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Umesh Wankhade

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPeds Pediatrics, College of Medicine
DivisionPeds Developmental Nutrition
Address1212 Marshall Street
Mail Slot # 512-20B
Little Rock AR 72202
Phone501-364-2866
ORCID ORCID Icon0000-0003-4810-221X Additional info
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    Collapse Research 
    Collapse research activities and funding
    ACRI # 034874     (WANKHADE, UMESH)Sep 21, 2018 - Aug 31, 2021
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    ACRI#034874     (WANKHADE, UMESH)Sep 21, 2018 - Aug 31, 2021
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator
    GR034018     (WANKHADE, UMESH)Sep 21, 2018 - Aug 31, 2021
    UAMS ACHRI Flow Through
    No FP attached
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Petersen C, Satheesh Babu AK, Della Lucia CM, Paz HA, Iglesias-Carres L, Zhong Y, Jalili T, Symons JD, Shankar K, Neilson AP, Wankhade UD, Anandh Babu PV. Gut microbes metabolize strawberry phytochemicals and mediate their beneficial effects on vascular inflammation. Gut Microbes. 2025 Dec; 17(1):2446375. PMID: 39760464.
      View in: PubMed
    2. Manfredi JN, Gupta SK, Vyavahare S, Deak F, Lu X, Buddha L, Wankhade U, Lohakare J, Isales C, Fulzele S. Gut microbiota dysbiosis in Alzheimer's disease (AD): Insights from human clinical studies and the mouse AD models. Physiol Behav. 2025 Mar 01; 290:114778. PMID: 39672482.
      View in: PubMed
    3. Satheesh Babu AK, Petersen C, Paz HA, Iglesias-Carres L, Li Y, Zhong Y, Neilson AP, Wankhade UD, Anandh Babu PV. Gut Microbiota Depletion Using Antibiotics to Investigate Diet-Derived Microbial Metabolites: An Efficient Strategy. Mol Nutr Food Res. 2024 Feb; 68(3):e2300386. PMID: 38054624.
      View in: PubMed
    4. Satheesh Babu AK, Petersen C, Paz HA, Benedict K, Nguyen M, Putich M, Saldivar-Gonzalez M, Zhong Y, Larsen S, Wankhade UD, Anandh Babu PV. Dose- and Time-Dependent Effect of Dietary Blueberries on Diabetic Vasculature Is Correlated with Gut Microbial Signature. Antioxidants (Basel). 2023 Jul 30; 12(8). PMID: 37627522.
      View in: PubMed
    5. Paz HA, Pilkington AC, Loy HD, Zhong Y, Shankar K, Wankhade UD. Beta-adrenergic agonist induces unique transcriptomic signature in inguinal white adipose tissue. Physiol Rep. 2023 03; 11(6):e15646. PMID: 36967237.
      View in: PubMed
    6. Chen JR, Caviness PC, Zhao H, Belcher B, Wankhade UD, Shankar K, Blackburn ML, Lazarenko OP. Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice. Epigenetics. 2022 12; 17(13):2209-2222. PMID: 35950595.
      View in: PubMed
    7. Li Y, Talbot CL, Chandravanshi B, Ksiazek A, Sood A, Chowdhury KH, Maschek JA, Cox J, Babu AKS, Paz HA, Babu PVA, Meyerholz DK, Wankhade UD, Holland W, Shyong Tai E, Summers SA, Chaurasia B. Cordyceps inhibits ceramide biosynthesis and improves insulin resistance and hepatic steatosis. Sci Rep. 2022 05 04; 12(1):7273. PMID: 35508667.
      View in: PubMed
    8. Knott B, Kocher MA, Paz HA, Hamm SE, Fink W, Mason J, Grange RW, Wankhade UD, Good DJ. Dietary Conjugated Linoleic Acid Reduces Body Weight and Fat in Snord116m+/p- and Snord116m-/p- Mouse Models of Prader-Willi Syndrome. Nutrients. 2022 Feb 18; 14(4). PMID: 35215509.
      View in: PubMed
    9. Yusufu I, Ding K, Smith K, Wankhade UD, Sahay B, Patterson GT, Pacholczyk R, Adusumilli S, Hamrick MW, Hill WD, Isales CM, Fulzele S. A Tryptophan-Deficient Diet Induces Gut Microbiota Dysbiosis and Increases Systemic Inflammation in Aged Mice. Int J Mol Sci. 2021 May 08; 22(9). PMID: 34066870.
