 Leucine
"Leucine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An essential branched-chain amino acid important for hemoglobin formation.
| Descriptor ID |
D007930
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| MeSH Number(s) |
D12.125.070.637 D12.125.142.441
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| Concept/Terms |
Leucine- Leucine
- L-Leucine
- Leucine, L-Isomer
- L-Isomer Leucine
- Leucine, L Isomer
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Below are MeSH descriptors whose meaning is more general than "Leucine".
Below are MeSH descriptors whose meaning is more specific than "Leucine".
This graph shows the total number of publications written about "Leucine" by people in UAMS Profiles by year, and whether "Leucine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2021 | 0 | 3 | 3 | | 2020 | 3 | 2 | 5 | | 2019 | 2 | 0 | 2 | | 2018 | 2 | 1 | 3 | | 2017 | 2 | 2 | 4 | | 2016 | 3 | 1 | 4 | | 2015 | 2 | 1 | 3 | | 2014 | 1 | 1 | 2 | | 2013 | 4 | 0 | 4 | | 2012 | 0 | 1 | 1 | | 2011 | 3 | 1 | 4 | | 2009 | 3 | 2 | 5 | | 2008 | 0 | 2 | 2 | | 2007 | 0 | 1 | 1 | | 2006 | 1 | 1 | 2 | | 2004 | 3 | 1 | 4 | | 2003 | 0 | 2 | 2 | | 2002 | 2 | 2 | 4 | | 2000 | 1 | 2 | 3 | | 1999 | 0 | 1 | 1 | | 1998 | 0 | 1 | 1 | | 1997 | 0 | 1 | 1 | | 1996 | 0 | 1 | 1 | | 1995 | 0 | 2 | 2 | | 1992 | 2 | 0 | 2 | | 1989 | 1 | 1 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Leucine" by people in Profiles over the past ten years.
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Saben JL, Sims CR, Pack L, Lan R, Børsheim E, Andres A. Infant intakes of human milk branched chain amino acids are negatively associated with infant growth and influenced by maternal body mass index. Pediatr Obes. 2022 05; 17(5):e12876.
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Arentson-Lantz EJ, Mikovic J, Bhattarai N, Fry CS, Lamon S, Porter C, Paddon-Jones D. Leucine augments specific skeletal muscle mitochondrial respiratory pathways during recovery following 7 days of physical inactivity in older adults. J Appl Physiol (1985). 2021 05 01; 130(5):1522-1533.
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Ten Have GAM, Jansen L, Schooneman MG, Engelen MPKJ, Deutz NEP. Metabolic flux analysis of branched-chain amino and keto acids (BCAA, BCKA) and ß-hydroxy ß-methylbutyric acid across multiple organs in the pig. Am J Physiol Endocrinol Metab. 2021 03 01; 320(3):E629-E640.
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Vlachos A, Atsidaftos E, Lababidi ML, Muir E, Rogers ZR, Alhushki W, Bernstein J, Glader B, Gruner B, Hartung H, Knoll C, Loew T, Nalepa G, Narla A, Panigrahi AR, Sieff CA, Walkovich K, Farrar JE, Lipton JM. L-leucine improves anemia and growth in patients with transfusion-dependent Diamond-Blackfan anemia: Results from a multicenter pilot phase I/II study from the Diamond-Blackfan Anemia Registry. Pediatr Blood Cancer. 2020 12; 67(12):e28748.
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Manjarín R, Boutry-Regard C, Suryawan A, Canovas A, Piccolo BD, Maj M, Abo-Ismail M, Nguyen HV, Fiorotto ML, Davis TA. Intermittent leucine pulses during continuous feeding alters novel components involved in skeletal muscle growth of neonatal pigs. Amino Acids. 2020 Sep; 52(9):1319-1335.
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Khalifa OA, Imtiaz F, Ramzan K, Zaki O, Gamal R, Elbaik L, Rihan S, Salam E, Abdul-Mawgoud R, Hassan M, Hassan N, Saleh E, Seoudi D, Moustafa AS. Genotype-phenotype correlation of 33 patients with maple syrup urine disease. Am J Med Genet A. 2020 11; 182(11):2486-2500.
