 Immunity, Innate
"Immunity, Innate" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The capacity of a normal organism to remain unaffected by microorganisms and their toxins. It results from the presence of naturally occurring ANTI-INFECTIVE AGENTS, constitutional factors such as BODY TEMPERATURE and immediate acting immune cells such as NATURAL KILLER CELLS.
| Descriptor ID |
D007113
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| MeSH Number(s) |
G12.450.564
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| Concept/Terms |
Immunity, Innate- Immunity, Innate
- Innate Immunity
- Immunity, Non-Specific
- Immunity, Non Specific
- Non-Specific Immunity
- Immunity, Native
- Native Immunity
- Immunity, Natural
- Natural Immunity
Innate Immune Response- Innate Immune Response
- Immune Response, Innate
- Immune Responses, Innate
- Innate Immune Responses
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Below are MeSH descriptors whose meaning is more general than "Immunity, Innate".
Below are MeSH descriptors whose meaning is more specific than "Immunity, Innate".
This graph shows the total number of publications written about "Immunity, Innate" by people in UAMS Profiles by year, and whether "Immunity, Innate" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 3 | 3 | 6 | | 2022 | 0 | 3 | 3 | | 2021 | 1 | 1 | 2 | | 2020 | 5 | 5 | 10 | | 2019 | 0 | 1 | 1 | | 2018 | 4 | 2 | 6 | | 2017 | 3 | 1 | 4 | | 2016 | 3 | 1 | 4 | | 2015 | 1 | 3 | 4 | | 2014 | 6 | 1 | 7 | | 2013 | 0 | 3 | 3 | | 2012 | 3 | 2 | 5 | | 2011 | 1 | 3 | 4 | | 2010 | 4 | 4 | 8 | | 2009 | 1 | 0 | 1 | | 2008 | 1 | 1 | 2 | | 2007 | 1 | 3 | 4 | | 2006 | 0 | 2 | 2 | | 1999 | 0 | 2 | 2 |
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Below are the most recent publications written about "Immunity, Innate" by people in Profiles over the past ten years.
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Spottiswoode N, Tsitsiklis A, Chu VT, Phan HV, DeVoe C, Love C, Ghale R, Bloomstein J, Zha BS, Maguire CP, Glascock A, Sarma A, Mourani PM, Kalantar KL, Detweiler A, Neff N, Haller SC, DeRisi JL, Erle DJ, Hendrickson CM, Kangelaris KN, Krummel MF, Matthay MA, Woodruff PG, Calfee CS, Langelier CR. Microbial dynamics and pulmonary immune responses in COVID-19 secondary bacterial pneumonia. Nat Commun. 2024 Oct 29; 15(1):9339.
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Liu Z, Kong N, Zhang Y, Zheng Y, Yang C, Fu Q, Zhang Z, Li F, Liu R, Wang L, Song L. The phytoplankton community affects the energy metabolism and immunomodulation strategy of oyster during breeding seasons. Fish Shellfish Immunol. 2024 Oct; 153:109819.
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Venugopal G, Pechous RD. Yersinia pestis and pneumonic plague: Insight into how a lethal pathogen interfaces with innate immune populations in the lung to cause severe disease. Cell Immunol. 2024 Sep-Oct; 403-404:104856.
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Pechous RD, Malaviarachchi PA, Banerjee SK, Byrum SD, Alkam DH, Ghaffarieh A, Kurten RC, Kennedy JL, Zhang X. An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy. J Virol. 2024 Jul 23; 98(7):e0079424.
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Ghimire L, Paudel S, Le J, Jin L, Cai S, Bhattarai D, Jeyaseelan S. NLRP6 negatively regulates host defense against polymicrobial sepsis. Front Immunol. 2024; 15:1248907.
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Gurung M, Schlegel BT, Rajasundaram D, Fox R, Bode L, Yao T, Lindemann SR, LeRoith T, Read QD, Simecka C, Carroll L, Andres A, Yeruva L. Microbiota from human infants consuming secretors or non-secretors mothers' milk impacts the gut and immune system in mice. mSystems. 2024 Apr 16; 9(4):e0029424.