      View in: PubMed
    10. Pilkington AC, Paz HA, Wankhade UD. Beige Adipose Tissue Identification and Marker Specificity-Overview. Front Endocrinol (Lausanne). 2021; 12:599134. PMID: 33776911.
      View in: PubMed
    11. Chen JR, Lazarenko OP, Zhao H, Wankhade UD, Pedersen K, Watt J, Ronis MJJ. Nox4 Expression Is Not Required for OVX-Induced Osteoblast Senescence and Bone Loss in Mice. JBMR Plus. 2020 Aug; 4(8):e10376. PMID: 32803108.
      View in: PubMed
    12. Mercer KE, Yeruva L, Pack L, Graham JL, Stanhope KL, Chintapalli SV, Wankhade UD, Shankar K, Havel PJ, Adams SH, Piccolo BD. Xenometabolite signatures in the UC Davis type 2 diabetes mellitus rat model revealed using a metabolomics platform enriched with microbe-derived metabolites. Am J Physiol Gastrointest Liver Physiol. 2020 08 01; 319(2):G157-G169. PMID: 32508155.
      View in: PubMed
    13. Zhang Y, Shaikh N, Ferey JL, Wankhade UD, Chintapalli SV, Higgins CB, Crowley JR, Heitmeier MR, Stothard AI, Mihi B, Good M, Higashiyama T, Swarts BM, Hruz PW, Shankar K, Tarr PI, DeBosch BJ. Lactotrehalose, an Analog of Trehalose, Increases Energy Metabolism Without Promoting Clostridioides difficile Infection in Mice. Gastroenterology. 2020 04; 158(5):1402-1416.e2. PMID: 31838076.
      View in: PubMed
    14. Chen JR, Wankhade UD, Alund AW, Blackburn ML, Shankar K, Lazarenko OP. 3-(3-Hydroxyphenyl)-Propionic Acid (PPA) Suppresses Osteoblastic Cell Senescence to Promote Bone Accretion in Mice. JBMR Plus. 2019 Sep; 3(9):e10201. PMID: 31667457.
      View in: PubMed
    15. Morris EM, Meers GME, Ruegsegger GN, Wankhade UD, Robinson T, Koch LG, Britton SL, Rector RS, Shankar K, Thyfault JP. Intrinsic High Aerobic Capacity in Male Rats Protects Against Diet-Induced Insulin Resistance. Endocrinology. 2019 05 01; 160(5):1179-1192. PMID: 31144719.
      View in: PubMed
    16. Pedersen KB, Pulliam CF, Patel A, Del Piero F, Watanabe TTN, Wankhade UD, Shankar K, Hicks C, Ronis MJ. Liver tumorigenesis is promoted by a high saturated fat diet specifically in male mice and is associated with hepatic expression of the proto-oncogene Agap2 and enrichment of the intestinal microbiome with Coprococcus. Carcinogenesis. 2019 04 29; 40(2):349-359. PMID: 30325408.
      View in: PubMed
    17. Wankhade UD, Zhong Y, Lazarenko OP, Chintapalli SV, Piccolo BD, Chen JR, Shankar K. Sex-Specific Changes in Gut Microbiome Composition following Blueberry Consumption in C57BL/6J Mice. Nutrients. 2019 Feb 01; 11(2). PMID: 30717265.
      View in: PubMed
    18. Petersen C, Wankhade UD, Bharat D, Wong K, Mueller JE, Chintapalli SV, Piccolo BD, Jalili T, Jia Z, Symons JD, Shankar K, Anandh Babu PV. Dietary supplementation with strawberry induces marked changes in the composition and functional potential of the gut microbiome in diabetic mice. J Nutr Biochem. 2019 04; 66:63-69. PMID: 30771735.
      View in: PubMed
    19. Wankhade UD, Zhong Y, Kang P, Alfaro M, Chintapalli SV, Piccolo BD, Mercer KE, Andres A, Thakali KM, Shankar K. Maternal High-Fat Diet Programs Offspring Liver Steatosis in a Sexually Dimorphic Manner in Association with Changes in Gut Microbial Ecology in Mice. Sci Rep. 2018 11 07; 8(1):16502. PMID: 30405201.
