 Virus Latency
"Virus Latency" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The ability of a pathogenic virus to lie dormant within a cell (latent infection). In eukaryotes, subsequent activation and viral replication is thought to be caused by extracellular stimulation of cellular transcription factors. Latency in bacteriophage is maintained by the expression of virally encoded repressors.
| Descriptor ID |
D017735
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| MeSH Number(s) |
G06.920.900
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| Concept/Terms |
Virus Latency- Virus Latency
- Latencies, Virus
- Latency, Virus
- Virus Latencies
- Viral Latency
- Latencies, Viral
- Latency, Viral
- Viral Latencies
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Below are MeSH descriptors whose meaning is more general than "Virus Latency".
Below are MeSH descriptors whose meaning is more specific than "Virus Latency".
This graph shows the total number of publications written about "Virus Latency" by people in UAMS Profiles by year, and whether "Virus Latency" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 1 | 1 | 2 | | 2024 | 0 | 1 | 1 | | 2023 | 1 | 1 | 2 | | 2022 | 0 | 2 | 2 | | 2021 | 0 | 1 | 1 | | 2020 | 0 | 2 | 2 | | 2019 | 0 | 4 | 4 | | 2018 | 0 | 1 | 1 | | 2017 | 1 | 2 | 3 | | 2016 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2014 | 2 | 0 | 2 | | 2013 | 1 | 0 | 1 | | 2010 | 2 | 1 | 3 | | 2009 | 1 | 0 | 1 | | 2008 | 0 | 3 | 3 | | 2007 | 1 | 1 | 2 | | 2003 | 0 | 1 | 1 | | 2001 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 1997 | 0 | 1 | 1 | | 1994 | 0 | 1 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Virus Latency" by people in Profiles over the past ten years.
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Fan J, Lin Z, Zhang H, Dai L, Qin Z. Infection of human induced pluripotent stem cells by an oncogenic herpesvirus. Front Cell Infect Microbiol. 2025; 15:1563440.
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Owens SM, Sifford JM, Li G, Murdock SJ, Salinas E, Oldenburg D, Ghosh D, Stumhofer JS, Nookaew I, Manzano M, Forrest JC. Intrinsic p53 activation restricts gammaherpesvirus driven germinal center B cell expansion during latency establishment. Nat Commun. 2025 Jan 22; 16(1):951.
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Hogan CH, Owens SM, Reynoso GV, Liao Y, Meyer TJ, Zelazowska MA, Liu B, Li X, Grosskopf AK, Khairallah C, Kirillov V, Reich NC, Sheridan BS, McBride KM, Gewurz BE, Hickman HD, Forrest JC, Krug LT. Multifaceted roles for STAT3 in gammaherpesvirus latency revealed through in vivo B cell knockout models. mBio. 2024 Feb 14; 15(2):e0299823.
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Wang L, Howell MEA, Hensley CR, Ning K, Moorman JP, Yao ZQ, Ning S. The master antioxidant defense is activated during EBV latent infection. J Virol. 2023 11 30; 97(11):e0095323.
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Chen J, Lin Z, Song J, Plaisance-Bonstaff K, James J, Mu S, Post SR, Dai L, Qin Z. Echinomycin as a promising therapeutic agent against KSHV-related malignancies. J Hematol Oncol. 2023 05 04; 16(1):48.
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Gupta A, Owens SM, Oldenburg DG, White DW, Forrest JC. Lytic Replication and Reactivation from B Cells Is Not Required for Establishing or Maintaining Gammaherpesvirus Latency In Vivo. J Virol. 2022 06 22; 96(12):e0069022.
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Gray WL. Comparative Analysis of the Simian Varicella Virus and Varicella Zoster Virus Genomes. Viruses. 2022 04 19; 14(5).
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Rasmussen TA, Rajdev L, Rhodes A, Dantanarayana A, Tennakoon S, Chea S, Spelman T, Lensing S, Rutishauser R, Bakkour S, Busch M, Siliciano JD, Siliciano RF, Einstein MH, Dittmer DP, Chiao E, Deeks SG, Durand C, Lewin SR. Impact of Anti-PD-1 and Anti-CTLA-4 on the Human Immunodeficiency Virus (HIV) Reservoir in People Living With HIV With Cancer on Antiretroviral Therapy: The AIDS Malignancy Consortium 095 Study. Clin Infect Dis. 2021 10 05; 73(7):e1973-e1981.
