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John Marecki

TitleInstructor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentBiochemistry & Molecular Biology, College of Medicine
DivisionBiochemistry & Molecular DNA & RNA
AddressB316 Biomedical Research I
200 South Cedar
Mail Slot # 516
Little Rock AR 72202
Phone501-686-7254
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    Collapse Research 
    Collapse research activities and funding
    P20GM152281     (EOFF, ROBERT L)Mar 5, 2024 - Dec 31, 2028
    NIH
    Center for Molecular Interactions in Cancer (CMIC)
    Role: Co-Investigator
    U19AI171954     (RANEY, KEVIN D)May 16, 2022 - Apr 30, 2027
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: University of Minnesota
    Midwest AViDD Center
    Role: Principal Investigator
    R01 AI161841     (RANEY, KEVIN D)May 1, 2022 - Feb 28, 2025
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: University of North Carolina - Chapel Hill
    Coronavirus Genome Replication Subcontract UNC-CH Craig Cameron
    Role: Principal Investigator
    R35GM122601     (RANEY, KEVIN DOUGLAS)May 1, 2017 - Apr 30, 2022
    NIH
    Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids
    Role: Co-Investigator
    R01NS040819     (CROW JR, JOHN)Dec 1, 2000 - Apr 30, 2013
    NIH/Nat. Inst. of Neurological Disorders & Stroke
    Mechanisms of Protection and Pathogenesis in ALS Mice
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Hong Z, Byrd AK, Gao J, Das P, Tan VQ, Malone EG, Osei B, Marecki JC, Protacio RU, Wahls WP, Raney KD, Song H. Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge. Nat Commun. 2024 Jul 19; 15(1):6104. PMID: 39030241.
      View in: PubMed
    2. Gao J, Proffitt DR, Marecki JC, Protacio RU, Wahls WP, Byrd AK, Raney KD. Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth. Nucleic Acids Res. 2024 Jun 24; 52(11):6543-6557. PMID: 38752483.
      View in: PubMed
    3. Byrd AK, Malone EG, Hazeslip L, Zafar MK, Harrison DK, Thompson MD, Gao J, Perumal SK, Marecki JC, Raney KD. A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA. Protein Sci. 2022 02; 31(2):407-421. PMID: 34761452.
      View in: PubMed
    4. Marecki JC, Belachew B, Gao J, Raney KD. RNA helicases required for viral propagation in humans. Enzymes. 2021; 50:335-367. PMID: 34861942.
      View in: PubMed
    5. Gao J, Gao Z, Putnam AA, Byrd AK, Venus SL, Marecki JC, Edwards AD, Lowe HM, Jankowsky E, Raney KD. G-quadruplex DNA inhibits unwinding activity but promotes liquid-liquid phase separation by the DEAD-box helicase Ded1p. Chem Commun (Camb). 2021 Jul 27; 57(60):7445-7448. PMID: 34232232.
      View in: PubMed
    6. Edwards AD, Marecki JC, Byrd AK, Gao J, Raney KD. G-Quadruplex loops regulate PARP-1 enzymatic activation. Nucleic Acids Res. 2021 01 11; 49(1):416-431. PMID: 33313902.
      View in: PubMed
    7. Marecki JC, Byrd AK, Raney KD. Identifying RNA Helicase Inhibitors Using Duplex Unwinding Assays. Methods Mol Biol. 2021; 2209:53-72. PMID: 33201462.
      View in: PubMed
    8. Stolarz AJ, Sarimollaoglu M, Marecki JC, Fletcher TW, Galanzha EI, Rhee SW, Zharov VP, Klimberg VS, Rusch NJ. Doxorubicin Activates Ryanodine Receptors in Rat Lymphatic Muscle Cells to Attenuate Rhythmic Contractions and Lymph Flow. J Pharmacol Exp Ther. 2019 11; 371(2):278-289. PMID: 31439806.
      View in: PubMed
    9. Gao J, Byrd AK, Zybailov BL, Marecki JC, Guderyon MJ, Edwards AD, Chib S, West KL, Waldrip ZJ, Mackintosh SG, Gao Z, Putnam AA, Jankowsky E, Raney KD. DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA. Chem Commun (Camb). 2019 Apr 11; 55(31):4467-4470. PMID: 30855040.
      View in: PubMed
    10. Marecki JC, Aarattuthodiyil S, Byrd AK, Penthala NR, Crooks PA, Raney KD. N-Naphthoyl-substituted indole thio-barbituric acid analogs inhibit the helicase activity of the hepatitis C virus NS3. Bioorg Med Chem Lett. 2019 02 01; 29(3):430-434. PMID: 30578035.
