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Edward Yeh

TitleDistinguished Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentDepartment Chairs, College of Medicine
Address324 UAMS Campus Dr.
Mail Slot # 832
Little Rock AR 72205
ORCID ORCID Icon0000-0001-8184-7294 Additional info
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    Collapse Affiliation 
    Collapse member of
    American Society of Clinical Investigation
    American Association of Physicians
    American Association for the Advancement of Science
    American Clinical and Climatology Association

    Collapse Biography 
    Collapse Leadership and Administrative Roles
    Chairman, Department of Internal Medicine

    Collapse education and training
    UC Berkeley, Berkeley CAA.B.05/1976Biochemistry
    UC Davis, Davis CAMD06/1980Medicine
    Collapse awards and honors
    2021 - 2024Scholar, Arkansas Research Alliances

    Collapse Research 
    Collapse research activities and funding
    7R01HL151993     (CHANG, HUI-MING)Jun 1, 2021 - May 31, 2025
    NIH/Nat. Heart, Lung & Blood Institute
    Prevention of Heart Failure induced by Doxorubicin with Early Administration of Dexrazoxane
    Role: Co-Investigator
    7R01HL126916     (YEH, EDWARD)Feb 1, 2021 - Aug 31, 2021
    NIH/Nat. Heart, Lung & Blood Institute
    Doxorubicin-induced Cardiotoxicity: The Role of Topoisomerase 2b
    Role: Principal Investigator
    7R01HL126916-06     (YEH, EDWARD)Feb 1, 2021 - Aug 31, 2021
    NIH/Nat. Heart, Lung & Blood Institute
    Doxorubicin-induced Cardiotoxicity: The Role of Topoisomerase 2b
    Role: Principal Investigator
    R01HL126916     (YEH, EDWARD T.H.)Apr 1, 2015 - Aug 31, 2021
    NIH
    Doxorubicin-induced Cardiotoxicity: the Role of Topoisomerase 2b
    Role: Principal Investigator
    R01CA139520     (YEH, EDWARD T.H.)Mar 1, 2009 - Dec 31, 2014
    NIH
    De-SUMOylation and the Hypoxic Response
    Role: Principal Investigator
    R01CA080089     (YEH, EDWARD T.H.)Feb 1, 2000 - Jan 31, 2006
    NIH
    PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIA
    Role: Principal Investigator
    R21GM057502     (YEH, EDWARD T.H.)Sep 1, 1999 - Aug 31, 2001
    NIH
    STUDIES OF THE SENTRIN FAMILY OF UBIQUITIN-LIKE PROTEINS
    Role: Principal Investigator
    R01HL045851     (YEH, EDWARD T.H.)Feb 1, 1991 - Jul 31, 1999
    NIH
    PATHOBIOLOGY OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse additional bibliographic sources
    The links below are provided by the researcher to provide access to external online bibliographies that they keep independently from the Profiles System.
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Chang HM, Hsu JY, Ahn C, Yeh ETH. Prevention of Heart Failure Induced by Doxorubicin with Early Administration of Dexrazoxane (PHOENIX Study): dose response and time course of dexrazoxane-induced degradation of topoisomerase 2b. Cardiooncology. 2025 May 02; 11(1):42. PMID: 40317097.
      View in: PubMed
    2. Wu YC, Su BH, Cheng WH, Zou CT, Yeh ETH, Yang FM. CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury. Cell Mol Life Sci. 2025 Mar 20; 82(1):124. PMID: 40108019.
      View in: PubMed
    3. Wang J, Zhang H, Augenreich M, Martinez-Lemus A L, Liu Z, Kang X, Lu B, Chang HM, Yeh ETH, Cata J, Rangaraju S, Wulff H, Li DP. Microglia-Mediated Synaptic Dysfunction Contributes to Chemotherapy-Related Cognitive Impairment. J Neurochem. 2025 Mar; 169(3):e70024. PMID: 40019120.
      View in: PubMed
    4. Kernohan KD, Gallagher L, Pigeon M, Yeh E, Lacaria M, Axford MM, MacCormick J, Papaioannou V, Quercia N, Rupar C, Zimmerman K, Weber S, Cushing SL, Chakraborty P. Newborn screening for common genetic variants associated with permanent hearing loss: Implementation in Ontario and review of the first 3?years. Genet Med. 2025 Apr; 27(4):101364. PMID: 39846246.
      View in: PubMed
    5. Yeh ETH, Chang HM. ANTHRACYCLINE-INDUCED CARDIOTOXICITY: MECHANISM AND PREVENTION. Trans Am Clin Climatol Assoc. 2025; 135:184-195. PMID: 40771595.
      View in: PubMed
    6. Sheng ZF, Zhang H, Phaup JG, Zheng P, Kang X, Liu Z, Chang HM, Yeh ETH, Johnson AK, Pan HL, Li DP. Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension. Cardiovasc Res. 2023 07 06; 119(8):1751-1762. PMID: 37041718.
      View in: PubMed
    7. Gautam N, Mounsey JP, Yeh ETH, Al'Aref SJ. Promises and challenges of machine learning for device therapy in heart failure. Eur Heart J. 2023 05 07; 44(18):1583-1585. PMID: 36806933.
