 Bone Resorption
"Bone Resorption" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Bone loss due to osteoclastic activity.
| Descriptor ID |
D001862
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| MeSH Number(s) |
C05.116.264 G11.427.590.195.150
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| Concept/Terms |
Bone Resorption- Bone Resorption
- Bone Resorptions
- Resorption, Bone
- Resorptions, Bone
- Osteoclastic Bone Loss
- Bone Loss, Osteoclastic
- Bone Losses, Osteoclastic
- Loss, Osteoclastic Bone
- Losses, Osteoclastic Bone
- Osteoclastic Bone Losses
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Below are MeSH descriptors whose meaning is more general than "Bone Resorption".
Below are MeSH descriptors whose meaning is more specific than "Bone Resorption".
This graph shows the total number of publications written about "Bone Resorption" by people in UAMS Profiles by year, and whether "Bone Resorption" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 3 | 3 | 6 | | 2023 | 3 | 0 | 3 | | 2022 | 7 | 0 | 7 | | 2021 | 1 | 2 | 3 | | 2020 | 3 | 2 | 5 | | 2019 | 1 | 1 | 2 | | 2018 | 5 | 3 | 8 | | 2017 | 1 | 2 | 3 | | 2016 | 6 | 8 | 14 | | 2015 | 4 | 1 | 5 | | 2014 | 6 | 2 | 8 | | 2013 | 5 | 1 | 6 | | 2012 | 3 | 2 | 5 | | 2011 | 4 | 2 | 6 | | 2010 | 1 | 6 | 7 | | 2009 | 2 | 3 | 5 | | 2008 | 3 | 3 | 6 | | 2007 | 1 | 1 | 2 | | 2006 | 5 | 4 | 9 | | 2005 | 6 | 0 | 6 | | 2004 | 1 | 0 | 1 | | 2003 | 0 | 3 | 3 | | 2002 | 2 | 2 | 4 | | 1998 | 1 | 0 | 1 | | 1997 | 1 | 1 | 2 | | 1996 | 1 | 0 | 1 | | 1995 | 0 | 1 | 1 | | 1993 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Bone Resorption" by people in Profiles over the past ten years.
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Lanzolla G, Sabini E, Beigel K, Khan MP, Sherry Liu X, Wang D, Laslow B, Taylor D, Bellido T, Giaccia A, Schipani E. Pharmacological inhibition of HIF2 protects against bone loss in an experimental model of estrogen deficiency. Proc Natl Acad Sci U S A. 2024 Dec 03; 121(49):e2416004121.
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Richardson KK, Adam GO, Ling W, Warren A, Marques-Carvalho A, Thostenson JD, Krager K, Aykin-Burns N, Byrum SD, Almeida M, Kim HN. Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice. Mol Metab. 2024 Oct; 88:102012.
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Wasi M, Chu T, Guerra RM, Kooker R, Maldonado K, Li X, Lin CY, Song X, Xiong J, You L, Wang L. Mitigating aging and doxorubicin induced bone loss in mature mice via mechanobiology based treatments. Bone. 2024 Nov; 188:117235.
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Campbell MJ, Bustamante-Gomez C, Fu Q, Beenken KE, Reyes-Pardo H, Smeltzer MS, O'Brien CA. RANKL-mediated osteoclast formation is required for bone loss in a murine model of Staphylococcus aureus osteomyelitis. Bone. 2024 Oct; 187:117181.
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Tenshin H, Delgado-Calle J, Windle JJ, Roodman GD, Chirgwin JM, Kurihara N. Osteocytes and Paget's Disease of Bone. Curr Osteoporos Rep. 2024 04; 22(2):266-272.
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Caviness PC, Lazarenko OP, Blackburn ML, Chen JF, Randolph CE, Zabaleta J, Zhan F, Chen JR. Phenolic acids prevent sex-steroid deficiency-induced bone loss and bone marrow adipogenesis in mice. J Nutr Biochem. 2024 05; 127:109601.
