 Receptor, Melanocortin, Type 4
"Receptor, Melanocortin, Type 4" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A melanocortin receptor subtype found primarily in BRAIN. It shows specificity for ALPHA-MSH; BETA-MSH and ADRENOCORTICOTROPIC HORMONE.
| Descriptor ID |
D044105
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| MeSH Number(s) |
D12.776.543.750.100.430.937 D12.776.543.750.720.600.285.500.937 D12.776.543.750.750.555.285.500.937 D12.776.543.750.750.660.285.500.937
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| Concept/Terms |
Receptor, Melanocortin, Type 4- Receptor, Melanocortin, Type 4
- Melanocortin Receptor 4
- Receptor 4, Melanocortin
- Receptor, Melanocortin-4
- Melanocortin 4 Receptor
- Receptor, Melanocortin 4
- Melanocortin-4 Receptor
- MC4 Receptor
- Receptor, MC4
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Below are MeSH descriptors whose meaning is more general than "Receptor, Melanocortin, Type 4".
- Chemicals and Drugs [D]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptors, G-Protein-Coupled [D12.776.543.750.100]
- Receptors, Melanocortin [D12.776.543.750.100.430]
- Receptor, Melanocortin, Type 4 [D12.776.543.750.100.430.937]
- Receptors, Neurotransmitter [D12.776.543.750.720]
- Receptors, Neuropeptide [D12.776.543.750.720.600]
- Receptors, Corticotropin [D12.776.543.750.720.600.285]
- Receptors, Melanocortin [D12.776.543.750.720.600.285.500]
- Receptor, Melanocortin, Type 4 [D12.776.543.750.720.600.285.500.937]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Neuropeptide [D12.776.543.750.750.555]
- Receptors, Corticotropin [D12.776.543.750.750.555.285]
- Receptors, Melanocortin [D12.776.543.750.750.555.285.500]
- Receptor, Melanocortin, Type 4 [D12.776.543.750.750.555.285.500.937]
- Receptors, Pituitary Hormone [D12.776.543.750.750.660]
- Receptors, Corticotropin [D12.776.543.750.750.660.285]
- Receptors, Melanocortin [D12.776.543.750.750.660.285.500]
- Receptor, Melanocortin, Type 4 [D12.776.543.750.750.660.285.500.937]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Melanocortin, Type 4".
This graph shows the total number of publications written about "Receptor, Melanocortin, Type 4" by people in UAMS Profiles by year, and whether "Receptor, Melanocortin, Type 4" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 0 | 1 | 1 | | 2017 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2014 | 2 | 0 | 2 | | 2013 | 1 | 0 | 1 | | 2012 | 2 | 0 | 2 | | 2011 | 1 | 0 | 1 | | 2010 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptor, Melanocortin, Type 4" by people in Profiles over the past ten years.
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Baldini G, Phelan KD. The melanocortin pathway and control of appetite-progress and therapeutic implications. J Endocrinol. 2019 04 01; 241(1):R1-R33.
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Cooney KA, Molden BM, Kowalczyk NS, Russell S, Baldini G. Lipid stress inhibits endocytosis of melanocortin-4 receptor from modified clathrin-enriched sites and impairs receptor desensitization. J Biol Chem. 2017 10 27; 292(43):17731-17745.
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Molden BM, Cooney KA, West K, Van Der Ploeg LH, Baldini G. Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists. Mol Endocrinol. 2015 Nov; 29(11):1619-33.
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Bazzi MD, Nasr FA, Alanazi MS, Alamri A, Turjoman AA, Moustafa AS, Alfadda AA, Pathan AA, Parine NR. Association between FTO, MC4R, SLC30A8, and KCNQ1 gene variants and type 2 diabetes in Saudi population. Genet Mol Res. 2014 Dec 04; 13(4):10194-203.
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Cragle FK, Baldini G. Mild lipid stress induces profound loss of MC4R protein abundance and function. Mol Endocrinol. 2014 Mar; 28(3):357-67.
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Granell S, Molden BM, Baldini G. Exposure of MC4R to agonist in the endoplasmic reticulum stabilizes an active conformation of the receptor that does not desensitize. Proc Natl Acad Sci U S A. 2013 Dec 03; 110(49):E4733-42.
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Granell S, Serra-Juhé C, Martos-Moreno GÁ, Díaz F, Pérez-Jurado LA, Baldini G, Argente J. A novel melanocortin-4 receptor mutation MC4R-P272L associated with severe obesity has increased propensity to be ubiquitinated in the ER in the face of correct folding. PLoS One. 2012; 7(12):e50894.
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McDaniel FK, Molden BM, Mohammad S, Baldini G, McPike L, Narducci P, Granell S, Baldini G. Constitutive cholesterol-dependent endocytosis of melanocortin-4 receptor (MC4R) is essential to maintain receptor responsiveness to a-melanocyte-stimulating hormone (a-MSH). J Biol Chem. 2012 Jun 22; 287(26):21873-90.
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Wankhade UD, Good DJ. Melanocortin 4 receptor is a transcriptional target of nescient helix-loop-helix-2. Mol Cell Endocrinol. 2011 Jul 20; 341(1-2):39-47.
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