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Maria Schuller De Almeida

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Endo
Address825 Cancer Institute Trailer 4
4104 Outpatient Circle
Mail Slot # 587
Little Rock AR 72205
Phone501-686-7856
vCardDownload vCard
    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentOrthopaedics, College of Medicine


    Collapse Research 
    Collapse research activities and funding
    R01AR082418     (SCHULLER DE ALMEIDA, MARIA)Mar 22, 2024 - Feb 28, 2025
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases
    Antagonism of RANKL signaling by estrogen in osteoclasts
    Role: Principal Investigator
    2P20GM125503     (OBRIEN, CHARLES A)Apr 1, 2023 - Jun 30, 2028
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Principal Investigator
    2P20GM125503-06     (OBRIEN, CHARLES A)Apr 1, 2023 - Jan 31, 2028
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Principal Investigator
    P20GM125503     (OBRIEN, CHARLES A)Apr 1, 2023 - Jan 31, 2028
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Co-Investigator
    2R56AR056679     (SCHULLER DE ALMEIDA, MARIA)Sep 1, 2021 - Aug 31, 2024
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases
    Mechanisms of decreased bone formation with aging
    Role: Principal Investigator
    2R56AR056679-11A1     (SCHULLER DE ALMEIDA, MARIA)Sep 1, 2021 - Aug 31, 2024
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases
    Mechanisms of decreased bone formation with aging
    Role: Principal Investigator
    R01AG068449     (OBRIEN, CHARLES A)Apr 1, 2021 - Dec 31, 2025
    NIH/Nat. Inst. on Aging
    Different consequences of cellular aging in cortical versus cancellous bone
    Role: Select
    1R01AG068449     (OBRIEN, CHARLES A)Apr 1, 2021 - Dec 31, 2025
    NIH/Nat. Inst. on Aging
    Different consequences of cellular aging in cortical versus cancellous bone
    Role: Principal Investigator
    1R01AG068449-01A1     (OBRIEN, CHARLES A)Apr 1, 2021 - Dec 31, 2025
    NIH/Nat. Inst. on Aging
    Different consequences of cellular aging in cortical versus cancellous bone
    Role: Principal Investigator
    S10OD026736     (MACKINTOSH, SAMUEL G.)Aug 1, 2019 - Jul 31, 2020
    NIH
    Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer
    Role: Co-Investigator
    R01AR056679     (SCHULLER DE ALMEIDA, MARIA)Dec 1, 2008 - Jan 31, 2022
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases
    Role of FoxOs in Skeletal Homeostasis- Resubmission - Continuation-Continuation - Continuation - Continuation
    Role: Principal Investigator
    R01AR051187     (KOUSTENI, STAVROULA)Feb 1, 2005 - Dec 31, 2008
    NIH
    OSTEOBLAST COMMITMENT AND DIFFERENTIATION BY ANGELS
    Role: Co-Investigator
    P01AG013918     (MANOLAGAS, STAVROS C.)Aug 27, 1996 - Apr 30, 2018
    NIH
    Molecular and Cellular Mechanisms of Osteoporosis
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Ling W, Krager K, Richardson KK, Warren AD, Ponte F, Aykin-Burns N, Manolagas SC, Almeida M, Kim HN. Mitochondrial Sirt3 contributes to the bone loss caused by aging or estrogen deficiency. JCI Insight. 2021 05 24; 6(10). PMID: 33878033.
      View in: PubMed
    2. Kim HN, Ponte F, Warren A, Ring R, Iyer S, Han L, Almeida M. A decrease in NAD+ contributes to the loss of osteoprogenitors and bone mass with aging. NPJ Aging Mech Dis. 2021 Apr 01; 7(1):8. PMID: 33795658.
      View in: PubMed
    3. Evans DS, O'Leary MN, Murphy R, Schmidt M, Koenig K, Presley M, Garrett B, Kim HN, Han L, Academia EC, Laye MJ, Edgar D, Zambataro CA, Barhydt T, Dewey CM, Mayfield J, Wilson J, Alavez S, Lucanic M, Kennedy BK, Almeida M, Andersen JK, Kapahi P, Lithgow GJ, Melov S. Longitudinal Functional Study of Murine Aging: A Resource for Future Study Designs. JBMR Plus. 2021 Mar; 5(3):e10466. PMID: 33778327.
