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Search Results to Alan Tackett

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overview My laboratory focuses on histone epigenetic mechanisms that regulate gene transcription and that are coupled to melanoma progression. We utilize a suite of techniques in our studies including proteomics of human biopsies, immunohistochemistry, cell culture, tumorigenicity assays, ChIPseq, biochemical and proteomic approaches for analyses of protein complexes, and cutting-edge mass spectrometry for the analysis of histone post-translational modifications. We have a unique environment that provides for discovery-based studies like proteomics as well as hypothesis-driven studies like those we perform in cell culture and with skin biopsies. In addition to our melanoma work, we develop new technologies for epigenetic studies such as tools for detection of in vivo protein interactions and quantitative assays for histone modifying proteins.

One or more keywords matched the following items that are connected to Tackett, Alan

Item TypeName
Academic Article Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF.
Academic Article The mobile nucleoporin Nup2p and chromatin-bound Prp20p function in endogenous NPC-mediated transcriptional control.
Academic Article Proteomic and genomic characterization of chromatin complexes at a boundary.
Academic Article Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro.
Academic Article I-DIRT, a general method for distinguishing between specific and nonspecific protein interactions.
Academic Article A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.
Academic Article Saccharomyces cerevisiae Yta7 regulates histone gene expression.
Academic Article NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations.
Academic Article Last step in the conversion of trehalose to glycogen: a mycobacterial enzyme that transfers maltose from maltose 1-phosphate to glycogen.
Academic Article Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitro.
Academic Article Identification of small molecule inhibitors of Jumonji AT-rich interactive domain 1B (JARID1B) histone demethylase by a sensitive high throughput screen.
Academic Article Misregulation of Rad50 expression in melanoma cells.
Academic Article Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini.
Academic Article Physical and functional interaction between yeast Pif1 helicase and Rim1 single-stranded DNA binding protein.
Academic Article A noncanonical bromodomain in the AAA ATPase protein Yta7 directs chromosomal positioning and barrier chromatin activity.
Academic Article Synergistic functions of SII and p300 in productive activator-dependent transcription of chromatin templates.
Academic Article Mapping the local protein interactome of the NuA3 histone acetyltransferase.
Academic Article ChAP-MS: a method for identification of proteins and histone posttranslational modifications at a single genomic locus.
Academic Article Analysis of stable and transient protein-protein interactions.
Academic Article Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes.
Academic Article GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome.
Academic Article sarA-mediated repression of protease production plays a key role in the pathogenesis of Staphylococcus aureus USA300 isolates.
Academic Article Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.
Academic Article Genetic and biochemical evaluation of the importance of Cdc6 in regulating mitotic exit.
Academic Article Development and evaluation of a structural model for SF1B helicase Dda.
Academic Article A quantitative proteomic analysis of FFPE melanoma.
Academic Article Purification of a specific native genomic locus for proteomic analysis.
Concept Blood Proteins
Concept Bacterial Proteins
Concept Fungal Proteins
Concept Eye Proteins
Concept DNA-Binding Proteins
Concept Chromosomal Proteins, Non-Histone
Concept Intermediate Filament Proteins
Concept Membrane Proteins
Concept Microfilament Proteins
Concept Proteins
Concept 14-3-3 Proteins
Concept Repressor Proteins
Concept Oncogene Proteins, Fusion
Concept Protozoan Proteins
Concept Recombinant Proteins
Concept T-Box Domain Proteins
Concept Homeodomain Proteins
Concept Mitochondrial Proteins
Concept Xenopus Proteins
Concept Nuclear Pore Complex Proteins
Concept Adaptor Proteins, Signal Transducing
Concept Proto-Oncogene Proteins c-mos
Concept tau Proteins
Concept Polycomb-Group Proteins
Concept Viral Proteins
Concept Nerve Tissue Proteins
Concept Proto-Oncogene Proteins c-myb
Concept Saccharomyces cerevisiae Proteins
Concept RNA-Binding Proteins
Concept Viral Nonstructural Proteins
Concept Intracellular Signaling Peptides and Proteins
Concept Cell Cycle Proteins
Concept Membrane Transport Proteins
Concept Proto-Oncogene Proteins c-ret
Concept Proto-Oncogene Proteins c-met
Concept Neoplasm Proteins
Concept Co-Repressor Proteins
