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James Forrest

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address506C Biomedical Research I
325 S. Elm St.
Mail Slot # 511
Little Rock AR 72205
Phone501-526-7141
ORCID ORCID Icon0000-0002-6695-0936 Additional info
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    Collapse Research 
    Collapse research activities and funding
    5R01AI181787-02     (FORREST, JAMES C)Jul 1, 2024 - May 31, 2029
    NIH/National Institutes of Health
    Defining KSHV LANA functions in viral pathogenesis and immune evasion
    Role: Principal Investigator
    5R01AI181787-03     (FORREST, JAMES C)Jul 1, 2024 - May 31, 2029
    NIH/National Institutes of Health
    Defining KSHV LANA functions in viral pathogenesis and immune evasion
    Role: Principal Investigator
    5R01AI181787-04     (FORREST, JAMES C)Jul 1, 2024 - May 31, 2029
    NIH/National Institutes of Health
    Defining KSHV LANA functions in viral pathogenesis and immune evasion
    Role: Principal Investigator
    5R01AI181787-05     (FORREST, JAMES C)Jul 1, 2024 - May 31, 2029
    NIH/National Institutes of Health
    Defining KSHV LANA functions in viral pathogenesis and immune evasion
    Role: Principal Investigator
    R01AI181787     (FORREST, JAMES CRAIG)Jul 1, 2024 - May 31, 2029
    NIH
    Defining KSHV LANA functions in viral pathogenesis and immune evasion
    Role: Principal Investigator
    R03DE031978     (DAI, LU)May 1, 2022 - Apr 30, 2025
    NIH/Nat. Inst. of Dental & Craniofacial Research
    Targeting ILlRAP in virus-associated malignancies
    Role: Co-Investigator
    R42NR017124     (ATCHERSON, SAMUEL R)Mar 1, 2022 - Aug 31, 2024
    NIH/Nat. Inst. of Nursing Research - Pass Through: FaceView Mask, LLC
    A Transparent Surgical Mask to Improve Patient/Caregiver Communication, Minimize Errors and Increase Patient Satisfaction
    Role: Co-Investigator
    U01CA260526     (NEMBHARD, WENDY N)Sep 30, 2020 - Feb 28, 2025
    NIH
    DISCOVAR:Disparities in Immune Response to SARS-CoV-2 in ARkansas
    Role: Co-Investigator
    R56AI150911     (FORREST, JAMES CRAIG)Sep 14, 2020 - Aug 31, 2021
    NIH
    Defining mechanisms of KSHV pathogenesis using MHV68-KSHV chimeric viruses
    Role: Principal Investigator
    GR039080     (QUANG, LAWRENCE)Aug 1, 2020 - Jul 31, 2021
    UAMS ACHRI Flow Through
    Quang ACRI GR039080 Epidemiologic and Clinical Features of COVID-19 in Pediatric Patients and Healthcare Workers in the Pediatric Emergency Department: A Prospective, Observational Analysis (COVID)
    Role: Co-Investigator
    R01CA228166     (POST, STEVEN R)May 1, 2019 - Apr 30, 2025
    NIH/Nat. Cancer Institute
    Periodontal bacteria enhance oral KSHV pathogenesis and Kaposi's Sarcoma development in HIV + patients - Continuation
    Role: Co-Principal Investigator
    R21AI139580     (FORREST, JAMES)Jan 15, 2019 - Dec 31, 2021
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Defining the efficacy of replication-dead viruses as gammaherpesvirus vaccines
    Role: Principal Investigator
    R21AI139797     (STUMHOFER, JASON S)Jun 12, 2018 - May 31, 2021
    NIH
    Understanding the contribution of atypical B cell progenitors to the humoral response
    Role: Co-Investigator
    COM MICER award     (FORREST, JAMES C)Feb 1, 2016 - Nov 30, 2017
    UAMS College of Medicine
    MICER
    Role: Principal Investigator
    117-1007010     (FORREST, JAMES C)Jul 1, 2015 - Jun 30, 2016
    UAMS College of Medicine
    No FP attached
    Role: Principal Investigator
    R01CA167065     (FORREST, JAMES CRAIG)Apr 4, 2014 - Feb 28, 2027
    NIH
    Defining mechanisms of gammaherpesvirus-driven genomic instability in B cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Hogan CH, Owens SM, Reynoso GV, Liao Y, Meyer TJ, Zelazowska MA, Liu B, Li X, Grosskopf AK, Khairallah C, Kirillov V, Reich NC, Sheridan BS, McBride KM, Gewurz BE, Hickman HD, Forrest JC, Krug LT. Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models. mBio. 2024 Feb 14; 15(2):e0299823. PMID: 38170993.