      View in: PubMed
    8. Cheng J, Yeh ETH. Lactate: an intracellular metabolite regulates cell cycle progression. Life Metab. 2023 Aug; 2(4):load017. PMID: 39872246.
      View in: PubMed
    9. Wang C, Nistala R, Cao M, Pan Y, Behrens M, Doll D, Hammer RD, Nistala P, Chang HM, Yeh ETH, Kang X. Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells. Cell Rep. 2023 02 28; 42(2):112105. PMID: 36807138.
      View in: PubMed
    10. Dufour D, Dumontet T, Sahut-Barnola I, Carusi A, Onzon M, Pussard E, Wilmouth JJ, Olabe J, Lucas C, Levasseur A, Damon-Soubeyrand C, Pointud JC, Roucher-Boulez F, Tauveron I, Bossis G, Yeh ET, Breault DT, Val P, Lefran?ois-Martinez AM, Martinez A. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice. Nat Commun. 2022 12 21; 13(1):7858. PMID: 36543805.
      View in: PubMed
    11. Zhang H, Sheng ZF, Wang J, Zheng P, Kang X, Chang HM, Yeh ETH, Li DP. Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. J Neurochem. 2022 06; 161(6):478-491. PMID: 35583089.
      View in: PubMed
    12. Wu YC, Hsu SP, Hu MC, Lan YT, Yeh ETH, Yang FM. PEP-sNASP Peptide Alleviates LPS-Induced Acute Lung Injury Through the TLR4/TRAF6 Axis. Front Med (Lausanne). 2022; 9:832713. PMID: 35386914.
      View in: PubMed
    13. Sheng ZF, Zhang H, Zheng P, Chen S, Gu Z, Zhou JJ, Phaup JG, Chang HM, Yeh ETH, Pan HL, Li DP. Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension. Cardiovasc Res. 2022 01 29; 118(2):585-596. PMID: 33512443.
      View in: PubMed
    14. Yang FM, Chang HM, Yeh ETH. Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4. Proc Natl Acad Sci U S A. 2021 11 23; 118(47). PMID: 34789577.
      View in: PubMed
    15. Chen X, Zhang Y, Ren X, Su Q, Liu Y, Dang X, Qin Y, Yang X, Xing Z, Shen Y, Wang Y, Bai Z, Yeh ETH, Wu H, Qi Y. The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels. J Biol Chem. 2021 10; 297(4):101183. PMID: 34509475.
      View in: PubMed
    16. Chen X, Qin Y, Zhang Y, Yang X, Xing Z, Shen Y, Cheng J, Yeh ETH, Wu H, Qi Y. SENP2-PLC?4 signaling regulates neurogenesis through the maintenance of calcium homeostasis. Cell Death Differ. 2022 02; 29(2):337-350. PMID: 34465891.
      View in: PubMed
    17. Chang HM, Yeh ETH. SUMO: From Bench to Bedside. Physiol Rev. 2020 10 01; 100(4):1599-1619. PMID: 32666886.
      View in: PubMed
    18. Li J, Chang HM, Banchs J, Araujo DM, Hassan SA, Wagar EA, Yeh ETH, Meng QH. Detection of subclinical cardiotoxicity in sarcoma patients receiving continuous doxorubicin infusion or pre-treatment with dexrazoxane before bolus doxorubicin. Cardiooncology. 2020; 6:1. PMID: 32154027.
      View in: PubMed
    19. Yeh ETH, Ewer MS, Moslehi J, Dlugosz-Danecka M, Banchs J, Chang HM, Minotti G. Mechanisms and clinical course of cardiovascular toxicity of cancer treatment I. Oncology. Semin Oncol. 2019 12; 46(6):397-402. PMID: 31753424.
      View in: PubMed
    20. Jiang L, Han X, Wang J, Wang C, Sun X, Xie J, Wu G, Phan H, Liu Z, Yeh ETH, Zhang C, Zhao M, Kang X. Correction: SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-? signaling. J Exp Med. 2018 08 06; 215(8):2227. PMID: 30006358.
      View in: PubMed
    21. Yang FM, Zuo Y, Zhou W, Xia C, Hahm B, Sullivan M, Cheng J, Chang HM, Yeh ET. sNASP inhibits TLR signaling to regulate immune response in sepsis. J Clin Invest. 2018 06 01; 128(6):2459-2472. PMID: 29733298.
      View in: PubMed
    22. Jiang L, Han X, Wang J, Wang C, Sun X, Xie J, Wu G, Phan H, Liu Z, Yeh ETH, Zhang C, Zhao M, Kang X. SHP-1 regulates hematopoietic stem cell quiescence by coordinating TGF-? signaling. J Exp Med. 2018 05 07; 215(5):1337-1347. PMID: 29669741.
      View in: PubMed
    23. Li J, Lu D, Dou H, Liu H, Weaver K, Wang W, Li J, Yeh ETH, Williams BO, Zheng L, Yang T. Publisher Correction: Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Nat Commun. 2018 02 08; 9(1):646. PMID: 29422621.