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Fu Q, Bustamante-Gomez NC, Reyes-Pardo H, Gubrij I, Escalona-Vargas D, Thostenson JD, Palmieri M, Goellner JJ, Nookaew I, Barnes CL, Stambough JB, Ambrogini E, O'Brien CA. Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation. JCI Insight. 2023 09 22; 8(18).
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Caviness PC, Gai D, Lazarenko OP, Blackburn ML, Zhan F, Chen JR. Decreased bone resorption in Ezh2 myeloid cell conditional knockout mouse model. FASEB J. 2023 07; 37(7):e23019.
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Hodges JK, Maiz M, Cao S, Lachcik PJ, Peacock M, McCabe GP, McCabe LD, Cladis DP, Jackson GS, Ferruzzi MG, Lila MA, Bailey RL, Martin BR, Weaver CM. Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention compared with no treatment in healthy postmenopausal women: a randomized crossover trial. Am J Clin Nutr. 2023 08; 118(2):382-390.
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Yuan X, Amin V, Zhu T, Kittaka M, Ueki Y, Bellido TM, Turkkahraman H. Type 1 diabetes mellitus leads to gingivitis and an early compensatory increase in bone remodeling. J Periodontol. 2023 02; 94(2):277-289.
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Wang X, Shao L, Richardson KK, Ling W, Warren A, Krager K, Aykin-Burns N, Hromas R, Zhou D, Almeida M, Kim HN. Hematopoietic cytoplasmic adaptor protein Hem1 promotes osteoclast fusion and bone resorption in mice. J Biol Chem. 2023 02; 299(2):102841.
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Gai D, Chen JR, Stewart JP, Nookaew I, Habelhah H, Ashby C, Sun F, Cheng Y, Li C, Xu H, Peng B, Garg TK, Schinke C, Thanendrarajan S, Zangari M, Chen F, Barlogie B, van Rhee F, Tricot G, Shaughnessy JD, Zhan F. CST6 suppresses osteolytic bone disease in multiple myeloma by blocking osteoclast differentiation. J Clin Invest. 2022 09 15; 132(18).
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Henning P, Conaway HH, Lerner UH. Stimulation of osteoclast formation and bone resorption by glucocorticoids: Synergistic interactions with the calcium regulating hormones parathyroid hormone and 1,25(OH)2-vitamin D3. Vitam Horm. 2022; 120:231-270.
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Das BK, Wang L, Fujiwara T, Zhou J, Aykin-Burns N, Krager KJ, Lan R, Mackintosh SG, Edmondson R, Jennings ML, Wang X, Feng JQ, Barrientos T, Gogoi J, Kannan A, Gao L, Xing W, Mohan S, Zhao H. Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton. Elife. 2022 06 27; 11.
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Chen JR, Lazarenko OP, Blackburn ML. GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice. Bone. 2022 08; 161:116422.
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Delgado-Calle J, McAndrews K, Wu G, Orr AL, Ferrari A, Tu X, Srinivasan V, Roodman GD, Ebetino FH, Boeckman RK, Bellido T. The Notch pathway regulates the bone gain induced by PTH anabolic signaling. FASEB J. 2022 03; 36(3):e22196.
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Richardson KK, Ling W, Krager K, Fu Q, Byrum SD, Pathak R, Aykin-Burns N, Kim HN. Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice. Int J Mol Sci. 2022 Jan 08; 23(2).
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Feresin RG, Johnson SA, Elam ML, Pourafshar S, Navaei N, Akhavan NS, Tenenbaum G, Figueroa A, Arjmandi BH. Effects of strawberries on bone biomarkers in pre- and stage 1-hypertensive postmenopausal women: a secondary analysis. Food Funct. 2021 Dec 13; 12(24):12526-12534.
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Delgado-Calle J, Bellido T. The osteocyte as a signaling cell. Physiol Rev. 2022 01 01; 102(1):379-410.