      View in: PubMed
    2. Owens SM, Sifford JM, Li G, Murdock SJ, Salinas E, Manzano M, Ghosh D, Stumhofer JS, Forrest JC. Intrinsic p53 Activation Restricts Gammaherpesvirus-Driven Germinal Center B Cell Expansion during Latency Establishment. bioRxiv. 2023 Nov 01. PMID: 37961505.
      View in: PubMed
    3. Bland WA, Owens S, McEvoy K, Hogan CH, Boccuzzi L, Kirillov V, Khairallah C, Sheridan BS, Forrest JC, Krug LT. Replication-dead gammaherpesvirus vaccine protects against acute replication, reactivation from latency, and lethal challenge in mice. bioRxiv. 2023 Sep 26. PMID: 37808844.
      View in: PubMed
    4. Smith KR, Paul S, Dong Q, Anannya O, Oldenburg DG, Forrest JC, McBride KM, Krug LT. Uracil-DNA glycosylase of murine gammaherpesvirus 68 binds cognate viral replication factors independently of its catalytic residues. mSphere. 2023 10 24; 8(5):e0027823. PMID: 37747202.
      View in: PubMed
    5. Karger AB, Brien JD, Christen JM, Dhakal S, Kemp TJ, Klein SL, Pinto LA, Premkumar L, Roback JD, Binder RA, Boehme KW, Boppana S, Cordon-Cardo C, Crawford JM, Daiss JL, Dupuis AP, Espino AM, Firpo-Betancourt A, Forconi C, Forrest JC, Girardin RC, Granger DA, Granger SW, Haddad NS, Heaney CD, Hunt DT, Kennedy JL, King CL, Krammer F, Kruczynski K, LaBaer J, Lee FE, Lee WT, Liu SL, Lozanski G, Lucas T, Mendu DR, Moormann AM, Murugan V, Okoye NC, Pantoja P, Payne AF, Park J, Pinninti S, Pinto AK, Pisanic N, Qiu J, Sariol CA, Simon V, Song L, Steffen TL, Stone ET, Styer LM, Suthar MS, Thomas SN, Thyagarajan B, Wajnberg A, Yates JL, Sobhani K. The Serological Sciences Network (SeroNet) for COVID-19: Depth and Breadth of Serology Assays and Plans for Assay Harmonization. mSphere. 2022 08 31; 7(4):e0019322. PMID: 35703544.
      View in: PubMed
    6. Gupta A, Owens SM, Oldenburg DG, White DW, Forrest JC. Lytic Replication and Reactivation from B Cells Is Not Required for Establishing or Maintaining Gammaherpesvirus Latency In Vivo. J Virol. 2022 06 22; 96(12):e0069022. PMID: 35647668.
      View in: PubMed
    7. Wilkins H, Jastaniah E, Spray B, Forrest JC, Boehme KW, Kirkpatrick C, Boyanton BL, Spiro DM, Crawley L, Quang L, Kennedy JL. Seroprevalence of SARS-CoV-2 antibodies in front-line pediatric health care workers. J Am Coll Emerg Physicians Open. 2022 Jun; 3(3):e12743. PMID: 35601650.
      View in: PubMed
    8. Cardenas VM, Kennedy JL, Williams M, Nembhard WN, Zohoori N, Du R, Jin J, Boothe D, Fischbach LA, Kirkpatrick C, Modi Z, Caid K, Owens S, Forrest JC, James L, Boehme KW, Olgaard E, Gardner SF, Amick BC. State-wide random seroprevalence survey of SARS-CoV-2 past infection in a southern US State, 2020. PLoS One. 2022; 17(4):e0267322. PMID: 35476717.
      View in: PubMed
    9. Dai L, Lu YC, Chen J, Plaisance-Bonstaff K, Mu S, Forrest JC, Whitby D, Post SR, Qin Z. Oral Shedding of an Oncogenic Virus Alters the Oral Microbiome in HIV+ Patients. Front Microbiol. 2022; 13:882520. PMID: 35516440.
