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Roger Pechous

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address325 S. Elm St.
Mail Slot # 511
Little Rock AR 72205
Phone501-686-5155
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    Collapse Research 
    Collapse research activities and funding
    P30GM145393     (SMELTZER, MARK S)May 5, 2022 - Apr 30, 2027
    NIH
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Co-Investigator
    R56AI153252     (PECHOUS, ROGER D)Sep 4, 2020 - Aug 31, 2021
    NIH
    Defining the Role of the Plasminogen Activator Protease in the Early Events that Establish Primary Pneumonic Plague
    Role: Principal Investigator
    R21AI133103     (PECHOUS, ROGER D)May 15, 2018 - Apr 30, 2020
    NIH
    Evaluating early host-pathogen interactions in pneumonic plague using an ex vivo human lung tissue platform
    Role: Principal Investigator
    COM Start up package     (PECHOUS, ROGER D)Jan 1, 2016 - Jun 30, 2016
    UAMS College of Medicine
    No FP attached
    Role: Principal Investigator
    F32AI085830     (PECHOUS, ROGER D)Jul 1, 2010 - Jun 30, 2013
    NIH
    Evaluating the Progression of Pneumonic Plague
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Venugopal G, Pechous RD. Yersinia pestis and pneumonic plague: Insight into how a lethal pathogen interfaces with innate immune populations in the lung to cause severe disease. Cell Immunol. 2024 Sep-Oct; 403-404:104856. PMID: 39002222.
      View in: PubMed
    2. Pechous RD, Malaviarachchi PA, Banerjee SK, Byrum SD, Alkam DH, Ghaffarieh A, Kurten RC, Kennedy JL, Zhang X. An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy. J Virol. 2024 Jul 23; 98(7):e0079424. PMID: 38940558.
      View in: PubMed
    3. Pechous RD, Malaviarachchi PA, Xing Z, Douglas A, Crane SD, Theriot HM, Zhang Z, Ghaffarieh A, Huang L, Yu YE, Zhang X. SARS-CoV-2 Infection Causes Heightened Disease Severity and Mortality in a Mouse Model of Down Syndrome. Biomedicines. 2024 Feb 28; 12(3). PMID: 38540156.
      View in: PubMed
    4. Theriot HM, Malaviarachchi PA, Scott MG, Appell KT, Banerjee SK, Pechous RD. Pulmonary Expression of Interleukin-17 Contributes to Neutrophil Infiltration into the Lungs during Pneumonic Plague. Infect Immun. 2023 07 18; 91(7):e0013123. PMID: 37338372.
      View in: PubMed
    5. Pechous RD, Malaviarachchi PA, Banerjee SK, Byrum SD, Alkam DH, Ghaffarieh A, Kurten RC, Kennedy JL, Zhang X. An ex vivo human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy. bioRxiv. 2023 Apr 19. PMID: 37131640.
      View in: PubMed
    6. Crane SD, Banerjee SK, Pechous RD. Treatment with Fluticasone Propionate Increases Antibiotic Efficacy during Treatment of Late-Stage Primary Pneumonic Plague. Antimicrob Agents Chemother. 2022 01 18; 66(1):e0127521. PMID: 34780267.
      View in: PubMed
    7. Francis ME, Richardson B, Goncin U, McNeil M, Rioux M, Foley MK, Ge A, Pechous RD, Kindrachuk J, Cameron CM, Richardson C, Lew J, Machtaler S, Cameron MJ, Gerdts V, Falzarano D, Kelvin AA. Sex and age bias viral burden and interferon responses during SARS-CoV-2 infection in ferrets. Sci Rep. 2021 07 15; 11(1):14536. PMID: 34267262.
      View in: PubMed
    8. Crane SD, Banerjee SK, Eichelberger KR, Kurten RC, Goldman WE, Pechous RD. The Yersinia pestis GTPase BipA Promotes Pathogenesis of Primary Pneumonic Plague. Infect Immun. 2021 01 19; 89(2). PMID: 33257531.
      View in: PubMed
    9. Francis ME, Richardson B, McNeil M, Rioux M, Foley MK, Ge A, Pechous RD, Kindrachuk J, Cameron CM, Richardson C, Lew J, Cameron MJ, Gerdts V, Falzarano D, Kelvin AA. Male sex and age biases viral burden, viral shedding, and type 1 and 2 interferon responses during SARS-CoV-2 infection in ferrets. bioRxiv. 2021 Jan 12. PMID: 33469587.
      View in: PubMed
    10. Banerjee SK, Crane SD, Pechous RD. A Dual Role for the Plasminogen Activator Protease During the Preinflammatory Phase of Primary Pneumonic Plague. J Infect Dis. 2020 07 06; 222(3):407-416. PMID: 32128567.