      View in: PubMed
    4. Almeida M, Kim HN, Han L, Zhou D, Thostenson J, Porter RM, Ambrogini E, Manolagas SC, Jilka RL. Increased marrow adipogenesis does not contribute to age-dependent appendicular bone loss in female mice. Aging Cell. 2020 11; 19(11):e13247. PMID: 33048436.
      View in: PubMed
    5. Kim HN, Xiong J, MacLeod RS, Iyer S, Fujiwara Y, Cawley KM, Han L, He Y, Thostenson JD, Ferreira E, Jilka RL, Zhou D, Almeida M, O'Brien CA. Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence. JCI Insight. 2020 10 02; 5(19). PMID: 32870816.
      View in: PubMed
    6. Kim HN, Ponte F, Nookaew I, Ucer Ozgurel S, Marques-Carvalho A, Iyer S, Warren A, Aykin-Burns N, Krager K, Sardao VA, Han L, de Cabo R, Zhao H, Jilka RL, Manolagas SC, Almeida M. Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors. Sci Rep. 2020 07 20; 10(1):11933. PMID: 32686739.
      View in: PubMed
    7. He Y, Zhang X, Chang J, Kim HN, Zhang P, Wang Y, Khan S, Liu X, Zhang X, Lv D, Song L, Li W, Thummuri D, Yuan Y, Wiegand JS, Ortiz YT, Budamagunta V, Elisseeff JH, Campisi J, Almeida M, Zheng G, Zhou D. Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity. Nat Commun. 2020 04 24; 11(1):1996. PMID: 32332723.
      View in: PubMed
    8. Ponte F, Kim HN, Iyer S, Han L, Almeida M, Manolagas SC. Cxcl12 Deletion in Mesenchymal Cells Increases Bone Turnover and Attenuates the Loss of Cortical Bone Caused by Estrogen Deficiency in Mice. J Bone Miner Res. 2020 08; 35(8):1441-1451. PMID: 32154948.
      View in: PubMed
    9. Iyer S, Melendez-Suchi C, Han L, Baldini G, Almeida M, Jilka RL. Elevation of the unfolded protein response increases RANKL expression. FASEB Bioadv. 2020 Apr; 2(4):207-218. PMID: 32259048.
      View in: PubMed
    10. Li X, Han L, Nookaew I, Mannen E, Silva MJ, Almeida M, Xiong J. Stimulation of Piezo1 by mechanical signals promotes bone anabolism. Elife. 2019 10 07; 8. PMID: 31588901.
      View in: PubMed
    11. Almeida M, Porter RM. Sirtuins and FoxOs in osteoporosis and osteoarthritis. Bone. 2019 04; 121:284-292. PMID: 30738214.
      View in: PubMed
    12. Farr JN, Almeida M. The Spectrum of Fundamental Basic Science Discoveries Contributing to Organismal Aging. J Bone Miner Res. 2018 09; 33(9):1568-1584. PMID: 30075061.
      View in: PubMed
    13. Xiong J, Almeida M, O'Brien CA. The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation. Bone. 2018 07; 112:1-9. PMID: 29626544.
      View in: PubMed
    14. Kim HN, Iyer S, Ring R, Almeida M. The Role of FoxOs in Bone Health and Disease. Curr Top Dev Biol. 2018; 127:149-163. PMID: 29433736.
      View in: PubMed
    15. Piemontese M, Almeida M, Robling AG, Kim HN, Xiong J, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA, Jilka RL. Old age causes de novo intracortical bone remodeling and porosity in mice. JCI Insight. 2017 09 07; 2(17). PMID: 28878136.
      View in: PubMed
    16. Kim HN, Chang J, Shao L, Han L, Iyer S, Manolagas SC, O'Brien CA, Jilka RL, Zhou D, Almeida M. DNA damage and senescence in osteoprogenitors expressing Osx1 may cause their decrease with age. Aging Cell. 2017 08; 16(4):693-703. PMID: 28401730.
