 Sepsis
"Sepsis" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
| Descriptor ID |
D018805
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| MeSH Number(s) |
C01.539.757 C23.550.470.790.500
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| Concept/Terms |
Pyemia- Pyemia
- Pyemias
- Pyohemia
- Pyohemias
- Pyaemia
- Pyaemias
Septicemia- Septicemia
- Septicemias
- Poisoning, Blood
- Blood Poisoning
- Blood Poisonings
- Poisonings, Blood
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Below are MeSH descriptors whose meaning is more general than "Sepsis".
Below are MeSH descriptors whose meaning is more specific than "Sepsis".
This graph shows the total number of publications written about "Sepsis" by people in UAMS Profiles by year, and whether "Sepsis" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2025 | 3 | 0 | 3 | | 2024 | 2 | 0 | 2 | | 2023 | 7 | 0 | 7 | | 2022 | 5 | 0 | 5 | | 2021 | 4 | 2 | 6 | | 2020 | 5 | 1 | 6 | | 2019 | 12 | 1 | 13 | | 2018 | 5 | 1 | 6 | | 2017 | 3 | 3 | 6 | | 2016 | 4 | 2 | 6 | | 2015 | 1 | 1 | 2 | | 2014 | 5 | 2 | 7 | | 2013 | 3 | 1 | 4 | | 2012 | 1 | 2 | 3 | | 2011 | 4 | 1 | 5 | | 2010 | 2 | 1 | 3 | | 2009 | 4 | 1 | 5 | | 2008 | 0 | 2 | 2 | | 2007 | 3 | 1 | 4 | | 2006 | 1 | 1 | 2 | | 2005 | 2 | 0 | 2 | | 2004 | 1 | 1 | 2 | | 2003 | 2 | 1 | 3 | | 2002 | 2 | 4 | 6 | | 1998 | 1 | 0 | 1 | | 1995 | 1 | 0 | 1 | | 1993 | 0 | 1 | 1 |
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Below are the most recent publications written about "Sepsis" by people in Profiles over the past ten years.
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Wu YC, Su BH, Cheng WH, Zou CT, Yeh ETH, Yang FM. CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury. Cell Mol Life Sci. 2025 Mar 20; 82(1):124.
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Paul R, Vyas D, Quinones Cardona V, Gilfillan M, Young M, Pough K, Carey AJ. Reduction of Overall Antibiotic Utilization Rate in a Level IV Neonatal Intensive Care Unit. Pediatrics. 2025 Mar 01; 155(3).
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Totapally A, Stark R, Danko M, Chen H, Altheimer A, Hardison D, Malone MP, Zivick E, Bridges B. Central or Peripheral Venoarterial Extracorporeal Membrane Oxygenation for Pediatric Sepsis: Outcomes Comparison in the Extracorporeal Life Support Organization Dataset, 2000-2021. Pediatr Crit Care Med. 2025 Apr 01; 26(4):e463-e472.
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Ghimire L, Paudel S, Le J, Jin L, Cai S, Bhattarai D, Jeyaseelan S. NLRP6 negatively regulates host defense against polymicrobial sepsis. Front Immunol. 2024; 15:1248907.
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Kausch SL, Lake DE, Di Fiore JM, Weese-Mayer DE, Claure N, Ambalavanan N, Vesoulis ZA, Fairchild KD, Dennery PA, Hibbs AM, Martin RJ, Indic P, Travers CP, Bancalari E, Hamvas A, Kemp JS, Carroll JL, Moorman JR, Sullivan BA. Apnea, Intermittent Hypoxemia, and Bradycardia Events Predict Late-Onset Sepsis in Infants Born Extremely Preterm. J Pediatr. 2024 Aug; 271:114042.
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Atreya MR, Banerjee S, Lautz AJ, Alder MN, Varisco BM, Wong HR, Muszynski JA, Hall MW, Sanchez-Pinto LN, Kamaleswaran R. Machine learning-driven identification of the gene-expression signature associated with a persistent multiple organ dysfunction trajectory in critical illness. EBioMedicine. 2024 Jan; 99:104938.
