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Search Results to Robert Reis

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One or more keywords matched the following properties of Reis, Robert

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overview My research group has been focused for the last 5 years on two areas: (1.) the role of PI 3-kinase in insulin-like signaling and extreme longevity, extending to a 10-fold increase in lifespan for C. elegans nematodes carrying a null mutation; and (2.) protein aggregation as a unifying feature of many or all age-progressive diseases. We have pursued specific aggregate proteins that favor the formation of aggregates (by promoting protein coallescence) or disrupt their clearance (through interference with proteasomes and autophagosomes). We use proteomics to identify proteins in aggregates of Alzheimer's and other human neurodegenerative diseases; their known or predicted structures allow molecular-dynamic simulations of protein-protein and protein-drug interactions. Predictions from in silico studies are then tested in vivo using models of Alzheimer’s and other human neurodegenerative diseases, in the nematode C. elegans, in cultured human cells, and in mouse models of neuropathy. Molecular genetics and bioinformatics provide complementary tools to discover and understand functional interactions. Water under the bridge (previous research): From the start of my research career, I have been fascinated by the genetic regulation of longevity and age-associated diseases. My group characterized a number of mutations that have large effects on lifespan in the nematode C. elegans. We also used gene mapping combined with bioinformatics approaches to discover and characterize the natural variation in genes that modulate lifespan. We found that Rec-8 protein (a cohesin) alters lifespan in nematodes and yeast, and a colleague then showed that it also contributed to the exceptional longevity of bowhead whales. In mammalian genetics, we were the first to identify the Pirin gene on the X chromosome as a determinant of post-menopausal bone loss in women, a discovery subsequently confirmed in a Chinese population. We also pioneered studies of homologous recombination (HR) and its roles in the etiology and subsequent progression of myeloma, prostate and breast cancers. Data from our laboratory, and subsequently many others, support the hypothesis that HR generates genetic diversity from which more highly oncogenic clones emerge by cell selection. We have exploited the heavy dependence of cancer cells on HR to develop synergistic combinations of chemotherapeutic drugs.

One or more keywords matched the following items that are connected to Reis, Robert

