 Parathyroid Hormone
"Parathyroid Hormone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A polypeptide hormone (84 amino acid residues) secreted by the PARATHYROID GLANDS which performs the essential role of maintaining intracellular CALCIUM levels in the body. Parathyroid hormone increases intracellular calcium by promoting the release of CALCIUM from BONE, increases the intestinal absorption of calcium, increases the renal tubular reabsorption of calcium, and increases the renal excretion of phosphates.
| Descriptor ID |
D010281
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| MeSH Number(s) |
D06.472.699.590 D12.644.548.587
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| Concept/Terms |
Parathyroid Hormone- Parathyroid Hormone
- Hormone, Parathyroid
- PTH (1-84)
- Parathyroid Hormone (1-84)
- Parathormone
- Parathyrin
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Below are MeSH descriptors whose meaning is more general than "Parathyroid Hormone".
Below are MeSH descriptors whose meaning is more specific than "Parathyroid Hormone".
This graph shows the total number of publications written about "Parathyroid Hormone" by people in UAMS Profiles by year, and whether "Parathyroid Hormone" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2024 | 0 | 1 | 1 | | 2023 | 1 | 1 | 2 | | 2022 | 2 | 4 | 6 | | 2021 | 1 | 3 | 4 | | 2020 | 2 | 1 | 3 | | 2019 | 4 | 1 | 5 | | 2018 | 3 | 0 | 3 | | 2017 | 1 | 1 | 2 | | 2016 | 3 | 2 | 5 | | 2015 | 4 | 2 | 6 | | 2014 | 2 | 0 | 2 | | 2013 | 1 | 2 | 3 | | 2012 | 4 | 1 | 5 | | 2011 | 1 | 0 | 1 | | 2010 | 4 | 3 | 7 | | 2009 | 1 | 2 | 3 | | 2008 | 2 | 0 | 2 | | 2007 | 2 | 2 | 4 | | 2006 | 2 | 1 | 3 | | 2005 | 4 | 2 | 6 | | 2004 | 0 | 4 | 4 | | 2003 | 1 | 0 | 1 | | 2002 | 2 | 1 | 3 | | 1999 | 1 | 0 | 1 | | 1998 | 1 | 1 | 2 | | 1997 | 1 | 1 | 2 | | 1996 | 0 | 1 | 1 | | 1994 | 0 | 2 | 2 | | 1993 | 0 | 1 | 1 | | 1990 | 1 | 0 | 1 | | 1989 | 4 | 1 | 5 |
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Below are the most recent publications written about "Parathyroid Hormone" by people in Profiles over the past ten years.
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Marino S, Ozgurel SU, McAndrews K, Cregor M, Villase?or A, Mamani-Huanca M, Barbas C, Gortazar A, Sato AY, Bellido T. Abaloparatide is more potent than teriparatide in restoring bone mass and strength in type 1 diabetic male mice. Bone. 2024 Apr; 181:117042.
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McWhorter CA, Mead MJ, Rodgers MD, Ebeling MD, Shary JR, Gregoski MJ, Newton DA, Baatz JE, Hollis BW, Hewison M, Wagner CL. Predicting comorbidities of pregnancy: A comparison between total and free 25(OH)D and their associations with parathyroid hormone. J Steroid Biochem Mol Biol. 2023 12; 235:106420.
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Stack BC. Secondary Hyperparathyroidism. Otolaryngol Clin North Am. 2024 Feb; 57(1):99-110.
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Atkinson EG, Adaway M, Horan DJ, Korff C, Klunk A, Orr AL, Ratz K, Bellido T, Plotkin LI, Robling AG, Bidwell JP. Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation. J Bone Miner Res. 2023 01; 38(1):70-85.
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Henning P, Conaway HH, Lerner UH. Stimulation of osteoclast formation and bone resorption by glucocorticoids: Synergistic interactions with the calcium regulating hormones parathyroid hormone and 1,25(OH)2-vitamin D3. Vitam Horm. 2022; 120:231-270.
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Suva LJ, Friedman PA. Structural pharmacology of PTH and PTHrP. Vitam Horm. 2022; 120:1-21.
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Ashrafzadeh-Kian S, Bornhorst J, Algeciras-Schimnich A. Development of a PTHrP chemiluminescent immunoassay to assess humoral hypercalcemia of malignancy. Clin Biochem. 2022 Jul-Aug; 105-106:75-80.
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Delgado-Calle J, McAndrews K, Wu G, Orr AL, Ferrari A, Tu X, Srinivasan V, Roodman GD, Ebetino FH, Boeckman RK, Bellido T. The Notch pathway regulates the bone gain induced by PTH anabolic signaling. FASEB J. 2022 03; 36(3):e22196.
