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Rushita Bagchi

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPhysiology & Cell Biology, College of Medicine
DivisionCardiovascular Medicine
Address CAMPUS
4301 W. Markham
Mail Slot # 532
Little Rock AR 72205
ORCID ORCID Icon0000-0002-9075-0766 Additional info
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    Collapse Biography 
    Collapse education and training
    University of Manitoba, CanadaPh.D.05/2016Molecular Cardiovascular Pathophysiology
    The Maharaja Sayajirao University of Baroda, IndiaMS05/2005Zoology
    The Maharaja Sayajirao University of Baroda, IndiaBS05/2003Zoology

    Collapse Research 
    Collapse research activities and funding
    23CDA1048663     (Rushita Bagchi)Apr 1, 2023 - Mar 31, 2026
    American Heart Association Career Development Award
    HDAC11 in Diabetic Cardiomyopathy
    Role: Principle Investigator
    23CDA1048663     (BAGCHI, RUSHITA)Apr 1, 2023 - Mar 31, 2026
    American Heart Association
    HDAC11 in Diabetic Cardiomyopathy
    Role: Principal Investigator
    AWD55580     (Rushita Bagchi)Jan 1, 2023 - Dec 31, 2023
    Brunson Endowment Grant for Cardiovascular Diseases Research/UAMS College of Medicine
    Mapping the interactome of a lysine demyristoylase in the diabetic heart
    Role: Principle Investigator
    AWD55281     (Rushita Bagchi)May 1, 2022 - Apr 30, 2023
    Sturgis Endowment Grant for Diabetes Research/UAMS College of Medicine
    A Multi-omics Approach to Identify Mechanisms of HDAC11 mediated Lipid Regulation in the Diabetic Heart
    Role: Principle Investigator
         (Rushita Bagchi)May 31, 2017 - May 30, 2020
    Canadian Institutes of Health Research (CIHR) Postdoctoral Research Fellowship
    Epigenetic regulation of cardiac hypertrophy by BET acetyl-lysine binding proteins
    Role: Principle Investigator
         (Rushita Bagchi)Sep 30, 2012 - Sep 29, 2015
    Canadian Institutes of Health Research (CIHR)/Research Manitoba Predoctoral Research Award
    Elucidation of the regulatory role of scleraxis in cardiac fibrosis
    Role: Principle Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Robinson EL, Bagchi RA, Major JL, Bergman BC, Matsuda JL, McKinsey TA. HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance. J Clin Invest. 2023 10 02; 133(19). PMID: 37607030.
      View in: PubMed
    2. Robinson EL, Bagchi RA, Major JL, Bergman BC, Madsuda JL, McKinsey TA. HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance. bioRxiv. 2023 Mar 30. PMID: 37034582.
      View in: PubMed
    3. Nagalingam RS, Chattopadhyaya S, Al-Hattab DS, Cheung DYC, Schwartz LY, Jana S, Aroutiounova N, Ledingham DA, Moffatt TL, Landry NM, Bagchi RA, Dixon IMC, Wigle JT, Oudit GY, Kassiri Z, Jassal DS, Czubryt MP. Scleraxis and fibrosis in the pressure-overloaded heart. Eur Heart J. 2022 Dec 01; 43(45):4739-4750. PMID: 36200607.
      View in: PubMed
    4. Rangarajan S, Locy ML, Chanda D, Kurundkar A, Kurundkar D, Larson-Casey JL, Londono P, Bagchi RA, Deskin B, Elajaili H, Nozik ES, Deshane JS, Zmijewski JW, Eickelberg O, Thannickal VJ. Mitochondrial uncoupling protein-2 reprograms metabolism to induce oxidative stress and myofibroblast senescence in age-associated lung fibrosis. Aging Cell. 2022 09; 21(9):e13674. PMID: 35934931.
      View in: PubMed
    5. Bagchi RA, Robinson EL, Hu T, Cao J, Hong JY, Tharp CA, Qasim H, Gavin KM, Pires da Silva J, Major JL, McConnell BK, Seto E, Lin H, McKinsey TA. Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling. Proc Natl Acad Sci U S A. 2022 02 15; 119(7). PMID: 35149557.
