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Lin-Xi Li

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentMicrobiology & Immunology, College of Medicine
DivisionMicrobiology & Immunology Faculty
Address325 S. Elm St.
Mail Slot # 511
Little Rock AR 72205
Phone501-686-6949
ORCID ORCID Icon0000-0002-5526-8966 Additional info
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    Collapse Research 
    Collapse research activities and funding
    1R21AI180670-01A1     (LI, LIN-XI)May 10, 2024 - Mar 31, 2026
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Exploring early protective immune responses to Chlamydia
    Role: Principal Investigator
    5R21AI180670-02     (LI, LIN-XI)May 10, 2024 - Mar 31, 2026
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Exploring early protective immune responses to Chlamydia
    Role: Principal Investigator
    2R01HL146713     (MU, SHENGYU)Apr 10, 2024 - Mar 31, 2029
    NIH/Nat. Heart, Lung & Blood Institute
    T cell homing to the kidney contributes to salt retention and blood pressure regulation - Continuation
    Role: Co-Investigator
    R01AI139124     (LI, LIN-XI)May 18, 2018 - Apr 30, 2024
    NIH/Nat. Inst. of Allergy & Infectious Diseases
    Mechanisms of memory CD4 T cell-mediated immune protection against Chlamydia - Continuation
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Andrews JT, Zhang Z, Prasad GVRK, Huey F, Nazarova EV, Wang J, Ranaraja A, Weinkopff T, Li LX, Mu S, Birrer MJ, Huang SC, Zhang N, Arg?ello RJ, Philips JA, Mattila JT, Huang L. Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis. Mucosal Immunol. 2024 Oct; 17(5):825-842. PMID: 38844208.
      View in: PubMed
    2. Mercado MAB, Li Q, Quick CM, Kim Y, Palmer R, Huang L, Li LX. BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia. PLoS Pathog. 2024 Jan; 20(1):e1011983. PMID: 38271477.
      View in: PubMed
    3. Benson LN, Deck KS, Mora CJ, Guo Y, Rafferty TM, Li LX, Huang L, Andrews JT, Qin Z, Trott DW, Hoover RS, Liu Y, Mu S. P2X7-Mediated Antigen-Independent Activation of CD8+ T Cells Promotes Salt-Sensitive Hypertension. Hypertension. 2024 Mar; 81(3):530-540. PMID: 38193292.
      View in: PubMed
    4. Mercado MAB, Li Q, Quick CM, Kim Y, Palmer R, Huang L, Li LX. BHLHE40 drives protective polyfunctional CD4 T cell differentiation in the female reproductive tract against Chlamydia. bioRxiv. 2023 Nov 05. PMID: 37961221.
      View in: PubMed
    5. Gann JI, Malaviarachchi PA, Du W, Mercado MAB, Li LX. IFN? and Antibody Synergize To Enhance Protective Immunity against Chlamydia Dissemination and Female Reproductive Tract Reinfections. Infect Immun. 2022 12 15; 90(12):e0032822. PMID: 36374101.
      View in: PubMed
    6. Benson LN, Liu Y, Wang X, Xiong Y, Rhee SW, Guo Y, Deck KS, Mora CJ, Li LX, Huang L, Andrews JT, Qin Z, Hoover RS, Ko B, Williams RM, Heller DA, Jaimes EA, Mu S. The IFN?-PDL1 Pathway Enhances CD8T-DCT Interaction to Promote Hypertension. Circ Res. 2022 05 13; 130(10):1550-1564. PMID: 35430873.
      View in: PubMed
    7. Alhallak I, Wolter KG, Castro Munoz A, Simmen FA, Ward RJ, Petty SA, Li LX, Simmen RCM. Breast adipose regulation of premenopausal breast epithelial phenotype involves interleukin 10. J Mol Endocrinol. 2021 09 09; 67(4):173-188. PMID: 34382943.
      View in: PubMed
    8. Mercado MAB, Du W, Malaviarachchi PA, Gann JI, Li LX. Innate IFN-? Is Essential for Systemic Chlamydia muridarum Control in Mice, While CD4 T Cell-Dependent IFN-? Production Is Highly Redundant in the Female Reproductive Tract. Infect Immun. 2021 02 16; 89(3). PMID: 33257535.