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Kieber-Emmons T. Broad Based Immunity? Monoclon Antib Immunodiagn Immunother. 2022 10; 41(5):229-230.
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Price AS, Kennedy JL. T-helper 2 mechanisms involved in human rhinovirus infections and asthma. Ann Allergy Asthma Immunol. 2022 12; 129(6):681-691.
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Caro J, Braunstein M, Williams L, Bruno B, Kaminetzky D, Siegel A, Razzo B, Alfandari S, Morgan GJ, Davies FE, Boyle EM. Inflammation and infection in plasma cell disorders: how pathogens shape the fate of patients. Leukemia. 2022 03; 36(3):613-624.
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Feng X, Lawrence MG, Payne SC, Mattos J, Etter E, Negri JA, Murphy D, Kennedy JL, Steinke JW, Borish L. Lower viral loads in subjects with rhinovirus-challenged allergy despite reduced innate immunity. Ann Allergy Asthma Immunol. 2022 04; 128(4):414-422.e2.
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Yang FM, Chang HM, Yeh ETH. Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4. Proc Natl Acad Sci U S A. 2021 11 23; 118(47).
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Mercado MAB, Du W, Malaviarachchi PA, Gann JI, Li LX. Innate IFN-? Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-? Production Is Highly Redundant in the Female Reproductive Tract. Infect Immun. 2021 02 16; 89(3).
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Petitjean O, Girardi E, Ngondo RP, Lupashin V, Pfeffer S. Genome-Wide CRISPR-Cas9 Screen Reveals the Importance of the Heparan Sulfate Pathway and the Conserved Oligomeric Golgi Complex for Synthetic Double-Stranded RNA Uptake and Sindbis Virus Infection. mSphere. 2020 11 11; 5(6).
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Stuart JD, Salinas E, Grakoui A. Immune system control of hepatitis C virus infection. Curr Opin Virol. 2021 02; 46:36-44.
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Faust HJ, Zhang H, Han J, Wolf MT, Jeon OH, Sadtler K, Pe?a AN, Chung L, Maestas DR, Tam AJ, Pardoll DM, Campisi J, Housseau F, Zhou D, Bingham CO, Elisseeff JH. IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis. J Clin Invest. 2020 10 01; 130(10):5493-5507.
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Osterman MT, Gordon IO, Davis EM, Ciorba M, Glover SC, Abraham B, Khan F, Guo X, Yee EU, Allard FD, Claggett B, Shen B, Liu JJ. Mucosal Biomarker of Innate Immune Activation Predicts Response to Vedolizumab in Crohn's Disease. Inflamm Bowel Dis. 2020 09 18; 26(10):1554-1561.
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Tepaamorndech S, Nookaew I, Higdon SM, Santiyanont P, Phromson M, Chantarasakha K, Mhuantong W, Plengvidhya V, Visessanguan W. Metagenomics in bioflocs and their effects on gut microbiome and immune responses in Pacific white shrimp. Fish Shellfish Immunol. 2020 Nov; 106:733-741.
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Chen X, Yang X, de Anda J, Huang J, Li D, Xu H, Shields KS, D?unkov? M, Hansen J, Patel IJ, Yee EU, Golenbock DT, Grant MA, Wong GCL, Kelly CP. Clostridioides difficile Toxin A Remodels Membranes and Mediates DNA Entry Into Cells to Activate Toll-Like Receptor 9 Signaling. Gastroenterology. 2020 12; 159(6):2181-2192.e1.
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Oh C, Verma A, Aachoui Y. Caspase-11 Non-canonical Inflammasomes in the Lung. Front Immunol. 2020; 11:1895.
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Batlle D, Soler MJ, Sparks MA, Hiremath S, South AM, Welling PA, Swaminathan S. Acute Kidney Injury in COVID-19: Emerging Evidence of a Distinct Pathophysiology. J Am Soc Nephrol. 2020 07; 31(7):1380-1383.