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Gwin JA, Church DD, Wolfe RR, Ferrando AA, Pasiakos SM. Muscle Protein Synthesis and Whole-Body Protein Turnover Responses to Ingesting Essential Amino Acids, Intact Protein, and Protein-Containing Mixed Meals with Considerations for Energy Deficit. Nutrients. 2020 Aug 15; 12(8).
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Bauer JM, Mikušová L, Verlaan S, Bautmans I, Brandt K, Donini LM, Maggio M, Mets T, Wijers SLJ, Garthoff JA, Luiking Y, Sieber C, Cederholm T. Safety and tolerability of 6-month supplementation with a vitamin D, calcium and leucine-enriched whey protein medical nutrition drink in sarcopenic older adults. Aging Clin Exp Res. 2020 Aug; 32(8):1501-1514.
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Liberman K, Njemini R, Luiking Y, Forti LN, Verlaan S, Bauer JM, Memelink R, Brandt K, Donini LM, Maggio M, Mets T, Wijers SLJ, Sieber C, Cederholm T, Bautmans I. Thirteen weeks of supplementation of vitamin D and leucine-enriched whey protein nutritional supplement attenuates chronic low-grade inflammation in sarcopenic older adults: the PROVIDE study. Aging Clin Exp Res. 2019 Jun; 31(6):845-854.
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Hamarsland H, Aas SN, Nordengen AL, Holte K, Garthe I, Paulsen G, Cotter M, Børsheim E, Benestad HB, Raastad T. Native Whey Induces Similar Post Exercise Muscle Anabolic Responses as Regular Whey, Despite Greater Leucinemia, in Elderly Individuals. J Nutr Health Aging. 2019; 23(1):42-50.
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Jonker R, Deutz NEP, Schols AMWJ, Veley EA, Harrykissoon R, Zachria AJ, Engelen MPKJ. Whole body protein anabolism in COPD patients and healthy older adults is not enhanced by adding either carbohydrates or leucine to a serving of protein. Clin Nutr. 2019 08; 38(4):1684-1691.
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Dijk FJ, van Dijk M, Walrand S, van Loon LJC, van Norren K, Luiking YC. Differential effects of leucine and leucine-enriched whey protein on skeletal muscle protein synthesis in aged mice. Clin Nutr ESPEN. 2018 04; 24:127-133.
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Jonker R, Deutz NEP, Harrykissoon R, Zachria AJ, Veley EA, Engelen MPKJ. A critical evaluation of the anabolic response after bolus or continuous feeding in COPD and healthy older adults. Clin Sci (Lond). 2018 01 16; 132(1):17-31.
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Hamarsland H, Nordengen AL, Nyvik Aas S, Holte K, Garthe I, Paulsen G, Cotter M, Børsheim E, Benestad HB, Raastad T. Native whey protein with high levels of leucine results in similar post-exercise muscular anabolic responses as regular whey protein: a randomized controlled trial. J Int Soc Sports Nutr. 2017; 14:43.
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Chanet A, Verlaan S, Salles J, Giraudet C, Patrac V, Pidou V, Pouyet C, Hafnaoui N, Blot A, Cano N, Farigon N, Bongers A, Jourdan M, Luiking Y, Walrand S, Boirie Y. Supplementing Breakfast with a Vitamin D and Leucine-Enriched Whey Protein Medical Nutrition Drink Enhances Postprandial Muscle Protein Synthesis and Muscle Mass in Healthy Older Men. J Nutr. 2017 12; 147(12):2262-2271.
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Jäger R, Kerksick CM, Campbell BI, Cribb PJ, Wells SD, Skwiat TM, Purpura M, Ziegenfuss TN, Ferrando AA, Arent SM, Smith-Ryan AE, Stout JR, Arciero PJ, Ormsbee MJ, Taylor LW, Wilborn CD, Kalman DS, Kreider RB, Willoughby DS, Hoffman JR, Krzykowski JL, Antonio J. International Society of Sports Nutrition Position Stand: protein and exercise. J Int Soc Sports Nutr. 2017; 14:20.
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de Betue CTI, Garcia Casal XC, van Waardenburg DA, Schexnayder SM, Joosten KFM, Deutz NEP, Engelen MPKJ. 24-Hour protein, arginine and citrulline metabolism in fed critically ill children - A stable isotope tracer study. Clin Nutr. 2017 06; 36(3):876-887.
