 Glucocorticoids
"Glucocorticoids" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of CORTICOSTEROIDS that affect carbohydrate metabolism (GLUCONEOGENESIS, liver glycogen deposition, elevation of BLOOD SUGAR), inhibit ADRENOCORTICOTROPIC HORMONE secretion, and possess pronounced anti-inflammatory activity. They also play a role in fat and protein metabolism, maintenance of arterial blood pressure, alteration of the connective tissue response to injury, reduction in the number of circulating lymphocytes, and functioning of the central nervous system.
| Descriptor ID |
D005938
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| MeSH Number(s) |
D06.472.040.543 D27.505.696.399.472.488
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| Concept/Terms |
Glucocorticoid Effect- Glucocorticoid Effect
- Effect, Glucocorticoid
- Glucorticoid Effects
- Effects, Glucorticoid
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Below are MeSH descriptors whose meaning is more general than "Glucocorticoids".
Below are MeSH descriptors whose meaning is more specific than "Glucocorticoids".
This graph shows the total number of publications written about "Glucocorticoids" by people in UAMS Profiles by year, and whether "Glucocorticoids" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2024 | 3 | 0 | 3 | | 2023 | 2 | 3 | 5 | | 2022 | 1 | 3 | 4 | | 2021 | 1 | 1 | 2 | | 2020 | 1 | 5 | 6 | | 2019 | 3 | 6 | 9 | | 2018 | 1 | 3 | 4 | | 2017 | 5 | 3 | 8 | | 2016 | 7 | 6 | 13 | | 2015 | 2 | 2 | 4 | | 2014 | 2 | 1 | 3 | | 2013 | 1 | 2 | 3 | | 2012 | 6 | 3 | 9 | | 2011 | 7 | 4 | 11 | | 2010 | 7 | 0 | 7 | | 2009 | 3 | 3 | 6 | | 2008 | 3 | 2 | 5 | | 2007 | 4 | 5 | 9 | | 2006 | 3 | 1 | 4 | | 2005 | 3 | 1 | 4 | | 2004 | 2 | 2 | 4 | | 2003 | 2 | 4 | 6 | | 2002 | 2 | 0 | 2 | | 2001 | 1 | 0 | 1 | | 2000 | 2 | 0 | 2 | | 1999 | 2 | 1 | 3 | | 1998 | 1 | 0 | 1 | | 1997 | 2 | 1 | 3 | | 1992 | 0 | 1 | 1 | | 1991 | 1 | 0 | 1 | | 1990 | 0 | 1 | 1 |
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Below are the most recent publications written about "Glucocorticoids" by people in Profiles over the past ten years.
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Wang X, Sato AY, Marino S, Akel N, Boysen G, Basnakian AG, Bellido TM, Li HY. Generation of BT-Amide, a Bone-Targeted Pyk2 Inhibitor, Effective via Oral Administration, for the Prevention of Glucocorticoid-Induced Bone Loss. J Med Chem. 2024 Nov 28; 67(22):20708-20720.
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Sato AY, Cregor M, McAndrews K, Schurman CA, Schaible E, Shutter J, Vyas P, Adhikari B, Willis MS, Boerma M, Alliston T, Bellido T. Pharmacologic or genetic interference with atrogene signaling protects against glucocorticoid-induced musculoskeletal and cardiac disease. JCI Insight. 2024 Nov 08; 9(21).
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Saito K, Gabbeta A, Mulvihill E, Al-Jaberi L, Beukelman T, Lewis JD, Rose CD, Strom BL, Horton DB. Validation of new medication use algorithms as proxies for worsening disease activity in patients with juvenile idiopathic arthritis. Pharmacoepidemiol Drug Saf. 2024 05; 33(5):e5803.
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Nemec-Bakk AS, Bel J, Niccoli S, Boreham DR, Tai TC, Lees SJ, Khaper N. Effects of prenatal dexamethasone exposure on adult C57BL/6J mouse metabolism and oxidative stress. Can J Physiol Pharmacol. 2024 Mar 01; 102(3):180-195.
