 Keratinocytes
"Keratinocytes" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Epidermal cells which synthesize keratin and undergo characteristic changes as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin. Successive stages of differentiation of the keratinocytes forming the epidermal layers are basal cell, spinous or prickle cell, and the granular cell.
| Descriptor ID |
D015603
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| MeSH Number(s) |
A11.436.397
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Keratinocytes".
Below are MeSH descriptors whose meaning is more specific than "Keratinocytes".
This graph shows the total number of publications written about "Keratinocytes" by people in UAMS Profiles by year, and whether "Keratinocytes" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2025 | 0 | 1 | 1 | | 2024 | 2 | 0 | 2 | | 2023 | 0 | 1 | 1 | | 2022 | 0 | 2 | 2 | | 2021 | 3 | 1 | 4 | | 2020 | 0 | 2 | 2 | | 2019 | 1 | 2 | 3 | | 2018 | 3 | 2 | 5 | | 2016 | 1 | 3 | 4 | | 2015 | 3 | 3 | 6 | | 2014 | 0 | 1 | 1 | | 2013 | 2 | 1 | 3 | | 2012 | 2 | 1 | 3 | | 2011 | 2 | 1 | 3 | | 2009 | 1 | 3 | 4 | | 2008 | 2 | 2 | 4 | | 2007 | 0 | 1 | 1 | | 2006 | 0 | 3 | 3 | | 2005 | 0 | 2 | 2 | | 2004 | 2 | 2 | 4 | | 2002 | 2 | 0 | 2 | | 2001 | 2 | 1 | 3 | | 2000 | 2 | 1 | 3 | | 1999 | 0 | 1 | 1 | | 1997 | 2 | 2 | 4 | | 1994 | 0 | 2 | 2 | | 1993 | 0 | 1 | 1 | | 1991 | 1 | 1 | 2 | | 1990 | 3 | 0 | 3 |
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Below are the most recent publications written about "Keratinocytes" by people in Profiles over the past ten years.
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Salim A, Marquez L, Jakkala K, Woo S, Caputo M, Fancello F, Deiana P, Santona M, Molinu MG, Quave CL, Zara S. Identification of Punicalagin as a Key Bioactive Compound Responsible for the Antimicrobial Properties of Punica granatum L. Peel Extract against Staphylococcus aureus. J Agric Food Chem. 2025 Jul 23; 73(29):18280-18290.
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Lee SS, Martinez Pe?a EG, Willis AA, Wang CC, Haddad NR, Garza LA. Cell Therapy and the Skin: Great Potential but in Need of Optimization. J Invest Dermatol. 2025 May; 145(5):1033-1038.
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Lee SS, Sweren E, Dare E, Derr P, Derr K, Wang CC, Hardesty B, Willis AA, Chen J, Vuillier JK, Du J, Wool J, Ruci A, Wang VY, Lee C, Iyengar S, Asami S, Daskam M, Lee C, Lee JC, Cho D, Kim J, Martinez-Pe?a EG, Lee SM, He X, Wakeman M, Sicilia I, Dobbs DT, van Ee A, Li A, Xue Y, Williams KL, Kirby CS, Kim D, Kim S, Xu L, Wang R, Ferrer M, Chen Y, Kang JU, Kalhor R, Kang S, Garza LA. The use of ectopic volar fibroblasts to modify skin identity. Science. 2024 09 06; 385(6713):eadi1650.
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Wang G, Sweren E, Andrews W, Li Y, Chen J, Xue Y, Wier E, Alphonse MP, Luo L, Miao Y, Chen R, Zeng D, Lee S, Li A, Dare E, Kim D, Archer NK, Reddy SK, Resar L, Hu Z, Grice EA, Kane MA, Garza LA. Commensal microbiome promotes hair follicle regeneration by inducing keratinocyte HIF-1a signaling and glutamine metabolism. Sci Adv. 2023 01 04; 9(1):eabo7555.