      View in: PubMed
    10. Arthur JM, Forrest JC, Boehme KW, Kennedy JL, Owens S, Herzog C, Liu J, Harville TO. Development of ACE2 autoantibodies after SARS-CoV-2 infection. PLoS One. 2021; 16(9):e0257016. PMID: 34478478.
      View in: PubMed
    11. Owens SM, Oldenburg DG, White DW, Forrest JC. Deletion of Murine Gammaherpesvirus Gene M2 in Activation-Induced Cytidine Deaminase-Expressing B Cells Impairs Host Colonization and Viral Reactivation. J Virol. 2020 12 09; 95(1). PMID: 33028711.
      View in: PubMed
    12. Wongsurawat T, Gupta A, Jenjaroenpun P, Owens S, Forrest JC, Nookaew I. Author Correction: R-loop-forming Sequences Analysis in Thousands of Viral Genomes Identify A New Common Element in Herpesviruses. Sci Rep. 2020 Jul 17; 10(1):12173. PMID: 32678142.
      View in: PubMed
    13. Dai L, Jung BG, Chen J, Samten B, Forrest JC, Post SR, Qin Z. The potential impacts of early secreted antigenic target of 6?kDa of Mycobacterium tuberculosis on KSHV-infected cells. J Med Virol. 2021 06; 93(6):4028-4032. PMID: 32648938.
      View in: PubMed
    14. Wongsurawat T, Gupta A, Jenjaroenpun P, Owens S, Forrest JC, Nookaew I. R-loop-forming Sequences Analysis in Thousands of Viral Genomes Identify A New Common Element in Herpesviruses. Sci Rep. 2020 04 14; 10(1):6389. PMID: 32286400.
      View in: PubMed
    15. Chen J, Dai L, Goldstein A, Zhang H, Tang W, Forrest JC, Post SR, Chen X, Qin Z. Identification of new antiviral agents against Kaposi's sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation. PLoS Pathog. 2019 12; 15(12):e1008156. PMID: 31790497.
      View in: PubMed
    16. Chen J, Del Valle L, Lin HY, Plaisance-Bonstaff K, Forrest JC, Post SR, Qin Z. Expression of PD-1 and PD-Ls in Kaposi's sarcoma and regulation by oncogenic herpesvirus lytic reactivation. Virology. 2019 10; 536:16-19. PMID: 31394407.
      View in: PubMed
    17. Gao Y, Wang L, Lei Z, Li J, Forrest JC, Liang X. IRF4 promotes Epstein-Barr virus activation in Burkitt's lymphoma cells. J Gen Virol. 2019 05; 100(5):851-862. PMID: 30907723.
      View in: PubMed
    18. Knowlton JJ, Fern?ndez de Castro I, Ashbrook AW, Gestaut DR, Zamora PF, Bauer JA, Forrest JC, Frydman J, Risco C, Dermody TS. The TRiC chaperonin controls reovirus replication through outer-capsid folding. Nat Microbiol. 2018 04; 3(4):481-493. PMID: 29531365.
      View in: PubMed
    19. Salinas E, Gupta A, Sifford JM, Oldenburg DG, White DW, Forrest JC. Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection. PLoS Pathog. 2018 01; 14(1):e1006865. PMID: 29364981.
      View in: PubMed
    20. Gupta A, Oldenburg DG, Salinas E, White DW, Forrest JC. Murine Gammaherpesvirus 68 Expressing Kaposi Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen (LANA) Reveals both Functional Conservation and Divergence in LANA Homologs. J Virol. 2017 10 01; 91(19). PMID: 28747501.
      View in: PubMed
    21. Li G, Ward C, Yeasmin R, Skiena S, Krug LT, Forrest JC. A codon-shuffling method to prevent reversion during production of replication-defective herpesvirus stocks: Implications for herpesvirus vaccines. Sci Rep. 2017 03 13; 7:44404. PMID: 28287622.
      View in: PubMed
    22. Dong S, Forrest JC, Liang X. Murine Gammaherpesvirus 68: A Small Animal Model for Gammaherpesvirus-Associated Diseases. Adv Exp Med Biol. 2017; 1018:225-236. PMID: 29052141.
      View in: PubMed
    23. Sifford JM, Stahl JA, Salinas E, Forrest JC. Murine Gammaherpesvirus 68 LANA and SOX Homologs Counteract ATM-Driven p53 Activity during Lytic Viral Replication. J Virol. 2015 Dec 16; 90(5):2571-85. PMID: 26676792.
