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Mark Smeltzer

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address519-2 Biomedical Research II
200 South Cedar
Mail Slot # 511
Little Rock AR 72202
Phone501-686-7958
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentOrthopaedics, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPathology, College of Medicine


    Collapse Research 
    Collapse research activities and funding
    1P30GM145393     (CANNON, MARTIN)May 5, 2022 - Apr 30, 2027
    NIH/Nat. Inst. of General Medical Sciences
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Principal Investigator
    5P30GM145393     (CANNON, MARTIN)May 5, 2022 - Apr 30, 2027
    NIH/Nat. Inst. of General Medical Sciences
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Principal Investigator
    P30GM145393     (SMELTZER, MARK S)May 5, 2022 - Apr 30, 2027
    NIH/Nat. Inst. of General Medical Sciences
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Principal Investigator
    P30GM145393     (SMELTZER, MARK S)May 5, 2022 - Apr 30, 2027
    NIH
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Principal Investigator
    R01 AI119380-06A1     (SMELTZER, MARK S)Sep 23, 2021 - Aug 31, 2026
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Defining the role of post-translational regulation by extracellular proteases in the pathogenesis of Staphylococcus aureus osteomyelitis
    Role: Principal Investigator
    R01 AI119380-08     (SMELTZER, MARK S)Sep 23, 2021 - Aug 31, 2026
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Defining the role of post-translational regulation by extracellular proteases in the pathogenesis of Staphylococcus aureus osteomyelitis
    Role: Principal Investigator
    W81XWH1920014     (SMELTZER, MARK S)Oct 1, 2020 - Aug 14, 2024
    U.S. Army Medical Research & Materiel Command - Pass Through: University of Arkansas at Little Rock
    Advanced Development and Testing of a Nanomaterial-Based Scaffold for Bone Regeneration and Drug Delivery
    Role: Principal Investigator
    W81XWK1910742     (SMELTZER, MARK S)Sep 15, 2019 - Sep 14, 2022
    Congressionally Directed Medical Research Programs - Pass Through: University of Arkansas at Little Rock
    Advanced Development and Validation of a Nanomaterial-Based Scaffold for Bone Regeneration and Antimicrobial Drug Delivery
    Role: Principal Investigator
    S10 OD026736     (MACKINTOSH, SAMUEL)Aug 1, 2019 - Jul 31, 2020
    NIH/Office of the Director
    Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer
    Role: Co-Investigator
    S10OD026736     (MACKINTOSH, SAMUEL G.)Aug 1, 2019 - Jul 31, 2020
    NIH
    Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer
    Role: Co-Investigator
    R21AI146693     (HUANG, EN)Jul 1, 2019 - Jan 31, 2022
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Novel linear lipopeptide paenipeptins sensitize multidrug-resistant Gram-negative pathogens to antibiotics - Continuation Year 2020-2021
    Role: Co-Investigator
    1826642     (SMELTZER, MARK S)Dec 1, 2018 - Nov 30, 2022
    National Science Foundation - Pass Through: University of Arkansas at Fayetteville
    Understanding the Antimicrobial Mechanism of Metal Nanoparticles using Super Resolution Fluorescence Microscopy
    Role: Principal Investigator
    R21AI142056     (VOTH, DANIEL E)Nov 19, 2018 - Oct 31, 2021
    NIH
    A Novel Human Lung Infection Platform to Define Staphylococcus aureus Virulence Determinants
    Role: Co-Investigator
    R01AR066050     (SMELTZER, MARK)Jan 1, 2016 - Dec 31, 2020
    DHHS - Biomedical Advanced Research and Development Authority - Pass Through: University of Memphis
    Investigating a Flexible, Degradable Local Antimicrobial Delivery System
    Role: Principal Investigator
    R01 AR066050     (SMELTZER, MARK)Jan 1, 2016 - Dec 31, 2018
    DHHS - Biomedical Advanced Research and Development Authority - Pass Through: University of Memphis
    Investigating a Flexible, Degradable Local Antimicrobial Delivery System
    Role: Principal Investigator
    W81XWH-15-1-0716     (SMELTZER, MARK)Sep 30, 2015 - Sep 30, 2019
    US Department of Defense
    Enhancing the prevention and treatment of orthopaedic infections associated with traumatic injury
    Role: Principal Investigator
    117     (CHILDS, GWEN V)Jul 1, 2015 - Jun 30, 2016
    UAMS College of Medicine
    No FP attached
    Role: Principal Investigator
    117-1002473     (SMELTZER, MARK S)Jul 1, 2015 - Jun 30, 2016
    UAMS College of Medicine
    Smeltzer Start Up Account
    Role: Principal Investigator
    R01AI119380     (SMELTZER, MARK S)Jun 15, 2015 - Aug 31, 2026
    NIH
    Defining the role of post-translational regulation by extracellular proteases in the pathogenesis of Staphylococcus aureus osteomyelitis
    Role: Principal Investigator
    S     (SMELTZER, MARK S)Apr 1, 2014 - Jun 30, 2014
    Biomet Manufacturing, LLC - Pass Through: University of Memphis
    INfection Prevention Through Implant Coating
    Role: Principal Investigator
    S-2555     (SMELTZER, MARK)Apr 1, 2014 - Jun 30, 2014
    Biomet Manufacturing, LLC - Pass Through: University of Memphis
    INfection Prevention Through Implant Coating
    Role: Principal Investigator
    W81XWH-12-2-002     (SMELTZER, MARK)Mar 1, 2014 - Mar 31, 2016
    US Department of Defense - Pass Through: University of Memphis
    Antibiotic-Loaded Biopolymer Sponge for Prevention of Polymicrobial Wound Infection
    Role: Principal Investigator
    R15AI099922     (SMELTZER, MARK S)Jan 1, 2013 - Dec 31, 2015
    NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: University of Southern Mississippi
    Biofilm Dissemination in Staphylococcus aureus
    Role: Principal Investigator
    P20GM103625     (SMELTZER, MARK S)Aug 15, 2012 - Apr 30, 2022
    NIH
    Center for Microbial Pathogenesis and Host Inflammatory Responses
    Role: Principal Investigator
    W81XWH-12-2-0020     (SMELTZER, MARK)Apr 1, 2012 - Feb 28, 2014
    US Department of Defense - Pass Through: University of Memphis
    Antibiotic-Loaded Biopolymer Sponge for Prevention of Polymicrobial Wound Infection
    Role: Principal Investigator
    W81XWH-10-1-0812     (SMELTZER, MARK S)Sep 15, 2011 - Aug 31, 2012
    US Department of Defense
    Controlled Delivery of Cis-2-decenoic Acid for the Prevention of Infection by Bacterial Biofilms
    Role: Principal Investigator
    R56AI093126     (SMELTZER, MARK S)Sep 1, 2011 - Aug 31, 2014
    NIH
    A nanotherapeutic approach to combat staphylococcal biofilm-associated infection
    Role: Principal Investigator
    W81XWH-10-1-0991     (SMELTZER, MARK)Sep 30, 2010 - Nov 29, 2014
    US Department of the Army
    sarA as a Target for the Treatment and Prevention of Staphylococcal Biofilm-Associated Infection
    Role: Principal Investigator
    W81XWH-08-1-0312     (SMELTZER, MARK S)Aug 3, 2009 - Nov 30, 2010
    US Department of the Army
    Chitosan films for prevention of wound infections
    Role: Principal Investigator
    R01AI067857     (LEE, CHIA Y.)Jul 5, 2007 - Jun 30, 2014
    NIH
    Regulation of Staphylococcus aureus biofilm by Rbf
    Role: Co-Investigator
    R56AI074935     (SMELTZER, MARK S)Jul 1, 2007 - Jul 31, 2015
    NIH
    Regulation of biofilm formation in clinical isolates of Staphylococcus aureus
    Role: Principal Investigator
    R01AI074935     (SMELTZER, MARK S)Jul 1, 2007 - Jun 30, 2013
    NIH
    Regulation of biofilm formation in clinical isolates of Staphylococcus aureus
    Role: Principal Investigator
    R01AI069087     (SMELTZER, MARK S)Feb 1, 2007 - Jul 31, 2013
    NIH
    Detection, diagnosis and treatment of musculoskeletal infection
    Role: Principal Investigator
    SOW2     (SMELTZER, MARK S)Jan 4, 2007 - Feb 28, 2008
    Cubist Pharmaceuticals, Inc.
