 Bone Density
"Bone Density" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.
| Descriptor ID |
D015519
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| MeSH Number(s) |
G11.427.100
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| Concept/Terms |
Bone Density- Bone Density
- Bone Densities
- Density, Bone
- Bone Mineral Density
- Bone Mineral Densities
- Density, Bone Mineral
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Below are MeSH descriptors whose meaning is more general than "Bone Density".
Below are MeSH descriptors whose meaning is more specific than "Bone Density".
This graph shows the total number of publications written about "Bone Density" by people in UAMS Profiles by year, and whether "Bone Density" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2024 | 1 | 3 | 4 | | 2023 | 1 | 5 | 6 | | 2022 | 2 | 5 | 7 | | 2021 | 2 | 0 | 2 | | 2020 | 0 | 5 | 5 | | 2019 | 2 | 4 | 6 | | 2018 | 0 | 6 | 6 | | 2017 | 3 | 6 | 9 | | 2016 | 4 | 6 | 10 | | 2015 | 4 | 5 | 9 | | 2014 | 3 | 6 | 9 | | 2013 | 4 | 6 | 10 | | 2012 | 4 | 6 | 10 | | 2011 | 4 | 6 | 10 | | 2010 | 3 | 8 | 11 | | 2009 | 2 | 6 | 8 | | 2008 | 4 | 3 | 7 | | 2007 | 5 | 4 | 9 | | 2006 | 5 | 5 | 10 | | 2005 | 5 | 6 | 11 | | 2004 | 3 | 4 | 7 | | 2003 | 2 | 3 | 5 | | 2002 | 3 | 4 | 7 | | 2001 | 0 | 2 | 2 | | 2000 | 0 | 1 | 1 | | 1999 | 0 | 1 | 1 | | 1998 | 1 | 0 | 1 | | 1997 | 1 | 1 | 2 | | 1989 | 1 | 0 | 1 |
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Below are the most recent publications written about "Bone Density" by people in Profiles over the past ten years.
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Li X, Zhang C, Vail CE, Sherrill JT, Xiong J. Piezo1 expression in mature osteocytes is dispensable for the skeletal response to mechanical loading. Bone. 2025 Jan; 190:117276.
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Dole NS, Betancourt-Torres A, Kaya S, Obata Y, Schurman CA, Yoon J, Yee CS, Khanal V, Luna CA, Carroll M, Salinas JJ, Miclau E, Acevedo C, Alliston T. High-fat and high-carbohydrate diets increase bone fragility through TGF-?-dependent control of osteocyte function. JCI Insight. 2024 Jul 09; 9(16).
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Zhu M, Zeiss C, Hamrick MW, Weinstein RS, Sun BH, Brotto M, Liu X, Siu E, Huttner A, Tommasini S, Simpson C, Insogna K. Mitofusin 2 plays a critical role in maintaining the functional integrity of the neuromuscular-skeletal axis. Bone. 2024 Jul; 184:117086.
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Koltun KJ, Strock NCA, Weaver C, Lee H, Williams NI, Rogers CJ, Damani J, Ferruzzi MG, Nakatsu CH, De Souza MJ. Prunes preserve cortical density and estimated strength of the tibia in a 12-month randomized controlled trial in postmenopausal women: The Prune Study. Osteoporos Int. 2024 May; 35(5):863-875.
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Marino S, Ozgurel SU, McAndrews K, Cregor M, Villase?or A, Mamani-Huanca M, Barbas C, Gortazar A, Sato AY, Bellido T. Abaloparatide is more potent than teriparatide in restoring bone mass and strength in type 1 diabetic male mice. Bone. 2024 Apr; 181:117042.
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Lewiecki EM, Bellido T, Bilezikian JP, Brown JP, Farooki A, Kovacs CS, Lee B, Leslie WD, McClung MR, Prasarn ML, Sellmeyer DE. Proceedings of the 2023 Santa Fe Bone Symposium: Progress and Controversies in the Management of Patients with Skeletal Diseases. J Clin Densitom. 2023 Oct-Dec; 26(4):101432.
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Zarate YA, Bosanko K, Andres A, Fish JL. Bone health in SATB2-associated syndrome: Results from a large prospective cohort and recommendations for surveillance. Am J Med Genet A. 2024 02; 194(2):203-210.
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Korff C, Adaway M, Atkinson EG, Horan DJ, Klunk A, Silva BS, Bellido T, Plotkin LI, Robling AG, Bidwell JP. Loss of Nmp4 enhances bone gain from sclerostin antibody administration. Bone. 2023 Dec; 177:116891.
