A syndrome characterized by growth retardation, severe MENTAL RETARDATION, short stature, a low-pitched growling cry, brachycephaly, low-set ears, webbed neck, carp mouth, depressed nasal bridge, bushy eyebrows meeting at the midline, hirsutism, and malformations of the hands. The condition may occur sporadically or be associated with an autosomal dominant pattern of inheritance or duplication of the long arm of chromosome 3. (Menkes, Textbook of Child Neurology, 5th ed, p231)

Descriptor ID	D003635
MeSH Number(s)	C10.597.606.643.210 C16.131.077.272 C16.131.260.210 C16.320.180.210
Concept/Terms	De Lange Syndrome De Lange Syndrome Syndrome, De Lange Cornelia De Lange Syndrome Brachmann-De Lange Syndrome Brachmann De Lange Syndrome Syndrome, Brachmann-De Lange De Lange's Syndrome Syndrome, De Lange's Typus Degenerativus Amstelodamensis Amstelodamensis, Typus Degenerativus Cornelia de Lange Syndrome 2 Cornelia de Lange Syndrome 2 Cornelia de Lange Syndrome, X-Linked Cornelia de Lange Syndrome, X Linked Cornelia de Lange Syndrome 3 Cornelia de Lange Syndrome 3 Cornelia de Lange Syndrome 1 Cornelia de Lange Syndrome 1

Below are MeSH descriptors whose meaning is more general than "De Lange Syndrome".

Below are MeSH descriptors whose meaning is related to "De Lange Syndrome".

Below are MeSH descriptors whose meaning is more specific than "De Lange Syndrome".