Sp1 Transcription Factor
"Sp1 Transcription Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.
| Descriptor ID |
D016329
|
| MeSH Number(s) |
D12.776.260.522.750.249 D12.776.930.375.750.249
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Sp1 Transcription Factor".
Below are MeSH descriptors whose meaning is more specific than "Sp1 Transcription Factor".
This graph shows the total number of publications written about "Sp1 Transcription Factor" by people in UAMS Profiles by year, and whether "Sp1 Transcription Factor" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 |
| 2022 | 0 | 1 | 1 |
| 2016 | 0 | 1 | 1 |
| 2009 | 1 | 0 | 1 |
| 2008 | 0 | 1 | 1 |
| 2007 | 0 | 2 | 2 |
| 2005 | 0 | 1 | 1 |
| 2004 | 1 | 0 | 1 |
| 2003 | 0 | 1 | 1 |
| 2002 | 1 | 1 | 2 |
| 1999 | 1 | 0 | 1 |
| 1996 | 1 | 0 | 1 |
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Below are the most recent publications written about "Sp1 Transcription Factor" by people in Profiles over the past ten years.
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Leung YK, Lee SG, Wang J, Guruvaiah P, Rusch NJ, Ho SM, Park C, Kim K. The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/?-catenin Signaling via Epigenetic Dysregulation that Enhances Sp1-? catenin-p300 Interactions in Hepatocellular Carcinoma. Adv Sci (Weinh). 2024 Aug; 11(29):e2308539.
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McDermott A, Kim K, Kasper S, Ho SM, Leung YK. The androgen receptor inhibits transcription of GPER1 by preventing Sp1 and Sp3 from binding to the promoters in prostate cancer cells. Oncotarget. 2022; 13:46-60.
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Raju I, Kaushal GP, Haun RS. Epigenetic regulation of KLK7 gene expression in pancreatic and cervical cancer cells. Biol Chem. 2016 11 01; 397(11):1135-1146.