 Tretinoin
"Tretinoin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
| Descriptor ID |
D014212
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| MeSH Number(s) |
D02.455.326.271.665.202.495.818.500 D02.455.426.392.368.367.379.249.700.860.500 D02.455.849.131.495.818.800 D23.767.261.700.780
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| Concept/Terms |
Tretinoin- Tretinoin
- Vitamin A Acid
- Acid, Vitamin A
- trans-Retinoic Acid
- Acid, trans-Retinoic
- trans Retinoic Acid
- all-trans-Retinoic Acid
- Acid, all-trans-Retinoic
- all trans Retinoic Acid
- Retinoic Acid
- Acid, Retinoic
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Below are MeSH descriptors whose meaning is more general than "Tretinoin".
Below are MeSH descriptors whose meaning is more specific than "Tretinoin".
This graph shows the total number of publications written about "Tretinoin" by people in UAMS Profiles by year, and whether "Tretinoin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2023 | 1 | 0 | 1 | | 2022 | 1 | 1 | 2 | | 2021 | 0 | 1 | 1 | | 2019 | 2 | 0 | 2 | | 2018 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2013 | 0 | 2 | 2 | | 2012 | 2 | 0 | 2 | | 2011 | 1 | 2 | 3 | | 2010 | 1 | 1 | 2 | | 2009 | 2 | 0 | 2 | | 2008 | 1 | 0 | 1 | | 2005 | 2 | 1 | 3 | | 2004 | 1 | 0 | 1 | | 2003 | 1 | 0 | 1 | | 2002 | 1 | 0 | 1 | | 2001 | 2 | 0 | 2 | | 2000 | 7 | 0 | 7 | | 1999 | 1 | 1 | 2 | | 1998 | 5 | 2 | 7 | | 1997 | 1 | 0 | 1 | | 1994 | 1 | 1 | 2 | | 1993 | 2 | 0 | 2 | | 1989 | 0 | 1 | 1 |
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Below are the most recent publications written about "Tretinoin" by people in Profiles over the past ten years.
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Garc?a-Guerrero E, Rodr?guez-Lobato LG, Sierro-Mart?nez B, Danhof S, Bates S, Frenz S, Haertle L, G?tz R, Sauer M, Rasche L, Kort?m KM, P?rez-Sim?n JA, Einsele H, Hudecek M, Prommersberger SR. All-trans retinoic acid works synergistically with the ?-secretase inhibitor crenigacestat to augment BCMA on multiple myeloma and the efficacy of BCMA-CAR T cells. Haematologica. 2023 02 01; 108(2):568-580.
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Paulissen E, Palmisano NJ, Waxman JS, Martin BL. Somite morphogenesis is required for axial blood vessel formation during zebrafish embryogenesis. Elife. 2022 02 09; 11.
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van Ee A, Kim D, Prizmic V, Rho H, Park Y, Evans B, Kim S, Lee S, Wang G, Yu J, Kane MA, Garza LA. CD14 Is Induced by Retinoic Acid and Is Required for Double Stranded Noncoding RNA-Induced Regeneration. J Invest Dermatol. 2022 08; 142(8):2291-2294.e7.
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Sanders S, Herpai DM, Rodriguez A, Huang Y, Chou J, Hsu FC, Seals D, Mott R, Miller LD, Debinski W. The Presence and Potential Role of ALDH1A2 in the Glioblastoma Microenvironment. Cells. 2021 09 20; 10(9).
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Kim D, Chen R, Sheu M, Kim N, Kim S, Islam N, Wier EM, Wang G, Li A, Park A, Son W, Evans B, Yu V, Prizmic VP, Oh E, Wang Z, Yu J, Huang W, Archer NK, Hu Z, Clemetson N, Nelson AM, Chien A, Okoye GA, Miller LS, Ghiaur G, Kang S, Jones JW, Kane MA, Garza LA. Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3. Nat Commun. 2019 06 26; 10(1):2811.
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Kim D, Garza LA. Hypothesis: Wound-induced TLR3 activation stimulates endogenous retinoic acid synthesis and signalling during regeneration. Exp Dermatol. 2019 04; 28(4):450-452.
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Lionikaite V, Westerlund A, Conaway HH, Henning P, Lerner UH. Effects of retinoids on physiologic and inflammatory osteoclastogenesis in vitro. J Leukoc Biol. 2018 12; 104(6):1133-1145.
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