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Mudambi S, Fitzgerald M, Pera P, Washington D, Chamberlain S, Fidrus E, Hegedus C, Remenyik E, Shafirstein G, Bellnier D, Paragh G. KDM1A inhibition increases UVA toxicity and enhances photodynamic therapy efficacy. Photodermatol Photoimmunol Photomed. 2023 May; 39(3):226-234.
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Dong X, Limjunyawong N, Sypek EI, Wang G, Ortines RV, Youn C, Alphonse MP, Dikeman D, Wang Y, Lay M, Kothari R, Vasavda C, Pundir P, Goff L, Miller LS, Lu W, Garza LA, Kim BS, Archer NK, Dong X. Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a/b to prevent skin dysbiosis and bacterial infection. Immunity. 2022 09 13; 55(9):1645-1662.e7.
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Xuan Ngo Y, Haga K, Suzuki A, Kato H, Yanagisawa H, Izumi K, Sada A. Isolation and Culture of Primary Oral Keratinocytes from the Adult Mouse Palate. J Vis Exp. 2021 09 24; (175).
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Tsai J, Rostom M, Garza LA. Understanding and Harnessing Epithelial?Mesenchymal Interactions in the Development of Palmoplantar Identity. J Invest Dermatol. 2022 02; 142(2):282-284.
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Wang G, Sweren E, Liu H, Wier E, Alphonse MP, Chen R, Islam N, Li A, Xue Y, Chen J, Park S, Chen Y, Lee S, Wang Y, Wang S, Archer NK, Andrews W, Kane MA, Dare E, Reddy SK, Hu Z, Grice EA, Miller LS, Garza LA. Bacteria induce skin regeneration via IL-1? signaling. Cell Host Microbe. 2021 05 12; 29(5):777-791.e6.
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Patrick GJ, Liu H, Alphonse MP, Dikeman DA, Youn C, Otterson JC, Wang Y, Ravipati A, Mazhar M, Denny G, Ortines RV, Zhang E, Miller RJ, Dillen CA, Liu Q, Nolan SJ, Nguyen K, Marcello L, Do DC, Wier EM, Zhang Y, Caviness G, Klimowicz AC, Mierz DV, Fine JS, Sun G, Goldbach-Mansky R, Marusina AI, Merleev AA, Maverakis E, Garza LA, Milner JD, Gao P, Ramanujam M, Raymond EL, Archer NK, Miller LS. Epicutaneous Staphylococcus aureus induces IL-36 to enhance IgE production and ensuing allergic disease. J Clin Invest. 2021 03 01; 131(5).
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Dettweiler M, Marquez L, Lin M, Sweeney-Jones AM, Chhetri BK, Zurawski DV, Kubanek J, Quave CL. Pentagalloyl glucose from Schinus terebinthifolia inhibits growth of carbapenem-resistant Acinetobacter baumannii. Sci Rep. 2020 09 18; 10(1):15340.
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Schultz F, Anywar G, Tang H, Chassagne F, Lyles JT, Garbe LA, Quave CL. Targeting ESKAPE pathogens with anti-infective medicinal plants from the Greater Mpigi region in Uganda. Sci Rep. 2020 07 20; 10(1):11935.
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Dettweiler M, Lyles JT, Nelson K, Dale B, Reddinger RM, Zurawski DV, Quave CL. American Civil War plant medicines inhibit growth, biofilm formation, and quorum sensing by multidrug-resistant bacteria. Sci Rep. 2019 05 22; 9(1):7692.
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Der E, Suryawanshi H, Morozov P, Kustagi M, Goilav B, Ranabothu S, Izmirly P, Clancy R, Belmont HM, Koenigsberg M, Mokrzycki M, Rominieki H, Graham JA, Rocca JP, Bornkamp N, Jordan N, Schulte E, Wu M, Pullman J, Slowikowski K, Raychaudhuri S, Guthridge J, James J, Buyon J, Tuschl T, Putterman C. Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways. Nat Immunol. 2019 07; 20(7):915-927.