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Ramani PK, Grigorian F, Lightle H, Joshi SV. Paediatric Cogan Syndrome masquerading as IgA vasculitis. Mod Rheumatol Case Rep. 2023 Dec 29; 8(1):229-236.
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Gandy K, Sapkota Y, Scoggins MA, Jacola LM, Koscik TR, Hudson MM, Pui CH, Krull KR, van der Plas E. Genetic variants, neurocognitive outcomes, and functional neuroimaging in survivors of childhood acute lymphoblastic leukemia. JNCI Cancer Spectr. 2023 07 03; 7(4).
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Soliman MK, Zarranz-Ventura J, Chakravarthy U, McKibbin M, Brand C, Menon G, Cilliers H, Natha S, Ross A, Sarhan M, Lobo A, Chong V, Mahmood S, Islam N, Akerele T, Shakarchi A, Sallam A. UNITED KINGDOM DATABASE STUDY OF INTRAVITREAL DEXAMETHASONE IMPLANT (OZURDEX) FOR MACULAR EDEMA RELATED TO RETINAL VEIN OCCLUSION. Retina. 2023 04 01; 43(4):679-687.
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Sherman MA, Kim H, Banschbach K, Brown A, Gewanter HL, Lang B, Perron M, Robinson AB, Spitznagle J, Stingl C, Syverson G, Tory HO, Spencer CH, Tarvin SE. Treatment escalation patterns to start biologics in refractory moderate juvenile dermatomyositis among members of the Childhood Arthritis and Rheumatology Research Alliance. Pediatr Rheumatol Online J. 2023 Jan 06; 21(1):3.
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Robles I, Eidsness MA, Travis KE, Feldman HM, Dubner SE. Effects of postnatal glucocorticoids on brain structure in preterm infants, a scoping review. Neurosci Biobehav Rev. 2023 02; 145:105034.
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Dufour D, Dumontet T, Sahut-Barnola I, Carusi A, Onzon M, Pussard E, Wilmouth JJ, Olabe J, Lucas C, Levasseur A, Damon-Soubeyrand C, Pointud JC, Roucher-Boulez F, Tauveron I, Bossis G, Yeh ET, Breault DT, Val P, Lefran?ois-Martinez AM, Martinez A. Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice. Nat Commun. 2022 12 21; 13(1):7858.
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Brown CE, Rodriguez A, Palmer J, Ostberg JR, Naranjo A, Wagner JR, Aguilar B, Starr R, Weng L, Synold TW, Tran V, Wang S, Reik A, D'Apuzzo M, Ressler JA, Zhou Y, Mendel M, Gregory PD, Holmes MC, Tang WW, Forman SJ, Jensen MC, Badie B. Off-the-shelf, steroid-resistant, IL13Ra2-specific CAR T cells for treatment of glioblastoma. Neuro Oncol. 2022 08 01; 24(8):1318-1330.
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Henning P, Conaway HH, Lerner UH. Stimulation of osteoclast formation and bone resorption by glucocorticoids: Synergistic interactions with the calcium regulating hormones parathyroid hormone and 1,25(OH)2-vitamin D3. Vitam Horm. 2022; 120:231-270.
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Adams SH, Wright R, Piccolo BD, Moody B, Sikes J, Avaritt N, Chintapalli SV, Ou X. C-section increases cecal abundance of the archetypal bile acid and glucocorticoid modifying Lachnoclostridium [clostridium] scindens in mice. Physiol Rep. 2022 07; 10(13):e15363.
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Rutlen C, Blatt P, Kim T, Burnett J. A Worsening Rash. Am J Med. 2022 01; 135(1):e1-e3.