    Daptomycin as an antimicrobial agent in the treatment of staphyloccal biofilm-associated infection
    Role: Principal Investigator
    59     (SMELTZER, MARK S)Jul 1, 2001 - Jun 30, 2004
    US Department of Agriculture
    Genetic Manipulation of sarA Mutants
    Role: Principal Investigator
    59-6435-2-0015-01     (SMELTZER, MARK)Jul 1, 2001 - Jun 30, 2004
    US Department of Agriculture
    Genetic Manipulation of sarA Mutants
    Role: Principal Investigator
    0120556Z     (SMELTZER, MARK)Jul 1, 2001 - Jun 30, 2002
    American Heart Association
    Identification of Novel Regulatory Elements Contributing to Virulence in Staphylococcal Endocarditis
    Role: Principal Investigator
    R01AI043356     (SMELTZER, MARK S)Jul 1, 1998 - Nov 30, 2009
    NIH
    sar-mediated regulation in Staphylococcus aureus
    Role: Principal Investigator
    R29AI037729     (SMELTZER, MARK S)Jul 1, 1996 - Jun 30, 2002
    NIH
    ADHESINS AND STAPHYLOCOCCAL OSTEOMYELITIS
    Role: Principal Investigator
    R01AI037027     (LEE, CHIA Y.)Dec 1, 1994 - Nov 30, 2014
    NIH
    Capsule regulatory network in S. aureus pathogenesis
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Campbell MJ, Beenken KE, Ramirez AM, Smeltzer MS. Increased production of aureolysin and staphopain A is a primary determinant of the reduced virulence of Staphylococcus aureus sarA mutants in osteomyelitis. mBio. 2024 Feb 28; e0338323. PMID: 38415646.
      View in: PubMed
    2. Campbell MJ, Beenken KE, Spencer HJ, Jayana B, Hester H, Sahukhal GS, Elasri MO, Smeltzer MS. Comparative evaluation of small molecules reported to be inhibitors of Staphylococcus aureus biofilm formation. Microbiol Spectr. 2024 Jan 11; 12(1):e0314723. PMID: 38059629.
      View in: PubMed
    3. Campbell MJ, Beenken KE, Ramirez AM, Smeltzer MS. The major role of sarA in limiting Staphylococcus aureus extracellular protease production in vitro is correlated with decreased virulence in diverse clinical isolates in osteomyelitis. Virulence. 2023 12; 14(1):2175496. PMID: 36748843.
      View in: PubMed
    4. Soltani-Kordshuli F, Choudhury D, Goss JA, Campbell M, Smith E, Sonntag S, Niyonshuti II, Okyere D, Smeltzer MS, Chen J, Zou M. Cartilage-inspired surface textures for improved tribological performance of orthopedic implants. J Mech Behav Biomed Mater. 2023 02; 138:105572. PMID: 36435033.
      View in: PubMed
    5. Yang F, Bettadapura SN, Smeltzer MS, Zhu H, Wang S. Pyroptosis and pyroptosis-inducing cancer drugs. Acta Pharmacol Sin. 2022 Oct; 43(10):2462-2473. PMID: 35288674.
      View in: PubMed
    6. Rom JS, Beenken KE, Ramirez AM, Walker CM, Echols EJ, Smeltzer MS. Limiting protease production plays a key role in the pathogenesis of the divergent clinical isolates of Staphylococcus aureus LAC and UAMS-1. Virulence. 2021 12; 12(1):584-600. PMID: 33538230.
      View in: PubMed
    7. Alkam D, Wongsurawat T, Nookaew I, Richardson AR, Ussery D, Smeltzer MS, Jenjaroenpun P. Is amplification bias consequential in transposon sequencing (TnSeq) assays? A case study with a Staphylococcus aureus TnSeq library subjected to PCR-based and amplification-free enrichment methods. Microb Genom. 2021 10; 7(10). PMID: 34596508.
      View in: PubMed
    8. Beenken KE, Campbell MJ, Ramirez AM, Alghazali K, Walker CM, Jackson B, Griffin C, King W, Bourdo SE, Rifkin R, Hecht S, Meeker DG, Anderson DE, Biris AS, Smeltzer MS. Evaluation of a bone filler scaffold for local antibiotic delivery to prevent Staphylococcus aureus infection in a contaminated bone defect. Sci Rep. 2021 05 13; 11(1):10254. PMID: 33986462.
      View in: PubMed
    9. Alkam D, Jenjaroenpun P, Ramirez AM, Beenken KE, Spencer HJ, Smeltzer MS. The Increased Accumulation of Staphylococcus aureus Virulence Factors Is Maximized in a purR Mutant by the Increased Production of SarA and Decreased Production of Extracellular Proteases. Infect Immun. 2021 03 17; 89(4). PMID: 33468580.
      View in: PubMed
    10. Albayati ZAF, Penthala NR, Bommagani S, Post GR, Smeltzer MS, Crooks PA. Evaluation of bone and kidney toxicity of BT2-peg2, a potential carrier for the targeted delivery of antibiotics to bone. Toxicol Rep. 2021; 8:359-364. PMID: 33665133.
      View in: PubMed
    11. Harrison ZL, Pace LR, Brown MN, Beenken KE, Smeltzer MS, Bumgardner JD, Haggard WO, Amber Jennings J. Staphylococcal infection prevention using antibiotic-loaded mannitol-chitosan paste in a?rabbit model of implant-associated osteomyelitis. J Orthop Res. 2021 11; 39(11):2455-2464. PMID: 33470467.
      View in: PubMed
    12. Ramirez AM, Beenken KE, Byrum SD, Tackett AJ, Shaw LN, Gimza BD, Smeltzer MS. SarA plays a predominant role in controlling the production of extracellular proteases in the diverse clinical isolates of Staphylococcus aureus LAC and UAMS-1. Virulence. 2020 12; 11(1):1738-1762. PMID: 33258416.