      View in: PubMed
    24. Lao Y, Yang K, Wang Z, Sun X, Zou Q, Yu X, Cheng J, Tong X, Yeh ETH, Yang J, Yi J. DeSUMOylation of MKK7 kinase by the SUMO2/3 protease SENP3 potentiates lipopolysaccharide-induced inflammatory signaling in macrophages. J Biol Chem. 2018 03 16; 293(11):3965-3980. PMID: 29352108.
      View in: PubMed
    25. Li J, Lu D, Dou H, Liu H, Weaver K, Wang W, Li J, Yeh ETH, Williams BO, Zheng L, Yang T. Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by suppressing the p53 pathway. Nat Commun. 2018 01 10; 9(1):143. PMID: 29321472.
      View in: PubMed
    26. Chang HM, Okwuosa TM, Scarabelli T, Moudgil R, Yeh ETH. Cardiovascular Complications of Cancer?Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 2. J Am Coll Cardiol. 2017 Nov 14; 70(20):2552-2565. PMID: 29145955.
      View in: PubMed
    27. Chang HM, Moudgil R, Scarabelli T, Okwuosa TM, Yeh ETH. Cardiovascular Complications of Cancer?Therapy: Best Practices in Diagnosis, Prevention, and Management: Part 1. J Am Coll Cardiol. 2017 Nov 14; 70(20):2536-2551. PMID: 29145954.
      View in: PubMed
    28. Yeh ETH, Chang HM. Cancer and Clot: Between a Rock and a Hard Place. J Am Coll Cardiol. 2017 08 22; 70(8):939-941. PMID: 28818203.
      View in: PubMed
    29. Wang R, Liu F, Zhao Y, Wu D, Chen L, Yeh ETH, Huang C. Reversible regulation of ORC2 SUMOylation by PIAS4 and SENP2. Oncotarget. 2017 Sep 19; 8(41):70142-70155. PMID: 29050267.
      View in: PubMed
    30. Chang HM, Yeh ETH. Potential of Oncocardiology-Reply. JAMA Cardiol. 2017 07 01; 2(7):818. PMID: 28273313.
      View in: PubMed
    31. Bawa-Khalfe T, Yang FM, Ritho J, Lin HK, Cheng J, Yeh ET. SENP1 regulates PTEN stability to dictate prostate cancer development. Oncotarget. 2017 Mar 14; 8(11):17651-17664. PMID: 27852060.
      View in: PubMed
    32. Yeh ET, Chang HM. Oncocardiology-Past, Present, and Future: A Review. JAMA Cardiol. 2016 Dec 01; 1(9):1066-1072. PMID: 27541948.
      View in: PubMed
    33. Abe J, Martin JF, Yeh ET. The Future of Onco-Cardiology: We Are Not Just "Side Effect Hunters". Circ Res. 2016 09 30; 119(8):896-9. PMID: 27688305.
      View in: PubMed
    34. Lenihan DJ, Stevens PL, Massey M, Plana JC, Araujo DM, Fanale MA, Fayad LE, Fisch MJ, Yeh ET. The Utility of Point-of-Care Biomarkers to Detect Cardiotoxicity During Anthracycline Chemotherapy: A Feasibility Study. J Card Fail. 2016 Jun; 22(6):433-8. PMID: 27079675.
      View in: PubMed
    35. Fadol AP, Banchs J, Hassan SA, Yeh ET, Fellman B. Withdrawal of Heart Failure Medications in Cancer Survivors With Chemotherapy-Induced Left Ventricular Dysfunction: A Pilot Study. J Card Fail. 2016 Jun; 22(6):481-2. PMID: 27036866.
      View in: PubMed
    36. Huang C, Cheng J, Bawa-Khalfe T, Yao X, Chin YE, Yeh ETH. SUMOylated ORC2 Recruits a Histone Demethylase to Regulate Centromeric Histone Modification and Genomic Stability. Cell Rep. 2016 Apr 05; 15(1):147-157. PMID: 27052177.
      View in: PubMed
    37. Moudgil R, Yeh ET. Mechanisms of Cardiotoxicity of Cancer Chemotherapeutic Agents: Cardiomyopathy and Beyond. Can J Cardiol. 2016 07; 32(7):863-870.e5. PMID: 27117975.
      View in: PubMed
    38. Ferdaoussi M, Dai X, Jensen MV, Wang R, Peterson BS, Huang C, Ilkayeva O, Smith N, Miller N, Hajmrle C, Spigelman AF, Wright RC, Plummer G, Suzuki K, Mackay JP, van de Bunt M, Gloyn AL, Ryan TE, Norquay LD, Brosnan MJ, Trimmer JK, Rolph TP, Kibbey RG, Manning Fox JE, Colmers WF, Shirihai OS, Neufer PD, Yeh ET, Newgard CB, MacDonald PE. Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional ? cells. J Clin Invest. 2015 Oct 01; 125(10):3847-60. PMID: 26389676.
      View in: PubMed
    39. Ritho J, Arold ST, Yeh ET. A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress. Cell Rep. 2015 Aug 04; 12(5):734-42. PMID: 26212320.
      View in: PubMed
    40. Yeh ET, Vejpongsa P. Subclinical Cardiotoxicity Associated With?Cancer Therapy: Early Detection and Future Directions. J Am Coll Cardiol. 2015 Jun 16; 65(23):2523-5. PMID: 26065991.