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Son MBF, Murray N, Friedman K, Young CC, Newhams MM, Feldstein LR, Loftis LL, Tarquinio KM, Singh AR, Heidemann SM, Soma VL, Riggs BJ, Fitzgerald JC, Kong M, Doymaz S, Giuliano JS, Keenaghan MA, Hume JR, Hobbs CV, Schuster JE, Clouser KN, Hall MW, Smith LS, Horwitz SM, Schwartz SP, Irby K, Bradford TT, Maddux AB, Babbitt CJ, Rowan CM, McLaughlin GE, Yager PH, Maamari M, Mack EH, Carroll CL, Montgomery VL, Halasa NB, Cvijanovich NZ, Coates BM, Rose CE, Newburger JW, Patel MM, Randolph AG. Multisystem Inflammatory Syndrome in Children - Initial Therapy and Outcomes. N Engl J Med. 2021 07 01; 385(1):23-34.
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Feldstein LR, Rose EB, Horwitz SM, Collins JP, Newhams MM, Son MBF, Newburger JW, Kleinman LC, Heidemann SM, Martin AA, Singh AR, Li S, Tarquinio KM, Jaggi P, Oster ME, Zackai SP, Gillen J, Ratner AJ, Walsh RF, Fitzgerald JC, Keenaghan MA, Alharash H, Doymaz S, Clouser KN, Giuliano JS, Gupta A, Parker RM, Maddux AB, Havalad V, Ramsingh S, Bukulmez H, Bradford TT, Smith LS, Tenforde MW, Carroll CL, Riggs BJ, Gertz SJ, Daube A, Lansell A, Coronado Munoz A, Hobbs CV, Marohn KL, Halasa NB, Patel MM, Randolph AG. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med. 2020 07 23; 383(4):334-346.
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Feldman AG, Parsons JA, Dutmer CM, Veerapandiyan A, Hafberg E, Maloney N, Mack CL. Subacute Liver Failure Following Gene Replacement Therapy for Spinal Muscular Atrophy Type 1. J Pediatr. 2020 10; 225:252-258.e1.
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Dare RK. Is fulminant myocarditis caused by circulating human coronaviruses? Eur Heart J. 2020 05 14; 41(19):1854.
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Jaros J, Hendricks AJ, Shi VY, Lio PA. A Practical Approach to Recalcitrant Face and Neck Dermatitis in Atopic Dermatitis. Dermatitis. 2020 May-Jun; 31(3):169-177.
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Pakbin M, Khabazkhoob M, Pakravan M, Fotouhi A, Jafarzadehpour E, Aghamirsalim M, Seyedian MA, Hashemi H. Duration of topical steroid application after photorefractive keratectomy with mitomycin C. J Cataract Refract Surg. 2020 04; 46(4):622-632.
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Taylor O, Mejia-Otero JD, Tannin GM, Gordon K. Topical triamcinolone induced Cushing syndrome: A case report. Pediatr Dermatol. 2020 May; 37(3):582-584.
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Kirkland KA, Uwaydat SH, Siddiqui MZ, Chancellor JR, Soliman MK, Kurup S, Sallam AB. Outcome of Intravitreal Dexamethasone Implant Use in Uveitic Eyes Undergoing Pars Plana Vitrectomy Surgery. Ocul Immunol Inflamm. 2021 Aug 18; 29(6):1126-1131.
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James KA, Gralla J, Ridall LA, Do TN, Czaja AS, Mourani PM, Ciafaloni E, Cunniff C, Donnelly J, Oleszek J, Pandya S, Price E, Yang ML, Auerbach SR. Left ventricular dysfunction in Duchenne muscular dystrophy. Cardiol Young. 2020 Feb; 30(2):171-176.
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Guess KE, Harada Y, Hill A, Ferry J, Veerapandiyan A. A Toddler With Bilateral Facial Weakness. Clin Pediatr (Phila). 2020 05; 59(4-5):529-531.
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Harada Y, Elkhider H, Masangkay N, Lotia M. Clinical Reasoning: A 65-year-old man with asymmetric weakness and paresthesias. Neurology. 2019 11 05; 93(19):856-861.
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Uwaydat SH, Wang H, Sallam AB. Intraoperative Injection of Intravitreal Dexamethasone Implant Using a Vitrectomy Trocar-Assisted Technique. Retina. 2019 Oct; 39 Suppl 1:S123-S124.