      View in: PubMed
    13. Rom JS, Ramirez AM, Beenken KE, Sahukhal GS, Elasri MO, Smeltzer MS. The Impacts of msaABCR on sarA-Associated Phenotypes Are Different in Divergent Clinical Isolates of Staphylococcus aureus. Infect Immun. 2020 01 22; 88(2). PMID: 31740526.
      View in: PubMed
    14. Harrington WN, Nolan J, Nedosekin DA, Smeltzer MS, Zharov VP. Real-Time Monitoring of Bacteria Clearance From Blood in a Murine Model. Cytometry A. 2020 07; 97(7):706-712. PMID: 31769208.
      View in: PubMed
    15. Ramirez AM, Byrum SD, Beenken KE, Washam C, Edmondson RD, Mackintosh SG, Spencer HJ, Tackett AJ, Smeltzer MS. Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis. ACS Infect Dis. 2020 02 14; 6(2):237-249. PMID: 31722523.
      View in: PubMed
    16. Greene E, Flees J, Dhamad A, Alrubaye A, Hennigan S, Pleimann J, Smeltzer M, Murray S, Kugel J, Goodrich J, Robertson A, Wideman R, Rhoads D, Dridi S. Double-Stranded RNA Is a Novel Molecular Target in Osteomyelitis Pathogenesis: A Translational Avian Model for Human Bacterial Chondronecrosis with Osteomyelitis. Am J Pathol. 2019 10; 189(10):2077-2089. PMID: 31381888.
      View in: PubMed
    17. Brann KR, Fullerton MS, Onyilagha FI, Prince AA, Kurten RC, Rom JS, Blevins JS, Smeltzer MS, Voth DE. Infection of Primary Human Alveolar Macrophages Alters Staphylococcus aureus Toxin Production and Activity. Infect Immun. 2019 07; 87(7). PMID: 31010814.
      View in: PubMed
    18. Blom A, Cho J, Fleischman A, Goswami K, Ketonis C, Kunutsor SK, Makar G, Meeker DG, Morgan-Jones R, Ortega-Pe?a S, Parvizi J, Smeltzer M, Stambough JB, Urish K, Ziliotto G. Erratum to 'General Assembly, Prevention, Antiseptic Irrigation Solution: Proceedings of International Consensus on Orthopedic Infections' [The Journal of Arthroplasty 34 (2019) S131-S138]. J Arthroplasty. 2019 Jun; 34(6):1299. PMID: 30930156.
      View in: PubMed
    19. Meeker DG, Cooper KB, Renard RL, Mears SC, Smeltzer MS, Barnes CL. Comparative Study of Antibiotic Elution Profiles From Alternative Formulations of Polymethylmethacrylate Bone Cement. J Arthroplasty. 2019 07; 34(7):1458-1461. PMID: 30935799.
      View in: PubMed
    20. Saeed K, McLaren AC, Schwarz EM, Antoci V, Arnold WV, Chen AF, Clauss M, Esteban J, Gant V, Hendershot E, Hickok N, Higuera CA, Cora?a-Huber DC, Choe H, Jennings JA, Joshi M, Li WT, Noble PC, Phillips KS, Pottinger PS, Restrepo C, Rohde H, Schaer TP, Shen H, Smeltzer M, Stoodley P, Webb JCJ, Wits? E. 2018 international consensus meeting on musculoskeletal infection: Summary from the biofilm workgroup and consensus on biofilm related musculoskeletal infections. J Orthop Res. 2019 05; 37(5):1007-1017. PMID: 30667567.
      View in: PubMed
    21. Blom A, Cho J, Fleischman A, Goswami K, Ketonis C, Kunutsor SK, Makar G, Meeker DG, Morgan-Jones R, Ortega-Pe?a S, Parvizi J, Smeltzer M, Stambough JB, Urish K, Ziliotto G. General Assembly, Prevention, Antiseptic Irrigation Solution: Proceedings of International Consensus on Orthopedic Infections. J Arthroplasty. 2019 02; 34(2S):S131-S138. PMID: 30348567.
      View in: PubMed
    22. Byrum SD, Loughran AJ, Beenken KE, Orr LM, Storey AJ, Mackintosh SG, Edmondson RD, Tackett AJ, Smeltzer MS. Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome. J Proteome Res. 2018 10 05; 17(10):3384-3395. PMID: 30209945.
      View in: PubMed
    23. Chopra R, Levi-Polyachenko N, Smeltzer MS. Introduction to the special issue on thermal therapy and infectious diseases. Int J Hyperthermia. 2018 03; 34(2):133-134. PMID: 29498313.
      View in: PubMed
    24. Boles LR, Awais R, Beenken KE, Smeltzer MS, Haggard WO, Jessica AJ. Local Delivery of Amikacin and Vancomycin from Chitosan Sponges Prevent Polymicrobial Implant-Associated Biofilm. Mil Med. 2018 03 01; 183(suppl_1):459-465. PMID: 29635622.
      View in: PubMed
    25. Wells CM, Beenken KE, Smeltzer MS, Courtney HS, Jennings JA, Haggard WO. Ciprofloxacin and Rifampin Dual Antibiotic-Loaded Biopolymer Chitosan Sponge for Bacterial Inhibition. Mil Med. 2018 03 01; 183(suppl_1):433-444. PMID: 29635619.
      View in: PubMed
    26. Meeker DG, Wang T, Harrington WN, Zharov VP, Johnson SA, Jenkins SV, Oyibo SE, Walker CM, Mills WB, Shirtliff ME, Beenken KE, Chen J, Smeltzer MS. Versatility of targeted antibiotic-loaded gold nanoconstructs for the treatment of biofilm-associated bacterial infections. Int J Hyperthermia. 2018 03; 34(2):209-219. PMID: 29025325.
      View in: PubMed
    27. Moon SH, Zhang X, Zheng G, Meeker DG, Smeltzer MS, Huang E. Novel Linear Lipopeptide Paenipeptins with Potential for Eradicating Biofilms and Sensitizing Gram-Negative Bacteria to Rifampicin and Clarithromycin. J Med Chem. 2017 12 14; 60(23):9630-9640. PMID: 29136469.
      View in: PubMed
    28. Rom JS, Atwood DN, Beenken KE, Meeker DG, Loughran AJ, Spencer HJ, Lantz TL, Smeltzer MS. Impact of Staphylococcus aureus regulatory mutations that modulate biofilm formation in the USA300 strain LAC on virulence in a murine bacteremia model. Virulence. 2017 11 17; 8(8):1776-1790. PMID: 28910576.
      View in: PubMed
    29. Harris MA, Beenken KE, Smeltzer MS, Haggard WO, Jennings JA. Phosphatidylcholine Coatings Deliver Local Antimicrobials and Reduce Infection in a Murine Model: A Preliminary Study. Clin Orthop Relat Res. 2017 Jul; 475(7):1847-1853. PMID: 28050817.
      View in: PubMed
    30. Berretta JM, Jennings JA, Courtney HS, Beenken KE, Smeltzer MS, Haggard WO. Blended Chitosan Paste for Infection Prevention: Preliminary and Preclinical Evaluations. Clin Orthop Relat Res. 2017 Jul; 475(7):1857-1870. PMID: 28097503.