Concept Cyclin-Dependent Kinase Inhibitor Proteins
Concept Poly(A)-Binding Proteins
Concept Nuclear Proteins
Concept Recombinant Fusion Proteins
Academic Article TBX2 blocks myogenesis and promotes proliferation in rhabdomyosarcoma cells.
Academic Article A CRISPR-based approach for proteomic analysis of a single genomic locus.
Academic Article A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions.
Academic Article Purification of specific chromatin loci for proteomic analysis.
Academic Article Methylation of histone H3K23 blocks DNA damage in pericentric heterochromatin during meiosis.
Academic Article The bromodomain of Gcn5 regulates site specificity of lysine acetylation on histone H3.
Academic Article Disruption of BRD4 at H3K27Ac-enriched enhancer region correlates with decreased c-Myc expression in Merkel cell carcinoma.
Academic Article Yeast transcription co-activator Sub1 and its human homolog PC4 preferentially bind to G-quadruplex DNA.
Academic Article Proteomic Identification of DNA-PK Involvement within the RET Signaling Pathway.
Academic Article Bioorthogonal labeling cell-surface proteins expressed in pancreatic cancer cells to identify potential diagnostic/therapeutic biomarkers.
Academic Article Identification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral Replication.
Academic Article Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls.
Academic Article Impact of sarA and Phenol-Soluble Modulins on the Pathogenesis of Osteomyelitis in Diverse Clinical Isolates of Staphylococcus aureus.
Academic Article Proteomics-Based Identification of Differentially Abundant Proteins from Human Keratinocytes Exposed to Arsenic Trioxide.
Academic Article Proteins that accumulate with age in human skeletal-muscle aggregates contribute to declines in muscle mass and function in Caenorhabditis elegans.
Academic Article Time- and radiation-dose dependent changes in the plasma proteome after total body irradiation of non-human primates: Implications for biomarker selection.
Academic Article KDM5 lysine demethylases are involved in maintenance of 3'UTR length.
Academic Article Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break.
Academic Article Oxidation resistance 1 is a novel senolytic target.
Academic Article Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome.
Academic Article Chromatin-mediated regulators of meiotic recombination revealed by proteomics of a recombination hotspot.
Academic Article Metaproteomics reveals potential mechanisms by which dietary resistant starch supplementation attenuates chronic kidney disease progression in rats.
Grant Melanocortin-4 Receptor Traffic and Signaling
Grant Early Events in Alzheimer Pathogenesis
Grant Analysis of Proteins Involed in Genome Duplication
Grant Development of MassSQUIRM to Quantitatively Measure Lysine Methylation
Grant Discovery and Target Identification of Senolytic Agents
Grant Development of technology for high resolution epigenetic profiling of chromatin
Grant Technology for Identification of Epiproteomes in Tissue Samples
Grant Role of the Leprecan Genes in Skeletal Formation
Grant Biochemistry of recombination in meiosis
Grant Identifying the Epigenetic Regulation of Arsenic Exposure
Grant Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids
Academic Article Proteomic characterization of the arsenic response locus in S. cerevisiae.
Academic Article Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.
Academic Article Characterization of mouse ocular response to a 35-day spaceflight mission: Evidence of blood-retinal barrier disruption and ocular adaptations.
Academic Article PHF19 promotes multiple myeloma tumorigenicity through PRC2 activation and broad H3K27me3 domain formation.
Academic Article Exploiting Correlations between Protein Abundance and the Functional Status of saeRS and sarA To Identify Virulence Factors of Potential Importance in the Pathogenesis of Staphylococcus aureus Osteomyelitis.
Academic Article Durable Suppression of Acquired MEK Inhibitor Resistance in Cancer by Sequestering MEK from ERK and Promoting Antitumor T-cell Immunity.
Academic Article SarA plays a predominant role in controlling the production of extracellular proteases in the diverse clinical isolates of Staphylococcus aureus LAC and UAMS-1.
Academic Article ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.
Academic Article Dysbiotic stress increases the sensitivity of the tumor vasculature to radiotherapy and c-Met inhibitors.
Academic Article A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing.
Academic Article Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer.
Academic Article Phase separation drives aberrant chromatin looping and cancer development.
Academic Article Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic.
Academic Article TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.

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