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Mousavian Z, Nowzari-Dalini A, Rahmatallah Y, Masoudi-Nejad A. Differential network analysis and protein-protein interaction study reveals active protein modules in glucocorticoid resistance for infant acute lymphoblastic leukemia. Mol Med. 2019 08 01; 25(1):36.
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Sato AY, Cregor M, McAndrews K, Li T, Condon KW, Plotkin LI, Bellido T. Glucocorticoid-Induced Bone Fragility Is Prevented in Female Mice by Blocking Pyk2/Anoikis Signaling. Endocrinology. 2019 07 01; 160(7):1659-1673.
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Thumma S, Idrees S, Phuyal P, Manchala V, Mattana J. When the Standard Treatment Fails: Rituximab Therapy for Refractory TTP. Am J Ther. 2019 Jul/Aug; 26(4):e552-e553.
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Arnall JR, Moore DC, Hill HL, Griffin S, Mueller MK, Lavery LA, Voorhees PM, Usmani SZ. Enhancing the feasibility of outpatient daratumumab administration via a split-dosing strategy with initial doses. Leuk Lymphoma. 2019 09; 60(9):2295-2298.
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Gebreselassie A, Aduli F, Howell CD. Rheumatologic Diseases and the Liver. Clin Liver Dis. 2019 05; 23(2):247-261.
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Evans MS, Culton DA, Diaz LA, Googe PB, Morrell DS. Childhood pemphigus foliaceus presenting as a polycyclic eruption: Case report and review of the literature. Pediatr Dermatol. 2019 Mar; 36(2):236-241.
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Beasley D, Goree JH. Cervical epidural hematoma following interlaminar epidural steroid injection via the contralateral oblique view in patient taking omega-3 fatty acids. Reg Anesth Pain Med. 2019 Feb; 44(2):253-255.
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Matulonis UA, Birrer MJ, O'Malley DM, Moore KN, Konner J, Gilbert L, Martin LP, Bauer TM, Oza AM, Malek K, Pinkas J, Kim SK. Evaluation of Prophylactic Corticosteroid Eye Drop Use in the Management of Corneal Abnormalities Induced by the Antibody-Drug Conjugate Mirvetuximab Soravtansine. Clin Cancer Res. 2019 03 15; 25(6):1727-1736.
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LePoidevin LM, Lee DE, Shi VY. A comparison of international management guidelines for atopic dermatitis. Pediatr Dermatol. 2019 Jan; 36(1):36-65.
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Maarouf M, Wickenheiser M, Krase JM, Wolter S, Shi VY. Trimethoprim-sulfamethoxazole-induced drug reaction with eosinophilia and systemic symptoms in a child with congenital renal disease. Pediatr Dermatol. 2018 Nov; 35(6):e391-e392.
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Pesek RD, Gupta SK. Emerging drugs for eosinophilic esophagitis. Expert Opin Emerg Drugs. 2018 06; 23(2):173-183.
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Sbeih F, Christov F, Gluth MB. Newly Diagnosed Meniere's Disease: Clinical Course With Initiation of Noninvasive Treatment Including an Accounting of Vestibular Migraine. Ann Otol Rhinol Laryngol. 2018 May; 127(5):331-337.
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Hardin JS, Ramakrishnaiah RH, Pemberton JD, Phillips PH, Chacko JG. Idiopathic Intracranial Hypertension Progressing to Venous Sinus Thrombosis, Subarachnoid Hemorrhage, and Stroke. J Neuroophthalmol. 2018 Mar; 38(1):60-64.
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Ali TK, Gibbons A, Cartes C, Zarei-Ghanavati S, Gomaa M, Gonzalez I, Gonzalez AE, Ozturk HE, Betancurt C, Perez VL. Use of Autologous Serum Tears for the Treatment of Ocular Surface Disease From Patients With Systemic Autoimmune Diseases. Am J Ophthalmol. 2018 05; 189:65-70.
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Weinstein RS, Hogan EA, Borrelli MJ, Liachenko S, O'Brien CA, Manolagas SC. The Pathophysiological Sequence of Glucocorticoid-Induced Osteonecrosis of the Femoral Head in Male Mice. Endocrinology. 2017 11 01; 158(11):3817-3831.