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Zhao Z, Patel PA, Slatnick L, Sitthi-Amorn A, Bielamowicz KJ, Nunez FA, Walsh AM, Hess J, Rossoff J, Elgarten C, Myers R, Saab R, Basbous M, Mccormick M, Aftandilian C, Richards R, Nessle CN, Tribble AC, Sheth Bhutada JK, Coven SL, Runco D, Wilkes J, Gurunathan A, Guinipero T, Belsky JA, Lee K, Wong V, Malhotra M, Armstrong A, Jerkins LP, Cross SJ, Fisher L, Stein MT, Wu NL, Yi T, Orgel E, Haeusler GM, Wolf J, Demedis JM, Miller TP, Esbenshade AJ. Prospective External Validation of the Esbenshade Vanderbilt Models Accurately Predicts Bloodstream Infection Risk in Febrile Non-Neutropenic Children With Cancer. J Clin Oncol. 2024 Mar 01; 42(7):832-841.
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Knappett M, Hooft A, Maqsood MB, Lavoie PM, Kortz T, Mehta S, Duby J, Akech S, Maina M, Carter R, Popescu CR, Daftary R, Mugisha NK, Mwesigwa D, Kabakyenga J, Kumbakumba E, Ansermino JM, Kissoon N, Mutekanga A, Hau D, Moschovis P, Kangwa M, Chen C, Firnberg M, Glomb N, Argent A, Reid SJ, Bhutta A, Wiens MO. Verbal Autopsy to Assess Postdischarge Mortality in Children With Suspected Sepsis in Uganda. Pediatrics. 2023 Nov 01; 152(5).
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Chang KM, Haghamad A, Saunders-Hao P, Shaffer A, Mirsaidi N, Zimilover A, Epstein M, Jain S, Streva V, Juretschko S, Demissie S, Gautam-Goyal P. The clinical impact of early detection of ESBL-producing Enterobacterales with PCR-based blood culture assays. Am J Infect Control. 2024 01; 52(1):73-80.
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VanBuren JM, Hall M, Zuppa AF, Mourani PM, Carcillo J, Dean JM, Watt K, Holubkov R. The Design of Nested Adaptive Clinical Trials of Multiple Organ Dysfunction Syndrome Children in a Single Study. Pediatr Crit Care Med. 2023 Dec 01; 24(12):e635-e646.
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Ma J, Wang X, Gu R, Guo D, Shi C, Kollisch-Singule M, Suo L, Luo J, Meng Q, Cooney RN. PROPHYLACTIC n CMT-3 ATTENUATES SEPSIS-INDUCED ACUTE KIDNEY INJURY IN ASSOCIATION WITH NLRP3 INFLAMMASOME ACTIVATION AND APOPTOSIS. Shock. 2023 06 01; 59(6):922-929.
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Crocker CE, Sharmeen R, Tran TT, Khan AM, Li W, Alcorn JL. Surfactant protein a attenuates generalized and localized neuroinflammation in neonatal mice. Brain Res. 2023 05 15; 1807:148308.
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Shafi O, Mir T, Liu D, Velumula PK, Tul Llah S, Korumilli R. Characteristics, outcomes, and 30-day readmissions following pediatric extracorporeal membrane oxygenation in the United States: A Nationwide Readmissions Database study. Perfusion. 2024 03; 39(2):399-407.
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Salud D, Reeder RW, Banks RK, Meert KL, Berg RA, Zuppa A, Newth CJ, Hall MW, Quasney M, Sapru A, Carcillo JA, McQuillen PS, Mourani PM, Varni JW, Zimmerman JJ. Association of Pathogen Type With Outcomes of Children Encountering Community-Acquired Pediatric Septic Shock. Pediatr Crit Care Med. 2022 08 01; 23(8):635-645.
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Kamps NN, Banks R, Reeder RW, Berg RA, Newth CJ, Pollack MM, Meert KL, Carcillo JA, Mourani PM, Sorenson S, Varni JW, Cengiz P, Zimmerman JJ. The Association of Early Corticosteroid Therapy With Clinical and Health-Related Quality of Life Outcomes in Children With Septic Shock. Pediatr Crit Care Med. 2022 09 01; 23(9):687-697.
