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Qiang Fu

TitleAssistant Research Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Endo
Address4301 W. Markham
Mail Slot # 587
Little Rock AR 72205
Phone501-686-6778
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    Collapse Research 
    Collapse research activities and funding
    R43AI138868     (FU, QIANG)Aug 14, 2018 - Jul 31, 2021
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: Innovation Pathways
    Evaluation of IPW-5371, a TGFRI kinase inhibitor, dosed as a single agent or in combination with G-CSF, as a medical countermeasure against the delayed effects of total body irradiation in mice
    Role: Principal Investigator
    W81XWH-15-C-0117     (HAUER-JENSEN, MARTIN)Oct 1, 2015 - Sep 20, 2021
    US Department of Defense - Pass Through: Armed Forces Radiobiology Research Institute
    Advanced Development of Gamma-Tocotrienol as a Radiation Countermeasure
    Role: Co-Investigator
    W81XWH-15-1-0489     (PAWAR, SNEHALATA)Sep 1, 2015 - Aug 31, 2019
    US Department of Defense
    Role of C/EBP delta in IR-induced sepsis
    Role: Co-Investigator
    R01AR049794     (OBRIEN, CHARLES)Apr 1, 2015 - Mar 31, 2021
    NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases
    Osteocyte Control of Bone Remodeling
    Role: Co-Investigator
    HU0001-09-1-0005     (HAUER-JENSEN, MARTIN)Jul 6, 2009 - Sep 30, 2011
    Uniformed Services University of the Health Sciences - Pass Through: Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
    Synergistic Radioprotection of Gastrointestinal Tract by Gamma-Tocotrienol (GT3) and Statins: Efficacy and Mechanisms
    Role: Co-Investigator
    HDTRA1-07-C-0028     (HAUER-JENSEN, MARTIN)Jan 26, 2007 - Jan 25, 2010
    Defense Threat Reduction Agency
    Radiation Prophylaxis by Gamma-Tocotrienol
    Role: Co-Investigator
    U19AI067798     (HAUER-JENSEN, MARTIN)Aug 31, 2005 - Jul 31, 2015
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: Duke University
    Somatostatin Analogues as Countermeasures Against Intestinal Radiation Toxicity
    Role: Co-Investigator
    U19AI67798     (HAUER-JENSEN, MARTIN)Aug 31, 2005 - Jul 31, 2010
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: Duke University
    Somatostatin analogues as countermeasures against intestinal radiation toxicity
    Role: Co-Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Akel N, MacLeod RS, Berryhill SB, Laster DJ, Dimori M, Crawford JA, Fu Q, Onal M. Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass. Sci Rep. 2022 02 24; 12(1):3134. PMID: 35210514.
      View in: PubMed
    2. Richardson KK, Ling W, Krager K, Fu Q, Byrum SD, Pathak R, Aykin-Burns N, Kim HN. Ionizing Radiation Activates Mitochondrial Function in Osteoclasts and Causes Bone Loss in Young Adult Male Mice. Int J Mol Sci. 2022 Jan 08; 23(2). PMID: 35054859.
      View in: PubMed
    3. Wang J, Garg S, Landes RD, Liu L, Fu Q, Seng J, Boerma M, Thrall K, Hauer-Jensen M, Pathak R. Differential Recovery of Small Intestinal Segments after Partial-Body Irradiation in Non-Human Primates. Radiat Res. 2021 08 01; 196(2):204-212. PMID: 34043805.
      View in: PubMed
    4. Liu X, Gao Z, Fu Q, Song L, Zhang P, Zhang X, Hendrickson H, Crooks PA, Zhou D, Zheng G. Deuteration of the farnesyl terminal methyl groups of d-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production. Bioorg Med Chem. 2020 06 01; 28(11):115498. PMID: 32291146.
      View in: PubMed
    5. Banerjee S, Fu Q, Shah SK, Melnyk SB, Sterneck E, Hauer-Jensen M, Pawar SA. C/EBPd protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress. Sci Rep. 2019 09 27; 9(1):13953. PMID: 31562350.
      View in: PubMed
    6. Deng L, Peng Y, Jiang Y, Wu Y, Ding Y, Wang Y, Xu D, Fu Q. Imipramine Protects against Bone Loss by Inhibition of Osteoblast-Derived Microvesicles. Int J Mol Sci. 2017 May 08; 18(5). PMID: 28481322.
      View in: PubMed
    7. Wu Y, Wang M, Peng Y, Ding Y, Deng L, Fu Q. Overexpression of Arl6ip5 in osteoblast regulates RANKL subcellualr localization. Biochem Biophys Res Commun. 2015 Sep 04; 464(4):1275-1281. PMID: 26220341.