      View in: PubMed
    6. ?akir I, Hadley CK, Pan PL, Bagchi RA, Ghamari-Langroudi M, Porter DT, Wang Q, Litt MJ, Jana S, Hagen S, Lee P, White A, Lin JD, McKinsey TA, Cone RD. Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity. Nat Metab. 2022 01; 4(1):44-59. PMID: 35039672.
      View in: PubMed
    7. Soranno DE, Baker P, Kirkbride-Romeo L, Wennersten SA, Ding K, Keith B, Cavasin MA, Altmann C, Bagchi RA, Haefner KR, Montford J, Gist KM, Vergnes L, Reue K, He Z, Elajaili H, Okamura K, Nozik E, McKinsey TA, Faubel S. Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia-reperfusion acute kidney injury. Sci Rep. 2022 01 12; 12(1):643. PMID: 35022484.
      View in: PubMed
    8. Jahan F, Bagchi RA. Enhancing NAD+ Metabolome in Cardiovascular Diseases: Promises and Considerations. Front Cardiovasc Med. 2021; 8:716989. PMID: 34513955.
      View in: PubMed
    9. Ambruso SL, Gil HW, Fox B, Park B, Altmann C, Bagchi RA, Baker PR, Reisz JA, Faubel S. Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion. Am J Physiol Lung Cell Mol Physiol. 2021 07 01; 321(1):L50-L64. PMID: 33949208.
      View in: PubMed
    10. Travers JG, Wennersten SA, Pe?a B, Bagchi RA, Smith HE, Hirsch RA, Vanderlinden LA, Lin YH, Dobrinskikh E, Demos-Davies KM, Cavasin MA, Mestroni L, Steink?hler C, Lin CY, Houser SR, Woulfe KC, Lam MPY, McKinsey TA. HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling. Circulation. 2021 05 11; 143(19):1874-1890. PMID: 33682427.
      View in: PubMed
    11. Soranno DE, Kirkbride-Romeo L, Wennersten SA, Ding K, Cavasin MA, Baker P, Altmann C, Bagchi RA, Haefner KR, Steink?hler C, Montford JR, Keith B, Gist KM, McKinsey TA, Faubel S. Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition. JACC Basic Transl Sci. 2021 Feb; 6(2):119-133. PMID: 33665513.
      View in: PubMed
    12. Major JL, Bagchi RA, Pires da Silva J. Application of microRNA Database Mining in Biomarker Discovery and Identification of Therapeutic Targets for Complex Disease. Methods Protoc. 2020 Dec 30; 4(1). PMID: 33396619.
      View in: PubMed
    13. Riching AS, Danis E, Zhao Y, Cao Y, Chi C, Bagchi RA, Klein BJ, Xu H, Kutateladze TG, McKinsey TA, Buttrick PM, Song K. Suppression of canonical TGF-? signaling enables GATA4 to interact with H3K27me3 demethylase JMJD3 to promote cardiomyogenesis. J Mol Cell Cardiol. 2021 04; 153:44-59. PMID: 33359755.
      View in: PubMed
    14. Hsu JY, Major JL, Riching AS, Sen R, Pires da Silva J, Bagchi RA. Beyond the genome: challenges and potential for epigenetics-driven therapeutic approaches in pulmonary arterial hypertension. Biochem Cell Biol. 2020 12; 98(6):631-646. PMID: 32706995.
      View in: PubMed
    15. Major JL, Bagchi RA, McKinsey TA. ERRing on the Side of a Mature Heart. Circ Res. 2020 06 05; 126(12):1703-1705. PMID: 32496915.
      View in: PubMed
    16. Riching AS, Major JL, Londono P, Bagchi RA. The Brain-Heart Axis: Alzheimer's, Diabetes, and Hypertension. ACS Pharmacol Transl Sci. 2020 Feb 14; 3(1):21-28. PMID: 32259085.