      View in: PubMed
    31. Rhodes CS, Alexander CM, Berretta JM, Courtney HS, Beenken KE, Smeltzer MS, Bumgardner JD, Haggard WO, Jennings JA. Evaluation of a chitosan-polyethylene glycol paste as a local antibiotic delivery device. World J Orthop. 2017 Feb 18; 8(2):130-141. PMID: 28251063.
      View in: PubMed
    32. Meeker DG, Beenken KE, Mills WB, Loughran AJ, Spencer HJ, Lynn WB, Smeltzer MS. Evaluation of Antibiotics Active against Methicillin-Resistant Staphylococcus aureus Based on Activity in an Established Biofilm. Antimicrob Agents Chemother. 2016 10; 60(10):5688-94. PMID: 27401574.
      View in: PubMed
    33. Loughran AJ, Gaddy D, Beenken KE, Meeker DG, Morello R, Zhao H, Byrum SD, Tackett AJ, Cassat JE, Smeltzer MS. Impact of sarA and Phenol-Soluble Modulins on the Pathogenesis of Osteomyelitis in Diverse Clinical Isolates of Staphylococcus aureus. Infect Immun. 2016 09; 84(9):2586-94. PMID: 27354444.
      View in: PubMed
    34. Jennings JA, Beenken KE, Skinner RA, Meeker DG, Smeltzer MS, Haggard WO, Troxel KS. Antibiotic-loaded phosphatidylcholine inhibits staphylococcal bone infection. World J Orthop. 2016 Aug 18; 7(8):467-74. PMID: 27622146.
      View in: PubMed
    35. Meeker DG, Chen J, Smeltzer MS. Could targeted, antibiotic-loaded gold nanoconstructs be a new magic bullet to fight infection? Nanomedicine (Lond). 2016 09; 11(18):2379-82. PMID: 27529572.
      View in: PubMed
    36. Smeltzer MS. Staphylococcus aureus Pathogenesis: The Importance of Reduced Cytotoxicity. Trends Microbiol. 2016 09; 24(9):681-682. PMID: 27450110.
      View in: PubMed
    37. Ord??ez PE, Quave CL, Reynolds WF, Varughese KI, Berry B, Breen PJ, Malag?n O, Vidari G, Smeltzer MS, Compadre CM. Corrigendum to "Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity" [J. Ethnopharmacol. 137 (2011) 1055-1059]. J Ethnopharmacol. 2016 06 20; 186:392. PMID: 27165010.
      View in: PubMed
    38. Atwood DN, Beenken KE, Loughran AJ, Meeker DG, Lantz TL, Graham JW, Spencer HJ, Smeltzer MS. XerC Contributes to Diverse Forms of Staphylococcus aureus Infection via agr-Dependent and agr-Independent Pathways. Infect Immun. 2016 Apr; 84(4):1214-1225. PMID: 26857575.
      View in: PubMed
    39. Meeker DG, Jenkins SV, Miller EK, Beenken KE, Loughran AJ, Powless A, Muldoon TJ, Galanzha EI, Zharov VP, Smeltzer MS, Chen J. Synergistic Photothermal and Antibiotic Killing of Biofilm-Associated Staphylococcus aureus Using Targeted Antibiotic-Loaded Gold Nanoconstructs. ACS Infect Dis. 2016 Apr 08; 2(4):241-250. PMID: 27441208.
      View in: PubMed
    40. Jennings JA, Beenken KE, Parker AC, Smith JK, Courtney HS, Smeltzer MS, Haggard WO. Polymicrobial Biofilm Inhibition Effects of Acetate-Buffered Chitosan Sponge Delivery Device. Macromol Biosci. 2016 Apr; 16(4):591-8. PMID: 26756211.
      View in: PubMed
    41. Atwood DN, Beenken KE, Lantz TL, Meeker DG, Lynn WB, Mills WB, Spencer HJ, Smeltzer MS. Regulatory Mutations Impacting Antibiotic Susceptibility in an Established Staphylococcus aureus Biofilm. Antimicrob Agents Chemother. 2016 Jan 11; 60(3):1826-9. PMID: 26824954.
      View in: PubMed
    42. Albayati ZA, Sunkara M, Schmidt-Malan SM, Karau MJ, Morris AJ, Steckelberg JM, Patel R, Breen PJ, Smeltzer MS, Taylor KG, Merten KE, Pierce WM, Crooks PA. Novel Bone-Targeting Agent for Enhanced Delivery of Vancomycin to Bone. Antimicrob Agents Chemother. 2015 Dec 14; 60(3):1865-8. PMID: 26666918.
      View in: PubMed
    43. Jennings JA, Carpenter DP, Troxel KS, Beenken KE, Smeltzer MS, Courtney HS, Haggard WO. Novel Antibiotic-loaded Point-of-care Implant Coating Inhibits Biofilm. Clin Orthop Relat Res. 2015 Jul; 473(7):2270-82. PMID: 25604874.
      View in: PubMed
    44. Cue D, Junecko JM, Lei MG, Blevins JS, Smeltzer MS, Lee CY. SaeRS-dependent inhibition of biofilm formation in Staphylococcus aureus Newman. PLoS One. 2015; 10(4):e0123027. PMID: 25853849.
      View in: PubMed
    45. Atwood DN, Loughran AJ, Courtney AP, Anthony AC, Meeker DG, Spencer HJ, Gupta RK, Lee CY, Beenken KE, Smeltzer MS. Comparative impact of diverse regulatory loci on Staphylococcus aureus biofilm formation. Microbiologyopen. 2015 Jun; 4(3):436-51. PMID: 25810138.
      View in: PubMed
    46. Parker AC, Beenken KE, Jennings JA, Hittle L, Shirtliff ME, Bumgardner JD, Smeltzer MS, Haggard WO. Characterization of local delivery with amphotericin B and vancomycin from modified chitosan sponges and functional biofilm prevention evaluation. J Orthop Res. 2015 Mar; 33(3):439-47. PMID: 25408519.
      View in: PubMed
    47. Loughran AJ, Atwood DN, Anthony AC, Harik NS, Spencer HJ, Beenken KE, Smeltzer MS. Impact of individual extracellular proteases on Staphylococcus aureus biofilm formation in diverse clinical isolates and their isogenic sarA mutants. Microbiologyopen. 2014 Dec; 3(6):897-909. PMID: 25257373.
      View in: PubMed
    48. Beenken KE, Smith JK, Skinner RA, Mclaren SG, Bellamy W, Gruenwald MJ, Spencer HJ, Jennings JA, Haggard WO, Smeltzer MS. Chitosan coating to enhance the therapeutic efficacy of calcium sulfate-based antibiotic therapy in the treatment of chronic osteomyelitis. J Biomater Appl. 2014 Oct; 29(4):514-23. PMID: 24854984.
      View in: PubMed
    49. Beenken KE, Mrak LN, Zielinska AK, Atwood DN, Loughran AJ, Griffin LM, Matthews KA, Anthony AM, Spencer HJ, Skinner RA, Post GR, Lee CY, Smeltzer MS. Impact of the functional status of saeRS on in vivo phenotypes of Staphylococcus aureus sarA mutants. Mol Microbiol. 2014 Jun; 92(6):1299-312. PMID: 24779437.