      View in: PubMed
    8. Deng L, Wang Y, Peng Y, Wu Y, Ding Y, Jiang Y, Shen Z, Fu Q. Osteoblast-derived microvesicles: A novel mechanism for communication between osteoblasts and osteoclasts. Bone. 2015 Oct; 79:37-42. PMID: 26013558.
      View in: PubMed
    9. Deng L, Ding Y, Peng Y, Wu Y, Fan J, Li W, Yang R, Yang M, Fu Q. ?-Tocotrienol protects against ovariectomy-induced bone loss via mevalonate pathway as HMG-CoA reductase inhibitor. Bone. 2014 Oct; 67:200-7. PMID: 25019595.
      View in: PubMed
    10. Deng L, Peng Y, Wu Y, Yang M, Ding Y, Chen Q, Fu Q. Tissue distribution of emulsified ?-tocotrienol and its long-term biological effects after subcutaneous administration. Lipids Health Dis. 2014 Apr 09; 13:66. PMID: 24712339.
      View in: PubMed
    11. Peng Y, Deng L, Ding Y, Chen Q, Wu Y, Yang M, Wang Y, Fu Q. Comparative study of somatostatin-human serum albumin fusion proteins and natural somatostatin on receptor binding, internalization and activation. PLoS One. 2014; 9(2):e89932. PMID: 24587133.
      View in: PubMed
    12. Pathak R, Pawar SA, Fu Q, Gupta PK, Berbée M, Garg S, Sridharan V, Wang W, Biju PG, Krager KJ, Boerma M, Ghosh SP, Cheema AK, Hendrickson HP, Aykin-Burns N, Hauer-Jensen M. Characterization of transgenic Gfrp knock-in mice: implications for tetrahydrobiopterin in modulation of normal tissue radiation responses. Antioxid Redox Signal. 2014 Mar 20; 20(9):1436-46. PMID: 23521531.
      View in: PubMed
    13. Onal M, Galli C, Fu Q, Xiong J, Weinstein RS, Manolagas SC, O'Brien CA. The RANKL distal control region is required for the increase in RANKL expression, but not the bone loss, associated with hyperparathyroidism or lactation in adult mice. Mol Endocrinol. 2012 Feb; 26(2):341-8. PMID: 22207718.
      View in: PubMed
    14. Fu Q, Berbée M, Wang W, Boerma M, Wang J, Schmid HA, Hauer-Jensen M. Preclinical evaluation of Som230 as a radiation mitigator in a mouse model: postexposure time window and mechanisms of action. Radiat Res. 2011 Jun; 175(6):728-35. PMID: 21529145.
      View in: PubMed
    15. Berbée M, Fu Q, Boerma M, Sree Kumar K, Loose DS, Hauer-Jensen M. Mechanisms underlying the radioprotective properties of ?-tocotrienol: comparative gene expression profiling in tocol-treated endothelial cells. Genes Nutr. 2012 Jan; 7(1):75-81. PMID: 21516479.
      View in: PubMed
    16. Berbée M, Fu Q, Garg S, Kulkarni S, Kumar KS, Hauer-Jensen M. Pentoxifylline enhances the radioprotective properties of ?-tocotrienol: differential effects on the hematopoietic, gastrointestinal and vascular systems. Radiat Res. 2011 Mar; 175(3):297-306. PMID: 21388273.
      View in: PubMed
    17. Berbée M, Fu Q, Kumar KS, Hauer-Jensen M. Novel strategies to ameliorate radiation injury: a possible role for tetrahydrobiopterin. Curr Drug Targets. 2010 Nov; 11(11):1366-74. PMID: 20583982.
      View in: PubMed
    18. Berbee M, Fu Q, Boerma M, Pathak R, Zhou D, Kumar KS, Hauer-Jensen M. Reduction of radiation-induced vascular nitrosative stress by the vitamin E analog ?-tocotrienol: evidence of a role for tetrahydrobiopterin. Int J Radiat Oncol Biol Phys. 2011 Mar 01; 79(3):884-91. PMID: 20950957.
      View in: PubMed
    19. Cui L, Pierce D, Light KE, Melchert RB, Fu Q, Kumar KS, Hauer-Jensen M. Sublethal total body irradiation leads to early cerebellar damage and oxidative stress. Curr Neurovasc Res. 2010 May; 7(2):125-35. PMID: 20334614.
      View in: PubMed
    20. Garg S, Boerma M, Wang J, Fu Q, Loose DS, Kumar KS, Hauer-Jensen M. Influence of sublethal total-body irradiation on immune cell populations in the intestinal mucosa. Radiat Res. 2010 Apr; 173(4):469-78. PMID: 20334519.
      View in: PubMed
    21. Fu Q, Berbée M, Boerma M, Wang J, Schmid HA, Hauer-Jensen M. The somatostatin analog SOM230 (pasireotide) ameliorates injury of the intestinal mucosa and increases survival after total-body irradiation by inhibiting exocrine pancreatic secretion. Radiat Res. 2009 Jun; 171(6):698-707. PMID: 19580476.
