 DNA Adducts
"DNA Adducts" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The products of chemical reactions that result in the addition of extraneous chemical groups to DNA.
| Descriptor ID |
D018736
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| MeSH Number(s) |
D13.444.308.135 G05.355.180.104
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "DNA Adducts".
Below are MeSH descriptors whose meaning is more specific than "DNA Adducts".
This graph shows the total number of publications written about "DNA Adducts" by people in UAMS Profiles by year, and whether "DNA Adducts" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2021 | 0 | 1 | 1 | | 2020 | 1 | 1 | 2 | | 2019 | 2 | 0 | 2 | | 2018 | 0 | 2 | 2 | | 2016 | 0 | 1 | 1 | | 2014 | 2 | 2 | 4 | | 2013 | 0 | 1 | 1 | | 2012 | 1 | 2 | 3 | | 2011 | 3 | 0 | 3 | | 2010 | 1 | 1 | 2 | | 2009 | 3 | 2 | 5 | | 2008 | 0 | 2 | 2 | | 2007 | 1 | 0 | 1 | | 2006 | 2 | 0 | 2 | | 2004 | 2 | 2 | 4 | | 2003 | 1 | 0 | 1 | | 2002 | 3 | 0 | 3 | | 2001 | 1 | 1 | 2 | | 2000 | 1 | 1 | 2 | | 1999 | 2 | 0 | 2 | | 1998 | 1 | 0 | 1 |
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Below are the most recent publications written about "DNA Adducts" by people in Profiles over the past ten years.
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Caipa Garcia AL, Kucab JE, Al-Serori H, Beck RSS, Fischer F, Hufnagel M, Hartwig A, Floeder A, Balbo S, Francies H, Garnett M, Huch M, Drost J, Zilbauer M, Arlt VM, Phillips DH. Metabolic Activation of Benzo[a]pyrene by Human Tissue Organoid Cultures. Int J Mol Sci. 2022 Dec 29; 24(1).
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Pujari SS, Jokipii Krueger CC, Chao C, Hutchins S, Hurben AK, Boysen G, Tretyakova N. DEB-FAPy-dG Adducts of 1,3-Butadiene: Synthesis, Structural Characterization, and Formation in 1,2,3,4-Diepoxybutane Treated DNA. Chemistry. 2022 Jan 13; 28(3):e202103245.
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Boysen G, Arora R, Degner A, Vevang KR, Chao C, Rodriguez F, Walmsley SJ, Erber L, Tretyakova NY, Peterson LA. Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA-DNA Cross-Links in Human Hapmap Cell Lines. Chem Res Toxicol. 2021 01 18; 34(1):119-131.
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Nookaew I, Jenjaroenpun P, Du H, Wang P, Wu J, Wongsurawat T, Moon SH, Huang E, Wang Y, Boysen G. Detection and Discrimination of DNA Adducts Differing in Size, Regiochemistry, and Functional Group by Nanopore Sequencing. Chem Res Toxicol. 2020 12 21; 33(12):2944-2952.
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Reed L, Jarvis IWH, Phillips DH, Arlt VM. Enhanced DNA adduct formation by benzo[a]pyrene in human liver cells lacking cytochrome P450 oxidoreductase. Mutat Res Genet Toxicol Environ Mutagen. 2020 Apr; 852:503162.
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Phillips DH, Arlt VM. 32P-Postlabeling Analysis of DNA Adducts. Methods Mol Biol. 2020; 2102:291-302.
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Reed L, Jarvis IWH, Phillips DH, Arlt VM. Deletion of cytochrome P450 oxidoreductase enhances metabolism and DNA adduct formation of benzo[a]pyrene in Hepa1c1c7 cells. Mutagenesis. 2019 12 19; 34(5-6):413-420.
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Lewis L, Borowa-Mazgaj B, de Conti A, Chappell GA, Luo YS, Bodnar W, Konganti K, Wright FA, Threadgill DW, Chiu WA, Pogribny IP, Rusyn I. Population-Based Analysis of DNA Damage and Epigenetic Effects of 1,3-Butadiene in the Mouse. Chem Res Toxicol. 2019 05 20; 32(5):887-898.
