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Melda Onal

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPhysiology & Biophysics, College of Medicine
DivisionPhysiology & Biophysics Faculty
Address200 South Cedar
Mail Slot # 505
Little Rock AR 72202
Phone501-320-7682
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    Collapse Research Funds 
    Collapse research activities
    R21AR076575     (ONAL, MELDA)Jan 1, 2020 - Dec 31, 2021
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases
    CRISPR inhibition as an alternate for Cre-loxP
    Role: Principal Investigator

    R01AR049794     (O'BRIEN, CHARLES A)Apr 1, 2003 - Mar 31, 2020
    NIH/NIAMS
    Osteocyte Control of Bone Remodeling
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Lee SM, Carlson AH, Onal M, Benkusky NA, Meyer MB, Pike JW. A Control Region Near the Fibroblast Growth Factor 23 Gene Mediates Response to Phosphate, 1,25(OH)2D3, and LPS In Vivo. Endocrinology. 2019 12 01; 160(12):2877-2891. PMID: 31599948.
      View in: PubMed
    2. MacLeod RS, Cawley KM, Gubrij I, Nookaew I, Onal M, O'Brien CA. Effective CRISPR interference of an endogenous gene via a single transgene in mice. Sci Rep. 2019 11 21; 9(1):17312. PMID: 31754144.
      View in: PubMed
    3. Onal M, Carlson AH, Thostenson JD, Benkusky NA, Meyer MB, Lee SM, Pike JW. A Novel Distal Enhancer Mediates Inflammation-, PTH-, and Early Onset Murine Kidney Disease-Induced Expression of the Mouse Fgf23 Gene. JBMR Plus. 2018 Jan; 2(1):32-47. PMID: 29527594.
      View in: PubMed
    4. Shamsuzzaman S, Onal M, St John HC, Pike JW. Deletion of a Distal RANKL Gene Enhancer Delays Progression of Atherosclerotic Plaque Calcification in Hypercholesterolemic Mice. J Cell Biochem. 2017 12; 118(12):4240-4253. PMID: 28419519.
      View in: PubMed
    5. Pike JW, Meyer MB, Lee SM, Onal M, Benkusky NA. The vitamin D receptor: contemporary genomic approaches reveal new basic and translational insights. J Clin Invest. 2017 Apr 03; 127(4):1146-1154. PMID: 28240603.
      View in: PubMed
    6. Shamsuzzaman S, Onal M, St John HC, Jeffery JJ, Pike JW. Absence of the Vitamin D Receptor Inhibits Atherosclerotic Plaque Calcification in Female Hypercholesterolemic Mice. J Cell Biochem. 2017 05; 118(5):1050-1064. PMID: 27567005.
      View in: PubMed
    7. Piemontese M, Onal M, Xiong J, Han L, Thostenson JD, Almeida M, O'Brien CA. Low bone mass and changes in the osteocyte network in mice lacking autophagy in the osteoblast lineage. Sci Rep. 2016 Apr 11; 6:24262. PMID: 27064143.
      View in: PubMed
    8. Onal M, St John HC, Danielson AL, Pike JW. Deletion of the Distal Tnfsf11 RL-D2 Enhancer That Contributes to PTH-Mediated RANKL Expression in Osteoblast Lineage Cells Results in a High Bone Mass Phenotype in Mice. J Bone Miner Res. 2016 Feb; 31(2):416-29. PMID: 26332516.
      View in: PubMed
    9. Xiong J, Piemontese M, Onal M, Campbell J, Goellner JJ, Dusevich V, Bonewald L, Manolagas SC, O'Brien CA. Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone. PLoS One. 2015; 10(9):e0138189. PMID: 26393791.
      View in: PubMed
    10. Meyer MB, Benkusky NA, Onal M, Pike JW. Selective regulation of Mmp13 by 1,25(OH)2D3, PTH, and Osterix through distal enhancers. J Steroid Biochem Mol Biol. 2016 11; 164:258-264. PMID: 26348136.
      View in: PubMed
    11. Onal M, Bishop KA, St John HC, Danielson AL, Riley EM, Piemontese M, Xiong J, Goellner JJ, O'Brien CA, Pike JW. A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse. J Bone Miner Res. 2015 May; 30(5):855-68. PMID: 25431114.
      View in: PubMed
    12. Piemontese M, Onal M, Xiong J, Wang Y, Almeida M, Thostenson JD, Weinstein RS, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes does not modify the adverse effects of glucocorticoids on cortical bone. Bone. 2015 Jun; 75:18-26. PMID: 25700544.
      View in: PubMed
    13. Onal M, Piemontese M, Xiong J, Wang Y, Han L, Ye S, Komatsu M, Selig M, Weinstein RS, Zhao H, Jilka RL, Almeida M, Manolagas SC, O'Brien CA. Suppression of autophagy in osteocytes mimics skeletal aging. J Biol Chem. 2013 Jun 14; 288(24):17432-40. PMID: 23645674.
      View in: PubMed
    14. Almeida M, Iyer S, Martin-Millan M, Bartell SM, Han L, Ambrogini E, Onal M, Xiong J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. Estrogen receptor-a signaling in osteoblast progenitors stimulates cortical bone accrual. J Clin Invest. 2013 Jan; 123(1):394-404. PMID: 23221342.
      View in: PubMed
    15. Onal M, Xiong J, Chen X, Thostenson JD, Almeida M, Manolagas SC, O'Brien CA. Receptor activator of nuclear factor ?B ligand (RANKL) protein expression by B lymphocytes contributes to ovariectomy-induced bone loss. J Biol Chem. 2012 Aug 24; 287(35):29851-60. PMID: 22782898.
      View in: PubMed
    16. Onal M, Galli C, Fu Q, Xiong J, Weinstein RS, Manolagas SC, O'Brien CA. The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice. Mol Endocrinol. 2012 Feb; 26(2):341-8. PMID: 22207718.
      View in: PubMed
    17. Xiong J, Onal M, Jilka RL, Weinstein RS, Manolagas SC, O'Brien CA. Matrix-embedded cells control osteoclast formation. Nat Med. 2011 Sep 11; 17(10):1235-41. PMID: 21909103.
      View in: PubMed
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