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Yoon J, Kaya S, Matsumae G, Dole N, Alliston T. miR181a/b-1 controls osteocyte metabolism and mechanical properties independently of bone morphology. Bone. 2023 10; 175:116836.
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Turkkahraman H, Flanagan S, Zhu T, Bellido TM, Yuan X. The LRP5 high-bone-mass mutation causes alveolar bone accrual with minor craniofacial alteration. J Periodontal Res. 2023 Aug; 58(4):723-732.
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Mourtakos S, Kavouras S, Vasiliou S, Soultanakis H, Bardis C, Sidossis L, Tenta R. Bone Mineral Content Distribution in Response to Long-term Training of Elite Rowers. In Vivo. 2023 Mar-Apr; 37(2):611-617.
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Palmieri M, Joseph TE, O'Brien CA, Gomez-Acevedo H, Kim HN, Manolagas SC, Ambrogini E. RETRACTED: Deletion of the scavenger receptor Scarb1 in myeloid cells does not affect bone mass Bone. 2023 05; 170:116702.
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Atkinson EG, Adaway M, Horan DJ, Korff C, Klunk A, Orr AL, Ratz K, Bellido T, Plotkin LI, Robling AG, Bidwell JP. Conditional Loss of Nmp4 in Mesenchymal Stem Progenitor Cells Enhances PTH-Induced Bone Formation. J Bone Miner Res. 2023 01; 38(1):70-85.
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De Souza MJ, Strock NCA, Williams NI, Lee H, Koltun KJ, Rogers C, Ferruzzi MG, Nakatsu CH, Weaver C. Prunes preserve hip bone mineral density in a 12-month randomized controlled trial in postmenopausal women: the Prune Study. Am J Clin Nutr. 2022 10 06; 116(4):897-910.
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Kalaitzoglou E, Fowlkes JL, Thrailkill KM. Mouse models of type 1 diabetes and their use in skeletal research. Curr Opin Endocrinol Diabetes Obes. 2022 08 01; 29(4):318-325.
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Ponte F, Kim HN, Warren A, Iyer S, Han L, Mannen E, Gomez-Acevedo H, Nookaew I, Almeida M, Manolagas SC. Mmp13 deletion in mesenchymal cells increases bone mass and may attenuate the cortical bone loss caused by estrogen deficiency. Sci Rep. 2022 06 17; 12(1):10257.
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Chen JR, Lazarenko OP, Blackburn ML. GPR109A gene deletion ameliorates gonadectomy-induced bone loss in mice. Bone. 2022 08; 161:116422.
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Citla-Sridhar D, Sidonio RF, Ahuja SP. Bone health in haemophilia carriers and persons with von Willebrand disease: A large database analysis. Haemophilia. 2022 Jul; 28(4):671-678.
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Palmieri M, Joseph TE, O'Brien CA, Gomez-Acevedo H, Manolagas SC, Ambrogini E. Deletion of the scavenger receptor Scarb1 in osteoblast progenitors does not affect bone mass. PLoS One. 2022; 17(3):e0265893.
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Kaya S, Schurman CA, Dole NS, Evans DS, Alliston T. Prioritization of Genes Relevant to Bone Fragility Through the Unbiased Integration of Aging Mouse Bone Transcriptomics and Human GWAS Analyses. J Bone Miner Res. 2022 04; 37(4):804-817.
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Feresin RG, Johnson SA, Elam ML, Pourafshar S, Navaei N, Akhavan NS, Tenenbaum G, Figueroa A, Arjmandi BH. Effects of strawberries on bone biomarkers in pre- and stage 1-hypertensive postmenopausal women: a secondary analysis. Food Funct. 2021 Dec 13; 12(24):12526-12534.
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MacLeod RS, Meyer MB, Xiong J, Cawley KM, Liu Y, Onal M, Benkusky NA, Thostenson JD, Pike JW, O'Brien CA. Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo. PLoS One. 2021; 16(5):e0250974.
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Hollowoa BR, Spencer HJ, Stack BC. Normocalcemic and Normohormonal Primary Hyperparathyroidism: Laboratory Values and End-Organ Effects. Otolaryngol Head Neck Surg. 2021 09; 165(3):387-397.
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Kim HN, Ponte F, Nookaew I, Ucer Ozgurel S, Marques-Carvalho A, Iyer S, Warren A, Aykin-Burns N, Krager K, Sardao VA, Han L, de Cabo R, Zhao H, Jilka RL, Manolagas SC, Almeida M. Estrogens decrease osteoclast number by attenuating mitochondria oxidative phosphorylation and ATP production in early osteoclast precursors. Sci Rep. 2020 07 20; 10(1):11933.