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Chen JR, Zhao H, Wankhade UD, Chintapalli SV, Li C, Gai D, Shankar K, Zhan F, Lazarenko OP. GPR109A mediates the effects of hippuric acid on regulating osteoclastogenesis and bone resorption in mice. Commun Biol. 2021 01 08; 4(1):53.
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Suva LJ, Cooper A, Watts AE, Ebetino FH, Price J, Gaddy D. Bisphosphonates in veterinary medicine: The new horizon for use. Bone. 2021 01; 142:115711.
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Mulcrone PL, Edwards SKE, Petrusca DN, Haneline LS, Delgado-Calle J, Roodman GD. Osteocyte Vegf-a contributes to myeloma-associated angiogenesis and is regulated by Fgf23. Sci Rep. 2020 10 14; 10(1):17319.
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Kim HN, Xiong J, MacLeod RS, Iyer S, Fujiwara Y, Cawley KM, Han L, He Y, Thostenson JD, Ferreira E, Jilka RL, Zhou D, Almeida M, O'Brien CA. Osteocyte RANKL is required for cortical bone loss with age and is induced by senescence. JCI Insight. 2020 10 02; 5(19).
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Ponte F, Kim HN, Iyer S, Han L, Almeida M, Manolagas SC. Cxcl12 Deletion in Mesenchymal Cells Increases Bone Turnover and Attenuates the Loss of Cortical Bone Caused by Estrogen Deficiency in Mice. J Bone Miner Res. 2020 08; 35(8):1441-1451.
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Khalaf OH, Chaki SP, Garcia-Gonzalez DG, Suva LJ, Gaddy D, Arenas-Gamboa AM. Interaction of Brucella abortus with Osteoclasts: a Step toward Understanding Osteoarticular Brucellosis and Vaccine Safety. Infect Immun. 2020 03 23; 88(4).
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Greene E, Flees J, Dhamad A, Alrubaye A, Hennigan S, Pleimann J, Smeltzer M, Murray S, Kugel J, Goodrich J, Robertson A, Wideman R, Rhoads D, Dridi S. Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with Osteomyelitis. Am J Pathol. 2019 10; 189(10):2077-2089.
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Sato AY, Cregor M, McAndrews K, Li T, Condon KW, Plotkin LI, Bellido T. Glucocorticoid-Induced Bone Fragility Is Prevented in Female Mice by Blocking Pyk2/Anoikis Signaling. Endocrinology. 2019 07 01; 160(7):1659-1673.
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Li JY, Yu M, Tyagi AM, Vaccaro C, Hsu E, Adams J, Bellido T, Weitzmann MN, Pacifici R. IL-17 Receptor Signaling in Osteoblasts/Osteocytes Mediates PTH-Induced Bone Loss and Enhances Osteocytic RANKL Production. J Bone Miner Res. 2019 02; 34(2):349-360.
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Lionikaite V, Gustafsson KL, Westerlund A, Windahl SH, Koskela A, Tuukkanen J, Johansson H, Ohlsson C, Conaway HH, Henning P, Lerner UH. Clinically relevant doses of vitamin A decrease cortical bone mass in mice J Endocrinol. 2018 10 31; 239(3):389-402.
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Bennink LL, Li Y, Kim B, Shin IJ, San BH, Zangari M, Yoon D, Yu SM. Visualizing collagen proteolysis by peptide hybridization: From 3D cell culture to in vivo imaging. Biomaterials. 2018 11; 183:67-76.
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Xiong J, Cawley K, Piemontese M, Fujiwara Y, Zhao H, Goellner JJ, O'Brien CA. Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss. Nat Commun. 2018 07 25; 9(1):2909.
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Pacheco-Costa R, Davis HM, Atkinson EG, Dilley JE, Byiringiro I, Aref MW, Allen MR, Bellido T, Plotkin LI. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 09; 114:22-31.
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Wang L, Fang B, Fujiwara T, Krager K, Gorantla A, Li C, Feng JQ, Jennings ML, Zhou J, Aykin-Burns N, Zhao H. Deletion of ferroportin in murine myeloid cells increases iron accumulation and stimulates osteoclastogenesis in vitro and in vivo. J Biol Chem. 2018 06 15; 293(24):9248-9264.
