Holoprosencephaly

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"Holoprosencephaly" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

Anterior midline brain, cranial, and facial malformations resulting from the failure of the embryonic prosencephalon to undergo segmentation and cleavage. Alobar prosencephaly is the most severe form and features anophthalmia; cyclopia; severe INTELLECTUAL DISABILITY; CLEFT LIP; CLEFT PALATE; SEIZURES; and microcephaly. Semilobar holoprosencepaly is characterized by hypotelorism, microphthalmia, coloboma, nasal malformations, and variable degrees of INTELLECTUAL DISABILITY. Lobar holoprosencephaly is associated with mild (or absent) facial malformations and intellectual abilities that range from mild INTELLECTUAL DISABILITY to normal. Holoprosencephaly is associated with CHROMOSOME ABNORMALITIES.

Descriptor ID	D016142
MeSH Number(s)	C05.660.207.410 C10.500.034.875 C16.131.077.410 C16.131.260.380 C16.131.621.207.410 C16.131.666.034.875 C16.131.666.410 C16.320.180.380
Concept/Terms	Holoprosencephaly Holoprosencephaly Holoprosencephalies Lobar Holoprosencephaly Lobar Holoprosencephaly Holoprosencephalies, Lobar Holoprosencephaly, Lobar Lobar Holoprosencephalies Arhinencephaly Arhinencephaly Arhinencephalies Semilobar Holoprosencephaly Semilobar Holoprosencephaly Holoprosencephalies, Semilobar Holoprosencephaly, Semilobar Semilobar Holoprosencephalies Alobar Holoprosencephaly Alobar Holoprosencephaly Alobar Holoprosencephalies Holoprosencephalies, Alobar Holoprosencephaly, Alobar Holoprosencephaly, Familial Alobar

Below are MeSH descriptors whose meaning is more general than "Holoprosencephaly".

Diseases [C]
Musculoskeletal Diseases [C05]
Musculoskeletal Abnormalities [C05.660]
Craniofacial Abnormalities [C05.660.207]
Holoprosencephaly [C05.660.207.410]
Nervous System Diseases [C10]
Nervous System Malformations [C10.500]
Agenesis of Corpus Callosum [C10.500.034]
Holoprosencephaly [C10.500.034.875]
Congenital, Hereditary, and Neonatal Diseases and Abnormalities [C16]
Congenital Abnormalities [C16.131]
Abnormalities, Multiple [C16.131.077]
Holoprosencephaly [C16.131.077.410]
Chromosome Disorders [C16.131.260]
Holoprosencephaly [C16.131.260.380]
Musculoskeletal Abnormalities [C16.131.621]
Craniofacial Abnormalities [C16.131.621.207]
Holoprosencephaly [C16.131.621.207.410]
Nervous System Malformations [C16.131.666]
Agenesis of Corpus Callosum [C16.131.666.034]
Holoprosencephaly [C16.131.666.034.875]
Holoprosencephaly [C16.131.666.410]
Genetic Diseases, Inborn [C16.320]
Chromosome Disorders [C16.320.180]
Holoprosencephaly [C16.320.180.380]

Below are MeSH descriptors whose meaning is related to "Holoprosencephaly".

Below are MeSH descriptors whose meaning is more specific than "Holoprosencephaly".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Holoprosencephaly" by people in UAMS Profiles by year, and whether "Holoprosencephaly" was a major or minor topic of these publications.

Bar chart showing 1 publications over 1 distinct years, with a maximum of 1 publications in 1996

To see the data from this visualization as text, click here.

Similar Concepts

Top Journals

Am J Med Genet