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Schootman M, Wiskow C, Loux T, Meyer L, Powell S, Gandhi A, Lacasse A. Evaluation of the effectiveness of an automated sepsis predictive tool on patient outcomes. J Crit Care. 2022 10; 71:154061.
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Elgarten CW, Otto WR, Shenton L, Stein MT, Horowitz J, Aftandilian C, Arnold SD, Bona KO, Caywood E, Collier AB, Gramatges MM, Henry M, Lotterman C, Maloney K, Modi AJ, Mian A, Mody R, Morgan E, Raetz EA, Verma A, Winick N, Wilkes JJ, Yu JC, Aplenc R, Fisher BT, Getz KD. Risk of bacterial bloodstream infection does not vary by central-line type during neutropenic periods in pediatric acute myeloid leukemia. Infect Control Hosp Epidemiol. 2023 02; 44(2):222-229.
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Lai H, Mubashir T, Shiwalkar N, Ahmad H, Balogh J, Williams G, Bauer C, Maroufy V. Association of pre-admission opioid abuse and/or dependence on major complications in traumatic brain injury (TBI) patients. J Clin Anesth. 2022 08; 79:110719.
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Maddux AB, Zimmerman JJ, Banks RK, Reeder RW, Meert KL, Czaja AS, Berg RA, Sapru A, Carcillo JA, Newth CJL, Quasney MW, Mourani PM. Health Resource Use in Survivors of Pediatric Septic Shock in the United States. Pediatr Crit Care Med. 2022 06 01; 23(6):e277-e288.
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Rom JS, Beenken KE, Ramirez AM, Walker CM, Echols EJ, Smeltzer MS. Limiting protease production plays a key role in the pathogenesis of the divergent clinical isolates of Staphylococcus aureus LAC and UAMS-1. Virulence. 2021 12; 12(1):584-600.
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Patel KM, Mears SC, Barnes CL, Stambough JB, Stronach BM. Sepsis and Total Joint Arthroplasty. Orthop Clin North Am. 2022 Jan; 53(1):13-24.
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Meert KL, Reeder RW, Maddux AB, Banks R, Berg RA, Newth CJ, Hall MW, Quasney M, Carcillo JA, McQuillen PS, Mourani PM, Chima RS, Holubkov R, Sorenson S, McGalliard J, Dean JM, Zimmerman JJ. Health-Related Quality of Life After Community-Acquired Septic Shock in Children With Preexisting Severe Developmental Disabilities. Pediatr Crit Care Med. 2021 05 01; 22(5):e302-e313.
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Klucher JM, Davis K, Lakkad M, Painter JT, Dare RK. Risk factors and clinical outcomes associated with blood culture contamination. Infect Control Hosp Epidemiol. 2022 03; 43(3):291-297.
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Zhang Y, Yan Y, Meng J, Girotra M, Ramakrishnan S, Roy S. Immune modulation mediated by extracellular vesicles of intestinal organoids is disrupted by opioids. Mucosal Immunol. 2021 07; 14(4):887-898.
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Zayed Y, Alzghoul BN, Banifadel M, Venigandla H, Hyde R, Sutchu S, Khasawneh M, Borok Z, Urbine D, Jantz M, Reddy R. Vitamin C, Thiamine, and Hydrocortisone in the Treatment of Sepsis: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials. J Intensive Care Med. 2022 Mar; 37(3):327-336.
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Sexton T, Chalhoub G, Ye S, Morris W, Annabathula R, Dugan A, Smyth S. Autotaxin Activity Predicts 30-Day Mortality in Sepsis Patients and Correlates With Platelet Count and Vascular Dysfunction. Shock. 2020 12; 54(6):738-743.
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Meert KL, Reeder R, Maddux AB, Banks R, Berg RA, Zuppa A, Newth CJ, Wessel D, Pollack MM, Hall MW, Quasney M, Sapru A, Carcillo JA, McQuillen PS, Mourani PM, Chima RS, Holubkov R, Sorenson S, Varni JW, McGalliard J, Haaland W, Whitlock KB, Dean JM, Zimmerman JJ. Trajectories and Risk Factors for Altered Physical and Psychosocial Health-Related Quality of Life After Pediatric Community-Acquired Septic Shock. Pediatr Crit Care Med. 2020 10; 21(10):869-878.