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Stenhouse C, Suva LJ, Gaddy D, Wu G, Bazer FW. Phosphate, Calcium, and Vitamin D: Key Regulators of Fetal and Placental Development in Mammals. Adv Exp Med Biol. 2022; 1354:77-107.
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Greer ML, Davis K, Stack BC. Machine learning can identify patients at risk of hyperparathyroidism without known calcium and intact parathyroid hormone. Head Neck. 2022 04; 44(4):817-822.
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Creighton EW, Dunlap Q, Peckham MM, Elms C, King D, Stack BC. Utility of intraoperative digital scintigraphy in radioguided parathyroidectomy. Head Neck. 2021 10; 43(10):2967-2972.
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MacLeod RS, Meyer MB, Xiong J, Cawley KM, Liu Y, Onal M, Benkusky NA, Thostenson JD, Pike JW, O'Brien CA. Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo. PLoS One. 2021; 16(5):e0250974.
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Hollowoa BR, Spencer HJ, Stack BC. Normocalcemic and Normohormonal Primary Hyperparathyroidism: Laboratory Values and End-Organ Effects. Otolaryngol Head Neck Surg. 2021 09; 165(3):387-397.
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Wright C, King D, Small M, Gibson C, Gardner R, Stack BC. The Utility of the Cl:PO4 Ratio in Patients With Variant Versions of Primary Hyperparathyroidism. Otolaryngol Head Neck Surg. 2021 02; 164(2):308-314.
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Gurram PR, Castillo NE, Esquer Garrigos Z, Vijayvargiya P, Abu Saleh OM. A Dimorphic Diagnosis of a Pleomorphic Disease: An Unusual Cause of Hypercalcemia. Am J Med. 2020 11; 133(11):e659-e662.
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Suva LJ, Friedman PA. PTH and PTHrP Actions on Bone. Handb Exp Pharmacol. 2020; 262:27-45.
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Conaway HH, Henning P, Lie A, Tuckermann J, Lerner UH. Glucocorticoids employ the monomeric glucocorticoid receptor to potentiate vitamin D3 and parathyroid hormone-induced osteoclastogenesis. FASEB J. 2019 12; 33(12):14394-14409.
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Caldwell M, Laux J, Clark M, Kim L, Rubin J. Persistently Elevated PTH After Parathyroidectomy at One Year: Experience in a Tertiary Referral Center. J Clin Endocrinol Metab. 2019 10 01; 104(10):4473-4480.
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Zafereo M, Yu J, Angelos P, Brumund K, Chuang HH, Goldenberg D, Lango M, Perrier N, Randolph G, Shindo ML, Singer M, Smith R, Stack BC, Steward D, Terris DJ, Vu T, Yao M, Tufano RP. American Head and Neck Society Endocrine Surgery Section update on parathyroid imaging for surgical candidates with primary hyperparathyroidism. Head Neck. 2019 07; 41(7):2398-2409.
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Saito H, Gasser A, Bolamperti S, Maeda M, Matthies L, J?hn K, Long CL, Schl?ter H, Kwiatkowski M, Saini V, Pajevic PD, Bellido T, van Wijnen AJ, Mohammad KS, Guise TA, Taipaleenm?ki H, Hesse E. TG-interacting factor 1 (Tgif1)-deficiency attenuates bone remodeling and blunts the anabolic response to parathyroid hormone. Nat Commun. 2019 03 22; 10(1):1354.
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Lawson BR, Hinson AM, Lucas JC, Bodenner DL, Stack BC. Relationship of Vitamin D Deficiency and Intraoperative Parathyroid Hormone Elevation in Completion and Total Thyroidectomy. Otolaryngol Head Neck Surg. 2019 04; 160(4):612-615.
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Varghese RT, Khasawneh K, Desikan RK, Subramaniam A, Weaver T, Nair GKV. Vitamin A and Hydrochlorothiazide Causing Severe Hypercalcemia in a Patient With Primary Hyperparathyroidism. J Investig Med High Impact Case Rep. 2019 Jan-Dec; 7:2324709618823805.
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Li JY, Yu M, Tyagi AM, Vaccaro C, Hsu E, Adams J, Bellido T, Weitzmann MN, Pacifici R. IL-17 Receptor Signaling in Osteoblasts/Osteocytes Mediates PTH-Induced Bone Loss and Enhances Osteocytic RANKL Production. J Bone Miner Res. 2019 02; 34(2):349-360.