      View in: PubMed
    41. Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J. Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. J Clin Invest. 2015 Mar 02; 125(3):1299-310. PMID: 25689261.
      View in: PubMed
    42. Cai R, Gu J, Sun H, Liu X, Mei W, Qi Y, Xue S, Ren S, Rabinowitz JE, Wang Y, Yeh ET, Cheng J. Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy. J Mol Cell Cardiol. 2015 Feb; 79:115-22. PMID: 25446185.
      View in: PubMed
    43. Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron. 2014 Sep 03; 83(5):1159-71. PMID: 25189211.
      View in: PubMed
    44. Vejpongsa P, Yeh ET. Prevention of anthracycline-induced cardiotoxicity: challenges and opportunities. J Am Coll Cardiol. 2014 Sep 02; 64(9):938-45. PMID: 25169180.
      View in: PubMed
    45. Ren YH, Liu KJ, Wang M, Yu YN, Yang K, Chen Q, Yu B, Wang W, Li QW, Wang J, Hou ZY, Fang JY, Yeh ET, Yang J, Yi J. De-SUMOylation of FOXC2 by SENP3 promotes the epithelial-mesenchymal transition in gastric cancer cells. Oncotarget. 2014 Aug 30; 5(16):7093-104. PMID: 25216525.
      View in: PubMed
    46. Ewer M, Gianni L, Pane F, Sandri MT, Steiner RK, Wojnowski L, Yeh ET, Carver JR, Lipshultz SE, Minotti G, Armstrong GT, Cardinale D, Colan SD, Darby SC, Force TL, Kremer LC, Lenihan DJ, Sallan SE, Sawyer DB, Suter TM, Swain SM, van Leeuwen FE. Report on the international colloquium on cardio-oncology (rome, 12-14 march 2014). Ecancermedicalscience. 2014; 8:433. PMID: 24932213.
      View in: PubMed
    47. Vejpongsa P, Yeh ET. Wrestling with heart failure: SUMO-1 to the rescue. Circ Res. 2014 May 09; 114(10):1561-3. PMID: 24812349.
      View in: PubMed
    48. Simari RD, Pepine CJ, Traverse JH, Henry TD, Bolli R, Spoon DB, Yeh E, Hare JM, Schulman IH, Anderson RD, Lambert C, Sayre SL, Taylor DA, Ebert RF, Moy? LA. Bone marrow mononuclear cell therapy for acute myocardial infarction: a perspective from the cardiovascular cell therapy research network. Circ Res. 2014 May 09; 114(10):1564-8. PMID: 24812350.
      View in: PubMed
    49. Qi Y, Zuo Y, Yeh ET, Cheng J. An essential role of small ubiquitin-like modifier (SUMO)-specific Protease 2 in myostatin expression and myogenesis. J Biol Chem. 2014 Feb 07; 289(6):3288-93. PMID: 24344126.
      View in: PubMed
    50. Ky B, Vejpongsa P, Yeh ET, Force T, Moslehi JJ. Emerging paradigms in cardiomyopathies associated with cancer therapies. Circ Res. 2013 Aug 30; 113(6):754-64. PMID: 23989717.
      View in: PubMed
    51. Heo KS, Chang E, Le NT, Cushman H, Yeh ET, Fujiwara K, Abe J. De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis. Circ Res. 2013 Mar 15; 112(6):911-23. PMID: 23381569.
      View in: PubMed
    52. Lee YC, Jin JK, Cheng CJ, Huang CF, Song JH, Huang M, Brown WS, Zhang S, Yu-Lee LY, Yeh ET, McIntyre BW, Logothetis CJ, Gallick GE, Lin SH. Targeting constitutively activated ?1 integrins inhibits prostate cancer metastasis. Mol Cancer Res. 2013 Apr; 11(4):405-17. PMID: 23339185.
      View in: PubMed
    53. Cai R, Yu T, Huang C, Xia X, Liu X, Gu J, Xue S, Yeh ET, Cheng J. SUMO-specific protease 1 regulates mitochondrial biogenesis through PGC-1a. J Biol Chem. 2012 Dec 28; 287(53):44464-70. PMID: 23152500.
      View in: PubMed
    54. Zhang S, Liu X, Bawa-Khalfe T, Lu LS, Lyu YL, Liu LF, Yeh ET. Identification of the molecular basis of doxorubicin-induced cardiotoxicity. Nat Med. 2012 Nov; 18(11):1639-42. PMID: 23104132.
      View in: PubMed
    55. Willerson JT, Yeh ET, Perin EC. Cytokine profile and ST-elevation myocardial infarction. Circ Res. 2012 Oct 26; 111(10):1256-7. PMID: 23104875.
      View in: PubMed
    56. Bawa-Khalfe T, Lu LS, Zuo Y, Huang C, Dere R, Lin FM, Yeh ET. Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):17466-71. PMID: 23045645.
      View in: PubMed
    57. Yeh ET, Willerson JT. Heparin and bone marrow-derived cell therapy: friend or foe? Circ Res. 2012 Sep 14; 111(7):819-20. PMID: 22982868.