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Agarwal S, Mirzoeva S, Readhead B, Dudley JT, Budunova I. PI3K inhibitors protect against glucocorticoid-induced skin atrophy. EBioMedicine. 2019 Mar; 41:526-537.
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Kim S, Kim BW, Prizmic VP, Oh E, Yu V, Evans B, Kim D, Garza LA. Simple cell culture media expansion of primary mouse keratinocytes. J Dermatol Sci. 2019 02; 93(2):135-138.
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Archer NK, Jo JH, Lee SK, Kim D, Smith B, Ortines RV, Wang Y, Marchitto MC, Ravipati A, Cai SS, Dillen CA, Liu H, Miller RJ, Ashbaugh AG, Uppal AS, Oyoshi MK, Malhotra N, Hoff S, Garza LA, Kong HH, Segre JA, Geha RS, Miller LS. Injury, dysbiosis, and filaggrin deficiency drive skin inflammation through keratinocyte IL-1a release. J Allergy Clin Immunol. 2019 04; 143(4):1426-1443.e6.
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Zhou R, Wang G, Kim D, Kim S, Islam N, Chen R, Wang Z, Li A, McCarthy EF, Li L, Hu Z, Garza LA. dsRNA Sensing Induces Loss of Cell Identity. J Invest Dermatol. 2019 01; 139(1):91-99.
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Mouritzen MV, Abourayale S, Ejaz R, Ardon CB, Carvalho E, Dalgaard LT, Roursgaard M, Jenssen H. Neurotensin, substance P, and insulin enhance cell migration. J Pept Sci. 2018 Jul; 24(7):e3093.
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Lesovaya E, Agarwal S, Readhead B, Vinokour E, Baida G, Bhalla P, Kirsanov K, Yakubovskaya M, Platanias LC, Dudley JT, Budunova I. Rapamycin Modulates Glucocorticoid Receptor Function, Blocks Atrophogene REDD1, and Protects Skin from Steroid?Atrophy. J Invest Dermatol. 2018 09; 138(9):1935-1944.
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Song E, Luo N, Alvarado JA, Lim M, Walnuss C, Neely D, Spandau D, Ghaffarieh A, Sun Y. Ocular Pathology of Oculocerebrorenal Syndrome of Lowe: Novel Mutations and Genotype-Phenotype Analysis. Sci Rep. 2017 05 04; 7(1):1442.
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Hirashima R, Itoh T, Tukey RH, Fujiwara R. Prediction of drug-induced liver injury using keratinocytes. J Appl Toxicol. 2017 07; 37(7):863-872.
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Greening GJ, Rajaram N, Muldoon TJ. Multimodal Imaging and Spectroscopy Fiber-bundle Microendoscopy Platform for Non-invasive, In Vivo Tissue Analysis. J Vis Exp. 2016 10 17; (116).
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Emanuelli T, Burgeiro A, Carvalho E. Effects of insulin on the skin: possible healing benefits for diabetic foot ulcers. Arch Dermatol Res. 2016 Dec; 308(10):677-694.
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Kim D, Hossain MZ, Nieves A, Gu L, Ratliff TS, Mi Oh S, Park A, Han S, Yang NB, Qi J, Taube JM, Kang S, Garza LA. To Control Site-Specific Skin Gene Expression, Autocrine Mimics Paracrine Canonical Wnt Signaling and Is Activated Ectopically in Skin Disease. Am J Pathol. 2016 05; 186(5):1140-50.
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Nelson AM, Katseff AS, Ratliff TS, Garza LA. Interleukin 6 and STAT3 regulate p63 isoform expression in keratinocytes during regeneration. Exp Dermatol. 2016 Feb; 25(2):155-7.
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Skeate JG, Porras TB, Woodham AW, Jang JK, Taylor JR, Brand HE, Kelly TJ, Jung JU, Da Silva DM, Yuan W, Martin Kast W. Herpes simplex virus downregulation of secretory leukocyte protease inhibitor enhances human papillomavirus type 16 infection. J Gen Virol. 2016 Feb; 97(2):422-434.
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