Item TypeName
Academic Article Extrachromosomal circular DNA and aging cells.
Academic Article Testing for treatment effects on gene ontology.
Academic Article Direct repeats in mitochondrial DNA and mammalian lifespan.
Academic Article Studies on the molecular-genetic basis of replicative senescence in Werner syndrome and normal fibroblasts.
Academic Article Extrachromosomal circular copies of an 'inter-Alu' unstable sequence in human DNA are amplified during in vitro and in vivo ageing.
Academic Article Gene categories differentially expressed in C. elegans age-1 mutants of extraordinary longevity: new insights from novel data-mining procedures.
Academic Article Lifespan extension in hypomorphic daf-2 mutants of Caenorhabditis elegans is partially mediated by glutathione transferase CeGSTP2-2.
Concept Alleles
Concept Amino Acid Sequence
Concept Genes
Concept Multigene Family
Concept Base Sequence
Concept Epistasis, Genetic
Concept DNA, Recombinant
Concept Molecular Structure
Concept Gene Rearrangement
Concept Molecular Sequence Data
Concept Genes, Helminth
Concept Gene Expression
Concept Gene Expression Regulation, Viral
Concept Gene Expression Regulation, Enzymologic
Concept Sequence Homology
Concept Gene Amplification
Concept Gene Library
Concept Proto-Oncogenes
Concept Transcriptome
Concept Gene Regulatory Networks
Concept Gene Expression Regulation, Developmental
Concept Gene Expression Regulation
Concept Oncogenes
Concept Genes, Regulator
Concept Catalytic Domain
Concept Genes, Viral
Concept Genome, Human
Concept Genes, ras
Concept Gene Deletion
Concept Repetitive Sequences, Nucleic Acid
Concept Templates, Genetic
Concept Genes, BRCA1
Concept Gene Expression Profiling
Concept Genes, Essential
Concept Gene Knockdown Techniques
Concept Polymorphism, Single Nucleotide
Concept Quantitative Trait Loci
Concept Nucleotide Motifs
Concept Gene Expression Regulation, Neoplastic
Concept Genes, Insect
Academic Article Longevity-determining genes in Caenorhabditis elegans: chromosomal mapping of multiple noninteractive loci.
Academic Article A peptide nucleic acid targeting nuclear RAD51 sensitizes multiple myeloma cells to melphalan treatment.
Academic Article Stability analysis of a model gene network links aging, stress resistance, and negligible senescence.
Academic Article Interpretation, design, and analysis of gene array expression experiments.
Academic Article Remarkable longevity and stress resistance of nematode PI3K-null mutants.
Academic Article Extreme-longevity mutations orchestrate silencing of multiple signaling pathways.
Academic Article Defining genes that govern longevity in Caenorhabditis elegans.
Academic Article Dysfunctional homologous recombination mediates genomic instability and progression in myeloma.
Academic Article Diverse Caenorhabditis elegans genes that are upregulated in dauer larvae also show elevated transcript levels in long-lived, aged, or starved adults.
Academic Article Dissecting the gene network of dietary restriction to identify evolutionarily conserved pathways and new functional genes.
Academic Article Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes.
Academic Article Caenorhabditis elegans PI3K mutants reveal novel genes underlying exceptional stress resistance and lifespan.
Academic Article Quantitative trait loci define genes and pathways underlying genetic variation in longevity.
Academic Article Expression of SV40 large T antigen stimulates reversion of a chromosomal gene duplication in human cells.
Academic Article Induction of duplication reversion in human fibroblasts, by wild-type and mutated SV40 T antigen, covaries with the ability to induce host DNA synthesis.
Academic Article A Cyclin-Dependent Kinase Inhibitor, Dinaciclib, Impairs Homologous Recombination and Sensitizes Multiple Myeloma Cells to PARP Inhibition.
Academic Article Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.
Academic Article Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans.
Academic Article Telomerase inhibition and cell growth arrest after telomestatin treatment in multiple myeloma.
Academic Article Interclonal variation in methylation patterns for expressed and non-expressed genes.
Academic Article Expression of alpha- and beta-human chorionic gonadotropin subunits in cultured human cells.
Academic Article Methylation patterns in the gene for the alpha subunit of chorionic gonadotropin are inherited with variable fidelity in clonal lineages of human fibroblasts.
Academic Article c-Ha-ras-1 proto-oncogene amplification and overexpression during the limited replicative life span of normal human fibroblasts.
Academic Article Cellular and molecular biomarkers indicate precocious in vitro senescence in fibroblasts from SAMP6 mice. Evidence supporting a murine model of premature senescence and osteopenia.
Academic Article Werner syndrome: a molecular genetic hypothesis.
Academic Article Homologous plasmid recombination is elevated in immortally transformed cells.
Academic Article Clonal variation in gene methylation: c-H-ras and alpha-hCG regions vary independently in human fibroblast lineages.
Academic Article From QTL mapping to genes: the long and winding road.
Academic Article Diverse gene sequences are overexpressed in werner syndrome fibroblasts undergoing premature replicative senescence.
Academic Article Apolipoprotein E4 inhibits autophagy gene products through direct, specific binding to CLEAR motifs.
Grant Polymorphic Genes Modulating Lifespan in C Elegans
Academic Article A universal transcriptomic signature of age reveals the temporal scaling of Caenorhabditis elegans aging trajectories.
Academic Article Interaction of adeno-associated virus Rep78 with SV40 T antigen: implications in Rep protein expression leading to the inhibition of SV40-mediated cell proliferation.
Academic Article Expression of AAV Rep proteins in SV40-transformed and untransformed cells: reciprocal interaction with host DNA synthesis.
Academic Article Changes in genetic organization and expression in aging cells.

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