      View in: PubMed
    17. Almeida M, Laurent MR, Dubois V, Claessens F, O'Brien CA, Bouillon R, Vanderschueren D, Manolagas SC. Estrogens and Androgens in Skeletal Physiology and Pathophysiology. Physiol Rev. 2017 01; 97(1):135-187. PMID: 27807202.
      View in: PubMed
    18. Ucer S, Iyer S, Kim HN, Han L, Rutlen C, Allison K, Thostenson JD, de Cabo R, Jilka RL, O'Brien C, Almeida M, Manolagas SC. The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct. J Bone Miner Res. 2017 Mar; 32(3):560-574. PMID: 27714847.
      View in: PubMed
    19. Iyer S, Han L, Ambrogini E, Yavropoulou M, Fowlkes J, Manolagas SC, Almeida M. Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes. J Bone Miner Res. 2017 01; 32(1):60-69. PMID: 27491024.
      View in: PubMed
    20. Liu Y, Almeida M, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice. Am J Physiol Endocrinol Metab. 2016 May 01; 310(9):E762-73. PMID: 26956187.
      View in: PubMed
    21. Kim HN, Han L, Iyer S, de Cabo R, Zhao H, O'Brien CA, Manolagas SC, Almeida M. Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs. Mol Endocrinol. 2015 Oct; 29(10):1498-509. PMID: 26287518.
      View in: PubMed
    22. Ucer S, Iyer S, Bartell SM, Martin-Millan M, Han L, Kim HN, Weinstein RS, Jilka RL, O'Brien CA, Almeida M, Manolagas SC. The Effects of Androgens on Murine Cortical Bone Do Not Require AR or ERa Signaling in Osteoblasts and Osteoclasts. J Bone Miner Res. 2015 Jul; 30(7):1138-49. PMID: 25704845.
      View in: PubMed
    23. Piemontese M, Onal M, Xiong J, Wang Y, Almeida M, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone. Bone. 2015 Jun; 75:18-26. PMID: 25700544.
      View in: PubMed
    24. Iyer S, Han L, Bartell SM, Kim HN, Gubrij I, de Cabo R, O'Brien CA, Manolagas SC, Almeida M. Sirtuin1 (Sirt1) promotes cortical bone formation by preventing ?-catenin sequestration by FoxO transcription factors in osteoblast progenitors. J Biol Chem. 2014 Aug 29; 289(35):24069-78. PMID: 25002589.
      View in: PubMed
    25. Mercken EM, Mitchell SJ, Martin-Montalvo A, Minor RK, Almeida M, Gomes AP, Scheibye-Knudsen M, Palacios HH, Licata JJ, Zhang Y, Becker KG, Khraiwesh H, Gonz?lez-Reyes JA, Villalba JM, Baur JA, Elliott P, Westphal C, Vlasuk GP, Ellis JL, Sinclair DA, Bernier M, de Cabo R. SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass. Aging Cell. 2014 Oct; 13(5):787-96. PMID: 24931715.
      View in: PubMed
    26. Bartell SM, Kim HN, Ambrogini E, Han L, Iyer S, Serra Ucer S, Rabinovitch P, Jilka RL, Weinstein RS, Zhao H, O'Brien CA, Manolagas SC, Almeida M. FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H2O2 accumulation. Nat Commun. 2014 Apr 30; 5:3773. PMID: 24781012.
      View in: PubMed
    27. Manolagas SC, O'Brien CA, Almeida M. The role of estrogen and androgen receptors in bone health and disease. Nat Rev Endocrinol. 2013 Dec; 9(12):699-712. PMID: 24042328.
      View in: PubMed
    28. Iyer S, Ambrogini E, Bartell SM, Han L, Roberson PK, de Cabo R, Jilka RL, Weinstein RS, O'Brien CA, Manolagas SC, Almeida M. FOXOs attenuate bone formation by suppressing Wnt signaling. J Clin Invest. 2013 Aug; 123(8):3409-19. PMID: 23867625.
      View in: PubMed
    29. Almeida M, O'Brien CA. Basic biology of skeletal aging: role of stress response pathways. J Gerontol A Biol Sci Med Sci. 2013 Oct; 68(10):1197-208. PMID: 23825036.