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Wang L, Howell MEA, Sparks-Wallace A, Zhao J, Hensley CR, Nicksic CA, Horne SR, Mohr KB, Moorman JP, Yao ZQ, Ning S. The Ubiquitin Sensor and Adaptor Protein p62 Mediates Signal Transduction of a Viral Oncogenic Pathway. mBio. 2021 10 26; 12(5):e0109721.
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Owens SM, Oldenburg DG, White DW, Forrest JC. Deletion of Murine Gammaherpesvirus Gene M2 in Activation-Induced Cytidine Deaminase-Expressing B Cells Impairs Host Colonization and Viral Reactivation. J Virol. 2020 12 09; 95(1).
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Dai L, Qiao J, Yin J, Goldstein A, Lin HY, Post SR, Qin Z. Kaposi Sarcoma-Associated Herpesvirus and Staphylococcus aureus Coinfection in Oral Cavities of HIV-Positive Patients: A Unique Niche for Oncogenic Virus Lytic Reactivation. J Infect Dis. 2020 03 28; 221(8):1331-1341.
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Chen J, Dai L, Goldstein A, Zhang H, Tang W, Forrest JC, Post SR, Chen X, Qin Z. Identification of new antiviral agents against Kaposi's sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation. PLoS Pathog. 2019 12; 15(12):e1008156.
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Chen J, Del Valle L, Lin HY, Plaisance-Bonstaff K, Forrest JC, Post SR, Qin Z. Expression of PD-1 and PD-Ls in Kaposi's sarcoma and regulation by oncogenic herpesvirus lytic reactivation. Virology. 2019 10; 536:16-19.
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Wang L, Howell MEA, Sparks-Wallace A, Hawkins C, Nicksic CA, Kohne C, Hall KH, Moorman JP, Yao ZQ, Ning S. p62-mediated Selective autophagy endows virus-transformed cells with insusceptibility to DNA damage under oxidative stress. PLoS Pathog. 2019 04; 15(4):e1007541.
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Gao Y, Wang L, Lei Z, Li J, Forrest JC, Liang X. IRF4 promotes Epstein-Barr virus activation in Burkitt's lymphoma cells. J Gen Virol. 2019 05; 100(5):851-862.
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Salinas E, Gupta A, Sifford JM, Oldenburg DG, White DW, Forrest JC. Conditional mutagenesis in vivo reveals cell type- and infection stage-specific requirements for LANA in chronic MHV68 infection. PLoS Pathog. 2018 01; 14(1):e1006865.
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Lavender KJ, Pace C, Sutter K, Messer RJ, Pouncey DL, Cummins NW, Natesampillai S, Zheng J, Goldsmith J, Widera M, Van Dis ES, Phillips K, Race B, Dittmer U, Kukolj G, Hasenkrug KJ. An advanced BLT-humanized mouse model for extended HIV-1 cure studies. AIDS. 2018 Jan 02; 32(1):1-10.
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Gupta A, Oldenburg DG, Salinas E, White DW, Forrest JC. Murine Gammaherpesvirus 68 Expressing Kaposi Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen (LANA) Reveals both Functional Conservation and Divergence in LANA Homologs. J Virol. 2017 10 01; 91(19).
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Dai L, Cao Y, Jiang W, Zabaleta J, Liu Z, Qiao J, Qin Z. KSHV co-infection down-regulates HPV16 E6 and E7 from cervical cancer cells. Oncotarget. 2017 May 30; 8(22):35792-35803.
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Dong S, Forrest JC, Liang X. Murine Gammaherpesvirus 68: A Small Animal Model for Gammaherpesvirus-Associated Diseases. Adv Exp Med Biol. 2017; 1018:225-236.
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Dai L, Bai L, Lin Z, Qiao J, Yang L, Flemington EK, Zabaleta J, Qin Z. Transcriptomic analysis of KSHV-infected primary oral fibroblasts: The role of interferon-induced genes in the latency of oncogenic virus. Oncotarget. 2016 Jul 26; 7(30):47052-47060.
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