      View in: PubMed
    22. Berbée M, Fu Q, Boerma M, Wang J, Kumar KS, Hauer-Jensen M. gamma-Tocotrienol ameliorates intestinal radiation injury and reduces vascular oxidative stress after total-body irradiation by an HMG-CoA reductase-dependent mechanism. Radiat Res. 2009 May; 171(5):596-605. PMID: 19580495.
      View in: PubMed
    23. Galli C, Fu Q, Wang W, Olsen BR, Manolagas SC, Jilka RL, O'Brien CA. Commitment to the osteoblast lineage is not required for RANKL gene expression. J Biol Chem. 2009 May 08; 284(19):12654-62. PMID: 19279010.
      View in: PubMed
    24. Boerma M, Fu Q, Wang J, Loose DS, Bartolozzi A, Ellis JL, McGonigle S, Paradise E, Sweetnam P, Fink LM, Vozenin-Brotons MC, Hauer-Jensen M. Comparative gene expression profiling in three primary human cell lines after treatment with a novel inhibitor of Rho kinase or atorvastatin. Blood Coagul Fibrinolysis. 2008 Oct; 19(7):709-18. PMID: 18832915.
      View in: PubMed
    25. Fu Q, Wang J, Boerma M, Berbée M, Qiu X, Fink LM, Hauer-Jensen M. Involvement of heat shock factor 1 in statin-induced transcriptional upregulation of endothelial thrombomodulin. Circ Res. 2008 Aug 15; 103(4):369-77. PMID: 18599869.
      View in: PubMed
    26. Galli C, Zella LA, Fretz JA, Fu Q, Pike JW, Weinstein RS, Manolagas SC, O'Brien CA. Targeted deletion of a distant transcriptional enhancer of the receptor activator of nuclear factor-kappaB ligand gene reduces bone remodeling and increases bone mass. Endocrinology. 2008 Jan; 149(1):146-53. PMID: 17932217.
      View in: PubMed
    27. Wang J, Boerma M, Fu Q, Kulkarni A, Fink LM, Hauer-Jensen M. Simvastatin ameliorates radiation enteropathy development after localized, fractionated irradiation by a protein C-independent mechanism. Int J Radiat Oncol Biol Phys. 2007 Aug 01; 68(5):1483-90. PMID: 17674978.
      View in: PubMed
    28. Wang J, Boerma M, Fu Q, Hauer-Jensen M. Significance of endothelial dysfunction in the pathogenesis of early and delayed radiation enteropathy. World J Gastroenterol. 2007 Jun 14; 13(22):3047-55. PMID: 17589919.
      View in: PubMed
    29. Hauer-Jensen M, Wang J, Boerma M, Fu Q, Denham JW. Radiation damage to the gastrointestinal tract: mechanisms, diagnosis, and management. Curr Opin Support Palliat Care. 2007 Apr; 1(1):23-9. PMID: 18660720.
      View in: PubMed
    30. Wang J, Boerma M, Fu Q, Hauer-Jensen M. Radiation responses in skin and connective tissues: effect on wound healing and surgical outcome. Hernia. 2006 Dec; 10(6):502-6. PMID: 17047884.
      View in: PubMed
    31. Fu Q, Manolagas SC, O'Brien CA. Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer. Mol Cell Biol. 2006 Sep; 26(17):6453-68. PMID: 16914731.
      View in: PubMed
    32. Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, O'Brien CA, Manolagas SC, Jilka RL. Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: a novel mechanism for hormonal control of osteoblastogenesis. Endocrinology. 2005 Nov; 146(11):4577-83. PMID: 16081646.
      View in: PubMed
    33. O'Brien CA, Jilka RL, Fu Q, Stewart S, Weinstein RS, Manolagas SC. IL-6 is not required for parathyroid hormone stimulation of RANKL expression, osteoclast formation, and bone loss in mice. Am J Physiol Endocrinol Metab. 2005 Nov; 289(5):E784-93. PMID: 15956054.
      View in: PubMed
    34. Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL. Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem. 2003 Dec 12; 278(50):50259-72. PMID: 14523023.
      View in: PubMed
    35. Kousteni S, Chen JR, Bellido T, Han L, Ali AA, O'Brien CA, Plotkin L, Fu Q, Mancino AT, Wen Y, Vertino AM, Powers CC, Stewart SA, Ebert R, Parfitt AM, Weinstein RS, Jilka RL, Manolagas SC. Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science. 2002 Oct 25; 298(5594):843-6. PMID: 12399595.
      View in: PubMed
    36. Fu Q, Jilka RL, Manolagas SC, O'Brien CA. Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein. J Biol Chem. 2002 Dec 13; 277(50):48868-75. PMID: 12364326.
      View in: PubMed
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