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Raes S, Eghbali A, Chappuis V, Raes F, De Bruyn H, Cosyn J. A long-term prospective cohort study on immediately restored single tooth implants inserted in extraction sockets and healed ridges: CBCT analyses, soft tissue alterations, aesthetic ratings, and patient-reported outcomes. Clin Implant Dent Relat Res. 2018 Aug; 20(4):522-530.
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Delgado-Calle J, Hancock B, Likine EF, Sato AY, McAndrews K, Sanudo C, Bruzzaniti A, Riancho JA, Tonra JR, Bellido T. MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production. FASEB J. 2018 05; 32(5):2878-2890.
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Kim HN, Iyer S, Ring R, Almeida M. The Role of FoxOs in Bone Health and Disease. Curr Top Dev Biol. 2018; 127:149-163.
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Davis HM, Pacheco-Costa R, Atkinson EG, Brun LR, Gortazar AR, Harris J, Hiasa M, Bolarinwa SA, Yoneda T, Ivan M, Bruzzaniti A, Bellido T, Plotkin LI. Disruption of the Cx43/miR21 pathway leads to osteocyte apoptosis and increased osteoclastogenesis with aging. Aging Cell. 2017 06; 16(3):551-563.
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Delgado-Calle J. Osteoclasts Control Lipid Secretion to Regulate Breast Cancer Bone Metastasis. Endocrinology. 2017 03 01; 158(3):458-460.
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Kalaitzoglou E, Popescu I, Bunn RC, Fowlkes JL, Thrailkill KM. Effects of Type 1 Diabetes on Osteoblasts, Osteocytes, and Osteoclasts. Curr Osteoporos Rep. 2016 12; 14(6):310-319.
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Ucer S, Iyer S, Kim HN, Han L, Rutlen C, Allison K, Thostenson JD, de Cabo R, Jilka RL, O'Brien C, Almeida M, Manolagas SC. The Effects of Aging and Sex Steroid Deficiency on the Murine Skeleton Are Independent and Mechanistically Distinct. J Bone Miner Res. 2017 Mar; 32(3):560-574.
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Hoscheit M, Conner G, Roemer J, Vuckovska A, Abbasnia P, Vana P, Shankar R, Kennedy R, Callaci J. Burn Injury Has Skeletal Site-Specific Effects on Bone Integrity and Markers of Bone Remodeling. J Burn Care Res. 2016 Nov/Dec; 37(6):367-378.
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Thrailkill KM, Nyman JS, Bunn RC, Uppuganti S, Thompson KL, Lumpkin CK, Kalaitzoglou E, Fowlkes JL. The impact of SGLT2 inhibitors, compared with insulin, on diabetic bone disease in a mouse model of type 1 diabetes. Bone. 2017 Jan; 94:141-151.
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Delgado-Calle J, Tu X, Pacheco-Costa R, McAndrews K, Edwards R, Pellegrini GG, Kuhlenschmidt K, Olivos N, Robling A, Peacock M, Plotkin LI, Bellido T. Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor. J Bone Miner Res. 2017 Mar; 32(3):522-535.
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Maycas M, McAndrews KA, Sato AY, Pellegrini GG, Brown DM, Allen MR, Plotkin LI, Gortazar AR, Esbrit P, Bellido T. PTHrP-Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading. J Bone Miner Res. 2017 Mar; 32(3):486-497.
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Fujiwara T, Ye S, Castro-Gomes T, Winchell CG, Andrews NW, Voth DE, Varughese KI, Mackintosh SG, Feng Y, Pavlos N, Nakamura T, Manolagas SC, Zhao H. PLEKHM1/DEF8/RAB7 complex regulates lysosome positioning and bone homeostasis. JCI Insight. 2016 Oct 20; 1(17):e86330.