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van Zwol A, Oosterloo NBC, de Betue CT, Bogers A, de Liefde II, Deutz NEP, Joosten KFM. Effects of glucocorticoids on serum amino acid levels during cardiac surgery in children. Clin Nutr ESPEN. 2018 02; 23:212-216.
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Uwaydat SH, Sallam AB, Wang H, Goyal S. Retinal Indentation by a Dexamethasone Implant in a Gas-Filled Eye: Report of an Unusual Complication. JAMA Ophthalmol. 2017 10 01; 135(10):1125-1127.
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Wang H, Hardin J, Kaintatzis A, Uwaydat SH, Sallam AB. Inadvertent Expulsion of Fluocinolone Acetonide Intravitreal Implant during Pars Plana Vitrectomy. Ophthalmol Retina. 2018 01; 2(1):75-77.
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Geer EB, Ayala A, Bonert V, Carmichael JD, Gordon MB, Katznelson L, Manuylova E, Shafiq I, Surampudi V, Swerdloff RS, Broder MS, Cherepanov D, Eagan M, Lee J, Said Q, Neary MP, Biller BMK. Follow-up intervals in patients with Cushing's disease: recommendations from a panel of experienced pituitary clinicians. Pituitary. 2017 Aug; 20(4):422-429.
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Veerapandiyan A, Chaudhari A, Deo P, Ming X. Chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids (CLIPPERS): A pediatric case report with six year follow-up. Mult Scler Relat Disord. 2017 Oct; 17:95-98.
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Chatterjee K, Rochlani YM, Kuriakose K, Khasawneh K, Paydak H. Amiodarone Induced Interstitial and Organizing Pneumonia Reversed with Steroids. J Ark Med Soc. 2017 Jun; 113(12):294-296.
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Sato AY, Richardson D, Cregor M, Davis HM, Au ED, McAndrews K, Zimmers TA, Organ JM, Peacock M, Plotkin LI, Bellido T. Glucocorticoids Induce Bone and Muscle Atrophy by Tissue-Specific Mechanisms Upstream of E3 Ubiquitin Ligases. Endocrinology. 2017 03 01; 158(3):664-677.
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Pakravan M, Esfandiari H, Hassanpour K, Razavi S, Pakravan P. The Effect of Combined Systemic Erythropoietin and Steroid on Non-arteritic Anterior Ischemic Optic Neuropathy: A Prospective Study. Curr Eye Res. 2017 07; 42(7):1079-1084.
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Garcia-Saenz-de-Sicilia M, Duvoor C, Altamirano J, Chavez-Araujo R, Prado V, de Lourdes Candolo-Martinelli A, Holanda-Almeida P, Becerra-Martins-de-Oliveira B, Fernandez-de-Almeida S, Bataller R, Caballeria J, Duarte-Rojo A. A Day-4 Lille Model Predicts Response to Corticosteroids and Mortality in Severe Alcoholic Hepatitis. Am J Gastroenterol. 2017 02; 112(2):306-315.
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Huang JH, Park H, Iaconelli J, Berkovitch SS, Watmuff B, McPhie D, ?ng?r D, Cohen BM, Clish CB, Karmacharya R. Unbiased Metabolite Profiling of Schizophrenia Fibroblasts under Stressful Perturbations Reveals Dysregulation of Plasmalogens and Phosphatidylcholines. J Proteome Res. 2017 02 03; 16(2):481-493.
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Theodoropoulou S, Ellabban AA, Johnston RL, Cilliers H, Mohamed Q, Sallam AB. Short-term safety of dexamethasone implant for treatment of macular edema due to retinal vein occlusion, in eyes with glaucoma or treated ocular hypertension. Graefes Arch Clin Exp Ophthalmol. 2017 Apr; 255(4):725-732.