      View in: PubMed
    11. Banerjee SK, Huckuntod SD, Mills SD, Kurten RC, Pechous RD. Modeling Pneumonic Plague in Human Precision-Cut Lung Slices Highlights a Role for the Plasminogen Activator Protease in Facilitating Type 3 Secretion. Infect Immun. 2019 08; 87(8). PMID: 31085709.
      View in: PubMed
    12. Pechous RD. Intranasal Inoculation of Mice with Yersinia pestis and Processing of Pulmonary Tissue for Analysis. Methods Mol Biol. 2019; 2010:17-28. PMID: 31177428.
      View in: PubMed
    13. Pechous RD. With Friends Like These: The Complex Role of Neutrophils in the Progression of Severe Pneumonia. Front Cell Infect Microbiol. 2017; 7:160. PMID: 28507954.
      View in: PubMed
    14. Pechous RD, Sivaraman V, Stasulli NM, Goldman WE. Pneumonic Plague: The Darker Side of Yersinia pestis. Trends Microbiol. 2016 Mar; 24(3):190-197. PMID: 26698952.
      View in: PubMed
    15. Stasulli NM, Eichelberger KR, Price PA, Pechous RD, Montgomery SA, Parker JS, Goldman WE. Spatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague. mBio. 2015 Oct 13; 6(5):e01530-15. PMID: 26463167.
      View in: PubMed
    16. Pechous RD, Goldman WE. Illuminating Targets of Bacterial Secretion. PLoS Pathog. 2015 Aug; 11(8):e1004981. PMID: 26247771.
      View in: PubMed
    17. Sivaraman V, Pechous RD, Stasulli NM, Eichelberger KR, Miao EA, Goldman WE. Yersinia pestis activates both IL-1? and IL-1 receptor antagonist to modulate lung inflammation during pneumonic plague. PLoS Pathog. 2015 Mar; 11(3):e1004688. PMID: 25781467.
      View in: PubMed
    18. Pechous RD, Broberg CA, Stasulli NM, Miller VL, Goldman WE. In vivo transcriptional profiling of Yersinia pestis reveals a novel bacterial mediator of pulmonary inflammation. mBio. 2015 Feb 17; 6(1):e02302-14. PMID: 25691593.
      View in: PubMed
    19. Pechous RD, Sivaraman V, Price PA, Stasulli NM, Goldman WE. Early host cell targets of Yersinia pestis during primary pneumonic plague. PLoS Pathog. 2013; 9(10):e1003679. PMID: 24098126.
      View in: PubMed
    20. Pechous RD, McCarthy TR, Zahrt TC. Working toward the future: insights into Francisella tularensis pathogenesis and vaccine development. Microbiol Mol Biol Rev. 2009 Dec; 73(4):684-711. PMID: 19946137.
      View in: PubMed
    21. Pechous RD, McCarthy TR, Mohapatra NP, Soni S, Penoske RM, Salzman NH, Frank DW, Gunn JS, Zahrt TC. A Francisella tularensis Schu S4 purine auxotroph is highly attenuated in mice but offers limited protection against homologous intranasal challenge. PLoS One. 2008 Jun 25; 3(6):e2487. PMID: 18575611.
      View in: PubMed
    22. Li J, Ryder C, Mandal M, Ahmed F, Azadi P, Snyder DS, Pechous RD, Zahrt T, Inzana TJ. Attenuation and protective efficacy of an O-antigen-deficient mutant of Francisella tularensis LVS. Microbiology (Reading). 2007 Sep; 153(Pt 9):3141-3153. PMID: 17768257.
      View in: PubMed
    23. Pechous R, Celli J, Penoske R, Hayes SF, Frank DW, Zahrt TC. Construction and characterization of an attenuated purine auxotroph in a Francisella tularensis live vaccine strain. Infect Immun. 2006 Aug; 74(8):4452-61. PMID: 16861631.
      View in: PubMed
    24. Maier TM, Pechous R, Casey M, Zahrt TC, Frank DW. In vivo Himar1-based transposon mutagenesis of Francisella tularensis. Appl Environ Microbiol. 2006 Mar; 72(3):1878-85. PMID: 16517634.
      View in: PubMed
    25. Pechous R, Ledala N, Wilkinson BJ, Jayaswal RK. Regulation of the expression of cell wall stress stimulon member gene msrA1 in methicillin-susceptible or -resistant Staphylococcus aureus. Antimicrob Agents Chemother. 2004 Aug; 48(8):3057-63. PMID: 15273121.
      View in: PubMed
    26. Scybert S, Pechous R, Sitthisak S, Nadakavukaren MJ, Wilkinson BJ, Jayaswal RK. NaCl-sensitive mutant of Staphylococcus aureus has a Tn917-lacZ insertion in its ars operon. FEMS Microbiol Lett. 2003 May 28; 222(2):171-6. PMID: 12770703.
      View in: PubMed
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