Morelli S. Osteoblastic protein tyrosine phosphatases inhibition and connexin 43 phosphorylation by alendronate. Exp Cell Res. 2014 May 15; 324(1):30-9. PMID: 24698731.
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    78. Liu S, Song W, Boulanger JH, Tang W, Sabbagh Y, Kelley B, Gotschall R, Ryan S, Phillips L, Malley K, Cao X, Xia TH, Zhen G, Cao X, Ling H, Dechow PC, Bellido TM, Ledbetter SR, Schiavi SC. Role of TGF-? in a mouse model of high turnover renal osteodystrophy. J Bone Miner Res. 2014; 29(5):1141-57. PMID: 24166835.
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    79. Bellido T. Osteocyte-driven bone remodeling. Calcif Tissue Int. 2014 Jan; 94(1):25-34. PMID: 24002178.
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    80. Rhee Y, Lee EY, Lezcano V, Ronda AC, Condon KW, Allen MR, Plotkin LI, Bellido T. Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes. J Biol Chem. 2013 Oct 11; 288(41):29809-20. PMID: 23963454.
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    81. Bivi N, Pacheco-Costa R, Brun LR, Murphy TR, Farlow NR, Robling AG, Bellido T, Plotkin LI. Absence of Cx43 selectively from osteocytes enhances responsiveness to mechanical force in mice. J Orthop Res. 2013 Jul; 31(7):1075-81. PMID: 23483620.
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    82. Gortazar AR, Martin-Millan M, Bravo B, Plotkin LI, Bellido T. Crosstalk between caveolin-1/extracellular signal-regulated kinase (ERK) and ?-catenin survival pathways in osteocyte mechanotransduction. J Biol Chem. 2013 Mar 22; 288(12):8168-8175. PMID: 23362257.
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    83. Plotkin LI, Bellido T. Beyond gap junctions: Connexin43 and bone cell signaling. Bone. 2013 Jan; 52(1):157-66. PMID: 23041511.
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    84. Bellido T, Saini V, Pajevic PD. Effects of PTH on osteocyte function. Bone. 2013 Jun; 54(2):250-7. PMID: 23017659.
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    85. Bivi N, Condon KW, Allen MR, Farlow N, Passeri G, Brun LR, Rhee Y, Bellido T, Plotkin LI. Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation. J Bone Miner Res. 2012 Feb; 27(2):374-89. PMID: 22028311.
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    86. Calvi LM, Bromberg O, Rhee Y, Weber JM, Smith JN, Basil MJ, Frisch BJ, Bellido T. Osteoblastic expansion induced by parathyroid hormone receptor signaling in murine osteocytes is not sufficient to increase hematopoietic stem cells. Blood. 2012 Mar 15; 119(11):2489-99. PMID: 22262765.
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    87. Turek J, Ebetino FH, Lundy MW, Sun S, Kashemirov BA, McKenna CE, Gallant MA, Plotkin LI, Bellido T, Duan X, Triffitt JT, Russell RG, Burr DB, Allen MR. Bisphosphonate binding affinity affects drug distribution in both intracortical and trabecular bone of rabbits. Calcif Tissue Int. 2012 Mar; 90(3):202-10. PMID: 22249525.
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    88. Lezcano V, Bellido T, Plotkin LI, Boland R, Morelli S. Role of connexin 43 in the mechanism of action of alendronate: dissociation of anti-apoptotic and proliferative signaling pathways. Arch Biochem Biophys. 2012 Feb 15; 518(2):95-102. PMID: 22230328.
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    89. Tu X, Rhee Y, Condon KW, Bivi N, Allen MR, Dwyer D, Stolina M, Turner CH, Robling AG, Plotkin LI, Bellido T. Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading. Bone. 2012 Jan; 50(1):209-17. PMID: 22075208.
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    90. Bivi N, Lezcano V, Romanello M, Bellido T, Plotkin LI. Connexin43 interacts with ?arrestin: a pre-requisite for osteoblast survival induced by parathyroid hormone. J Cell Biochem. 2011 Oct; 112(10):2920-30. PMID: 21630325.
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    91. Khosla S, Bellido TM, Drezner MK, Gordon CM, Harris TB, Kiel DP, Kream BE, LeBoff MS, Lian JB, Peterson CA, Rosen CJ, Williams JP, Winer KK, Sherman SS. Forum on aging and skeletal health: summary of the proceedings of an ASBMR workshop. J Bone Miner Res. 2011 Nov; 26(11):2565-78. PMID: 21915901.