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Mousavian Z, Nowzari-Dalini A, Stam RW, Rahmatallah Y, Masoudi-Nejad A. Network-based expression analysis reveals key genes related to glucocorticoid resistance in infant acute lymphoblastic leukemia. Cell Oncol (Dordr). 2017 Feb; 40(1):33-45.
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Koyanagi S, Kusunose N, Taniguchi M, Akamine T, Kanado Y, Ozono Y, Masuda T, Kohro Y, Matsunaga N, Tsuda M, Salter MW, Inoue K, Ohdo S. Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia. Nat Commun. 2016 10 14; 7:13102.
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Conaway HH, Henning P, Lie A, Tuckermann J, Lerner UH. Activation of dimeric glucocorticoid receptors in osteoclast progenitors potentiates RANKL induced mature osteoclast bone resorbing activity. Bone. 2016 12; 93:43-54.
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Haram K, Mortensen JH, Magann EF, Morrison JC. Antenatal corticosteroid treatment: factors other than lung maturation. J Matern Fetal Neonatal Med. 2017 Jun; 30(12):1437-1441.
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Pakravan M, Sanjari N, Esfandiari H, Pakravan P, Yaseri M. The effect of high-dose steroids, and normobaric oxygen therapy, on recent onset non-arteritic anterior ischemic optic neuropathy: a randomized clinical trial. Graefes Arch Clin Exp Ophthalmol. 2016 Oct; 254(10):2043-2048.
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Soliman MK, Gauldin D, Uwaydat SH, Sallam AB. Projectile propagation of dexamethasone implant in air- and balanced salt solution-filled vitrectomized eyes. Acta Ophthalmol. 2017 Feb; 95(1):e79.
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Willis E, Ramakrishnaiah R, Archer R. Neuromyelitis Optica Spectrum Disorder in a Pediatric Patient. J Ark Med Soc. 2016 Aug; 113(2):34-35.
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Pakravan M, Esfandiari H, Sanjari N, Ghahari E. Erythropoietin as an adjunctive treatment for methanol-induced toxic optic neuropathy. Am J Drug Alcohol Abuse. 2016 11; 42(6):633-639.
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Piemontese M, Xiong J, Fujiwara Y, Thostenson JD, O'Brien CA. Cortical bone loss caused by glucocorticoid excess requires RANKL production by osteocytes and is associated with reduced OPG expression in mice. Am J Physiol Endocrinol Metab. 2016 09 01; 311(3):E587-93.
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Butto A, Nandi D, O'Connor MJ. Clinical Characteristics of Children With Eosinophilic Cardiac Disease. Circ Heart Fail. 2016 06; 9(6):e003172.
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Sato AY, Cregor M, Delgado-Calle J, Condon KW, Allen MR, Peacock M, Plotkin LI, Bellido T. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin. J Bone Miner Res. 2016 10; 31(10):1791-1802.
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Pinheiro BS, Lemos C, Neutzling Kaufmann F, Marques JM, da Silva-Santos CS, Carvalho E, Mackie K, Rodrigues RJ, Cunha RA, K?falvi A. Hierarchical glucocorticoid-endocannabinoid interplay regulates the activation of the nucleus accumbens by insulin. Brain Res Bull. 2016 06; 124:222-30.
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Gupta HV, Samant R, Gokden M, Lee RW, Sahaya K, Virmani T. Clinical Reasoning: A 73-year-old man with diplopia and ataxia. Neurology. 2015 Sep 29; 85(13):e96-100.
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Davies BW, Smith JM, Hink EM, Durairaj VD. C-Reactive Protein As a Marker for Initiating Steroid Treatment in Children With Orbital Cellulitis. Ophthalmic Plast Reconstr Surg. 2015 Sep-Oct; 31(5):364-8.
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Xie H, Li C, He Y, Griffin R, Ye Q, Li L. Chronic stress promotes oral cancer growth and angiogenesis with increased circulating catecholamine and glucocorticoid levels in a mouse model. Oral Oncol. 2015 Nov; 51(11):991-997.
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Piemontese M, Onal M, Xiong J, Wang Y, Almeida M, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone. Bone. 2015 Jun; 75:18-26.
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