 tau Proteins
"tau Proteins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Microtubule-associated proteins that are mainly expressed in neurons. Tau proteins constitute several isoforms and play an important role in the assembly of tubulin monomers into microtubules and in maintaining the cytoskeleton and axonal transport. Aggregation of specific sets of tau proteins in filamentous inclusions is the common feature of intraneuronal and glial fibrillar lesions (NEUROFIBRILLARY TANGLES; NEUROPIL THREADS) in numerous neurodegenerative disorders (ALZHEIMER DISEASE; TAUOPATHIES).
| Descriptor ID |
D016875
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| MeSH Number(s) |
D12.776.220.600.450.510 D12.776.641.560.510
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| Concept/Terms |
tau Proteins- tau Proteins
- Proteins, tau
- tau Protein
- Protein, tau
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Below are MeSH descriptors whose meaning is more general than "tau Proteins".
Below are MeSH descriptors whose meaning is more specific than "tau Proteins".
This graph shows the total number of publications written about "tau Proteins" by people in UAMS Profiles by year, and whether "tau Proteins" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 2 | 1 | 3 | | 2023 | 0 | 1 | 1 | | 2022 | 0 | 1 | 1 | | 2020 | 2 | 0 | 2 | | 2019 | 2 | 0 | 2 | | 2018 | 0 | 1 | 1 | | 2016 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 | | 2014 | 0 | 2 | 2 | | 2012 | 0 | 1 | 1 | | 2004 | 1 | 1 | 2 | | 2003 | 2 | 0 | 2 |
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Below are the most recent publications written about "tau Proteins" by people in Profiles over the past ten years.
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Figdore DJ, Griswold M, Bornhorst JA, Graff-Radford J, Ramanan VK, Vemuri P, Lowe VJ, Knopman DS, Jack CR, Petersen RC, Algeciras-Schimnich A. Optimizing cutpoints for clinical interpretation of brain amyloid status using plasma p-tau217 immunoassays. Alzheimers Dement. 2024 Sep; 20(9):6506-6516.
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Li W, Petersen RC, Algeciras-Schimnich A, Cogswell PM, Bornhorst JA, Kremers WK, Boeve BF, Jones DT, Botha H, Ramanan VK, Knopman DS, Savica R, Josephs KA, Cliatt-Brown C, Andersen E, Day GS, Graff-Radford NR, Ertekin-Taner N, Lachner C, Wicklund M, van Harten A, Woodruff BK, Caselli RJ, Graff-Radford J. Alzheimer Disease Cerebrospinal Fluid Biomarkers in a Tertiary Neurology Practice. Mayo Clin Proc. 2024 Aug; 99(8):1284-1296.
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Abdelnour C, Young CB, Shahid-Besanti M, Smith A, Wilson EN, Ramos Benitez J, Vossler H, Plastini MJ, Winer JR, Kerchner GA, Cholerton B, Andreasson KI, Henderson VW, Yutsis M, Montine TJ, Tian L, Mormino EC, Poston KL. Plasma pTau181 Reveals a Pathological Signature that Predicts Cognitive Outcomes in Lewy Body Disease. Ann Neurol. 2024 Sep; 96(3):526-538.
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Younes K, Smith V, Johns E, Carlson ML, Winer J, He Z, Henderson VW, Greicius MD, Young CB, Mormino EC. Temporal tau asymmetry spectrum influences divergent behavior and language patterns in Alzheimer's disease. Brain Behav Immun. 2024 Jul; 119:807-817.
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Young CB, Smith V, Karjadi C, Grogan SM, Ang TFA, Insel PS, Henderson VW, Sumner M, Poston KL, Au R, Mormino EC. Speech patterns during memory recall relates to early tau burden across adulthood. Alzheimers Dement. 2024 04; 20(4):2552-2563.
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Algeciras-Schimnich A, Bornhorst JA. Importance of cerebrospinal fluid (CSF) collection protocol for the accurate diagnosis of Alzheimer's disease when using CSF biomarkers. Alzheimers Dement. 2024 05; 20(5):3657-3658.
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Abiose O, Rutledge J, Moran-Losada P, Belloy ME, Wilson EN, He Z, Trelle AN, Channappa D, Romero A, Park J, Yutsis MV, Sha SJ, Andreasson KI, Poston KL, Henderson VW, Wagner AD, Wyss-Coray T, Mormino EC. Post-translational modifications linked to preclinical Alzheimer's disease-related pathological and cognitive changes. Alzheimers Dement. 2024 03; 20(3):1851-1867.