      View in: PubMed
    20. Wankhade UD, Lee JH, Dagur PK, Yadav H, Shen M, Chen W, Kulkarni AB, McCoy JP, Finkel T, Cypess AM, Rane SG. TGF-? receptor 1 regulates progenitors that promote browning of white fat. Mol Metab. 2018 10; 16:160-171. PMID: 30100246.
      View in: PubMed
    21. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 28244037.
      View in: PubMed
    22. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 29087435.
      View in: PubMed
    23. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 33420329.
      View in: PubMed
    24. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 34258504.
      View in: PubMed
    25. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 35120277.
      View in: PubMed
    26. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 36077057.
      View in: PubMed
    27. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 36112603.
      View in: PubMed
    28. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 39489538.
      View in: PubMed
    29. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 40343339.
      View in: PubMed
    30. Panasevich MR, Meers GM, Linden MA, Booth FW, Perfield JW, Fritsche KL, Wankhade UD, Chintapalli SV, Shankar K, Ibdah JA, Rector RS. High-fat, high-fructose, high-cholesterol feeding causes severe NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine. Am J Physiol Endocrinol Metab. 2018 01 01; 314(1):E78-E92. PMID: 28899857.
      View in: PubMed
    31. Wankhade UD, Zhong Y, Kang P, Alfaro M, Chintapalli SV, Thakali KM, Shankar K. Enhanced offspring predisposition to steatohepatitis with maternal high-fat diet is associated with epigenetic and microbiome alterations. PLoS One. 2017; 12(4):e0175675. PMID: 28414763.
      View in: PubMed
    32. Wankhade UD, Shen M, Yadav H, Thakali KM. Novel Browning Agents, Mechanisms, and Therapeutic Potentials of Brown Adipose Tissue. Biomed Res Int. 2016; 2016:2365609. PMID: 28105413.
      View in: PubMed
    33. Panasevich MR, Morris EM, Chintapalli SV, Wankhade UD, Shankar K, Britton SL, Koch LG, Thyfault JP, Rector RS. Gut microbiota are linked to increased susceptibility to hepatic steatosis in low-aerobic-capacity rats fed an acute high-fat diet. Am J Physiol Gastrointest Liver Physiol. 2016 07 01; 311(1):G166-79. PMID: 27288420.
      View in: PubMed
    34. Wankhade UD, Shen M, Kolhe R, Fulzele S. Advances in Adipose-Derived Stem Cells Isolation, Characterization, and Application in Regenerative Tissue Engineering. Stem Cells Int. 2016; 2016:3206807. PMID: 26981130.
      View in: PubMed
    35. Wankhade UD, Good DJ. Melanocortin 4 receptor is a transcriptional target of nescient helix-loop-helix-2. Mol Cell Endocrinol. 2011 Jul 20; 341(1-2):39-47. PMID: 21664420.
      View in: PubMed
    36. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 24056369.
      View in: PubMed
    37. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 23026212.
      View in: PubMed
    38. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 27392497.
      View in: PubMed
    39. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 28605664.
      View in: PubMed
    40. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 29521600.
      View in: PubMed
    41. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 30016149.
      View in: PubMed
    42. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 33969705.
      View in: PubMed
    43. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 37921575.
      View in: PubMed
    44. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 38936927.
      View in: PubMed
    45. Wankhade UD, Vella KR, Fox DL, Good DJ. Deletion of Nhlh2 results in a defective torpor response and reduced Beta adrenergic receptor expression in adipose tissue. PLoS One. 2010 Aug 23; 5(8):e12324. PMID: 20808804.
      View in: PubMed
    46. Guri AJ, Hontecillas R, Ferrer G, Casagran O, Wankhade U, Noble AM, Eizirik DL, Ortis F, Cnop M, Liu D, Si H, Bassaganya-Riera J. Loss of PPAR gamma in immune cells impairs the ability of abscisic acid to improve insulin sensitivity by suppressing monocyte chemoattractant protein-1 expression and macrophage infiltration into white adipose tissue. J Nutr Biochem. 2008 Apr; 19(4):216-28. PMID: 17618105.
      View in: PubMed
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