      View in: PubMed
    9. Malaviarachchi PA, Mercado MAB, McSorley SJ, Li LX. Antibody, but not B-cell-dependent antigen presentation, plays an essential role in preventing Chlamydia systemic dissemination in mice. Eur J Immunol. 2020 05; 50(5):676-684. PMID: 32026472.
      View in: PubMed
    10. Li LX, Labuda JC, Imai DM, Griffey SM, McSorley SJ. CCR7 Deficiency Allows Accelerated Clearance of Chlamydia from the Female Reproductive Tract. J Immunol. 2017 10 01; 199(7):2547-2554. PMID: 28801359.
      View in: PubMed
    11. Jiang J, Liu G, Kickhoefer VA, Rome LH, Li LX, McSorley SJ, Kelly KA. A Protective Vaccine against Chlamydia Genital Infection Using Vault Nanoparticles without an Added Adjuvant. Vaccines (Basel). 2017 Jan 19; 5(1). PMID: 28106821.
      View in: PubMed
    12. Li LX, Benoun JM, Weiskopf K, Garcia KC, McSorley SJ. Salmonella Infection Enhances Erythropoietin Production by the Kidney and Liver, Which Correlates with Elevated Bacterial Burdens. Infect Immun. 2016 10; 84(10):2833-41. PMID: 27456828.
      View in: PubMed
    13. Qualai J, Cantero J, Li LX, Carrascosa JM, Cabr? E, Dern O, Sumoy L, Requena G, McSorley SJ, Genesc? M. Adhesion Molecules Associated with Female Genital Tract Infection. PLoS One. 2016; 11(6):e0156605. PMID: 27272720.
      View in: PubMed
    14. Qualai J, Li LX, Cantero J, Tarrats A, Fern?ndez MA, Sumoy L, Rodolosse A, McSorley SJ, Genesc? M. Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential. PLoS One. 2016; 11(4):e0154253. PMID: 27119555.
      View in: PubMed
    15. Li LX, McSorley SJ. A re-evaluation of the role of B cells in protective immunity to Chlamydia infection. Immunol Lett. 2015 Apr; 164(2):88-93. PMID: 25704502.
      View in: PubMed
    16. Atif SM, Lee SJ, Li LX, Uematsu S, Akira S, Gorjestani S, Lin X, Schweighoffer E, Tybulewicz VL, McSorley SJ. Rapid CD4+ T-cell responses to bacterial flagellin require dendritic cell expression of Syk and CARD9. Eur J Immunol. 2015 Feb; 45(2):513-24. PMID: 25430631.
      View in: PubMed
    17. O'Donnell H, Pham OH, Li LX, Atif SM, Lee SJ, Ravesloot MM, Stolfi JL, Nuccio SP, Broz P, Monack DM, Baumler AJ, McSorley SJ. Toll-like receptor and inflammasome signals converge to amplify the innate bactericidal capacity of T helper 1 cells. Immunity. 2014 Feb 20; 40(2):213-24. PMID: 24508233.
      View in: PubMed
    18. Li LX, McSorley SJ. B cells enhance antigen-specific CD4 T cell priming and prevent bacteria dissemination following Chlamydia muridarum genital tract infection. PLoS Pathog. 2013 Oct; 9(10):e1003707. PMID: 24204262.
      View in: PubMed
    19. Li LX, Atif SM, Schmiel SE, Lee SJ, McSorley SJ. Increased susceptibility to Salmonella infection in signal regulatory protein a-deficient mice. J Immunol. 2012 Sep 01; 189(5):2537-44. PMID: 22851710.
      View in: PubMed
    20. Griffin AJ, Li LX, Voedisch S, Pabst O, McSorley SJ. Dissemination of persistent intestinal bacteria via the mesenteric lymph nodes causes typhoid relapse. Infect Immun. 2011 Apr; 79(4):1479-88. PMID: 21263018.
      View in: PubMed
    21. Vang KB, Yang J, Pag?n AJ, Li LX, Wang J, Green JM, Beg AA, Farrar MA. Cutting edge: CD28 and c-Rel-dependent pathways initiate regulatory T cell development. J Immunol. 2010 Apr 15; 184(8):4074-7. PMID: 20228198.
      View in: PubMed
    22. Li LX, Goetz CA, Katerndahl CD, Sakaguchi N, Farrar MA. A Flt3- and Ras-dependent pathway primes B cell development by inducing a state of IL-7 responsiveness. J Immunol. 2010 Feb 15; 184(4):1728-36. PMID: 20065110.
      View in: PubMed
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