      View in: PubMed
    50. Cassat JE, Smeltzer MS, Lee CY. Investigation of biofilm formation in clinical isolates of Staphylococcus aureus. Methods Mol Biol. 2014; 1085:195-211. PMID: 24085698.
      View in: PubMed
    51. Snowden JN, Beaver M, Beenken K, Smeltzer M, Horswill AR, Kielian T. Staphylococcus aureus sarA regulates inflammation and colonization during central nervous system biofilm formation. PLoS One. 2013; 8(12):e84089. PMID: 24386336.
      View in: PubMed
    52. Cassat JE, Hammer ND, Campbell JP, Benson MA, Perrien DS, Mrak LN, Smeltzer MS, Torres VJ, Skaar EP. A secreted bacterial protease tailors the Staphylococcus aureus virulence repertoire to modulate bone remodeling during osteomyelitis. Cell Host Microbe. 2013 Jun 12; 13(6):759-72. PMID: 23768499.
      View in: PubMed
    53. Nedosekin DA, Juratli MA, Sarimollaoglu M, Moore CL, Rusch NJ, Smeltzer MS, Zharov VP, Galanzha EI. Photoacoustic and photothermal detection of circulating tumor cells, bacteria and nanoparticles in cerebrospinal fluid in vivo and ex vivo. J Biophotonics. 2013 Jun; 6(6-7):523-33. PMID: 23681943.
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    54. Hart ME, Tsang LH, Deck J, Daily ST, Jones RC, Liu H, Hu H, Hart MJ, Smeltzer MS. Hyaluronidase expression and biofilm involvement in Staphylococcus aureus UAMS-1 and its sarA, agr and sarA agr regulatory mutants. Microbiology (Reading). 2013 Apr; 159(Pt 4):782-791. PMID: 23393148.
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    55. Hobby GH, Quave CL, Nelson K, Compadre CM, Beenken KE, Smeltzer MS. Quercus cerris extracts limit Staphylococcus aureus biofilm formation. J Ethnopharmacol. 2012 Dec 18; 144(3):812-5. PMID: 23127649.
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    56. Zielinska AK, Beenken KE, Mrak LN, Spencer HJ, Post GR, Skinner RA, Tackett AJ, Horswill AR, Smeltzer MS. sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates. Mol Microbiol. 2012 Dec; 86(5):1183-96. PMID: 23075270.
      View in: PubMed
    57. Galanzha EI, Shashkov E, Sarimollaoglu M, Beenken KE, Basnakian AG, Shirtliff ME, Kim JW, Smeltzer MS, Zharov VP. In vivo magnetic enrichment, photoacoustic diagnosis, and photothermal purging of infected blood using multifunctional gold and magnetic nanoparticles. PLoS One. 2012; 7(9):e45557. PMID: 23049814.
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    58. Beenken KE, Bradney L, Bellamy W, Skinner RA, McLaren SG, Gruenwald MJ, Spencer HJ, Smith JK, Haggard WO, Smeltzer MS. Use of xylitol to enhance the therapeutic efficacy of polymethylmethacrylate-based antibiotic therapy in treatment of chronic osteomyelitis. Antimicrob Agents Chemother. 2012 Nov; 56(11):5839-44. PMID: 22948866.
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    59. Brown TL, Spencer HJ, Beenken KE, Alpe TL, Bartel TB, Bellamy W, Gruenwald JM, Skinner RA, McLaren SG, Smeltzer MS. Evaluation of dynamic [18F]-FDG-PET imaging for the detection of acute post-surgical bone infection. PLoS One. 2012; 7(7):e41863. PMID: 22860021.
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    60. Snowden JN, Beaver M, Smeltzer MS, Kielian T. Biofilm-infected intracerebroventricular shunts elicit inflammation within the central nervous system. Infect Immun. 2012 Sep; 80(9):3206-14. PMID: 22753376.
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    61. Mrak LN, Zielinska AK, Beenken KE, Mrak IN, Atwood DN, Griffin LM, Lee CY, Smeltzer MS. saeRS and sarA act synergistically to repress protease production and promote biofilm formation in Staphylococcus aureus. PLoS One. 2012; 7(6):e38453. PMID: 22685571.
      View in: PubMed
    62. Morrison JM, Anderson KL, Beenken KE, Smeltzer MS, Dunman PM. The staphylococcal accessory regulator, SarA, is an RNA-binding protein that modulates the mRNA turnover properties of late-exponential and stationary phase Staphylococcus aureus cells. Front Cell Infect Microbiol. 2012; 2:26. PMID: 22919618.
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    63. Beenken KE, Spencer H, Griffin LM, Smeltzer MS. Impact of extracellular nuclease production on the biofilm phenotype of Staphylococcus aureus under in vitro and in vivo conditions. Infect Immun. 2012 May; 80(5):1634-8. PMID: 22354028.
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    64. Quave CL, Est?vez-Carmona M, Compadre CM, Hobby G, Hendrickson H, Beenken KE, Smeltzer MS. Ellagic acid derivatives from Rubus ulmifolius inhibit Staphylococcus aureus biofilm formation and improve response to antibiotics. PLoS One. 2012; 7(1):e28737. PMID: 22242149.
      View in: PubMed
    65. Kiedrowski MR, Kavanaugh JS, Malone CL, Mootz JM, Voyich JM, Smeltzer MS, Bayles KW, Horswill AR. Nuclease modulates biofilm formation in community-associated methicillin-resistant Staphylococcus aureus. PLoS One. 2011; 6(11):e26714. PMID: 22096493.
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    66. Ord??ez PE, Quave CL, Reynolds WF, Varughese KI, Berry B, Breen PJ, Malag?n O, Smeltzer MS, Compadre CM. Sesquiterpene lactones from Gynoxys verrucosa and their anti-MRSA activity. J Ethnopharmacol. 2011 09 02; 137(2):1055-9. PMID: 21782013.
      View in: PubMed
    67. Abel J, Goldmann O, Ziegler C, H?ltje C, Smeltzer MS, Cheung AL, Bruhn D, Rohde M, Medina E. Staphylococcus aureus evades the extracellular antimicrobial activity of mast cells by promoting its own uptake. J Innate Immun. 2011; 3(5):495-507. PMID: 21654154.
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    68. Gurjala AN, Geringer MR, Seth AK, Hong SJ, Smeltzer MS, Galiano RD, Leung KP, Mustoe TA. Development of a novel, highly quantitative in vivo model for the study of biofilm-impaired cutaneous wound healing. Wound Repair Regen. 2011 May-Jun; 19(3):400-10. PMID: 21518094.
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    69. Zielinska AK, Beenken KE, Joo HS, Mrak LN, Griffin LM, Luong TT, Lee CY, Otto M, Shaw LN, Smeltzer MS. Defining the strain-dependent impact of the Staphylococcal accessory regulator (sarA) on the alpha-toxin phenotype of Staphylococcus aureus. J Bacteriol. 2011 Jun; 193(12):2948-58. PMID: 21478342.