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Palacios C, Trak-Fellermeier MA, P?rez CM, Huffman F, Hernandez Suarez Y, Bursac Z, Gambon TB, Nakatsu CH, Weaver CM. Effect of soluble corn fiber supplementation for 1?year on bone metabolism in children, the MetA-bone trial: Rationale and design. Contemp Clin Trials. 2020 08; 95:106061.
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Dole NS, Yee CS, Mazur CM, Acevedo C, Alliston T. TGF? Regulation of Perilacunar/Canalicular Remodeling Is Sexually Dimorphic. J Bone Miner Res. 2020 08; 35(8):1549-1561.
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Robinson JW, Blixt NC, Norton A, Mansky KC, Ye Z, Aparicio C, Wagner BM, Benton AM, Warren GL, Khosla S, Gaddy D, Suva LJ, Potter LR. Male mice with elevated C-type natriuretic peptide-dependent guanylyl cyclase-B activity have increased osteoblasts, bone mass and bone strength. Bone. 2020 06; 135:115320.
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Cladis DP, Li S, Reddivari L, Cox A, Ferruzzi MG, Weaver CM. A 90 day oral toxicity study of blueberry polyphenols in ovariectomized sprague-dawley rats. Food Chem Toxicol. 2020 May; 139:111254.
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Thrailkill KM, Bunn RC, Uppuganti S, Ray P, Garrett K, Popescu I, Pennings JS, Fowlkes JL, Nyman JS. Genetic ablation of SGLT2 function in mice impairs tissue mineral density but does not affect fracture resistance of bone. Bone. 2020 04; 133:115254.
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Rochester E, Wickman BE, Bell A, Simecka C, Clayton ZS, Hakkak R, Hooshmand S. A diet containing high- versus low-daidzein does not affect bone density and osteogenic gene expression in the obese Zucker rat model. Food Funct. 2019 Oct 16; 10(10):6851-6857.
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Davis HM, Deosthale PJ, Pacheco-Costa R, Essex AL, Atkinson EG, Aref MW, Dilley JE, Bellido T, Ivan M, Allen MR, Plotkin LI. Osteocytic miR21 deficiency improves bone strength independent of sex despite having sex divergent effects on osteocyte viability and bone turnover. FEBS J. 2020 03; 287(5):941-963.
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Huseman CJ, Sigler DH, Welsh TH, Suva LJ, Vogelsang MM, Dominguez BJ, Huggins S, Paulk C. Skeletal response to whole body vibration and dietary calcium and phosphorus in growing pigs. J Anim Sci. 2019 Jul 30; 97(8):3369-3378.
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Blue MNM, Hirsch KR, Pihoker AA, Trexler ET, Smith-Ryan AE. Normative fat-free mass index values for a diverse sample of collegiate female athletes. J Sports Sci. 2019 Aug; 37(15):1741-1745.
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Kim HN, Chang J, Iyer S, Han L, Campisi J, Manolagas SC, Zhou D, Almeida M. Elimination of senescent osteoclast progenitors has no effect on the age-associated loss of bone mass in mice. Aging Cell. 2019 06; 18(3):e12923.
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Suva LJ. A Link between the Gut and Bone: Bone Health Impacted by Changes in Gut Microbiota. Am J Pathol. 2019 02; 189(2):229-230.
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Costantini A, Valta H, Baratang NV, Yap P, Bertola DR, Yamamoto GL, Kim CA, Chen J, Wierenga KJ, Fanning EA, Escobar L, McWalter K, McLaughlin H, Willaert R, Begtrup A, Alm JJ, Reinhardt DP, M?kitie O, Campeau PM. Novel fibronectin mutations and expansion of the phenotype in spondylometaphyseal dysplasia with "corner fractures". Bone. 2019 04; 121:163-171.
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Stack BC, Tolley NS, Bartel TB, Bilezikian JP, Bodenner D, Camacho P, Cox JPDT, Dralle H, Jackson JE, Morris JC, Orloff LA, Palazzo F, Ridge JA, Scott-Coombes D, Steward DL, Terris DJ, Thompson G, Randolph GW. AHNS Series: Do you know your guidelines? Optimizing outcomes in reoperative parathyroid surgery: Definitive multidisciplinary joint consensus guidelines of the American Head and Neck Society and the British Association of Endocrine and Thyroid Surgeons. Head Neck. 2018 08; 40(8):1617-1629.