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Kar UK, Joosten LAB. Training the trainable cells of the immune system and beyond. Nat Immunol. 2020 02; 21(2):115-119.
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Coleman CM. Determining How Coronaviruses Overcome the Interferon and Innate Immune Response. Methods Mol Biol. 2020; 2203:223-229.
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Svahn SL, Guti?rrez S, Ulleryd MA, Nookaew I, Osla V, Beckman F, Nilsson S, Karlsson A, Jansson JO, Johansson ME. Dietary Polyunsaturated Fatty Acids Promote Neutrophil Accumulation in the Spleen by Altering Chemotaxis and Delaying Cell Death. Infect Immun. 2019 08; 87(8).
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Giebel AM, Hu S, Rajaram K, Finethy R, Toh E, Brothwell JA, Morrison SG, Suchland RJ, Stein BD, Coers J, Morrison RP, Nelson DE. Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture. mBio. 2019 04 09; 10(2).
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Tokatlian T, Read BJ, Jones CA, Kulp DW, Menis S, Chang JYH, Steichen JM, Kumari S, Allen JD, Dane EL, Liguori A, Sangesland M, Lingwood D, Crispin M, Schief WR, Irvine DJ. Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers. Science. 2019 02 08; 363(6427):649-654.
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Zimmer A, Bagchi AK, Vinayak K, Bello-Klein A, Singal PK. Innate immune response in the pathogenesis of heart failure in survivors of myocardial infarction. Am J Physiol Heart Circ Physiol. 2019 03 01; 316(3):H435-H445.
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Cabrera SM, Engle S, Kaldunski M, Jia S, Geoffrey R, Simpson P, Szabo A, Speake C, Greenbaum CJ, Chen YG, Hessner MJ. Innate immune activity as a predictor of persistent insulin secretion and association with responsiveness to CTLA4-Ig treatment in recent-onset type 1 diabetes. Diabetologia. 2018 11; 61(11):2356-2370.
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Pashov A, Hernandez Puente CV, Ibrahim SM, Monzavi-Karbassi B, Makhoul I, Kieber-Emmons T. Thinking Cancer. Monoclon Antib Immunodiagn Immunother. 2018 Jun; 37(3):117-125.
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Yang FM, Zuo Y, Zhou W, Xia C, Hahm B, Sullivan M, Cheng J, Chang HM, Yeh ET. sNASP inhibits TLR signaling to regulate immune response in sepsis. J Clin Invest. 2018 06 01; 128(6):2459-2472.
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Bhattarai D, Worku T, Dad R, Rehman ZU, Gong X, Zhang S. Mechanism of pattern recognition receptors (PRRs) and host pathogen interplay in bovine mastitis. Microb Pathog. 2018 Jul; 120:64-70.
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Gao X, Cao Q, Cheng Y, Zhao D, Wang Z, Yang H, Wu Q, You L, Wang Y, Lin Y, Li X, Wang Y, Bian JS, Sun D, Kong L, Birnbaumer L, Yang Y. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proc Natl Acad Sci U S A. 2018 03 27; 115(13):E2960-E2969.
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Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ETH, Yang J, Yi J. DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages. J Biol Chem. 2018 03 16; 293(11):3965-3980.
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Ayoub KF, Pothineni NVK, Rutland J, Ding Z, Mehta JL. Immunity, Inflammation, and Oxidative Stress in Heart Failure: Emerging Molecular Targets. Cardiovasc Drugs Ther. 2017 Dec; 31(5-6):593-608.
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Jevtic S, Sengar AS, Salter MW, McLaurin J. The role of the immune system in Alzheimer disease: Etiology and treatment. Ageing Res Rev. 2017 Nov; 40:84-94.
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Huang L, Russell DG. Protective immunity against tuberculosis: what does it look like and how do we find it? Curr Opin Immunol. 2017 Oct; 48:44-50.
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Pechous RD. With Friends Like These: The Complex Role of Neutrophils in the Progression of Severe Pneumonia. Front Cell Infect Microbiol. 2017; 7:160.