      View in: PubMed
    30. Onal M, Piemontese M, Xiong J, Wang Y, Han L, Ye S, Komatsu M, Selig M, Weinstein RS, Zhao H, Jilka RL, Almeida M, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes mimics skeletal aging. J Biol Chem. 2013 Jun 14; 288(24):17432-40. PMID: 23645674.
      View in: PubMed
    31. Bartell SM, Han L, Kim HN, Kim SH, Katzenellenbogen JA, Katzenellenbogen BS, Chambliss KL, Shaul PW, Roberson PK, Weinstein RS, Jilka RL, Almeida M, Manolagas SC. Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass. Mol Endocrinol. 2013 Apr; 27(4):649-56. PMID: 23443267.
      View in: PubMed
    32. Almeida M, Iyer S, Martin-Millan M, Bartell SM, Han L, Ambrogini E, Onal M, Xiong J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. Estrogen receptor-alpha signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest. 2013; 123(1):394 - 404.
    33. Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, Manolagas SC, O'Brien CA. Receptor activator of nuclear factor kappaB ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 2012; 287(35):29851 - 29860.
    34. Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, Manolagas SC, O'Brien CA. Receptor activator of nuclear factor ?B ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 2012 Aug 24; 287(35):29851-60. PMID: 22782898.
      View in: PubMed
    35. Almeida M. Aging mechanisms in bone. BoneKEy Reports. 2012; 1:102.
    36. Almeida M, Han L, Ambrogini E, Weinstein RS, Manolagas SC. Glucocorticoids and tumor necrosis factor alpha increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem. 2011; 286(52):44326 - 44335.
    37. Almeida M, Han L, Ambrogini E, Weinstein RS, Manolagas SC. Glucocorticoids and tumor necrosis factor a increase oxidative stress and suppress Wnt protein signaling in osteoblasts. J Biol Chem. 2011 Dec 30; 286(52):44326-35. PMID: 22030390.
      View in: PubMed
    38. Weinstein RS, O'Brien CA, Almeida M, Zhao H, Roberson PK, Jilka RL, Manolagas SC. Osteoprotegerin prevents glucocorticoid-induced osteocyte apoptosis in mice. Endocrinology. 2011 Sep; 152(9):3323-31. PMID: 21771887.
      View in: PubMed
    39. Almeida M. Unraveling the role of FoxOs in bone--insights from mouse models. Bone. 2011 Sep; 49(3):319-27. PMID: 21664311.
      View in: PubMed
    40. Jilka RL, Almeida M, Ambrogini E, Han L, Roberson PK, Weinstein RS, Manolagas SC. Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration. Aging Cell. 2010 Oct; 9(5):851-67. PMID: 20698835.
      View in: PubMed
    41. Almeida M, Han L, Ambrogini E, Bartell SM, Manolagas SC. Oxidative stress stimulates apoptosis and activates NF-kappaB in osteoblastic cells via a PKCbeta/p66shc signaling cascade: counter regulation by estrogens or androgens. Mol Endocrinol. 2010 Oct; 24(10):2030-7. PMID: 20685851.
      View in: PubMed
    42. Weinstein RS, Jilka RL, Almeida M, Roberson PK, Manolagas SC. Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice. Endocrinology. 2010 Jun; 151(6):2641-9. PMID: 20410195.
      View in: PubMed
    43. Almeida M, Martin-Millan M, Ambrogini E, Bradsher R, Han L, Chen XD, Roberson PK, Weinstein RS, O'Brien CA, Jilka RL, Manolagas SC. Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions of the ERalpha. J Bone Miner Res. 2010 Apr; 25(4):769-81. PMID: 19821774.
      View in: PubMed
    44. Ambrogini E, Almeida M, Martin-Millan M, Paik JH, Depinho RA, Han L, Goellner J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab. 2010 Feb 03; 11(2):136-46. PMID: 20142101.
      View in: PubMed
    45. Martin-Millan M, Almeida M, Ambrogini E, Han L, Zhao H, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. The estrogen receptor-alpha in osteoclasts mediates the protective effects of estrogens on cancellous but not cortical bone. Mol Endocrinol. 2010 Feb; 24(2):323-34. PMID: 20053716.