      View in: PubMed
    24. Salinas E, Byrum SD, Moreland LE, Mackintosh SG, Tackett AJ, Forrest JC. Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication. J Virol. 2016 02 01; 90(3):1397-413. PMID: 26581985.
      View in: PubMed
    25. Cieniewicz B, Dong Q, Li G, Forrest JC, Mounce BC, Tarakanova VL, van der Velden A, Krug LT. Murine Gammaherpesvirus 68 Pathogenesis Is Independent of Caspase-1 and Caspase-11 in Mice and Impairs Interleukin-1? Production upon Extrinsic Stimulation in Culture. J Virol. 2015 Jul; 89(13):6562-74. PMID: 25855746.
      View in: PubMed
    26. Cao J, Forrest JC, Zhang X. A screen of the NIH Clinical Collection small molecule library identifies potential anti-coronavirus drugs. Antiviral Res. 2015 Feb; 114:1-10. PMID: 25451075.
      View in: PubMed
    27. Coleman CB, McGraw JE, Feldman ER, Roth AN, Keyes LR, Grau KR, Cochran SL, Waldschmidt TJ, Liang C, Forrest JC, Tibbetts SA. A gammaherpesvirus Bcl-2 ortholog blocks B cell receptor-mediated apoptosis and promotes the survival of developing B cells in vivo. PLoS Pathog. 2014 Feb; 10(2):e1003916. PMID: 24516386.
      View in: PubMed
    28. Stahl JA, Chavan SS, Sifford JM, MacLeod V, Voth DE, Edmondson RD, Forrest JC. Phosphoproteomic analyses reveal signaling pathways that facilitate lytic gammaherpesvirus replication. PLoS Pathog. 2013 Sep; 9(9):e1003583. PMID: 24068923.
      View in: PubMed
    29. Stahl JA, Paden CR, Chavan SS, MacLeod V, Edmondson RD, Speck SH, Forrest JC. Amplification of JNK signaling is necessary to complete the murine gammaherpesvirus 68 lytic replication cycle. J Virol. 2012 Dec; 86(24):13253-62. PMID: 23015701.
      View in: PubMed
    30. Paden CR, Forrest JC, Tibbetts SA, Speck SH. Unbiased mutagenesis of MHV68 LANA reveals a DNA-binding domain required for LANA function in vitro and in vivo. PLoS Pathog. 2012 Sep; 8(9):e1002906. PMID: 22969427.
      View in: PubMed
    31. Cheng BY, Zhi J, Santana A, Khan S, Salinas E, Forrest JC, Zheng Y, Jaggi S, Leatherwood J, Krug LT. Tiled microarray identification of novel viral transcript structures and distinct transcriptional profiles during two modes of productive murine gammaherpesvirus 68 infection. J Virol. 2012 Apr; 86(8):4340-57. PMID: 22318145.
      View in: PubMed
    32. Paden CR, Forrest JC, Moorman NJ, Speck SH. Murine gammaherpesvirus 68 LANA is essential for virus reactivation from splenocytes but not long-term carriage of viral genome. J Virol. 2010 Jul; 84(14):7214-24. PMID: 20444892.
      View in: PubMed
    33. Gray KS, Forrest JC, Speck SH. The de novo methyltransferases DNMT3a and DNMT3b target the murine gammaherpesvirus immediate-early gene 50 promoter during establishment of latency. J Virol. 2010 May; 84(10):4946-59. PMID: 20200245.
      View in: PubMed
    34. Gargano LM, Forrest JC, Speck SH. Signaling through Toll-like receptors induces murine gammaherpesvirus 68 reactivation in vivo. J Virol. 2009 Feb; 83(3):1474-82. PMID: 19019960.
      View in: PubMed
    35. Gray KS, Allen RD, Farrell ML, Forrest JC, Speck SH. Alternatively initiated gene 50/RTA transcripts expressed during murine and human gammaherpesvirus reactivation from latency. J Virol. 2009 Jan; 83(1):314-28. PMID: 18971285.
      View in: PubMed
    36. Forrest JC, Speck SH. Establishment of B-cell lines latently infected with reactivation-competent murine gammaherpesvirus 68 provides evidence for viral alteration of a DNA damage-signaling cascade. J Virol. 2008 Aug; 82(15):7688-99. PMID: 18495760.