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de Conti A, Tryndyak V, VonTungeln LS, Churchwell MI, Beland FA, Antunes AMM, Pogribny IP. Genotoxic and Epigenotoxic Alterations in the Lung and Liver of Mice Induced by Acrylamide: A 28 Day Drinking Water Study. Chem Res Toxicol. 2019 05 20; 32(5):869-877.
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Reed L, Indra R, Mrizova I, Moserova M, Schmeiser HH, Wolf CR, Henderson CJ, Stiborova M, Phillips DH, Arlt VM. Application of hepatic cytochrome b5/P450 reductase null (HBRN) mice to study the role of cytochrome b5 in the cytochrome P450-mediated bioactivation of the anticancer drug ellipticine. Toxicol Appl Pharmacol. 2019 03 01; 366:64-74.
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Lewis L, Chappell GA, Kobets T, O'Brian BE, Sangaraju D, Kosyk O, Bodnar W, Tretyakova NY, Pogribny IP, Rusyn I. Sex-specific differences in genotoxic and epigenetic effects of 1,3-butadiene among mouse tissues. Arch Toxicol. 2019 03; 93(3):791-800.
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Rynning I, Arlt VM, Vrbova K, Neca J, Rossner P, Klema J, Ulvestad B, Petersen E, Skare ?, Haugen A, Phillips DH, Machala M, Topinka J, Mollerup S. Bulky DNA adducts, microRNA profiles, and lipid biomarkers in Norwegian tunnel finishing workers occupationally exposed to diesel exhaust. Occup Environ Med. 2019 01; 76(1):10-16.
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Boysen G. Response to Interpretation of Mass Spectral Data for the Cisplatin 1,2 Intrastrand Guanine-Guanine Adduct. Chem Res Toxicol. 2018 11 19; 31(11):1108.
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Wohak LE, Baranski AC, Krais AM, Schmeiser HH, Phillips DH, Arlt VM. The impact of p53 function on the metabolic activation of the carcinogenic air pollutant 3-nitrobenzanthrone and its metabolites 3-aminobenzanthrone and N-hydroxy-3-aminobenzanthrone in human cells. Mutagenesis. 2018 10 11; 33(4):311-321.
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Chepelev NL, Long AS, Bowers WJ, Gagn? R, Williams A, Kuo B, Phillips DH, Arlt VM, White PA, Yauk CL. Transcriptional profiling of the mouse hippocampus supports an NMDAR-mediated neurotoxic mode of action for benzo[a]pyrene. Environ Mol Mutagen. 2016 06; 57(5):350-63.
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Yeom M, Kim IH, Kim JK, Kang K, Eoff RL, Guengerich FP, Choi JY. Effects of Twelve Germline Missense Variations on DNA Lesion and G-Quadruplex Bypass Activities of Human DNA Polymerase REV1. Chem Res Toxicol. 2016 Mar 21; 29(3):367-79.
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Kucab JE, Zwart EP, van Steeg H, Luijten M, Schmeiser HH, Phillips DH, Arlt VM. TP53 and lacZ mutagenesis induced by 3-nitrobenzanthrone in Xpa-deficient human TP53 knock-in mouse embryo fibroblasts. DNA Repair (Amst). 2016 Mar; 39:21-33.
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Chepelev NL, Long AS, Williams A, Kuo B, Gagn? R, Kennedy DA, Phillips DH, Arlt VM, White PA, Yauk CL. Transcriptional Profiling of Dibenzo[def,p]chrysene-induced Spleen Atrophy Provides Mechanistic Insights into its Immunotoxicity in MutaMouse. Toxicol Sci. 2016 Jan; 149(1):251-68.
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Krais AM, Speksnijder EN, Melis JP, Singh R, Caldwell A, Gamboa da Costa G, Luijten M, Phillips DH, Arlt VM. Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) mice. Int J Cancer. 2016 Feb 15; 138(4):976-82.
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