      View in: PubMed
    46. Almeida M. Aging and oxidative stress: a new look at old bone. BoneKEy-Osteovision. 2010; 7(10):340-52.
    47. Almeida M. Osteoporosis: Pathophysiology and Clinical Management. The basic biology of estrogen and bone. 2010.
    48. Weinstein RS, Wan C, Liu Q, Wang Y, Almeida M, O'Brien CA, Thostenson J, Roberson PK, Boskey AL, Clemens TL, Manolagas SC. Endogenous glucocorticoids decrease skeletal angiogenesis, vascularity, hydration, and strength in aged mice. Aging Cell. 2010 Apr; 9(2):147-61. PMID: 20047574.
      View in: PubMed
    49. Almeida M, Ambrogini E, Han L, Manolagas SC, Jilka RL. Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeleton. J Biol Chem. 2009 Oct 02; 284(40):27438-48. PMID: 19657144.
      View in: PubMed
    50. Jilka RL, Bellido T, Almeida M, Plotkin LI, O'Brien CA, Weinstein RS, Manolagas SC. Principles of Bone Biology. Apoptosis of Bone Cells. 2008.
    51. Almeida M, Han L, Martin-Millan M, Plotkin LI, Stewart SA, Roberson PK, Kousteni S, O'Brien CA, Bellido T, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroids. J Biol Chem. 2007 Sep 14; 282(37):27285-27297. PMID: 17623659.
      View in: PubMed
    52. Almeida M, Han L, Martin-Millan M, O'Brien CA, Manolagas SC. Oxidative stress antagonizes Wnt signaling in osteoblast precursors by diverting beta-catenin from T cell factor- to forkhead box O-mediated transcription. J Biol Chem. 2007 Sep 14; 282(37):27298-27305. PMID: 17623658.
      View in: PubMed
    53. Manolagas SC, Almeida M. Gone with the Wnts: beta-catenin, T-cell factor, forkhead box O, and oxidative stress in age-dependent diseases of bone, lipid, and glucose metabolism. Mol Endocrinol. 2007 Nov; 21(11):2605-14. PMID: 17622581.
      View in: PubMed
    54. Kousteni S, Almeida M, Han L, Bellido T, Jilka RL, Manolagas SC. Induction of osteoblast differentiation by selective activation of kinase-mediated actions of the estrogen receptor. Mol Cell Biol. 2007 Feb; 27(4):1516-30. PMID: 17158928.
      View in: PubMed
    55. Almeida M, Han L, O'brien CA, Kousteni S, Manolagas SC. Classical genotropic versus kinase-initiated regulation of gene transcription by the estrogen receptor alpha. Endocrinology. 2006 Apr; 147(4):1986-96. PMID: 16384865.
      View in: PubMed
    56. Almeida M, Han L, Bellido T, Manolagas SC, Kousteni S. Wnt proteins prevent apoptosis of both uncommitted osteoblast progenitors and differentiated osteoblasts by beta-catenin-dependent and -independent signaling cascades involving Src/ERK and phosphatidylinositol 3-kinase/AKT. J Biol Chem. 2005 Dec 16; 280(50):41342-51. PMID: 16251184.
      View in: PubMed
    57. Vertino AM, Bula CM, Chen JR, Almeida M, Han L, Bellido T, Kousteni S, Norman AW, Manolagas SC. Nongenotropic, anti-apoptotic signaling of 1alpha,25(OH)2-vitamin D3 and analogs through the ligand binding domain of the vitamin D receptor in osteoblasts and osteocytes. Mediation by Src, phosphatidylinositol 3-, and JNK kinases. J Biol Chem. 2005 Apr 08; 280(14):14130-7. PMID: 15671029.
      View in: PubMed
    58. Kousteni S, Han L, Chen JR, Almeida M, Plotkin LI, Bellido T, Manolagas SC. Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest. 2003 Jun; 111(11):1651-64. PMID: 12782668.
      View in: PubMed
    59. Rousseau M, Pereira-Mouries L, Almeida MJ, Milet C, Lopez E. The water-soluble matrix fraction from the nacre of Pinctada maxima produces earlier mineralization of MC3T3-E1 mouse pre-osteoblasts. Comp Biochem Physiol B Biochem Mol Biol. 2003; 135(1):1 - 7.
