ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism.
Li J, Galbo PM, Gong W, Storey AJ, Tsai YH, Yu X, Ahn JH, Guo Y, Mackintosh SG, Edmondson RD, Byrum SD, Farrar JE, He S, Cai L, Jin J, Tackett AJ, Zheng D, Wang GG. ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism. Nat Commun. 2021 02 16; 12(1):1045.
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Acetylation
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Animals
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Cell Cycle Proteins
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Cell Differentiation
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Cell Proliferation
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Cell Transformation, Neoplastic
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Chromatin
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Chromosomal Proteins, Non-Histone
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Co-Repressor Proteins
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Disease Models, Animal
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DNA-Binding Proteins
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Enhancer Elements, Genetic
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Gene Expression Regulation, Leukemic
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Genome, Human
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HEK293 Cells
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Hematopoietic Stem Cells
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Histones
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Humans
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Leukemia, Myeloid, Acute
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Mice
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Mice, Inbred BALB C
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Neoplastic Stem Cells
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Oncogene Proteins, Fusion
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Protein Binding
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Transcription Factors