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Fujiwara Y, Piemontese M, Liu Y, Thostenson JD, Xiong J, O'Brien CA. RANKL (Receptor Activator of NF?B Ligand) Produced by Osteocytes Is Required for the Increase in B Cells and Bone Loss Caused by Estrogen Deficiency in Mice. J Biol Chem. 2016 Nov 25; 291(48):24838-24850.
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Delgado-Calle J, Sato AY, Bellido T. Role and mechanism of action of sclerostin in bone. Bone. 2017 03; 96:29-37.
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Iyer S, Han L, Ambrogini E, Yavropoulou M, Fowlkes J, Manolagas SC, Almeida M. Deletion of FoxO1, 3, and 4 in Osteoblast Progenitors Attenuates the Loss of Cancellous Bone Mass in a Mouse Model of Type 1 Diabetes. J Bone Miner Res. 2017 01; 32(1):60-69.
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Conaway HH, Henning P, Lie A, Tuckermann J, Lerner UH. Activation of dimeric glucocorticoid receptors in osteoclast progenitors potentiates RANKL induced mature osteoclast bone resorbing activity. Bone. 2016 12; 93:43-54.
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Piemontese M, Xiong J, Fujiwara Y, Thostenson JD, O'Brien CA. Cortical bone loss caused by glucocorticoid excess requires RANKL production by osteocytes and is associated with reduced OPG expression in mice. Am J Physiol Endocrinol Metab. 2016 09 01; 311(3):E587-93.
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Shahnazari M, Turner RT, Iwaniec UT, Wronski TJ, Li M, Ferruzzi MG, Nissenson RA, Halloran BP. Dietary dried plum increases bone mass, suppresses proinflammatory cytokines and promotes attainment of peak bone mass in male mice. J Nutr Biochem. 2016 08; 34:73-82.
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Delgado-Calle J, Anderson J, Cregor MD, Hiasa M, Chirgwin JM, Carlesso N, Yoneda T, Mohammad KS, Plotkin LI, Roodman GD, Bellido T. Bidirectional Notch Signaling and Osteocyte-Derived Factors in the Bone Marrow Microenvironment Promote Tumor Cell Proliferation and Bone Destruction in Multiple Myeloma. Cancer Res. 2016 Mar 01; 76(5):1089-100.
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Chowdhury P, Akel N, Jamshidi-Parsian A, Gaddy D, Griffin RJ, Yadlapalli JS, Dobretsov M. Degenerative Tissue Responses to Space-like Radiation Doses in a Rodent Model of Simulated Microgravity. Ann Clin Lab Sci. 2016; 46(2):190-7.
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Plotkin LI, Gortazar AR, Davis HM, Condon KW, Gabilondo H, Maycas M, Allen MR, Bellido T. Inhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor ?B ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading. J Biol Chem. 2015 Jul 31; 290(31):18934-42.
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Wright LE, Buijs JT, Kim HS, Coats LE, Scheidler AM, John SK, She Y, Murthy S, Ma N, Chin-Sinex HJ, Bellido TM, Bateman TA, Mendonca MS, Mohammad KS, Guise TA. Single-Limb Irradiation Induces Local and Systemic Bone Loss in a Murine Model. J Bone Miner Res. 2015 Jul; 30(7):1268-79.
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Gu Z, Wang H, Xia J, Yang Y, Jin Z, Xu H, Shi J, De Domenico I, Tricot G, Zhan F. Decreased ferroportin promotes myeloma cell growth and osteoclast differentiation. Cancer Res. 2015 Jun 01; 75(11):2211-21.
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Fowler TW, Kamalakar A, Akel NS, Kurten RC, Suva LJ, Gaddy D. Activin A inhibits RANKL-mediated osteoclast formation, movement and function in murine bone marrow macrophage cultures. J Cell Sci. 2015 Feb 15; 128(4):683-94.
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Illing EA, Dunlap Q, Woodworth BA. Outcomes of pressure-induced cranial neuropathies from allergic fungal rhinosinusitis. Otolaryngol Head Neck Surg. 2015 Mar; 152(3):541-5.
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