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Mark Manzano

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address325 S. Elm St.
Mail Slot # 511
Little Rock AR 72205
Phone501-214-2074
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    Collapse Research 
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    1R21CA285135     (NOOKAEW, INTAWAT)Aug 1, 2023 - Jul 31, 2025
    NIH/National Institutes of Health - Pass Through: NIH/Nat. Cancer Institute
    Role of a latent OriLyt RNA in KSHV latency in primary effusion lymphoma
    Role: Principal Investigator
    1R21CA285135-01     (NOOKAEW, INTAWAT)Aug 1, 2023 - Jul 31, 2025
    NIH/National Institutes of Health - Pass Through: NIH/Nat. Cancer Institute
    Role of a latent OriLyt RNA in KSHV latency in primary effusion lymphoma
    Role: Principal Investigator
    5R21CA285135     (NOOKAEW, INTAWAT)Aug 1, 2023 - Jul 31, 2025
    NIH/National Institutes of Health - Pass Through: NIH/Nat. Cancer Institute
    Role of a latent OriLyt RNA in KSHV latency in primary effusion lymphoma
    Role: Principal Investigator
    5R21CA285135-02     (NOOKAEW, INTAWAT)Aug 1, 2023 - Jul 31, 2025
    NIH/National Institutes of Health - Pass Through: NIH/Nat. Cancer Institute
    Role of a latent OriLyt RNA in KSHV latency in primary effusion lymphoma
    Role: Principal Investigator
    K22CA241355     (MANZANO, MARK)Sep 4, 2020 - Aug 31, 2023
    NIH/Nat. Cancer Institute
    Oncogenic Roles and Therapeutic Potential of MCL1 Addiction in Primary Effusion Lymphoma
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Dunham D, Viswanathan P, Gill J, Manzano M. Expression Ratios of the Antiapoptotic BCL2 Family Members Dictate the Selective Addiction of Kaposi's Sarcoma-Associated Herpesvirus-Transformed Primary Effusion Lymphoma Cell Lines to MCL1. J Virol. 2022 12 14; 96(23):e0136022. PMID: 36416587.
      View in: PubMed
    2. Morrison K, Manzano M, Chung K, Schipma MJ, Bartom ET, Gottwein E. The Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Encodes a Mimic of the Tumor-Suppressive miR-15/16 miRNA Family. Cell Rep. 2019 12 03; 29(10):2961-2969.e6. PMID: 31801064.
      View in: PubMed
    3. Patil A, Manzano M, Gottwein E. Genome-wide CRISPR screens reveal genetic mediators of cereblon modulator toxicity in primary effusion lymphoma. Blood Adv. 2019 07 23; 3(14):2105-2117. PMID: 31300418.
      View in: PubMed
    4. Manzano M, Patil A, Waldrop A, Dave SS, Behdad A, Gottwein E. Gene essentiality landscape and druggable oncogenic dependencies in herpesviral primary effusion lymphoma. Nat Commun. 2018 08 15; 9(1):3263. PMID: 30111820.
      View in: PubMed
    5. Patil A, Manzano M, Gottwein E. CK1a and IRF4 are essential and independent effectors of immunomodulatory drugs in primary effusion lymphoma. Blood. 2018 08 09; 132(6):577-586. PMID: 29954751.
      View in: PubMed
    6. Balasubramanian A, Manzano M, Teramoto T, Pilankatta R, Padmanabhan R. High-throughput screening for the identification of small-molecule inhibitors of the flaviviral protease. Antiviral Res. 2016 10; 134:6-16. PMID: 27539384.
      View in: PubMed
    7. Manzano M, Forte E, Raja AN, Schipma MJ, Gottwein E. Divergent target recognition by coexpressed 5'-isomiRs of miR-142-3p and selective viral mimicry. RNA. 2015 Sep; 21(9):1606-20. PMID: 26137849.
      View in: PubMed
    8. Forte E, Raja AN, Shamulailatpam P, Manzano M, Schipma MJ, Casey JL, Gottwein E. MicroRNA-mediated transformation by the Kaposi's sarcoma-associated herpesvirus Kaposin locus. J Virol. 2015 Feb; 89(4):2333-41. PMID: 25505059.
      View in: PubMed
    9. Grosswendt S, Filipchyk A, Manzano M, Klironomos F, Schilling M, Herzog M, Gottwein E, Rajewsky N. Unambiguous identification of miRNA:target site interactions by different types of ligation reactions. Mol Cell. 2014 Jun 19; 54(6):1042-1054. PMID: 24857550.
      View in: PubMed
    10. Zhang W, Nandakumar N, Shi Y, Manzano M, Smith A, Graham G, Gupta S, Vietsch EE, Laughlin SZ, Wadhwa M, Chetram M, Joshi M, Wang F, Kallakury B, Toretsky J, Wellstein A, Yi C. Downstream of mutant KRAS, the transcription regulator YAP is essential for neoplastic progression to pancreatic ductal adenocarcinoma. Sci Signal. 2014 May 06; 7(324):ra42. PMID: 24803537.
      View in: PubMed
    11. Boonyasuppayakorn S, Reichert ED, Manzano M, Nagarajan K, Padmanabhan R. Amodiaquine, an antimalarial drug, inhibits dengue virus type 2 replication and infectivity. Antiviral Res. 2014 Jun; 106:125-34. PMID: 24680954.
      View in: PubMed
    12. Manzano M, Padia J, Padmanabhan R. Small molecule inhibitor discovery for dengue virus protease using high-throughput screening. Methods Mol Biol. 2014; 1138:331-44. PMID: 24696346.
      View in: PubMed
    13. Manzano M, Padmanabhan R. Targeted mutagenesis of dengue virus type 2 replicon RNA by yeast in vivo recombination. Methods Mol Biol. 2014; 1138:151-60. PMID: 24696336.
      View in: PubMed
    14. Manzano M, Shamulailatpam P, Raja AN, Gottwein E. Kaposi's sarcoma-associated herpesvirus encodes a mimic of cellular miR-23. J Virol. 2013 Nov; 87(21):11821-30. PMID: 23986579.
      View in: PubMed
    15. Teramoto T, Chiang HS, Takhampunya R, Manzano M, Padmanabhan R, Maric M. Gamma interferon-inducible lysosomal thioreductase (GILT) ablation renders mouse fibroblasts sensitive to dengue virus replication. Virology. 2013 Jul 05; 441(2):146-51. PMID: 23642353.
      View in: PubMed
    16. Manzano M, Reichert ED, Polo S, Falgout B, Kasprzak W, Shapiro BA, Padmanabhan R. Identification of cis-acting elements in the 3'-untranslated region of the dengue virus type 2 RNA that modulate translation and replication. J Biol Chem. 2011 Jun 24; 286(25):22521-34. PMID: 21515677.
      View in: PubMed
    17. Alcaraz-Estrada SL, Manzano MI, Del Angel RM, Levis R, Padmanabhan R. Construction of a dengue virus type 4 reporter replicon and analysis of temperature-sensitive mutations in non-structural proteins 3 and 5. J Gen Virol. 2010 Nov; 91(Pt 11):2713-8. PMID: 20631089.
      View in: PubMed
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