 Gene Amplification
"Gene Amplification" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A selective increase in the number of copies of a gene coding for a specific protein without a proportional increase in other genes. It occurs naturally via the excision of a copy of the repeating sequence from the chromosome and its extrachromosomal replication in a plasmid, or via the production of an RNA transcript of the entire repeating sequence of ribosomal RNA followed by the reverse transcription of the molecule to produce an additional copy of the original DNA sequence. Laboratory techniques have been introduced for inducing disproportional replication by unequal crossing over, uptake of DNA from lysed cells, or generation of extrachromosomal sequences from rolling circle replication.
| Descriptor ID |
D005784
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| MeSH Number(s) |
G05.355.315.250 G05.355.600.315 G05.365.590.310
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Gene Amplification".
Below are MeSH descriptors whose meaning is more specific than "Gene Amplification".
This graph shows the total number of publications written about "Gene Amplification" by people in UAMS Profiles by year, and whether "Gene Amplification" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 | | 2019 | 1 | 1 | 2 | | 2018 | 0 | 1 | 1 | | 2016 | 1 | 0 | 1 | | 2015 | 1 | 1 | 2 | | 2014 | 1 | 0 | 1 | | 2013 | 0 | 1 | 1 | | 2012 | 1 | 1 | 2 | | 2010 | 0 | 3 | 3 | | 2009 | 2 | 1 | 3 | | 2007 | 0 | 2 | 2 | | 2005 | 1 | 1 | 2 | | 2004 | 0 | 1 | 1 | | 2003 | 0 | 1 | 1 | | 1999 | 1 | 0 | 1 | | 1998 | 0 | 1 | 1 | | 1997 | 1 | 0 | 1 | | 1996 | 0 | 2 | 2 | | 1993 | 1 | 1 | 2 | | 1990 | 1 | 1 | 2 | | 1989 | 0 | 2 | 2 |
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Below are the most recent publications written about "Gene Amplification" by people in Profiles over the past ten years.
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Johnson TS, Sudha P, Liu E, Becker N, Robertson S, Blaney P, Morgan G, Chopra VS, Dos Santos C, Nixon M, Huang K, Suvannasankha A, Zaid MA, Abonour R, Walker BA. 1q amplification and PHF19 expressing high-risk cells are associated with relapsed/refractory multiple myeloma. Nat Commun. 2024 May 16; 15(1):4144.
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Wilcock DM, McMurtry V, Coleman JF, Kim JT, Khalili P, Deftereos G, Albertson D, Gulbahce EH, Liu T, Sirohi D. Histopathological Correlation of Chromosome 12 Polysomy by Fluorescence in Situ Hybridization in Adipocytic Neoplasms. Int J Surg Pathol. 2022 Oct; 30(7):734-742.
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Mohan M, Weinhold N, Schinke C, Thanedrarajan S, Rasche L, Sawyer JR, Tian E, van Rhee F, Zangari M. Daratumumab in high-risk relapsed/refractory multiple myeloma patients: adverse effect of chromosome 1q21 gain/amplification and GEP70 status on outcome. Br J Haematol. 2020 04; 189(1):67-71.
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Farra C, Fedda F, Tfayli A, Tawil A, Zaatari G, Ashkar H, Issa G, Boulos F. The Impact of Partial Weak Staining in Normal Breast Epithelium on the Reliability of Immunohistochemistry Results in HercepTest-positive Breast Cancer. Clin Breast Cancer. 2019 10; 19(5):340-344.
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Hovelson DH, Udager AM, McDaniel AS, Grivas P, Palmbos P, Tamura S, Lazo de la Vega L, Palapattu G, Veeneman B, El-Sawy L, Sadis SE, Morgan TM, Montgomery JS, Weizer AZ, Day KC, Neamati N, Liebert M, Keller ET, Day ML, Mehra R, Tomlins SA. Targeted DNA and RNA Sequencing of Paired Urothelial and Squamous Bladder Cancers Reveals Discordant Genomic and Transcriptomic Events and Unique Therapeutic Implications. Eur Urol. 2018 12; 74(6):741-753.
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Bock F, Lu G, Srour SA, Gaballa S, Lin HY, Baladandayuthapani V, Honhar M, Stich M, Shah ND, Bashir Q, Patel K, Popat U, Hosing C, Korbling M, Delgado R, Rondon G, Shah JJ, Thomas SK, Manasanch EE, Isermann B, Orlowski RZ, Champlin RE, Qazilbash MH. Outcome of Patients with Multiple Myeloma and CKS1B Gene Amplification after Autologous Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2016 12; 22(12):2159-2164.
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McDaniel AS, Hovelson DH, Cani AK, Liu CJ, Zhai Y, Zhang Y, Weizer AZ, Mehra R, Feng FY, Alva AS, Morgan TM, Montgomery JS, Siddiqui J, Sadis S, Bandla S, Williams PD, Cho KR, Rhodes DR, Tomlins SA. Genomic Profiling of Penile Squamous Cell Carcinoma Reveals New Opportunities for Targeted Therapy. Cancer Res. 2015 Dec 15; 75(24):5219-27.
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Xiang Z, Abdallah AO, Govindarajan R, Mehta P, Emanuel PD, Papenhausen P, Schichman SA. MYC amplification in multiple marker chromosomes and EZH2 microdeletion in a man with acute myeloid leukemia. Cancer Genet. 2015 Mar; 208(3):96-100.
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