      View in: PubMed
    17. Stratton MS, Bagchi RA, Felisbino MB, Hirsch RA, Smith HE, Riching AS, Enyart BY, Koch KA, Cavasin MA, Alexanian M, Song K, Qi J, Lemieux ME, Srivastava D, Lam MPY, Haldar SM, Lin CY, McKinsey TA. Dynamic Chromatin Targeting of BRD4 Stimulates Cardiac Fibroblast Activation. Circ Res. 2019 09 13; 125(7):662-677. PMID: 31409188.
      View in: PubMed
    18. Bagchi RA, Weeks KL. Histone deacetylases in cardiovascular and metabolic diseases. J Mol Cell Cardiol. 2019 05; 130:151-159. PMID: 30978343.
      View in: PubMed
    19. Hu T, Schreiter FC, Bagchi RA, Tatman PD, Hannink M, McKinsey TA. HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression. J Biol Chem. 2019 05 24; 294(21):8640-8652. PMID: 30962285.
      View in: PubMed
    20. Fox BM, Gil HW, Kirkbride-Romeo L, Bagchi RA, Wennersten SA, Haefner KR, Skrypnyk NI, Brown CN, Soranno DE, Gist KM, Griffin BR, Jovanovich A, Reisz JA, Wither MJ, D'Alessandro A, Edelstein CL, Clendenen N, McKinsey TA, Altmann C, Faubel S. Metabolomics assessment reveals oxidative stress and altered energy production in the heart after ischemic acute kidney injury in mice. Kidney Int. 2019 03; 95(3):590-610. PMID: 30709662.
      View in: PubMed
    21. Wang R, Lin J, Bagchi RA. Novel molecular therapeutic targets in cardiac fibrosis: a brief overview 1. Can J Physiol Pharmacol. 2019 Apr; 97(4):246-256. PMID: 30388374.
      View in: PubMed
    22. Maksymiuk AW, Sitar DS, Ahmed R, Cheng B, Bach H, Bagchi RA, Aroutiounova N, Tappia PS, Ramjiawan B. Spermidine/spermine N1-acetyltransferase-1?as a diagnostic biomarker in human cancer. Future Sci OA. 2018 Dec; 4(10):FSO345. PMID: 30450232.
      View in: PubMed
    23. Bagchi RA, Ferguson BS, Stratton MS, Hu T, Cavasin MA, Sun L, Lin YH, Liu D, Londono P, Song K, Pino MF, Sparks LM, Smith SR, Scherer PE, Collins S, Seto E, McKinsey TA. HDAC11 suppresses the thermogenic program of adipose tissue via BRD2. JCI Insight. 2018 08 09; 3(15). PMID: 30089714.
      View in: PubMed
    24. Al-Hattab DS, Safi HA, Nagalingam RS, Bagchi RA, Stecy MT, Czubryt MP. Scleraxis regulates Twist1 and Snai1 expression in the epithelial-to-mesenchymal transition. Am J Physiol Heart Circ Physiol. 2018 09 01; 315(3):H658-H668. PMID: 29906225.
      View in: PubMed
    25. Nagalingam RS, Safi HA, Al-Hattab DS, Bagchi RA, Landry NM, Dixon IMC, Wigle JT, Czubryt MP. Regulation of cardiac fibroblast MMP2 gene expression by scleraxis. J Mol Cell Cardiol. 2018 07; 120:64-73. PMID: 29750994.
      View in: PubMed
    26. Habibian JS, Jefic M, Bagchi RA, Lane RH, McKnight RA, McKinsey TA, Morrison RF, Ferguson BS. DUSP5 functions as a feedback regulator of TNFa-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes. Sci Rep. 2017 10 10; 7(1):12879. PMID: 29018280.
      View in: PubMed
    27. Roche PL, Nagalingam RS, Bagchi RA, Aroutiounova N, Belisle BM, Wigle JT, Czubryt MP. Role of scleraxis in mechanical stretch-mediated regulation of cardiac myofibroblast phenotype. Am J Physiol Cell Physiol. 2016 08 01; 311(2):C297-307. PMID: 27357547.
      View in: PubMed
    28. Bagchi RA, Lin J, Wang R, Czubryt MP. Regulation of fibronectin gene expression in cardiac fibroblasts by scleraxis. Cell Tissue Res. 2016 Nov; 366(2):381-391. PMID: 27324126.