      View in: PubMed
    58. Wang Q, Xia N, Li T, Xu Y, Zou Y, Zuo Y, Fan Q, Bawa-Khalfe T, Yeh ET, Cheng J. SUMO-specific protease 1 promotes prostate cancer progression and metastasis. Oncogene. 2013 May 09; 32(19):2493-8. PMID: 22733136.
      View in: PubMed
    59. Van Nguyen T, Angkasekwinai P, Dou H, Lin FM, Lu LS, Cheng J, Chin YE, Dong C, Yeh ET. SUMO-specific protease 1 is critical for early lymphoid development through regulation of STAT5 activation. Mol Cell. 2012 Jan 27; 45(2):210-21. PMID: 22284677.
      View in: PubMed
    60. Schwartz RJ, Yeh ET. Weighing in on heart failure: the role of SERCA2a SUMOylation. Circ Res. 2012 Jan 20; 110(2):198-9. PMID: 22267837.
      View in: PubMed
    61. Calabr? P, Golia E, Yeh ET. Role of C-reactive protein in acute myocardial infarction and stroke: possible therapeutic approaches. Curr Pharm Biotechnol. 2012 Jan; 13(1):4-16. PMID: 21470166.
      View in: PubMed
    62. Yeh ET. Microphthalmia-associated transcription factor, melanoma, and renal carcinoma: the small ubiquitin-like modifier connection. Pigment Cell Melanoma Res. 2011 Dec; 24(6):1079-80. PMID: 22216437.
      View in: PubMed
    63. Wang J, Najjar A, Zhang S, Rabinovich B, Willerson JT, Gelovani JG, Yeh ET. Molecular imaging of mesenchymal stem cell: mechanistic insight into cardiac repair after experimental myocardial infarction. Circ Cardiovasc Imaging. 2012 Jan; 5(1):94-101. PMID: 22135400.
      View in: PubMed
    64. Yeh ET, Lau SC, Su WJ, Tsai DJ, Tu YY, Lai YL. An examination of cancer-related fatigue through proposed diagnostic criteria in a sample of cancer patients in Taiwan. BMC Cancer. 2011 Sep 06; 11:387. PMID: 21896191.
      View in: PubMed
    65. Lin FM, Yeh ET. Balancing act during development: lessons from a SUMO-less SF-1. Dev Cell. 2011 Aug 16; 21(2):191-2. PMID: 21839916.
      View in: PubMed
    66. Lee MH, Mabb AM, Gill GB, Yeh ET, Miyamoto S. NF-?B induction of the SUMO protease SENP2: A negative feedback loop to attenuate cell survival response to genotoxic stress. Mol Cell. 2011 Jul 22; 43(2):180-91. PMID: 21777808.
      View in: PubMed
    67. Chen CT, Yamaguchi H, Lee HJ, Du Y, Lee HH, Xia W, Yu WH, Hsu JL, Yen CJ, Sun HL, Wang Y, Yeh ET, Hortobagyi GN, Hung MC. Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase. Mol Cancer Ther. 2011 Aug; 10(8):1327-36. PMID: 21610170.
      View in: PubMed
    68. Dou H, Huang C, Van Nguyen T, Lu LS, Yeh ET. SUMOylation and de-SUMOylation in response to DNA damage. FEBS Lett. 2011 Sep 16; 585(18):2891-6. PMID: 21486569.
      View in: PubMed
    69. Yeh ET. Onco-cardiology: the time has come. Tex Heart Inst J. 2011; 38(3):246-7. PMID: 21748048.
      View in: PubMed
    70. Yan S, Sun X, Xiang B, Cang H, Kang X, Chen Y, Li H, Shi G, Yeh ET, Wang B, Wang X, Yi J. Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90. EMBO J. 2010 Nov 17; 29(22):3773-86. PMID: 20924358.
      View in: PubMed
    71. Xu Y, Zuo Y, Zhang H, Kang X, Yue F, Yi Z, Liu M, Yeh ET, Chen G, Cheng J. Induction of SENP1 in endothelial cells contributes to hypoxia-driven VEGF expression and angiogenesis. J Biol Chem. 2010 Nov 19; 285(47):36682-8. PMID: 20841360.
      View in: PubMed
    72. Dou H, Huang C, Singh M, Carpenter PB, Yeh ET. Regulation of DNA repair through deSUMOylation and SUMOylation of replication protein A complex. Mol Cell. 2010 Aug 13; 39(3):333-45. PMID: 20705237.
      View in: PubMed
    73. Leja MJ, Yeh ET. Cardiovascular risk associated with androgen deprivation therapy. Oncology (Williston Park). 2010 Aug; 24(9):799, 803, 806. PMID: 20923032.
      View in: PubMed
    74. Kang X, Li J, Zou Y, Yi J, Zhang H, Cao M, Yeh ET, Cheng J. PIASy stimulates HIF1a SUMOylation and negatively regulates HIF1a activity in response to hypoxia. Oncogene. 2010 Oct 14; 29(41):5568-78. PMID: 20661221.
      View in: PubMed
    75. Bawa-Khalfe T, Yeh ET. SUMO Losing Balance: SUMO Proteases Disrupt SUMO Homeostasis to Facilitate Cancer Development and Progression. Genes Cancer. 2010 Jul; 1(7):748-752. PMID: 21152235.