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Fay L, Rechner-Neven G, Hammond DA, DeMott JM, Sullivan MJ. Evaluating the Risk of Developing Thrombocytopenia Within Five Days of Continuous Renal Replacement Therapy Initiation in Septic Patients. J Pharm Pract. 2022 Feb; 35(1):94-100.
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McCarson KL, Walters CA, Cantu RM. Unusual Cause of Sepsis in a 10-Year-Old Female. Clin Pediatr (Phila). 2020 10; 59(11):1036-1039.
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Mir F, Pearce RE, Baig-Ansari N, Qazi S, Barrett JS, Abdel-Rahman S, Kearns G, Zaidi AK. Serum amoxicillin levels in young infants (0-59 days) with sepsis treated with oral amoxicillin. Arch Dis Child. 2020 12; 105(12):1208-1214.
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Hammond DA, Peksa GD, Rech MA. Balanced Crystalloids in Sepsis: Are We There Yet? Am J Respir Crit Care Med. 2020 05 01; 201(9):1162-1163.
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Zimmerman JJ, Banks R, Berg RA, Zuppa A, Newth CJ, Wessel D, Pollack MM, Meert KL, Hall MW, Quasney M, Sapru A, Carcillo JA, McQuillen PS, Mourani PM, Wong H, Chima RS, Holubkov R, Coleman W, Sorenson S, Varni JW, McGalliard J, Haaland W, Whitlock K, Dean JM, Reeder RW. Trajectory of Mortality and Health-Related Quality of Life Morbidity Following Community-Acquired Pediatric Septic Shock. Crit Care Med. 2020 03; 48(3):329-337.
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Owen AM, Patel SP, Smith JD, Balasuriya BK, Mori SF, Hawk GS, Stromberg AJ, Kuriyama N, Kaneki M, Rabchevsky AG, Butterfield TA, Esser KA, Peterson CA, Starr ME, Saito H. Chronic muscle weakness and mitochondrial dysfunction in the absence of sustained atrophy in a preclinical sepsis model. Elife. 2019 12 03; 8.
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Hanna B, Desai R, Kumar G, Sachdeva R. The authors reply. Crit Care Med. 2019 12; 47(12):e1032-e1033.
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Banerjee S, Fu Q, Shah SK, Melnyk SB, Sterneck E, Hauer-Jensen M, Pawar SA. C/EBPd protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress. Sci Rep. 2019 09 27; 9(1):13953.
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Desai R, Parekh T, Hanna B, Sachdeva R, Kumar G. Reply to: Regional variation in cardiac arrest for patients with sepsis. Resuscitation. 2019 11; 144:211-212.
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Ilaiwy A, Ten Have GAM, Bain JR, Muehlbauer MJ, O'Neal SK, Berthiaume JM, Parry TL, Deutz NE, Willis MS. Identification of Metabolic Changes in Ileum, Jejunum, Skeletal Muscle, Liver, and Lung in a Continuous I.V. Pseudomonas aeruginosa Model of Sepsis Using Nontargeted Metabolomics Analysis. Am J Pathol. 2019 09; 189(9):1797-1813.
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Luiking YC, Poeze M, Deutz NE. A randomized-controlled trial of arginine infusion in severe sepsis on microcirculation and metabolism. Clin Nutr. 2020 06; 39(6):1764-1773.
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Desai R, Parekh T, Patel U, Hanna B, Damarlapally N, Patel C, Doshi R, Savani S, Sachdeva R, Kumar G. Regional trends in In-hospital Cardiac Arrest following sepsis-related admissions and subsequent mortality. Resuscitation. 2019 10; 143:35-41.
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Desai R, Hanna B, Singh S, Omar A, Deshmukh A, Kumar G, Foreman MG, Sachdeva R. Trends and Outcomes in Sepsis Hospitalizations With and Without Atrial Fibrillation: A Nationwide Inpatient Analysis. Crit Care Med. 2019 08; 47(8):e630-e638.