    60. Pereira-Mouries L, Almeida MJ, Ribeiro C, Peduzzi J, Barthelemy M, Milet C, Lopez E. Soluble silk-like organic matrix in the nacreous layer of the bivalve Pinctada maxima. Eur J Biochem. 2002; 269(20):4994 - 5003.
    61. Mouries LP, Almeida MJ, Milet C, Berland S, Lopez E. Bioactivity of nacre water-soluble organic matrix from the bivalve mollusk Pinctada maxima in three mammalian cell types: fibroblasts, bone marrow stromal cells and osteoblasts. Comp Biochem Physiol B Biochem Mol Biol. 2002; 132(1):217 - 229.
    62. Almeida MJ, Pereira L, Milet C, Haigle J, Barbosa M, Lopez E. Comparative effects of nacre water-soluble matrix and dexamethasone on the alkaline phosphatase activity of MRC-5 fibroblasts. J Biomed Mater Res. 2001; 57(2):306 - 312.
    63. Bedouet L, Schuller MJ, Marin F, Milet C, Lopez E, Giraud M. Soluble proteins of the nacre of the giant oyster Pinctada maxima and of the abalone Haliotis tuberculata: extraction and partial analysis of nacre proteins. Comp Biochem Physiol B Biochem Mol Biol. 2001; 128(3):389 - 400.
    64. Zeutz F, Bedouet L, Almeida MJ, Milet C, Lopez E. Characterization and quantification of chitosan extracted from the nacre of the abalone Haliotis tuberculata and the oyster Pinctada maxima. Marine Biotechnology. 2001; 3:36-44.
    65. Almeida MJ, Milet C, Peduzzi J, Pereira L, Haigle J, Barthelemy M, Lopez E. Effect of water-soluble matrix fraction extracted from the nacre of Pinctada maxima on the alkaline phosphatase activity of cultured fibroblasts. J Exp Zool. 2000; 288(4):327 - 334.
    66. Lamghari M, Almeida MJ, Berland S, Huet H, Laurent A, Milet C, Lopez E. Stimulation of bone marrow cells and bone formation by nacre: in vivo and in vitro studies. Bone. 1999; 25(2 Suppl):91S - 94S.
    67. Almeida MJ, Coimbra J, Machado J, Coelho MA, Soares de Silva P. L-3,4-dihydroxyphenylalanine (L-DOPA) secreted by oysters (Crassostrea gigas) mantle cells: functional aspects. Comparative Biochemistry and Phisiology. 1998; 120B:709-713.
    68. Almeida MJ, Machado J, Moura T, Pinheiro, Coimbra J. Modifications in Crassostrea gigas shell composition treated with lead. Aquatic Toxicology. 1998; 40:323-334.
    69. Soares da Silva IM, Almeida MJ, Serrao PM, Coelho MA, Machado J. L-3,4-dihydroxyphenylalanine (L-DOPA) in Anodonta cygnea: variation with acidosis. Comparative Biochemistry and Phisiology. 1998; 120A:463-468.
    70. Almeida MJ, Machado J, Moura G, Azevedo M, Coimbra J. Temporal and local variations in biochemical composition of Crassostrea gigas shells. Journal of Sea Research. 1998; 40:233-249.
    71. Almeida MJ, Machado J, Coimbra J. Growth and biochemical composition of Crassostrea gigas (Thunberg) and Ostrea edulis (Linne) in two estuaries from the North of Portugal. Journal of Shellfish Research. 1998; 18(1):139-146.
    72. Almeida MJ, Machado J, Coimbra J. Growth and biochemical composition of Crassostrea gigas (Thunberg) at three fishfarm earthen ponds. Journal of Shellfish Research. 1997; 16(2):455-462.
    73. Almeida MJ, Coimbra J, Machado J, Moura G, Vilarinho L, Soares da Silva P, Ribeiro C. Amino acids and metal content of Crassostrea gigas shell infested by Polydora sp. in the prismatic layer insoluble matrix and blister membrane. Aquatic Living Resources. 1996; 9(2):179-186.
    74. Almeida MJ, Machado J, Coimbra J. The effect of Polydora sp. infestation on the shell calcification of the oyster Crassostrea gigas. Bulletin de l'Institut Oceanographique. 1996; 14(4):195-202.
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