      View in: PubMed
    70. Olson PD, Kuechenmeister LJ, Anderson KL, Daily S, Beenken KE, Roux CM, Reniere ML, Lewis TL, Weiss WJ, Pulse M, Nguyen P, Simecka JW, Morrison JM, Sayood K, Asojo OA, Smeltzer MS, Skaar EP, Dunman PM. Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turnover, exhibit antimicrobial activity, and attenuate pathogenesis. PLoS Pathog. 2011 Feb 10; 7(2):e1001287. PMID: 21347352.
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    71. Zielinska, A, Beenken, K. E., Joo, H-S, Mrak, L, Griffin, L. M, Luong, T. T, Lee, C. Y, Otto, M, Shaw, L. N, Smeltzer, M. S. Stopping the flow of extracellular proteases: The role of sarA in promoting the ability of agr to modulate the phenotype of Staphylococcus aureus clinical isolates. Journal of Bacteriology. 2011; (Submitted).
    72. Olsen, P. D, Kuechenmeister, L. J, Anderson, K. L, Beenken, K. E, Reniere, M. L, Lewis, T. L, Weiss, W. J, Pulse, M, Nguyen, P, Simecka, J. W, Morrison, J. M, Saygood, K, Asojo, O. A, Smeltzer, M. S, Skaar, E. P, Dunman, P. M. Small molecule inhibitors of Staphylococcus aureus RnpA-mediated RNA degradation exhibit antimicrobial activity and diminish pathogenesis. PLoS Pathogens. 2011; In Press.
    73. Quave, C. L, Campadre, C, Hendrickson, H, Beenken, K, Smeltzer, M. S. Antibiotic susceptibility of biofilm-associated Staphylococcus aureus is potential by synergy with elmleaf blackberry extract. Journal of Antimicrobial Chemotherapy. 2011; (Submitted).
    74. Smith JK, Bumgardner JD, Courtney HS, Smeltzer MS, Haggard WO. Antibiotic-loaded chitosan film for infection prevention: A preliminary in vitro characterization. J Biomed Mater Res B Appl Biomater. 2010 Jul; 94(1):203-11. PMID: 20524196.
      View in: PubMed
    75. Beenken KE, Mrak LN, Griffin LM, Zielinska AK, Shaw LN, Rice KC, Horswill AR, Bayles KW, Smeltzer MS. Epistatic relationships between sarA and agr in Staphylococcus aureus biofilm formation. PLoS One. 2010 May 24; 5(5):e10790. PMID: 20520723.
      View in: PubMed
    76. Harik NS, Smeltzer MS. Management of acute hematogenous osteomyelitis in children. Expert Rev Anti Infect Ther. 2010 Feb; 8(2):175-81. PMID: 20109047.
      View in: PubMed
    77. Harik, N.S., Smeltzer M. Management of osteomyelitis in children. Expert Review of Anti-infective Therapy. 2010; (8):175-181.
    78. Fujimoto DF, Higginbotham RH, Sterba KM, Maleki SJ, Segall AM, Smeltzer MS, Hurlburt BK. Staphylococcus aureus SarA is a regulatory protein responsive to redox and pH that can support bacteriophage lambda integrase-mediated excision/recombination. Mol Microbiol. 2009 Dec; 74(6):1445-58. PMID: 19919677.
      View in: PubMed
    79. Weiss EC, Zielinska A, Beenken KE, Spencer HJ, Daily SJ, Smeltzer MS. Impact of sarA on daptomycin susceptibility of Staphylococcus aureus biofilms in vivo. Antimicrob Agents Chemother. 2009 Oct; 53(10):4096-102. PMID: 19651914.
      View in: PubMed
    80. Mann EE, Rice KC, Boles BR, Endres JL, Ranjit D, Chandramohan L, Tsang LH, Smeltzer MS, Horswill AR, Bayles KW. Modulation of eDNA release and degradation affects Staphylococcus aureus biofilm maturation. PLoS One. 2009 Jun 09; 4(6):e5822. PMID: 19513119.
      View in: PubMed
    81. Nagarajan V, Smeltzer MS, Elasri MO. Genome-scale transcriptional profiling in Staphylococcus aureus : bringing order out of chaos. FEMS Microbiol Lett. 2009 Jun; 295(2):204-10. PMID: 19459979.
      View in: PubMed
    82. Weiss EC, Spencer HJ, Daily SJ, Weiss BD, Smeltzer MS. Impact of sarA on antibiotic susceptibility of Staphylococcus aureus in a catheter-associated in vitro model of biofilm formation. Antimicrob Agents Chemother. 2009 Jun; 53(6):2475-82. PMID: 19289527.
      View in: PubMed
    83. Weiss BD, Weiss EC, Haggard WO, McLaren SG, Smeltzer M. Optimized elution of daptomycin from polymethmethacrylate (PMMA) beads. Antimicrob. Agents Chemother. 2009; 53:264-266.
    84. Smeltzer M, Lee CY, Harik N, Hart ME. The Staphylococci in Human Disease. The molecular basis of pathogenicity. 2009.
    85. Smeltzer, M. S, Nelson, C. L, Evans, R. P. Biofilms and aseptic loosening. 2009.
    86. Weiss, E.C., Zielinska, A., Beenken, K.E., Spencer, H.J., Daily, S.J., Smeltzer M. Mutation od sarA increases the susceptibility of Staphylococcus aureus biofilms to daptomycin in vivo. Antimicrobial Agents and Chemotheraphy. 2009; 53:4096-4102.
    87. Smeltzer M, C.Y. Lee, N. Harik, M.E. Hart. The molecular basis of pathogenesis, p. X-X. In K. The staphylococcus in human disease. 2009; Pp. 65-108.
    88. Weiss EC, Spencer HJ, Daily SJ, Weiss BD, Smeltzer M. Mutation of sarA increases the susceptibility of Staphylococcus aureus biofilms to daptomycin in vivo. Antimicrobial Agents and Chemotherapy. 2009; (53):4096-4102.
    89. Weiss, E.C., Spencer, H.J., Daily, S.J., Weiss, B.D., Smeltzer M. Impact of sarA on the antibiotic susceptibility of Staphylococcus aureus in vitro in a catheter-associated biofilm model. Antimicrobial Agents and Chemotheraphy. 2009; 53:2475-2482.
    90. Weiss, B.D., Weiss, E.C., Haggard, W.O., McLaren, S.G., Smeltzer, M. S. Optimized elution of daptomycin from polymethymethacrylate (PMMA) beads. Antimicrobial Agents and Chemotheraphy. 2009; 53:264-266.
    91. Weiss, E. C, Spencer, H. J, Daily, S. J, Weiss, B. D, Smeltzer, M. S. Impact of sarA on the antibiotic susceptibility of Staphylococcus aureus in vitro in a catheter-associated biofilm model. Antimicrobial Agents and Chemotherapy. 2009; (53):2475-2482.
    92. Weiss BD, Weiss EC, Haggard WO, Evans RP, McLaren SG, Smeltzer MS. Optimized elution of daptomycin from polymethylmethacrylate beads. Antimicrob Agents Chemother. 2009 Jan; 53(1):264-6. PMID: 18955530.