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Zangari M, Yoo H, Shin I, Kim B, Edmondson R, Morgan GJ, Suva LJ, Yoon D. Thymic PTH Increases After Thyroparathyroidectomy in C57BL/KaLwRij Mice. Endocrinology. 2018 04 01; 159(4):1561-1569.
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Delgado-Calle J, Hancock B, Likine EF, Sato AY, McAndrews K, Sanudo C, Bruzzaniti A, Riancho JA, Tonra JR, Bellido T. MMP14 is a novel target of PTH signaling in osteocytes that controls resorption by regulating soluble RANKL production. FASEB J. 2018 05; 32(5):2878-2890.
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Yang Y, Lei H, Qiang YW, Wang B. Ixazomib enhances parathyroid hormone-induced ?-catenin/T-cell factor signaling by dissociating ?-catenin from the parathyroid hormone receptor. Mol Biol Cell. 2017 Jul 01; 28(13):1792-1803.
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Deng L, Peng Y, Jiang Y, Wu Y, Ding Y, Wang Y, Xu D, Fu Q. Imipramine Protects against Bone Loss by Inhibition of Osteoblast-Derived Microvesicles. Int J Mol Sci. 2017 May 08; 18(5).
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Delgado-Calle J, Tu X, Pacheco-Costa R, McAndrews K, Edwards R, Pellegrini GG, Kuhlenschmidt K, Olivos N, Robling A, Peacock M, Plotkin LI, Bellido T. Control of Bone Anabolism in Response to Mechanical Loading and PTH by Distinct Mechanisms Downstream of the PTH Receptor. J Bone Miner Res. 2017 Mar; 32(3):522-535.
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Delgado-Calle J, Sato AY, Bellido T. Role and mechanism of action of sclerostin in bone. Bone. 2017 03; 96:29-37.
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Nelson KL, Hinson AM, Lawson BR, Middleton D, Bodenner DL, Stack BC. Postoperative Calcium Management in Same-Day Discharge Thyroid and Parathyroid Surgery. Otolaryngol Head Neck Surg. 2016 05; 154(5):854-60.
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Terris DJ, Stack BC. Parathyroid Surgery: Getting It Right the First Time. Otolaryngol Head Neck Surg. 2016 Feb; 154(2):396.
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Onal M, St John HC, Danielson AL, Pike JW. Deletion of the Distal Tnfsf11 RL-D2 Enhancer That Contributes to PTH-Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice. J Bone Miner Res. 2016 Feb; 31(2):416-29.
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Stack BC. Response to "Critical Points Regarding Hypocalcemia after Total Thyroidectomy". Otolaryngol Head Neck Surg. 2015 Dec; 153(6):1080-1.
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Hinson AM, Wilkerson BM, Rothman-Fitts I, Riggs AT, Stack BC, Bodenner DL. Hyperparathyroidism Associated with Long-Term Proton Pump Inhibitors Independent of Concurrent Bisphosphonate Therapy in Elderly Adults. J Am Geriatr Soc. 2015 Oct; 63(10):2070-3.
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Pacheco-Costa R, Davis HM, Sorenson C, Hon MC, Hassan I, Reginato RD, Allen MR, Bellido T, Plotkin LI. Defective cancellous bone structure and abnormal response to PTH in cortical bone of mice lacking Cx43 cytoplasmic C-terminus domain. Bone. 2015 Dec; 81:632-643.
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Meyer MB, Benkusky NA, Onal M, Pike JW. Selective regulation of Mmp13 by 1,25(OH)2D3, PTH, and Osterix through distal enhancers. J Steroid Biochem Mol Biol. 2016 11; 164:258-264.
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Lee DR, Hinson AM, Siegel ER, Steelman SC, Bodenner DL, Stack BC. Comparison of Intraoperative versus Postoperative Parathyroid Hormone Levels to Predict Hypocalcemia Earlier after Total Thyroidectomy. Otolaryngol Head Neck Surg. 2015 Sep; 153(3):343-9.
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Onal M, Bishop KA, St John HC, Danielson AL, Riley EM, Piemontese M, Xiong J, Goellner JJ, O'Brien CA, Pike JW. A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse. J Bone Miner Res. 2015 May; 30(5):855-68.
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Rivere AE, Brooks AJ, Hayek GA, Wang H, Corsetti RL, Fuhrman GM. Parathyroid hormone levels predict posttotal thyroidectomy hypoparathyroidism. Am Surg. 2014 Aug; 80(8):817-20.
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Ben-awadh AN, Delgado-Calle J, Tu X, Kuhlenschmidt K, Allen MR, Plotkin LI, Bellido T. Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes. Endocrinology. 2014 Aug; 155(8):2797-809.
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