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    92. Rhee Y, Bivi N, Farrow E, Lezcano V, Plotkin LI, White KE, Bellido T. Parathyroid hormone receptor signaling in osteocytes increases the expression of fibroblast growth factor-23 in vitro and in vivo. Bone. 2011 Oct; 49(4):636-43. PMID: 21726676.
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    93. Robling AG, Kedlaya R, Ellis SN, Childress PJ, Bidwell JP, Bellido T, Turner CH. Anabolic and catabolic regimens of human parathyroid hormone 1-34 elicit bone- and envelope-specific attenuation of skeletal effects in Sost-deficient mice. Endocrinology. 2011 Aug; 152(8):2963-75. PMID: 21652726.
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    94. Rhee Y, Allen MR, Condon K, Lezcano V, Ronda AC, Galli C, Olivos N, Passeri G, O'Brien CA, Bivi N, Plotkin LI, Bellido T. PTH receptor signaling in osteocytes governs periosteal bone formation and intracortical remodeling. J Bone Miner Res. 2011 May; 26(5):1035-46. PMID: 21140374.
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    95. Gurkan UA, Kishore V, Condon KW, Bellido TM, Akkus O. A scaffold-free multicellular three-dimensional in vitro model of osteogenesis. Calcif Tissue Int. 2011 May; 88(5):388-401. PMID: 21318400.
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    96. Bellido T. Antagonistic interplay between mechanical forces and glucocorticoids in bone: a tale of kinases. J Cell Biochem. 2010 Sep 01; 111(1):1-6. PMID: 20506204.
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    97. Plotkin LI, Bivi N, Bellido T. A bisphosphonate that does not affect osteoclasts prevents osteoblast and osteocyte apoptosis and the loss of bone strength induced by glucocorticoids in mice. Bone. 2011 Jul; 49(1):122-7. PMID: 20736091.
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    98. Bellido T, Plotkin LI. Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viability. Bone. 2011 Jul; 49(1):50-5. PMID: 20727997.
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    99. Turner CH, Warden SJ, Bellido T, Plotkin LI, Kumar N, Jasiuk I, Danzig J, Robling AG. Mechanobiology of the skeleton. Sci Signal. 2009 Apr 28; 2(68):pt3. PMID: 19401590.
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    100. Bilezikian JP, Matsumoto T, Bellido T, Khosla S, Martin J, Recker RR, Heaney R, Seeman E, Papapoulos S, Goldring SR. Targeting bone remodeling for the treatment of osteoporosis: summary of the proceedings of an ASBMR workshop. J Bone Miner Res. 2009 Mar; 24(3):373-85. PMID: 19260805.
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    101. Plotkin LI, Lezcano V, Thostenson J, Weinstein RS, Manolagas SC, Bellido T. Connexin 43 is required for the anti-apoptotic effect of bisphosphonates on osteocytes and osteoblasts in vivo. J Bone Miner Res. 2008 Nov; 23(11):1712-21. PMID: 18597631.
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    102. O'Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling AG, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC, Bellido T. Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS One. 2008 Aug 13; 3(8):e2942. PMID: 18698360.
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    103. Bellido T, Plotkin LI. Detection of apoptosis of bone cells in vitro. Methods Mol Biol. 2008; 455:51-75. PMID: 18463810.
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    104. Robling AG, Niziolek PJ, Baldridge LA, Condon KW, Allen MR, Alam I, Mantila SM, Gluhak-Heinrich J, Bellido TM, Harris SE, Turner CH. Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem. 2008 Feb 29; 283(9):5866-75. PMID: 18089564.
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    105. Almeida M, Han L, Martin-Millan M, Plotkin LI, Stewart SA, Roberson PK, Kousteni S, O'Brien CA, Bellido T, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem. 2007 Sep 14; 282(37):27285-27297. PMID: 17623659.
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    106. Aguirre JI, Plotkin LI, Gortazar AR, Millan MM, O'Brien CA, Manolagas SC, Bellido T. A novel ligand-independent function of the estrogen receptor is essential for osteocyte and osteoblast mechanotransduction. J Biol Chem. 2007 Aug 31; 282(35):25501-8. PMID: 17609204.
