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Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes.
Ayyadevara S, Balasubramaniam M, Gao Y, Yu LR, Alla R, Shmookler Reis R. Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes. Aging Cell. 2015 Feb; 14(1):35-48.
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PubMed
subject areas
Amyloid beta-Peptides
Animals
Blotting, Western
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Cell Death
Disease Models, Animal
Fertility
Fluorescent Antibody Technique
Gene Knockdown Techniques
Molecular Dynamics Simulation
Neurodegenerative Diseases
Proteasome Endopeptidase Complex
Proteasome Inhibitors
Protein Multimerization
RNA Interference
Ubiquitin
authors with profiles
Robert Reis
Srinivas Ayyadevara
Meenakshisundaram Balasubraman