      View in: PubMed
    29. Bagchi RA, Roche P, Aroutiounova N, Espira L, Abrenica B, Schweitzer R, Czubryt MP. The transcription factor scleraxis is a critical regulator of cardiac fibroblast phenotype. BMC Biol. 2016 Mar 17; 14:21. PMID: 26988708.
      View in: PubMed
    30. Bagchi RA, Wang R, Jahan F, Wigle JT, Czubryt MP. Regulation of scleraxis transcriptional activity by serine phosphorylation. J Mol Cell Cardiol. 2016 Mar; 92:140-8. PMID: 26883788.
      View in: PubMed
    31. Dakshinamurti K, Bagchi RA, Abrenica B, Czubryt MP. Microarray analysis of pancreatic gene expression during biotin repletion in biotin-deficient rats. Can J Physiol Pharmacol. 2015 Dec; 93(12):1103-10. PMID: 26312779.
      View in: PubMed
    32. Bagchi RA, Mozolevska V, Abrenica B, Czubryt MP. Development of a high throughput luciferase reporter gene system for screening activators and repressors of human collagen Ia2 gene expression. Can J Physiol Pharmacol. 2015 Oct; 93(10):887-92. PMID: 25955599.
      View in: PubMed
    33. Roche PL, Filomeno KL, Bagchi RA, Czubryt MP. Intracellular signaling of cardiac fibroblasts. Compr Physiol. 2015 Apr; 5(2):721-60. PMID: 25880511.
      View in: PubMed
    34. Ramjiawan A, Bagchi RA, Blant A, Albak L, Cavasin MA, Horn TR, McKinsey TA, Czubryt MP. Roles of histone deacetylation and AMP kinase in regulation of cardiomyocyte PGC-1a gene expression in hypoxia. Am J Physiol Cell Physiol. 2013 Jun 01; 304(11):C1064-72. PMID: 23515531.
      View in: PubMed
    35. Ramjiawan A, Bagchi RA, Albak L, Czubryt MP. Mechanism of cardiomyocyte PGC-1a gene regulation by ERRa. Biochem Cell Biol. 2013 Jun; 91(3):148-54. PMID: 23668787.
      View in: PubMed
    36. Wright DB, Trian T, Siddiqui S, Pascoe CD, Johnson JR, Dekkers BG, Dakshinamurti S, Bagchi R, Burgess JK, Kanabar V, Ojo OO. Phenotype modulation of airway smooth muscle in asthma. Pulm Pharmacol Ther. 2013 Feb; 26(1):42-9. PMID: 22939888.
      View in: PubMed
    37. Wright DB, Trian T, Siddiqui S, Pascoe CD, Ojo OO, Johnson JR, Dekkers BG, Dakshinamurti S, Bagchi R, Burgess JK, Kanabar V. Functional phenotype of airway myocytes from asthmatic airways. Pulm Pharmacol Ther. 2013 Feb; 26(1):95-104. PMID: 22921313.
      View in: PubMed
    38. Yeganeh B, Mukherjee S, Moir LM, Kumawat K, Kashani HH, Bagchi RA, Baarsma HA, Gosens R, Ghavami S. Novel non-canonical TGF-? signaling networks: emerging roles in airway smooth muscle phenotype and function. Pulm Pharmacol Ther. 2013 Feb; 26(1):50-63. PMID: 22874922.
      View in: PubMed
    39. Bagchi RA, Czubryt MP. Synergistic roles of scleraxis and Smads in the regulation of collagen 1a2 gene expression. Biochim Biophys Acta. 2012 Oct; 1823(10):1936-44. PMID: 22796342.
      View in: PubMed
    40. Rydell-T?rm?nen K, Risse PA, Kanabar V, Bagchi R, Czubryt MP, Johnson JR. Smooth muscle in tissue remodeling and hyper-reactivity: airways and arteries. Pulm Pharmacol Ther. 2013 Feb; 26(1):13-23. PMID: 22561160.
      View in: PubMed
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