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    107. Plotkin LI, Manolagas SC, Bellido T. Glucocorticoids induce osteocyte apoptosis by blocking focal adhesion kinase-mediated survival. Evidence for inside-out signaling leading to anoikis. J Biol Chem. 2007 Aug 17; 282(33):24120-30. PMID: 17581824.
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    108. Kousteni S, Almeida M, Han L, Bellido T, Jilka RL, Manolagas SC. Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor. Mol Cell Biol. 2007 Feb; 27(4):1516-30. PMID: 17158928.
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    109. Manolagas SC, Jilka RL, Kousteni S, Bellido T, Weinstein RS, O'Brien CA, Plotkin L, Han L. Response to Windahl et al. J Clin Invest. 2006 Nov; 116(11):2834. PMID: 17080186.
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    110. Robling AG, Bellido T, Turner CH. Mechanical stimulation in vivo reduces osteocyte expression of sclerostin. J Musculoskelet Neuronal Interact. 2006 Oct-Dec; 6(4):354. PMID: 17185821.
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    111. Bellido T. Downregulation of SOST/sclerostin by PTH: a novel mechanism of hormonal control of bone formation mediated by osteocytes. J Musculoskelet Neuronal Interact. 2006 Oct-Dec; 6(4):358-9. PMID: 17185824.
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    112. Plotkin LI, Manolagas SC, Bellido T. Dissociation of the pro-apoptotic effects of bisphosphonates on osteoclasts from their anti-apoptotic effects on osteoblasts/osteocytes with novel analogs. Bone. 2006 Sep; 39(3):443-52. PMID: 16627025.
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    113. Aguirre JI, Plotkin LI, Stewart SA, Weinstein RS, Parfitt AM, Manolagas SC, Bellido T. Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. J Bone Miner Res. 2006 Apr; 21(4):605-15. PMID: 16598381.
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    114. Almeida M, Han L, Bellido T, Manolagas SC, Kousteni S. Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J Biol Chem. 2005 Dec 16; 280(50):41342-51. PMID: 16251184.
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    115. Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, O'Brien CA, Manolagas SC, Jilka RL. Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. Endocrinology. 2005 Nov; 146(11):4577-83. PMID: 16081646.
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    116. Plotkin LI, Mathov I, Aguirre JI, Parfitt AM, Manolagas SC, Bellido T. Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs. Am J Physiol Cell Physiol. 2005 Sep; 289(3):C633-43. PMID: 15872009.
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    117. Vertino AM, Bula CM, Chen JR, Almeida M, Han L, Bellido T, Kousteni S, Norman AW, Manolagas SC. Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases. J Biol Chem. 2005 Apr 08; 280(14):14130-7. PMID: 15671029.
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    118. Plotkin LI, Aguirre JI, Kousteni S, Manolagas SC, Bellido T. Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation. J Biol Chem. 2005 Feb 25; 280(8):7317-25. PMID: 15590626.
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    119. Chen JR, Plotkin LI, Aguirre JI, Han L, Jilka RL, Kousteni S, Bellido T, Manolagas SC. Transient versus sustained phosphorylation and nuclear accumulation of ERKs underlie anti-versus pro-apoptotic effects of estrogens. J Biol Chem. 2005 Feb 11; 280(6):4632-8. PMID: 15557324.
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    120. Manolagas SC, Kousteni S, Chen JR, Schuller M, Plotkin L, Bellido T. Kinase-mediated transcription, activators of nongenotropic estrogen-like signaling (ANGELS), and osteoporosis: a different perspective on the HRT dilemma. Kidney Int Suppl. 2004 Oct; (91):S41-9. PMID: 15461702.
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    121. O'Brien CA, Jia D, Plotkin LI, Bellido T, Powers CC, Stewart SA, Manolagas SC, Weinstein RS. Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength. Endocrinology. 2004 Apr; 145(4):1835-41. PMID: 14691012.
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    122. Liu Y, Porta A, Peng X, Gengaro K, Cunningham EB, Li H, Dominguez LA, Bellido T, Christakos S. Prevention of glucocorticoid-induced apoptosis in osteocytes and osteoblasts by calbindin-D28k. J Bone Miner Res. 2004 Mar; 19(3):479-90. PMID: 15040837.
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    123. Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem. 2003 Dec 12; 278(50):50259-72. PMID: 14523023.
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    124. Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T, Manolagas SC. Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest. 2003 Jun; 111(11):1651-64. PMID: 12782668.