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Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Effectiveness of essential amino acid supplementation in stimulating whole body net protein anabolism is comparable between COPD patients and healthy older adults. Metabolism. 2017 Apr; 69:120-129.
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Kramer IF, Verdijk LB, Hamer HM, Verlaan S, Luiking YC, Kouw IWK, Senden JM, van Kranenburg J, Gijsen AP, Bierau J, Poeze M, van Loon LJC. Both basal and post-prandial muscle protein synthesis rates, following the ingestion of a leucine-enriched whey protein supplement, are not impaired in sarcopenic older males. Clin Nutr. 2017 10; 36(5):1440-1449.
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Church DD, Schwarz NA, Spillane MB, McKinley-Barnard SK, Andre TL, Ramirez AJ, Willoughby DS. l-Leucine Increases Skeletal Muscle IGF-1 but Does Not Differentially Increase Akt/mTORC1 Signaling and Serum IGF-1 Compared to Ursolic Acid in Response to Resistance Exercise in Resistance-Trained Men. J Am Coll Nutr. 2016 Sep-Oct; 35(7):627-638.
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van Dijk M, Dijk FJ, Bunschoten A, van Dartel DA, van Norren K, Walrand S, Jourdan M, Verlaan S, Luiking Y. Improved muscle function and quality after diet intervention with leucine-enriched whey and antioxidants in antioxidant deficient aged mice. Oncotarget. 2016 Apr 05; 7(14):17338-55.
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Kramer IF, Verdijk LB, Hamer HM, Verlaan S, Luiking Y, Kouw IW, Senden JM, van Kranenburg J, Gijsen AP, Poeze M, van Loon LJ. Impact of the Macronutrient Composition of a Nutritional Supplement on Muscle Protein Synthesis Rates in Older Men: A Randomized, Double Blind, Controlled Trial. J Clin Endocrinol Metab. 2015 Nov; 100(11):4124-32.
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Luiking YC, Abrahamse E, Ludwig T, Boirie Y, Verlaan S. Protein type and caloric density of protein supplements modulate postprandial amino acid profile through changes in gastrointestinal behaviour: A randomized trial. Clin Nutr. 2016 Feb; 35(1):48-58.
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Tsien C, Davuluri G, Singh D, Allawy A, Ten Have GA, Thapaliya S, Schulze JM, Barnes D, McCullough AJ, Engelen MP, Deutz NE, Dasarathy S. Metabolic and molecular responses to leucine-enriched branched chain amino acid supplementation in the skeletal muscle of alcoholic cirrhosis. Hepatology. 2015 Jun; 61(6):2018-29.
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Lee SM, Goellner JJ, O'Brien CA, Pike JW. A humanized mouse model of hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia. Endocrinology. 2014 Nov; 155(11):4137-48.
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Luiking YC, Deutz NE, Memelink RG, Verlaan S, Wolfe RR. Postprandial muscle protein synthesis is higher after a high whey protein, leucine-enriched supplement than after a dairy-like product in healthy older people: a randomized controlled trial. Nutr J. 2014 Jan 22; 13:9.
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Salles J, Chanet A, Giraudet C, Patrac V, Pierre P, Jourdan M, Luiking YC, Verlaan S, Migné C, Boirie Y, Walrand S. 1,25(OH)2-vitamin D3 enhances the stimulating effect of leucine and insulin on protein synthesis rate through Akt/PKB and mTOR mediated pathways in murine C2C12 skeletal myotubes. Mol Nutr Food Res. 2013 Dec; 57(12):2137-46.
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Jonker R, Deutz NE, Erbland ML, Anderson PJ, Engelen MP. Hydrolyzed casein and whey protein meals comparably stimulate net whole-body protein synthesis in COPD patients with nutritional depletion without an additional effect of leucine co-ingestion. Clin Nutr. 2014 Apr; 33(2):211-20.
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Jourdan M, Deutz NE, Cynober L, Aussel C. Consequences of age-related splanchnic sequestration of leucine on interorgan glutamine metabolism in old rats. J Appl Physiol (1985). 2013 Jul 15; 115(2):229-34.
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She P, Olson KC, Kadota Y, Inukai A, Shimomura Y, Hoppel CL, Adams SH, Kawamata Y, Matsumoto H, Sakai R, Lang CH, Lynch CJ. Leucine and protein metabolism in obese Zucker rats. PLoS One. 2013; 8(3):e59443.
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