      View in: PubMed
    76. Bawa-Khalfe T, Cheng J, Lin SH, Ittmann MM, Yeh ET. SENP1 induces prostatic intraepithelial neoplasia through multiple mechanisms. J Biol Chem. 2010 Aug 13; 285(33):25859-66. PMID: 20551310.
      View in: PubMed
    77. Wang J, Zhang S, Rabinovich B, Bidaut L, Soghomonyan S, Alauddin MM, Bankson JA, Shpall E, Willerson JT, Gelovani JG, Yeh ET. Human CD34+ cells in experimental myocardial infarction: long-term survival, sustained functional improvement, and mechanism of action. Circ Res. 2010 Jun 25; 106(12):1904-11. PMID: 20448213.
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    78. Kang X, Qi Y, Zuo Y, Wang Q, Zou Y, Schwartz RJ, Cheng J, Yeh ET. SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development. Mol Cell. 2010 Apr 23; 38(2):191-201. PMID: 20417598.
      View in: PubMed
    79. Darby SC, Cutter DJ, Boerma M, Constine LS, Fajardo LF, Kodama K, Mabuchi K, Marks LB, Mettler FA, Pierce LJ, Trott KR, Yeh ET, Shore RE. Radiation-related heart disease: current knowledge and future prospects. Int J Radiat Oncol Biol Phys. 2010 Mar 01; 76(3):656-65. PMID: 20159360.
      View in: PubMed
    80. Han Y, Huang C, Sun X, Xiang B, Wang M, Yeh ET, Chen Y, Li H, Shi G, Cang H, Sun Y, Wang J, Wang W, Gao F, Yi J. SENP3-mediated de-conjugation of SUMO2/3 from promyelocytic leukemia is correlated with accelerated cell proliferation under mild oxidative stress. J Biol Chem. 2010 Apr 23; 285(17):12906-15. PMID: 20181954.
      View in: PubMed
    81. Bawa-Khalfe T, Yeh ET. The in vivo functions of desumoylating enzymes. Subcell Biochem. 2010; 54:170-83. PMID: 21222282.
      View in: PubMed
    82. Huang C, Han Y, Wang Y, Sun X, Yan S, Yeh ET, Chen Y, Cang H, Li H, Shi G, Cheng J, Tang X, Yi J. SENP3 is responsible for HIF-1 transactivation under mild oxidative stress via p300 de-SUMOylation. EMBO J. 2009 Sep 16; 28(18):2748-62. PMID: 19680224.
      View in: PubMed
    83. Yeh ET, Bickford CL. Cardiovascular complications of cancer therapy: incidence, pathogenesis, diagnosis, and management. J Am Coll Cardiol. 2009 Jun 16; 53(24):2231-47. PMID: 19520246.
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    84. Calabr? P, Golia E, Yeh ET. CRP and the risk of atherosclerotic events. Semin Immunopathol. 2009 Jun; 31(1):79-94. PMID: 19415283.
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    85. Yeh ET. Adult progenitor cells for cardiac repair: preclinical studies. Tex Heart Inst J. 2009; 36(2):150-1. PMID: 19436811.
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    86. Willerson JT, Cable G, Yeh ET. PROCLAIM: pilot study to examine the effects of clopidogrel on inflammatory markers in patients with metabolic syndrome receiving low-dose aspirin. Tex Heart Inst J. 2009; 36(6):530-9. PMID: 20069077.
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    87. Yeh ET. SUMOylation and De-SUMOylation: wrestling with life's processes. J Biol Chem. 2009 Mar 27; 284(13):8223-7. PMID: 19008217.
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    88. Daher IN, Yeh ET. Vascular complications of selected cancer therapies. Nat Clin Pract Cardiovasc Med. 2008 Dec; 5(12):797-805. PMID: 18852710.
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    89. Khakoo AY, Yeh ET. Therapy insight: Management of cardiovascular disease in patients with cancer and cardiac complications of cancer therapy. Nat Clin Pract Oncol. 2008 Nov; 5(11):655-67. PMID: 18797437.
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    90. Chu K, Cheng CJ, Ye X, Lee YC, Zurita AJ, Chen DT, Yu-Lee LY, Zhang S, Yeh ET, Hu MC, Logothetis CJ, Lin SH. Cadherin-11 promotes the metastasis of prostate cancer cells to bone. Mol Cancer Res. 2008 Aug; 6(8):1259-67. PMID: 18708358.
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    91. Yusuf SW, Razeghi P, Yeh ET. The diagnosis and management of cardiovascular disease in cancer patients. Curr Probl Cardiol. 2008 Apr; 33(4):163-96. PMID: 18319102.
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    92. Yeh E, Ng S, Zhang M, Bouhours M, Wang Y, Wang M, Hung W, Aoyagi K, Melnik-Martinez K, Li M, Liu F, Schafer WR, Zhen M. A putative cation channel, NCA-1, and a novel protein, UNC-80, transmit neuronal activity in C. elegans. PLoS Biol. 2008 Mar 11; 6(3):e55. PMID: 18336069.
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    93. Calabro P, Yeh ET. Intra-abdominal adiposity, inflammation, and cardiovascular risk: new insight into global cardiometabolic risk. Curr Hypertens Rep. 2008 Feb; 10(1):32-8. PMID: 18367024.