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    125. Ahuja SS, Zhao S, Bellido T, Plotkin LI, Jimenez F, Bonewald LF. CD40 ligand blocks apoptosis induced by tumor necrosis factor alpha, glucocorticoids, and etoposide in osteoblasts and the osteocyte-like cell line murine long bone osteocyte-Y4. Endocrinology. 2003 May; 144(5):1761-9. PMID: 12697681.
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    126. Kousteni S, Chen JR, Bellido T, Han L, Ali AA, O'Brien CA, Plotkin L, Fu Q, Mancino AT, Wen Y, Vertino AM, Powers CC, Stewart SA, Ebert R, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science. 2002 Oct 25; 298(5594):843-6. PMID: 12399595.
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    127. Weinstein RS, Chen JR, Powers CC, Stewart SA, Landes RD, Bellido T, Jilka RL, Parfitt AM, Manolagas SC. Promotion of osteoclast survival and antagonism of bisphosphonate-induced osteoclast apoptosis by glucocorticoids. J Clin Invest. 2002 Apr; 109(8):1041-8. PMID: 11956241.
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    128. Plotkin LI, Manolagas SC, Bellido T. Transduction of cell survival signals by connexin-43 hemichannels. J Biol Chem. 2002 Mar 08; 277(10):8648-57. PMID: 11741942.
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    129. Mathov I, Plotkin LI, Sgarlata CL, Leoni J, Bellido T. Extracellular signal-regulated kinases and calcium channels are involved in the proliferative effect of bisphosphonates on osteoblastic cells in vitro. J Bone Miner Res. 2001 Nov; 16(11):2050-6. PMID: 11697801.
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    130. Kousteni S, Bellido T, Plotkin LI, O'Brien CA, Bodenner DL, Han L, Han K, DiGregorio GB, Katzenellenbogen JA, Katzenellenbogen BS, Roberson PK, Weinstein RS, Jilka RL, Manolagas SC. Nongenotropic, sex-nonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell. 2001 Mar 09; 104(5):719-30. PMID: 11257226.
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    131. Plotkin LI, Bellido T. Bisphosphonate-induced, hemichannel-mediated, anti-apoptosis through the Src/ERK pathway: a gap junction-independent action of connexin43. Cell Commun Adhes. 2001; 8(4-6):377-82. PMID: 12064622.
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    132. O'Brien CA, Lin SC, Bellido T, Manolagas SC. Expression levels of gp130 in bone marrow stromal cells determine the magnitude of osteoclastogenic signals generated by IL-6-type cytokines. J Cell Biochem. 2000 Sep 14; 79(4):532-41. PMID: 10996844.
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    133. Bellido T, Huening M, Raval-Pandya M, Manolagas SC, Christakos S. Calbindin-D28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity. J Biol Chem. 2000 Aug 25; 275(34):26328-32. PMID: 10835428.
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    134. Plotkin LI, Weinstein RS, Parfitt AM, Roberson PK, Manolagas SC, Bellido T. Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. J Clin Invest. 1999 Nov; 104(10):1363-74. PMID: 10562298.
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    135. Jilka RL, Weinstein RS, Bellido T, Roberson P, Parfitt AM, Manolagas SC. Increased bone formation by prevention of osteoblast apoptosis with parathyroid hormone. J Clin Invest. 1999 Aug; 104(4):439-46. PMID: 10449436.
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    136. Carter CA, Bellido T. Decrease in protein tyrosine phosphorylation is associated with F-actin reorganization by retinoic acid in human endometrial adenocarcinoma (RL95-2) cells. J Cell Physiol. 1999 Mar; 178(3):320-32. PMID: 9989778.
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    137. Bellido T, O'Brien CA, Roberson PK, Manolagas SC. Transcriptional activation of the p21(WAF1,CIP1,SDI1) gene by interleukin-6 type cytokines. A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells. J Biol Chem. 1998 Aug 14; 273(33):21137-44. PMID: 9694869.
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    138. Jilka RL, Weinstein RS, Bellido T, Parfitt AM, Manolagas SC. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J Bone Miner Res. 1998 May; 13(5):793-802. PMID: 9610743.
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    139. Lin SC, Yamate T, Taguchi Y, Borba VZ, Girasole G, O'Brien CA, Bellido T, Abe E, Manolagas SC. Regulation of the gp80 and gp130 subunits of the IL-6 receptor by sex steroids in the murine bone marrow. J Clin Invest. 1997 Oct 15; 100(8):1980-90. PMID: 9329961.