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Hammond DA, Lam SW, Rech MA, Smith MN, Westrick J, Trivedi AP, Balk RA. Balanced Crystalloids Versus Saline in Critically Ill Adults: A Systematic Review and Meta-analysis. Ann Pharmacother. 2020 01; 54(1):5-13.
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Newsome AS, Bissell BD, Burry LD, Defayette AA, Gagnon DJ, Gilbert BW, Kramer CJ, Miller CJ, Semanco M, Smith MN, Hammond DA. Major publications in critical care pharmacotherapy literature in 2018. J Crit Care. 2019 08; 52:200-207.
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Ten Have GAM, Engelen MPKJ, Wolfe RR, Deutz NEP. Inhibition of jejunal protein synthesis and breakdown in Pseudomonas aeruginosa-induced sepsis pig model. Am J Physiol Gastrointest Liver Physiol. 2019 06 01; 316(6):G755-G762.
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Gadre SK, Shah M, Mireles-Cabodevila E, Patel B, Duggal A. Epidemiology and Predictors of 30-Day Readmission in Patients With Sepsis. Chest. 2019 03; 155(3):483-490.
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Ming DK, Otter JA, Ghani R, Brannigan ET, Boonyasiri A, Mookerjee S, Gilchrist M, Holmes AH, Davies F. Clinical risk stratification and antibiotic management of NDM and OXA-48 carbapenemase-producing Enterobacteriaceae bloodstream infections in the UK. J Hosp Infect. 2019 05; 102(1):95-97.
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Ittleman BR, Szabo JS. Staphylococcus lugdunensis sepsis and endocarditis in a newborn following lotus birth. Cardiol Young. 2018 Nov; 28(11):1367-1369.
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Buckley MS, Hartsock NC, Berry AJ, Bikin DS, Richards EC, Yerondopoulos MJ, Kobic E, Wicks LM, Hammond DA. Comparison of acute kidney injury risk associated with vancomycin and concomitant piperacillin/tazobactam or cefepime in the intensive care unit. J Crit Care. 2018 12; 48:32-38.
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Rontoyanni VG, Malagaris I, Herndon DN, Rivas E, Capek KD, Delgadillo AD, Bhattarai N, Elizondo A, Voigt CD, Finnerty CC, Suman OE, Porter C. Skeletal Muscle Mitochondrial Function is Determined by Burn Severity, Sex, and Sepsis, and is Associated With Glucose Metabolism and Functional Capacity in Burned Children. Shock. 2018 08; 50(2):141-148.
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Claushuis TAM, de Stoppelaar SF, de Vos AF, Grootemaat AE, van der Wel NN, Roelofs JJTH, Ware J, Van't Veer C, van der Poll T. Nbeal2 Deficiency Increases Organ Damage but Does Not Affect Host Defense During Gram-Negative Pneumonia-Derived Sepsis. Arterioscler Thromb Vasc Biol. 2018 08; 38(8):1772-1784.
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Yang FM, Zuo Y, Zhou W, Xia C, Hahm B, Sullivan M, Cheng J, Chang HM, Yeh ET. sNASP inhibits TLR signaling to regulate immune response in sepsis. J Clin Invest. 2018 06 01; 128(6):2459-2472.
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Gadre SK, Duggal A, Mireles-Cabodevila E, Krishnan S, Wang XF, Zell K, Guzman J. Acute respiratory failure requiring mechanical ventilation in severe chronic obstructive pulmonary disease (COPD). Medicine (Baltimore). 2018 Apr; 97(17):e0487.
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Annane D, Pastores SM, Rochwerg B, Arlt W, Balk RA, Beishuizen A, Briegel J, Carcillo J, Christ-Crain M, Cooper MS, Marik PE, Umberto Meduri G, Olsen KM, Rodgers SC, Russell JA, Van den Berghe G. Guidelines for the Diagnosis and Management of Critical Illness-Related Corticosteroid Insufficiency (CIRCI) in Critically Ill Patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017. Crit Care Med. 2017 Dec; 45(12):2078-2088.