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    94. Cheng J, Kang X, Zhang S, Yeh ET. SUMO-specific protease 1 is essential for stabilization of HIF1alpha during hypoxia. Cell. 2007 Nov 02; 131(3):584-95. PMID: 17981124.
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    95. Bawa-Khalfe T, Cheng J, Wang Z, Yeh ET. Induction of the SUMO-specific protease 1 transcription by the androgen receptor in prostate cancer cells. J Biol Chem. 2007 Dec 28; 282(52):37341-9. PMID: 17932034.
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    96. Zhang S, Shpall E, Willerson JT, Yeh ET. Fusion of human hematopoietic progenitor cells and murine cardiomyocytes is mediated by alpha 4 beta 1 integrin/vascular cell adhesion molecule-1 interaction. Circ Res. 2007 Mar 16; 100(5):693-702. PMID: 17303762.
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    97. Calabro P, Yeh ET. Obesity, inflammation, and vascular disease: the role of the adipose tissue as an endocrine organ. Subcell Biochem. 2007; 42:63-91. PMID: 17612046.
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    98. Gao F, Cheng J, Shi T, Yeh ET. Neddylation of a breast cancer-associated protein recruits a class III histone deacetylase that represses NFkappaB-dependent transcription. Nat Cell Biol. 2006 Oct; 8(10):1171-7. PMID: 16998474.
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    99. Yeh ET, Khan BV. The potential role of antiplatelet agents in modulating inflammatory markers in atherothrombosis. J Thromb Haemost. 2006 Nov; 4(11):2308-16. PMID: 16961584.
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    100. Cheng J, Bawa T, Lee P, Gong L, Yeh ET. Role of desumoylation in the development of prostate cancer. Neoplasia. 2006 Aug; 8(8):667-76. PMID: 16925949.
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    101. Itahana Y, Yeh ET, Zhang Y. Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2. Mol Cell Biol. 2006 Jun; 26(12):4675-89. PMID: 16738331.
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    102. Gong L, Yeh ET. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. J Biol Chem. 2006 Jun 09; 281(23):15869-77. PMID: 16608850.
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    103. Yusuf SW, Ali SS, Swafford J, Durand JB, Bodey GP, Chemaly RF, Kontoyiannis DP, Tarrand J, Rolston KV, Yeh E, Raad II, Safdar A. Culture-positive and culture-negative endocarditis in patients with cancer: a retrospective observational study, 1994-2004. Medicine (Baltimore). 2006 Mar; 85(2):86-94. PMID: 16609347.
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    104. Yeh ET, Zhang S. A novel approach to studying transformation of human stem cells into cardiac cells in vivo. Can J Cardiol. 2006 Feb; 22 Suppl B:66B-71B. PMID: 16498515.
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    105. Yeh ET. Cardiotoxicity induced by chemotherapy and antibody therapy. Annu Rev Med. 2006; 57:485-98. PMID: 16409162.
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    106. Calabr? P, Yeh ET. The pleiotropic effects of statins. Curr Opin Cardiol. 2005 Nov; 20(6):541-6. PMID: 16234628.
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    107. Willerson JT, Yeh ET, Geng YJ, Perin EC. Blood-derived progenitor cells after recanalization of chronic coronary artery occlusions in humans. Circ Res. 2005 Oct 14; 97(8):735-6. PMID: 16224072.
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    108. Paul A, Yeh ET, Chan L. A proatherogenic role for C-reactive protein in vivo. Curr Opin Lipidol. 2005 Oct; 16(5):512-7. PMID: 16148535.
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    109. Yeh ET. A new perspective on the biology of C-reactive protein. Circ Res. 2005 Sep 30; 97(7):609-11. PMID: 16195483.
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    110. Owerbach D, McKay EM, Yeh ET, Gabbay KH, Bohren KM. A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation. Biochem Biophys Res Commun. 2005 Nov 18; 337(2):517-20. PMID: 16198310.
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    111. Calabro P, Chang DW, Willerson JT, Yeh ET. Release of C-reactive protein in response to inflammatory cytokines by human adipocytes: linking obesity to vascular inflammation. J Am Coll Cardiol. 2005 Sep 20; 46(6):1112-3. PMID: 16168299.
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    112. Calabr? P, Samudio I, Safe SH, Willerson JT, Yeh ET. Inhibition of tumor-necrosis-factor-alpha induced endothelial cell activation by a new class of PPAR-gamma agonists. An in vitro study showing receptor-independent effects. J Vasc Res. 2005 Nov-Dec; 42(6):509-16. PMID: 16155367.
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    113. Yeh ET. High-sensitivity C-reactive protein as a risk assessment tool for cardiovascular disease. Clin Cardiol. 2005 Sep; 28(9):408-12. PMID: 16250263.
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    114. Izumiya Y, Ellison TJ, Yeh ET, Jung JU, Luciw PA, Kung HJ. Kaposi's sarcoma-associated herpesvirus K-bZIP represses gene transcription via SUMO modification. J Virol. 2005 Aug; 79(15):9912-25. PMID: 16014952.