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Karta MR, Rosenthal PS, Beppu A, Vuong CY, Miller M, Das S, Kurten RC, Doherty TA, Broide DH. ?2 integrins rather than ?1 integrins mediate Alternaria-induced group 2 innate lymphoid cell trafficking to the lung. J Allergy Clin Immunol. 2018 01; 141(1):329-338.e12.
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Qiang YW, Ye S, Chen Y, Buros AF, Edmonson R, van Rhee F, Barlogie B, Epstein J, Morgan GJ, Davies FE. MAF protein mediates innate resistance to proteasome inhibition therapy in multiple myeloma. Blood. 2016 12 22; 128(25):2919-2930.
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Lee J, Moraes-Vieira PM, Castoldi A, Aryal P, Yee EU, Vickers C, Parnas O, Donaldson CJ, Saghatelian A, Kahn BB. Branched Fatty Acid Esters of Hydroxy Fatty Acids (FAHFAs) Protect against Colitis by Regulating Gut Innate and Adaptive Immune Responses. J Biol Chem. 2016 Oct 14; 291(42):22207-22217.
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Wells AJ, Hoffman JR, Jajtner AR, Varanoske AN, Church DD, Gonzalez AM, Townsend JR, Boone CH, Baker KM, Beyer KS, Mangine GT, Oliveira LP, Fukuda DH, Stout JR. Monocyte Recruitment after High-Intensity and High-Volume Resistance Exercise. Med Sci Sports Exerc. 2016 06; 48(6):1169-78.
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Cho NE, Bang BR, Gurung P, Li M, Clemens DL, Underhill TM, James LP, Chase JR, Saito T. Retinoid regulation of antiviral innate immunity in hepatocytes. Hepatology. 2016 06; 63(6):1783-95.
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Huang L, Beiting DP, Gebreselassie NG, Gagliardo LF, Ruyechan MC, Lee NA, Lee JJ, Appleton JA. Eosinophils and IL-4 Support Nematode Growth Coincident with an Innate Response to Tissue Injury. PLoS Pathog. 2015 Dec; 11(12):e1005347.
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Panchanathan R, Liu H, Leung YK, Ho SM, Choubey D. Bisphenol A (BPA) stimulates the interferon signaling and activates the inflammasome activity in myeloid cells. Mol Cell Endocrinol. 2015 Nov 05; 415:45-55.
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Doherty TA, Baum R, Newbury RO, Yang T, Dohil R, Aquino M, Doshi A, Walford HH, Kurten RC, Broide DH, Aceves S. Group 2 innate lymphocytes (ILC2) are enriched in active eosinophilic esophagitis. J Allergy Clin Immunol. 2015 Sep; 136(3):792-794.e3.
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Moerman-Herzog A, Nakagawa M. Early Defensive Mechanisms against Human Papillomavirus Infection. Clin Vaccine Immunol. 2015 Aug; 22(8):850-7.
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Gielen V, Sykes A, Zhu J, Chan B, Macintyre J, Regamey N, Kieninger E, Gupta A, Shoemark A, Bossley C, Davies J, Saglani S, Walker P, Nicholson SE, Dalpke AH, Kon OM, Bush A, Johnston SL, Edwards MR. Increased nuclear suppressor of cytokine signaling 1 in asthmatic bronchial epithelium suppresses rhinovirus induction of innate interferons. J Allergy Clin Immunol. 2015 Jul; 136(1):177-188.e11.
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Deretic V, Kimura T, Timmins G, Moseley P, Chauhan S, Mandell M. Immunologic manifestations of autophagy. J Clin Invest. 2015 Jan; 125(1):75-84.
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Atif SM, Lee SJ, Li LX, Uematsu S, Akira S, Gorjestani S, Lin X, Schweighoffer E, Tybulewicz VL, McSorley SJ. Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9. Eur J Immunol. 2015 Feb; 45(2):513-24.
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Liu J, McFadden G. SAMD9 is an innate antiviral host factor with stress response properties that can be antagonized by poxviruses. J Virol. 2015 Feb; 89(3):1925-31.
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