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Ten Have GAM, Deutz RCI, Engelen MPKJ, Wolfe RR, Deutz NEP. Characteristics of a Pseudomonas aeruginosa induced porcine sepsis model for multi-organ metabolic flux measurements. Lab Anim. 2018 Apr; 52(2):163-175.
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Ussia GP, Cammalleri V, Mehta JL, Sarkar K, Muscoli S, de Vico P, Ruvolo G, Romeo F. Transcatheter mitral valve replacement with a novel self-expandable prosthesis: single institutional experience procedural outcomes and follow-up. J Cardiovasc Med (Hagerstown). 2017 Jun; 18(6):415-424.
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Shah NN, McClellan W, Flowers CR, Lonial S, Khoury H, Waller EK, Langston A, Nooka AK. Evaluating Risk Factors for Clostridium difficile Infection In Stem Cell Transplant Recipients: A National Study. Infect Control Hosp Epidemiol. 2017 06; 38(6):651-657.
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Ten Have GAM, Engelen MPKJ, Wolfe RR, Deutz NEP. Phenylalanine isotope pulse method to measure effect of sepsis on protein breakdown and membrane transport in the pig. Am J Physiol Endocrinol Metab. 2017 06 01; 312(6):E519-E529.
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Kent M, Over DR. Clostridium Perfringens Sepsis With Massive Intravascular Hemolysis. J Ark Med Soc. 2017 Mar; 113(9):212-214.
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Chan L, Mehta S, Chauhan K, Poojary P, Patel S, Pawar S, Patel A, Correa A, Patel S, Garimella PS, Annapureddy N, Agarwal SK, Gidwani U, Coca SG, Nadkarni GN. National Trends and Impact of Acute Kidney Injury Requiring Hemodialysis in Hospitalizations With Atrial Fibrillation. J Am Heart Assoc. 2016 12 20; 5(12).
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Ganatra HA, Varisco BM, Harmon K, Lahni P, Opoka A, Wong HR. Zinc supplementation leads to immune modulation and improved survival in a juvenile model of murine sepsis. Innate Immun. 2017 01; 23(1):67-76.
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Beck MK, Jensen AB, Nielsen AB, Perner A, Moseley PL, Brunak S. Diagnosis trajectories of prior multi-morbidity predict sepsis mortality. Sci Rep. 2016 11 04; 6:36624.
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Smith JA, Mayeux PR, Schnellmann RG. Delayed Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Inhibition by Trametinib Attenuates Systemic Inflammatory Responses and Multiple Organ Injury in Murine Sepsis. Crit Care Med. 2016 08; 44(8):e711-20.
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Hammond DA, Smith MN, Meena N. Considerations on Midodrine Use in Resolving Septic Shock. Chest. 2016 06; 149(6):1582-3.
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Li Y, Hadden C, Cooper A, Ahmed A, Wu H, Lupashin VV, Mayeux PR, Kilic F. Sepsis-induced elevation in plasma serotonin facilitates endothelial hyperpermeability. Sci Rep. 2016 Mar 09; 6:22747.
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Ince C, Mayeux PR, Nguyen T, Gomez H, Kellum JA, Ospina-Tasc?n GA, Hernandez G, Murray P, De Backer D. THE ENDOTHELIUM IN SEPSIS. Shock. 2016 Mar; 45(3):259-70.
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Sims CR, Nguyen TC, Mayeux PR. Could Biomarkers Direct Therapy for the Septic Patient? J Pharmacol Exp Ther. 2016 May; 357(2):228-39.
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Kaushal GP, Shah SV. Autophagy in acute kidney injury. Kidney Int. 2016 Apr; 89(4):779-91.
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Verma V, Muttineni S, Kulkarni RR, Silva-Lopez E, West WW, Thompson RB. Enormous, rapidly growing breast mass. BMC Cancer. 2015 Dec 24; 15:1008.
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Steinbach WJ. Blood-based Diagnosis of Invasive Fungal Infections in Immunocompromised/Oncology Patients. Pediatr Infect Dis J. 2015 Sep; 34(9):1020-2.
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