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    140. Bellido T, Borba VZ, Roberson P, Manolagas SC. Activation of the Janus kinase/STAT (signal transducer and activator of transcription) signal transduction pathway by interleukin-6-type cytokines promotes osteoblast differentiation. Endocrinology. 1997 Sep; 138(9):3666-76. PMID: 9275051.
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    141. Bellido T, Stahl N, Farruggella TJ, Borba V, Yancopoulos GD, Manolagas SC. Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells. J Clin Invest. 1996 Jan 15; 97(2):431-7. PMID: 8567964.
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    142. Yu XP, Bellido T, Manolagas SC. Down-regulation of NF-kappa B protein levels in activated human lymphocytes by 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A. 1995 Nov 21; 92(24):10990-4. PMID: 7479923.
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    143. Bellido T, Jilka RL, Boyce BF, Girasole G, Broxmeyer H, Dalrymple SA, Murray R, Manolagas SC. Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest. 1995 Jun; 95(6):2886-95. PMID: 7769130.
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    144. Manolagas SC, Bellido T, Jilka RL. New insights into the cellular, biochemical, and molecular basis of postmenopausal and senile osteoporosis: roles of IL-6 and gp130. Int J Immunopharmacol. 1995 Feb; 17(2):109-16. PMID: 7657404.
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    145. Manolagas SC, Bellido T, Jilka RL. Sex steroids, cytokines and the bone marrow: new concepts on the pathogenesis of osteoporosis. Ciba Found Symp. 1995; 191:187-96; discussion 197-202. PMID: 8582197.
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    146. Sell?s J, Bellido T, Boland R. Modulation of calcium uptake in cultured cardiac muscle cells by 1,25-dihydroxyvitamin D3. J Mol Cell Cardiol. 1994 Dec; 26(12):1593-9. PMID: 7731054.
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    147. Manolagas SC, Yu XP, Girasole G, Bellido T. Vitamin D and the hematolymphopoietic tissue: a 1994 update. Semin Nephrol. 1994 Mar; 14(2):129-43. PMID: 8177980.
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    148. Pottratz ST, Bellido T, Mocharla H, Crabb D, Manolagas SC. 17 beta-Estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J Clin Invest. 1994 Mar; 93(3):944-50. PMID: 8132780.
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    149. Bellido T, Girasole G, Passeri G, Yu XP, Mocharla H, Jilka RL, Notides A, Manolagas SC. Demonstration of estrogen and vitamin D receptors in bone marrow-derived stromal cells: up-regulation of the estrogen receptor by 1,25-dihydroxyvitamin-D3. Endocrinology. 1993 Aug; 133(2):553-62. PMID: 8393768.
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    150. Manolagas SC, Jilka RL, Girasole G, Passeri G, Bellido T. Estrogen, cytokines, and the control of osteoclast formation and bone resorption in vitro and in vivo. Osteoporos Int. 1993; 3 Suppl 1:114-6. PMID: 8461536.
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    151. Bellido T, Morelli S, Fern?ndez LM, Boland R. Evidence for the participation of protein kinase C and 3',5'-cyclic AMP-dependent protein kinase in the stimulation of muscle cell proliferation by 1,25-dihydroxy-vitamin D3. Mol Cell Endocrinol. 1993 Jan; 90(2):231-8. PMID: 7684342.
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    152. Bellido T, Boland R, Teresita B, Ricardo B. Effects of 1,25-dihydroxy-vitamin D3 on phosphate accumulation by myoblasts. Horm Metab Res. 1991 Mar; 23(3):113-6. PMID: 1650748.
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    153. Bellido T, Boland R. Stimulation of myoblast membrane protein synthesis by 25-hydroxy-vitamin D3. Z Naturforsch C J Biosci. 1989 Sep-Oct; 44(9-10):807-12. PMID: 2590342.
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    154. Bellido T, Drittanti L, Boland R, de Boland AR. The phospholipid and fatty acid composition of skeletal muscle cells during culture in the presence of vitamin D-3 metabolites. Biochim Biophys Acta. 1987 Nov 21; 922(2):162-9. PMID: 3676341.
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    155. Bellido T, Boland R. Phosphate accumulation by muscle in vitro and the influence of vitamin D3 metabolites. Z Naturforsch C J Biosci. 1987 Mar; 42(3):237-44. PMID: 2954321.
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