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    115. Veltman IM, Vreede LA, Cheng J, Looijenga LH, Janssen B, Schoenmakers EF, Yeh ET, van Kessel AG. Fusion of the SUMO/Sentrin-specific protease 1 gene SENP1 and the embryonic polarity-related mesoderm development gene MESDC2 in a patient with an infantile teratoma and a constitutional t(12;15)(q13;q25). Hum Mol Genet. 2005 Jul 15; 14(14):1955-63. PMID: 15917269.
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    116. Cheng J, Perkins ND, Yeh ET. Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases. J Biol Chem. 2005 Apr 15; 280(15):14492-8. PMID: 15701643.
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    117. Zhang S, Wang D, Estrov Z, Raj S, Willerson JT, Yeh ET. Both cell fusion and transdifferentiation account for the transformation of human peripheral blood CD34-positive cells into cardiomyocytes in vivo. Circulation. 2004 Dec 21; 110(25):3803-7. PMID: 15596566.
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    118. Calabro P, Samudio I, Willerson JT, Yeh ET. Resistin promotes smooth muscle cell proliferation through activation of extracellular signal-regulated kinase 1/2 and phosphatidylinositol 3-kinase pathways. Circulation. 2004 Nov 23; 110(21):3335-40. PMID: 15545519.
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    119. Yeh ET. C-reactive protein is an essential aspect of cardiovascular risk factor stratification. Can J Cardiol. 2004 Aug; 20 Suppl B:93B-96B. PMID: 15309212.
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    120. Cheng J, Wang D, Wang Z, Yeh ET. SENP1 enhances androgen receptor-dependent transcription through desumoylation of histone deacetylase 1. Mol Cell Biol. 2004 Jul; 24(13):6021-8. PMID: 15199155.
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    121. Yeh ET, Tong AT, Lenihan DJ, Yusuf SW, Swafford J, Champion C, Durand JB, Gibbs H, Zafarmand AA, Ewer MS. Cardiovascular complications of cancer therapy: diagnosis, pathogenesis, and management. Circulation. 2004 Jun 29; 109(25):3122-31. PMID: 15226229.
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    122. Yeh ET. CRP as a mediator of disease. Circulation. 2004 Jun 01; 109(21 Suppl 1):II11-4. PMID: 15173057.
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    123. Verma S, Szmitko PE, Yeh ET. C-reactive protein: structure affects function. Circulation. 2004 Apr 27; 109(16):1914-7. PMID: 15117860.
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    124. Tanaka T, Yeh ET, Kamitani T. NUB1-mediated targeting of the ubiquitin precursor UbC1 for its C-terminal hydrolysis. Eur J Biochem. 2004 Mar; 271(5):972-82. PMID: 15009209.
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    125. Calabro P, Yeh ET. Multitasking of the 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitor: beyond cardiovascular diseases. Curr Atheroscler Rep. 2004 Jan; 6(1):36-41. PMID: 14662106.
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    126. Verma S, Yeh ET. C-reactive protein and atherothrombosis--beyond a biomarker: an actual partaker of lesion formation. Am J Physiol Regul Integr Comp Physiol. 2003 Nov; 285(5):R1253-6; discussion R1257-8. PMID: 14557241.
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    127. Yeh ET, Zhang S, Wu HD, K?rbling M, Willerson JT, Estrov Z. Transdifferentiation of human peripheral blood CD34+-enriched cell population into cardiomyocytes, endothelial cells, and smooth muscle cells in vivo. Circulation. 2003 Oct 28; 108(17):2070-3. PMID: 14568894.
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    128. Calabr? P, Willerson JT, Yeh ET. Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation. 2003 Oct 21; 108(16):1930-2. PMID: 14530191.
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    129. Tanaka T, Kawashima H, Yeh ET, Kamitani T. Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L. J Biol Chem. 2003 Aug 29; 278(35):32905-13. PMID: 12816948.
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    130. Yeh ET, Palusinski RP. C-reactive protein: the pawn has been promoted to queen. Curr Atheroscler Rep. 2003 Mar; 5(2):101-5. PMID: 12573194.
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    131. Nefkens I, Negorev DG, Ishov AM, Michaelson JS, Yeh ET, Tanguay RM, M?ller WE, Maul GG. Heat shock and Cd2+ exposure regulate PML and Daxx release from ND10 by independent mechanisms that modify the induction of heat-shock proteins 70 and 25 differently. J Cell Sci. 2003 Feb 01; 116(Pt 3):513-24. PMID: 12508112.
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    132. Yeh ET, Willerson JT. Coming of age of C-reactive protein: using inflammation markers in cardiology. Circulation. 2003 Jan 28; 107(3):370-1. PMID: 12551854.
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    133. Yeh ET. Ubiquitin, proteasome, and restenosis: a brave new world for cardiovascular research. Circulation. 2002 Jan 29; 105(4):408-10. PMID: 11815419.
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    134. Ware RE, Howard TA, Kamitani T, Chang H-M, Yeh ETH, Seldin MF. Chromosomal assignment of genes involved in glycosylphosphatidylinositol anchor biosynthesis: implications for the pathogenesis of paroxysmal nocturnal hemoglobinuria. Blood. 1994 06 15; 83(12):3753-7. PMID: 8204896.
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