      View in: PubMed
    11. Byrd AK, Zybailov BL, Maddukuri L, Gao J, Marecki JC, Jaiswal M, Bell MR, Griffin WC, Reed MR, Chib S, Mackintosh SG, MacNicol AM, Baldini G, Eoff RL, Raney KD. Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress. J Biol Chem. 2016 08 19; 291(34):18041-57. PMID: 27369081.
      View in: PubMed
    12. Marecki JC, Parajuli N, Crow JP, MacMillan-Crow LA. The use of the Cre/loxP system to study oxidative stress in tissue-specific manganese superoxide dismutase knockout models. Antioxid Redox Signal. 2014 Apr 01; 20(10):1655-70. PMID: 23641945.
      View in: PubMed
    13. Crow JP, Marecki JC, Thompson M. D-Serine Production, Degradation, and Transport in ALS: Critical Role of Methodology. Neurol Res Int. 2012; 2012:625245. PMID: 23029613.
      View in: PubMed
    14. Thompson M, Marecki JC, Marinesco S, Labrie V, Roder JC, Barger SW, Crow JP. Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis. J Neurochem. 2012 Feb; 120(4):598-610. PMID: 22117694.
      View in: PubMed
    15. Marecki JC, Ronis MJ, Shankar K, Badger TM. Hyperinsulinemia and ectopic fat deposition can develop in the face of hyperadiponectinemia in young obese rats. J Nutr Biochem. 2011 Feb; 22(2):142-52. PMID: 20435456.
      View in: PubMed
    16. Shankar K, Kang P, Harrell A, Zhong Y, Marecki JC, Ronis MJ, Badger TM. Maternal overweight programs insulin and adiponectin signaling in the offspring. Endocrinology. 2010 Jun; 151(6):2577-89. PMID: 20371699.
      View in: PubMed
    17. He L, Marecki JC, Serrero G, Simmen FA, Ronis MJ, Badger TM. Dose-dependent effects of alcohol on insulin signaling: partial explanation for biphasic alcohol impact on human health. Mol Endocrinol. 2007 Oct; 21(10):2541-50. PMID: 17622585.
      View in: PubMed
    18. Tuder RM, Marecki JC, Richter A, Fijalkowska I, Flores S. Pathology of pulmonary hypertension. Clin Chest Med. 2007 Mar; 28(1):23-42, vii. PMID: 17338926.
      View in: PubMed
    19. Marecki JC, Cool CD, Parr JE, Beckey VE, Luciw PA, Tarantal AF, Carville A, Shannon RP, Cota-Gomez A, Tuder RM, Voelkel NF, Flores SC. HIV-1 Nef is associated with complex pulmonary vascular lesions in SHIV-nef-infected macaques. Am J Respir Crit Care Med. 2006 Aug 15; 174(4):437-45. PMID: 16728715.
      View in: PubMed
    20. El Mezayen R, El Gazzar M, Nicolls MR, Marecki JC, Dreskin SC, Nomiyama H. Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. Immunol Lett. 2006 Jul 15; 106(1):72-81. PMID: 16762422.
      View in: PubMed
    21. El Gazzar M, El Mezayen R, Nicolls MR, Marecki JC, Dreskin SC. Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma. Biochim Biophys Acta. 2006 Jul; 1760(7):1088-95. PMID: 16624488.
      View in: PubMed
    22. El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC. Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. Int Immunopharmacol. 2006 Jul; 6(7):1135-42. PMID: 16714217.
      View in: PubMed
    23. Marecki J, Cool C, Voelkel N, Luciw P, Flores S. Evidence for vascular remodeling in the lungs of macaques infected with simian immunodeficiency virus/HIV NEF recombinant virus. Chest. 2005 Dec; 128(6 Suppl):621S-622S. PMID: 16373878.
      View in: PubMed
    24. Ling X, Cota-Gomez A, Flores NC, Hernandez-Saavedra D, McCord JM, Marecki JC, Haskins K, McDuffie M, Powers K, Kench J, Oka M, McMurtry I, Flores SC. Alterations in redox homeostasis and prostaglandins impair endothelial-dependent vasodilation in euglycemic autoimmune nonobese diabetic mice. Free Radic Biol Med. 2005 Oct 15; 39(8):1089-98. PMID: 16198235.
      View in: PubMed
    25. Marecki JC, Cota-Gomez A, Vaitaitis GM, Honda JR, Porntadavity S, St Clair DK, Flores SC. HIV-1 Tat regulates the SOD2 basal promoter by altering Sp1/Sp3 binding activity. Free Radic Biol Med. 2004 Sep 15; 37(6):869-80. PMID: 15706661.
      View in: PubMed
    26. Marecki JC, McCord JM. The inhibition of poly(ADP-ribose) polymerase enhances growth rates of ataxia telangiectasia cells. Arch Biochem Biophys. 2002 Jun 15; 402(2):227-34. PMID: 12051667.
      View in: PubMed
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