      View in: PubMed
    93. Tsang LH, Cassat JE, Shaw LN, Beenken KE, Smeltzer MS. Factors contributing to the biofilm-deficient phenotype of Staphylococcus aureus sarA mutants. PLoS One. 2008; 3(10):e3361. PMID: 18846215.
      View in: PubMed
    94. Zhu Y, Weiss EC, Otto M, Fey PD, Smeltzer MS, Somerville GA. Staphylococcus aureus biofilm metabolism and the influence of arginine on polysaccharide intercellular adhesin synthesis, biofilm formation, and pathogenesis. Infect Immun. 2007 Sep; 75(9):4219-26. PMID: 17576756.
      View in: PubMed
    95. Tsang LH, Daily ST, Weiss EC, Smeltzer MS. Mutation of traP in Staphylococcus aureus has no impact on expression of agr or biofilm formation. Infect Immun. 2007 Sep; 75(9):4528-33. PMID: 17548479.
      View in: PubMed
    96. Rice KC, Mann EE, Endres JL, Weiss EC, Cassat JE, Smeltzer MS, Bayles KW. The cidA murein hydrolase regulator contributes to DNA release and biofilm development in Staphylococcus aureus. Proc Natl Acad Sci U S A. 2007 May 08; 104(19):8113-8. PMID: 17452642.
      View in: PubMed
    97. Zhu Y, Weiss EC, Otto M, Fey PD, Smeltzer MS, Somerville GA. Staphylococcus aureus biofilm metabolism and the influence of arginine on polysaccharide intercellular adhedin synthesis, biofilm formation, and pathogenesis. Infection and Immunity. 2007; 75:4219-4226.
    98. Cassat JE, Lee CY, Smeltzer MS. Investigation of biofilm formation in clinical isolates of Staphylococcus aureus. Methods Mol Biol. 2007; 391:127-44. PMID: 18025674.
      View in: PubMed
    99. Tsang LH, Daily S, Weiss EC, Smeltzer MS. Mutation of traP in clinical isolates of Staphylococcus aureus has not impact on expression of agr or on biofilm formation. Infection and Immunity. 2007; 75:4528-4533.
    100. McLaren AC, McLaren SG, Smeltzer M. Xylitol and glycine fillers increase permeability of PMMA to enhance elution of daptomycin. Clin Orthop Relat Res. 2006 Oct; 451:25-8. PMID: 16906079.
      View in: PubMed
    101. Cassat J, Dunman PM, Murphy E, Projan SJ, Beenken KE, Palm KJ, Yang SJ, Rice KC, Bayles KW, Smeltzer MS. Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences in comparison to the laboratory strain RN6390. Microbiology (Reading). 2006 Oct; 152(Pt 10):3075-3090. PMID: 17005987.
      View in: PubMed
    102. Sambanthamoorthy K, Smeltzer MS, Elasri MO. Identification and characterization of msa (SA1233), a gene involved in expression of SarA and several virulence factors in Staphylococcus aureus. Microbiology (Reading). 2006 Sep; 152(Pt 9):2559-2572. PMID: 16946251.
      View in: PubMed
    103. Roberts C, Anderson KL, Murphy E, Projan SJ, Mounts W, Hurlburt B, Smeltzer M, Overbeek R, Disz T, Dunman PM. Characterizing the effect of the Staphylococcus aureus virulence factor regulator, SarA, on log-phase mRNA half-lives. J Bacteriol. 2006 Apr; 188(7):2593-603. PMID: 16547047.
      View in: PubMed
    104. Kanangat S, Postlethwaite A, Hasty K, Kang A, Smeltzer M, Appling W, Schaberg D. Induction of multiple matrix metalloproteinases in human dermal and synovial fibroblasts by Staphylococcus aureus: implications in the pathogenesis of septic arthritis and other soft tissue infections. Arthritis Res Ther. 2006; 8(6):R176. PMID: 17129374.
      View in: PubMed
    105. Sambanthamoorthy K, Smeltzer M, Elasri MO. Identification and characterization of msa (SA1233), a gene that is involved in expression of sarA and several virulence factors in Staphylococcus aureus. Microbiology. 2006; 152:2559-2572.
    106. Kanangat S, Postlehwaite A, Hasty K, Kang A, Smeltzer M, Appling W, Schaberg D. Induction of multiple matrix metalloproteinases in human dermal and synovia fibroblasts by Staphylococcus aureus: Implications in the pathogenesis of septic arthritis and other soft tissue infections. Arthritis Research and Theraphy. 2006.
    107. Cassat JE, Weiss EC, Beenken KE, Yang S-J, Bayles KW, Smeltzer M. Disruption of acetolactate synthase (alsS) and acetolactate decarboxylase (alsD) in Staphylococcus aureus limits biofilm formation in vitro and in vivo. Microbiology. 2006.
    108. Cassat JE, Dunman PM, Murphy EJ, Projan SJ, Beenken KE, Palm KJ, Yang S-J, Rice KC, Bayles KW, Smeltzer MS. Transcriptional profiling of a Staphylococcus aureus clinical isolate and its isogenic agr and sarA mutants reveals global differences by comparison to the laboratory strain RN6390. Microbiology. 2006; 152:3075-3090.
    109. Jones-Jackson L, Walker R, Purnell G, McLaren SG, Skinner RA, Thomas JR, Suva LJ, Anaissie E, Miceli M, Nelson CL, Ferris EJ, Smeltzer MS. Early detection of bone infection and differentiation from post-surgical inflammation using 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography (FDG-PET) in an animal model. J Orthop Res. 2005 Nov; 23(6):1484-9. PMID: 15896941.
      View in: PubMed
    110. Zharov VP, Mercer KE, Galitovskaya EN, Smeltzer MS. Photothermal nanotherapeutics and nanodiagnostics for selective killing of bacteria targeted with gold nanoparticles. Biophys J. 2006 Jan 15; 90(2):619-27. PMID: 16239330.
      View in: PubMed
    111. Nelson CL, McLaren AC, McLaren SG, Johnson JW, Smeltzer MS. Is aseptic loosening truly aseptic? Clin Orthop Relat Res. 2005 Aug; (437):25-30. PMID: 16056022.
      View in: PubMed
    112. Cassat JE, Dunman PM, McAleese F, Murphy E, Projan SJ, Smeltzer MS. Comparative genomics of Staphylococcus aureus musculoskeletal isolates. J Bacteriol. 2005 Jan; 187(2):576-92. PMID: 15629929.
      View in: PubMed
    113. Nelson CL, McLaren AC, McLaren SG, Johnson JW, Smeltzer M. Is aseptic loosening really aseptic?. Clinical Orthopaedics and Related Research. 2005; 437:25-30.
    114. Jones-Jackson L, Walker R, Purnell G, McLaren SG, Skinner RA, Thomas JR, Suva L, Anaissie E, Miceli M, Nelson CL, Ferris E, Smeltzer M. Early detection of bone infection and differentiation form post-surgical inflammation using 2-deoxy-2-[18F]-fluoro-D-glucose positron emission tomography (FDG-PET) in an animal model. Journal of Orthopaedic Research. 2005; 23:1484-1489.