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Murphy PZ, Iranikhah M, Deas CM, Freeman MK. Fracture Risk Following Discontinuation of Teriparatide: A Review of the Literature. Consult Pharm. 2018 Jul 01; 33(7):365-375.
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Pacheco-Costa R, Davis HM, Atkinson EG, Dilley JE, Byiringiro I, Aref MW, Allen MR, Bellido T, Plotkin LI. Reversal of loss of bone mass in old mice treated with mefloquine. Bone. 2018 09; 114:22-31.
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Johannsen MM, Shin KJ, Priebe K, Coker RH. Alaska Mountain Wilderness Ski Classic: Alterations in Caloric Expenditure and Body Composition. Wilderness Environ Med. 2018 06; 29(2):221-225.
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Blue MNM, Hirsch KR, Trexler ET, Smith-Ryan AE. Validity of the 4-compartment model using dual energy X-ray absorptiometry-derived body volume in overweight individuals. Appl Physiol Nutr Metab. 2018 Jul; 43(7):742-746.
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Manolagas SC. The Quest for Osteoporosis Mechanisms and Rational Therapies: How Far We've Come, How Much Further We Need to Go. J Bone Miner Res. 2018 03; 33(3):371-385.
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O'Brien CE, Com G, Fowlkes J, Tang X, James LP. Peripheral quantitative computed tomography detects differences at the radius in prepubertal children with cystic fibrosis compared to healthy controls. PLoS One. 2018; 13(1):e0191013.
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Weinstein RS, Hogan EA, Borrelli MJ, Liachenko S, O'Brien CA, Manolagas SC. The Pathophysiological Sequence of Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Male Mice. Endocrinology. 2017 11 01; 158(11):3817-3831.
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Singh-Ospina N, Maraka S, Rodriguez-Gutierrez R, Davidge-Pitts C, Nippoldt TB, Prokop LJ, Murad MH. Effect of Sex Steroids on the Bone Health of Transgender Individuals: A Systematic Review and Meta-Analysis. J Clin Endocrinol Metab. 2017 11 01; 102(11):3904-3913.
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Commean PK, Smith KE, Hildebolt CF, Bohnert KL, Sinacore DR, Prior FW. A Candidate Imaging Marker for Early Detection of Charcot Neuroarthropathy. J Clin Densitom. 2018 Oct - Dec; 21(4):485-492.
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Raisingani M, Preneet B, Kohn B, Yakar S. Skeletal growth and bone mineral acquisition in type 1 diabetic children; abnormalities of the GH/IGF-1 axis. Growth Horm IGF Res. 2017 06; 34:13-21.
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Komaba H, Kaludjerovic J, Hu DZ, Nagano K, Amano K, Ide N, Sato T, Densmore MJ, Hanai JI, Olauson H, Bellido T, Larsson TE, Baron R, Lanske B. Klotho expression in osteocytes regulates bone metabolism and controls bone formation. Kidney Int. 2017 09; 92(3):599-611.
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Sinacore DR, Bohnert KL, Smith KE, Hastings MK, Commean PK, Gutekunst DJ, Johnson JE, Prior FW. Persistent inflammation with pedal osteolysis 1year after Charcot neuropathic osteoarthropathy. J Diabetes Complications. 2017 Jun; 31(6):1014-1020.
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Cox TM, Drelichman G, Cravo R, Balwani M, Burrow TA, Martins AM, Lukina E, Rosenbloom B, Goker-Alpan O, Watman N, El-Beshlawy A, Kishnani PS, Pedroso ML, Gaemers SJM, Tayag R, Peterschmitt MJ. Eliglustat maintains long-term clinical stability in patients with Gaucher disease type 1 stabilized on enzyme therapy. Blood. 2017 04 27; 129(17):2375-2383.
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Pellegrini GG, Cregor M, McAndrews K, Morales CC, McCabe LD, McCabe GP, Peacock M, Burr D, Weaver C, Bellido T. Nrf2 regulates mass accrual and the antioxidant endogenous response in bone differently depending on the sex and age. PLoS One. 2017; 12(2):e0171161.
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Trexler ET, Smith-Ryan AE, Mann JB, Ivey PA, Hirsch KR, Mock MG. Longitudinal Body Composition Changes in NCAA Division I College Football Players. J Strength Cond Res. 2017 Jan; 31(1):1-8.
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Alund AW, Mercer KE, Pulliam CF, Suva LJ, Chen JR, Badger TM, Ronis MJ. Partial Protection by Dietary Antioxidants Against Ethanol-Induced Osteopenia and Changes in Bone Morphology in Female Mice. Alcohol Clin Exp Res. 2017 01; 41(1):46-56.