      View in: PubMed
    37. Forrest JC, Paden CR, Allen RD, Collins J, Speck SH. ORF73-null murine gammaherpesvirus 68 reveals roles for mLANA and p53 in virus replication. J Virol. 2007 Nov; 81(21):11957-71. PMID: 17699571.
      View in: PubMed
    38. Maginnis MS, Forrest JC, Kopecky-Bromberg SA, Dickeson SK, Santoro SA, Zutter MM, Nemerow GR, Bergelson JM, Dermody TS. Beta1 integrin mediates internalization of mammalian reovirus. J Virol. 2006 Mar; 80(6):2760-70. PMID: 16501085.
      View in: PubMed
    39. Danthi P, Hansberger MW, Campbell JA, Forrest JC, Dermody TS. JAM-A-independent, antibody-mediated uptake of reovirus into cells leads to apoptosis. J Virol. 2006 Feb; 80(3):1261-70. PMID: 16415003.
      View in: PubMed
    40. O'Donnell SM, Hansberger MW, Connolly JL, Chappell JD, Watson MJ, Pierce JM, Wetzel JD, Han W, Barton ES, Forrest JC, Valyi-Nagy T, Yull FE, Blackwell TS, Rottman JN, Sherry B, Dermody TS. Organ-specific roles for transcription factor NF-kappaB in reovirus-induced apoptosis and disease. J Clin Invest. 2005 Sep; 115(9):2341-50. PMID: 16100570.
      View in: PubMed
    41. Campbell JA, Schelling P, Wetzel JD, Johnson EM, Forrest JC, Wilson GA, Aurrand-Lions M, Imhof BA, Stehle T, Dermody TS. Junctional adhesion molecule a serves as a receptor for prototype and field-isolate strains of mammalian reovirus. J Virol. 2005 Jul; 79(13):7967-78. PMID: 15956543.
      View in: PubMed
    42. Forrest JC, Campbell JA, Schelling P, Stehle T, Dermody TS. Structure-function analysis of reovirus binding to junctional adhesion molecule 1. Implications for the mechanism of reovirus attachment. J Biol Chem. 2003 Nov 28; 278(48):48434-44. PMID: 12966102.
      View in: PubMed
    43. Forrest JC, Dermody TS. Reovirus receptors and pathogenesis. J Virol. 2003 Sep; 77(17):9109-15. PMID: 12915527.
      View in: PubMed
    44. Barton ES, Youree BE, Ebert DH, Forrest JC, Connolly JL, Valyi-Nagy T, Washington K, Wetzel JD, Dermody TS. Utilization of sialic acid as a coreceptor is required for reovirus-induced biliary disease. J Clin Invest. 2003 Jun; 111(12):1823-33. PMID: 12813018.
      View in: PubMed
    45. Prota AE, Campbell JA, Schelling P, Forrest JC, Watson MJ, Peters TR, Aurrand-Lions M, Imhof BA, Dermody TS, Stehle T. Crystal structure of human junctional adhesion molecule 1: implications for reovirus binding. Proc Natl Acad Sci U S A. 2003 Apr 29; 100(9):5366-71. PMID: 12697893.
      View in: PubMed
    46. Barton ES, Chappell JD, Connolly JL, Forrest JC, Dermody TS. Reovirus receptors and apoptosis. Virology. 2001 Nov 25; 290(2):173-80. PMID: 11883182.
      View in: PubMed
    47. Barton ES, Forrest JC, Connolly JL, Chappell JD, Liu Y, Schnell FJ, Nusrat A, Parkos CA, Dermody TS. Junction adhesion molecule is a receptor for reovirus. Cell. 2001 Feb 09; 104(3):441-51. PMID: 11239401.
      View in: PubMed
    48. Barton ES, Connolly JL, Forrest JC, Chappell JD, Dermody TS. Utilization of sialic acid as a coreceptor enhances reovirus attachment by multistep adhesion strengthening. J Biol Chem. 2001 Jan 19; 276(3):2200-11. PMID: 11054410.
      View in: PubMed
    49. Forrest JC, Krug LT, Speck SH. Murine Gammaherpesvirus 68 Infection of Mice -a Small Animal Model for Characterizing Basic Aspects of Gammaherpesvirus Pathogenesis in The DNA Tumor Viruses.
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