    115. Koenig RL, Ray JL, Maleki SJ, Smeltzer MS, Hurlburt BK. Staphylococcus aureus AgrA binding to the RNAIII-agr regulatory region. J Bacteriol. 2004 Nov; 186(22):7549-55. PMID: 15516566.
      View in: PubMed
    116. O'Leary JO, Langevin MJ, Price CT, Blevins JS, Smeltzer MS, Gustafson JE. Effects of sarA inactivation on the intrinsic multidrug resistance mechanism of Staphylococcus aureus. FEMS Microbiol Lett. 2004 Aug 15; 237(2):297-302. PMID: 15321676.
      View in: PubMed
    117. Beenken KE, Dunman PM, McAleese F, Macapagal D, Murphy E, Projan SJ, Blevins JS, Smeltzer MS. Global gene expression in Staphylococcus aureus biofilms. J Bacteriol. 2004 Jul; 186(14):4665-84. PMID: 15231800.
      View in: PubMed
    118. Koenig RL, Ray JL, Maleki SJ, Smeltzer M, Hurlburt BK. Staphylococcal aureus AgrA binding to the RNAIII-agr regulatory region. Journal of Bacteriology. 2004; 186:7549-7555.
    119. O'Leary JO, Langevin MJ, Price CTD, Blevins JS, Smeltzer M, Gustafson JE. Effects of sarA inactivation on the intrinsic multidrug resistance mechanisms of Staphylococcus aureus. FEMS Microbiol. Lett. 2004; 237:297-302.
    120. Sterba KM, Mackintosh SG, Blevins JS, Hurlburt BK, Smeltzer MS. Characterization of Staphylococcus aureus SarA binding sites. J Bacteriol. 2003 Aug; 185(15):4410-7. PMID: 12867449.
      View in: PubMed
    121. Beenken KE, Blevins JS, Smeltzer MS. Mutation of sarA in Staphylococcus aureus limits biofilm formation. Infect Immun. 2003 Jul; 71(7):4206-11. PMID: 12819120.
      View in: PubMed
    122. Blevins JS, Elasri MO, Allmendinger SD, Beenken KE, Skinner RA, Thomas JR, Smeltzer MS. Role of sarA in the pathogenesis of Staphylococcus aureus musculoskeletal infection. Infect Immun. 2003 Jan; 71(1):516-23. PMID: 12496203.
      View in: PubMed
    123. Beenken KE, Blevins JS, Smeltzer M. Mutation of sarA impairs biofilm formation in Stapjylococcus aureus SarA binding sites. Infection and Immunity. 2003; 71:4206-4211.
    124. Blevins JS, Elasri MO, Skinner RA, Thomas JR, Smeltzer M. Role of sarA in the pathogenesis of Staphylococcus aureus muskoskeletal infection. Infection and Immunity. 2003; 71:516-523.
    125. Nelson CL, McLaren SG, Skinner RA, Smeltzer MS, Thomas JR, Olsen KM. The treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. J Orthop Res. 2002 Jul; 20(4):643-7. PMID: 12168649.
      View in: PubMed
    126. Blevins JS, Beenken KE, Elasri MO, Hurlburt BK, Smeltzer MS. Strain-dependent differences in the regulatory roles of sarA and agr in Staphylococcus aureus. Infect Immun. 2002 Feb; 70(2):470-80. PMID: 11796572.
      View in: PubMed
    127. Elasri MO, Thomas JR, Skinner RA, Blevins JS, Beenken KE, Nelson CL, Smeltzer M. Staphylococcus aureus collagen adhesion contributes to the pathogenesis of osteomyelitis. Bone. 2002; 30:275-280.
    128. Nelson CL, McLaren SG, Skinner RA, Smeltzer M, Thomas JR, Olsen KM. Treatment of experimental osteomyelitis by surgical debridement and the implantation of calcium sulfate tobramycin pellets. Journal of Orthopaedic Research. 2002; 20:643-647.
    129. Smeltzer M, Nelson CL. Staphylococcus aureus Infection and Disease. Osteomyrlitis and septic arthritis. 2001; Pgs. 213-246.
    130. Smeltzer M, Gillaspy AF. Molecular pathogenesis of staphylococcal osteomyelitis. Poultry Science. 2000; 79:1042-1049.
    131. Smeltzer M. Handbook for Studying Bacterial Adhesion. Characterization of staphylococcal adhesins for adherence to host tissues. 2000; Pgs. 411-444.
    132. Snodgrass JL, Mohammed N, Ross JM, Sau S, Lee CY, Smeltzer M. Functional characterization of the Staphylococcus aureus collagen adhesion B domain. Infection and Immunity. 1999; 67:3952-3959.
    133. Blevins JS, Gillaspy AF, Rechtin TM, Hurlburt BK, Smeltzer M. The staphylococcal accessory regulator (sar) controls expression of the Staphylococcus aureus collagen adhesion gene (cna) in an agr-independent manner. Molecular Microbiology. 1999; 33:317-326.
    134. Rechtin TM, Gillaspy AF, Schumacher M, Brennan RG, Smeltzer M, Hurlburt BK. Characterization of SarA virulence gene regulator of Staphylococcus aureus. Molecular Microbiology. 1999; 33:307-316.
    135. Smeltzer M, Gillaspy AF, Pratt FL Jr, Thames MD. Comparative evaluation of cna, fnbA, fnbB and hlb genomic fingerprinting for the epidemiological typing of Staphylococcus aureus. Journal of Clinical Microbiology. 1997; 35:2444-2449.
    136. Gillaspy AF, Patti JM, Pratt FL Jr, Smeltzer M. Transcriptional regulation of the staphylococcus aureus collagen adhesin gene (cna). Infection and Immunity. 1997; 65:1536-1540.
    137. Smeltzer M, Gillaspy AF, Pratt FL, Iandolo JJ. Prevalence and chromosomal map location of Staphylococcus aureus adhesion genes. Gene. 1997; 196:249-259.
    138. Smeltzer M, Pratt FL Jr, Gillaspy AF, Young LA. Genomic fingerprinting for the epidemiological differentiation of Staphylococcus aureus clinical isolates. Journal of Clinical Microbiology. 1996; 34:1364-1372.
    139. Gillaspy AF, Hickmon SG, Skinner RA, Thomas JR, Nelson CL, Smeltzer M. Role of the accessory gene regulator (agr) in the pathogenesis of staphylococcal osteomyelitis. Infection and Immunity. 1995; 63:3373-3380.
    140. Smeltzer M, Hart ME, Iandolo JJ. Quantitative spectrophotometric assay for lipase activity in Staphylococcus aureus. Appl. Environ. Microbiol. 1992; 58:2815-2819.
    141. Rahaley RS, Dennis SM, Smeltzer M. Comparison of the enzyme-linked immunosorbent assay and complement fixation test for detecting Brucella ovis antibodies in sheep. Veterinary Record. 1983; 113:467-470.
    142. Smeltzer M, Darville T, Saccente M, Nelson CL. Infectious Disease and Theraphy. Staphylococcal osteomyelitis.
    143. Smeltzer M. The Staphylococci in Human Disease. The molecular basis of pathogenicity.
    144. Smeltzer M. The Role of Biofilms in Device-Related Infections. Biofilms and aseptic loosening.
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