Pregnancy-Associated Plasma Protein-A
"Pregnancy-Associated Plasma Protein-A" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A product of the PLACENTA, and DECIDUA, secreted into the maternal circulation during PREGNANCY. It has been identified as an IGF binding protein (IGFBP)-4 protease that proteolyzes IGFBP-4 and thus increases IGF bioavailability. It is found also in human FIBROBLASTS, ovarian FOLLICULAR FLUID, and GRANULOSA CELLS. The enzyme is a heterotetramer of about 500-kDa.
| Descriptor ID |
D011266
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| MeSH Number(s) |
D08.811.277.656.300.480.632 D08.811.277.656.675.374.632 D12.776.780.700
|
| Concept/Terms |
Pregnancy-Associated Plasma Protein-A- Pregnancy-Associated Plasma Protein-A
- Pregnancy Associated Plasma Protein A
- IGFBP-4 Protease
- IGFBP 4 Protease
- Protease, IGFBP-4
- IGFBP-4-Specific Proteinase
- Insulin-Like Growth Factor-Dependent IGF Binding Protein-4 Protease
- Insulin Like Growth Factor Dependent IGF Binding Protein 4 Protease
- PAPP-A
- PAPP-alpha
- PAPP alpha
- Pregnancy Associated alpha Plasma Protein
- Pregnancy-Associated alpha-Plasma Protein
- IGFBP-4 Metalloproteinase
- IGFBP 4 Metalloproteinase
- Metalloproteinase, IGFBP-4
- Insulin-Like-Growth Factor Binding Protein-4 Protease
- Insulin Like Growth Factor Binding Protein 4 Protease
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Below are MeSH descriptors whose meaning is more general than "Pregnancy-Associated Plasma Protein-A".
Below are MeSH descriptors whose meaning is more specific than "Pregnancy-Associated Plasma Protein-A".
This graph shows the total number of publications written about "Pregnancy-Associated Plasma Protein-A" by people in UAMS Profiles by year, and whether "Pregnancy-Associated Plasma Protein-A" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 1 | 0 | 1 |
| 2004 | 1 | 0 | 1 |
| 1997 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pregnancy-Associated Plasma Protein-A" by people in Profiles over the past ten years.
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Johnson LM, Genzen JR, Algeciras-Schimnich A, Bornhorst J, Lambert-Messerlian G. PAPP-A Results Cannot Be Used to Accurately Estimate Gestational Age. J Appl Lab Med. 2022 06 30; 7(4):1000-1002.