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Hoscheit M, Conner G, Roemer J, Vuckovska A, Abbasnia P, Vana P, Shankar R, Kennedy R, Callaci J. Burn Injury Has Skeletal Site-Specific Effects on Bone Integrity and Markers of Bone Remodeling. J Burn Care Res. 2016 Nov/Dec; 37(6):367-378.
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Maycas M, McAndrews KA, Sato AY, Pellegrini GG, Brown DM, Allen MR, Plotkin LI, Gortazar AR, Esbrit P, Bellido T. PTHrP-Derived Peptides Restore Bone Mass and Strength in Diabetic Mice: Additive Effect of Mechanical Loading. J Bone Miner Res. 2017 Mar; 32(3):486-497.
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Chen JR, Lazarenko OP, Blackburn ML, Shankar K. Dietary factors during early life program bone formation in female rats. FASEB J. 2017 01; 31(1):376-387.
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Singh Ospina N, Maraka S, Rodriguez-Gutierrez R, Espinosa de Ycaza AE, Jasim S, Gionfriddo M, Castaneda-Guarderas A, Brito JP, Al Nofal A, Erwin P, Wermers R, Montori V. Comparative efficacy of parathyroidectomy and active surveillance in patients with mild primary hyperparathyroidism: a systematic review and meta-analysis. Osteoporos Int. 2016 12; 27(12):3395-3407.
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Abshire DA, Moser DK, Clasey JL, Chung ML, Pressler SJ, Dunbar SB, Heo S, Lennie TA. Body Composition and Bone Mineral Density in Patients With Heart Failure. West J Nurs Res. 2017 04; 39(4):582-599.
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Alund AW, Mercer KE, Suva LJ, Pulliam CF, Chen JR, Badger TM, Van Remmen H, Ronis MJ. Reactive Oxygen Species Differentially Regulate Bone Turnover in an Age-Specific Manner in Catalase Transgenic Female Mice. J Pharmacol Exp Ther. 2016 07; 358(1):50-60.
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Piemontese M, Onal M, Xiong J, Han L, Thostenson JD, Almeida M, O'Brien CA. Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage. Sci Rep. 2016 Apr 11; 6:24262.
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Liu Y, Almeida M, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Skeletal inflammation and attenuation of Wnt signaling, Wnt ligand expression, and bone formation in atherosclerotic ApoE-null mice. Am J Physiol Endocrinol Metab. 2016 May 01; 310(9):E762-73.
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Johnson SA, Feresin RG, Soung do Y, Elam ML, Arjmandi BH. Vitamin E suppresses ex vivo osteoclastogenesis in ovariectomized rats. Food Funct. 2016 Mar; 7(3):1628-33.
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Dole NS, Delany AM. MicroRNA variants as genetic determinants of bone mass. Bone. 2016 Mar; 84:57-68.
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Niziolek PJ, MacDonald BT, Kedlaya R, Zhang M, Bellido T, He X, Warman ML, Robling AG. High Bone Mass-Causing Mutant LRP5 Receptors Are Resistant to Endogenous Inhibitors In Vivo. J Bone Miner Res. 2015 Oct; 30(10):1822-30.
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Xiong J, Piemontese M, Onal M, Campbell J, Goellner JJ, Dusevich V, Bonewald L, Manolagas SC, O'Brien CA. Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone. PLoS One. 2015; 10(9):e0138189.
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Maraka S, Kennel KA. Bisphosphonates for the prevention and treatment of osteoporosis. BMJ. 2015 Sep 02; 351:h3783.
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Hinton PS, Shankar K, Eaton LM, Rector RS. Obesity-related changes in bone structural and material properties in hyperphagic OLETF rats and protection by voluntary wheel running. Metabolism. 2015 Aug; 64(8):905-16.
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O'Keeffe DT, Maraka S, Wermers R. The significance of bone mineral density in the depiction of memento mori. J Bone Miner Res. 2015 Apr; 30(4):747.
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Hood WR, Hobensack M. The effect of locomotion on the mobilization of minerals from the maternal skeleton. PLoS One. 2015; 10(3):e0122702.
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Piemontese M, Onal M, Xiong J, Wang Y, Almeida M, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone. Bone. 2015 Jun; 75:18-26.
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Tu X, Delgado-Calle J, Condon KW, Maycas M, Zhang H, Carlesso N, Taketo MM, Burr DB, Plotkin LI, Bellido T. Osteocytes mediate the anabolic actions of canonical Wnt/?-catenin signaling in bone. Proc Natl Acad Sci U S A. 2015 Feb 03; 112(5):E478-86.
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