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Manna PR, Bose C, Reddy PH. Downregulation of StAR driven neurosteroid biosynthesis as a distinctive feature in the brains of Alzheimer's disease patients. Biochim Biophys Acta Mol Basis Dis. 2023 08; 1869(6):166757.
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Wilson EN, Young CB, Ramos Benitez J, Swarovski MS, Feinstein I, Vandijck M, Le Guen Y, Kasireddy NM, Shahid M, Corso NK, Wang Q, Kennedy G, Trelle AN, Lind B, Channappa D, Belnap M, Ramirez V, Skylar-Scott I, Younes K, Yutsis MV, Le Bastard N, Quinn JF, van Dyck CH, Nairn A, Fredericks CA, Tian L, Kerchner GA, Montine TJ, Sha SJ, Davidzon G, Henderson VW, Longo FM, Greicius MD, Wagner AD, Wyss-Coray T, Poston KL, Mormino EC, Andreasson KI. Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer's disease. Alzheimers Res Ther. 2022 11 12; 14(1):172.
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Zhao YL, Ou YN, Ma YH, Huang YY, Bi YL, Tan L, Yu JT. Association between Life's Simple 7 and cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact adults: the CABLE study. Alzheimers Res Ther. 2022 05 26; 14(1):74.
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Huang SJ, Ma YH, Bi YL, Shen XN, Hou XH, Cao XP, Ou YN, Zhao B, Dong Q, Tan L, Yu JT. Metabolically healthy obesity and lipids may be protective factors for pathological changes of alzheimer's disease in cognitively normal adults. J Neurochem. 2021 05; 157(3):834-845.
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Arya S, Ganguly P, Arsiccio A, Claud SL, Trapp B, Schonfeld GE, Liu X, Lazar Cantrell K, Shea JE, Bowers MT. Terminal Capping of an Amyloidogenic Tau Fragment Modulates Its Fibrillation Propensity. J Phys Chem B. 2020 10 08; 124(40):8772-8783.
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Ahmad RHMA, Fakhoury M, Lawand N. Electromagnetic Field in Alzheimer's Disease: A Literature Review of Recent Preclinical and Clinical Studies. Curr Alzheimer Res. 2020; 17(11):1001-1012.
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Pase MP, Himali JJ, Aparicio HJ, Romero JR, Satizabal CL, Maillard P, DeCarli C, Beiser AS, Seshadri S. Plasma total-tau as a biomarker of stroke risk in the community. Ann Neurol. 2019 09; 86(3):463-467.
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Melchior B, Mittapalli GK, Lai C, Duong-Polk K, Stewart J, G?ner B, Hofilena B, Tjitro A, Anderson SD, Herman DS, Dellamary L, Swearingen CJ, Sunil KC, Yazici Y. Tau pathology reduction with SM07883, a novel, potent, and selective oral DYRK1A inhibitor: A potential therapeutic for Alzheimer's disease. Aging Cell. 2019 10; 18(5):e13000.
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Fertan E, Wong AA, Vienneau NA, Brown RE. Age and sex differences in motivation and spatial working memory in 3xTg-AD mice in the Hebb-Williams maze. Behav Brain Res. 2019 09 16; 370:111937.
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G?r E, Fertan E, Kosel F, Wong AA, Balci F, Brown RE. Sex differences in the timing behavior performance of 3xTg-AD and wild-type mice in the peak interval procedure. Behav Brain Res. 2019 03 15; 360:235-243.
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Massaro AN, Wu YW, Bammler TK, Comstock B, Mathur A, McKinstry RC, Chang T, Mayock DE, Mulkey SB, Van Meurs K, Juul S. Plasma Biomarkers of Brain Injury in Neonatal Hypoxic-Ischemic Encephalopathy. J Pediatr. 2018 03; 194:67-75.e1.
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King JL, Wong AA, Brown RE. Age-Related Changes in the Spatial Frequency Threshold of Male and Female 3xTg-AD Mice Using OptoMotry. J Alzheimers Dis. 2018; 62(2):591-596.
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Ayyadevara S, Balasubramaniam M, Parcon PA, Barger SW, Griffin WS, Alla R, Tackett AJ, Mackintosh SG, Petricoin E, Zhou W, Shmookler Reis RJ. Proteins that mediate protein aggregation and cytotoxicity distinguish Alzheimer's hippocampus from normal controls. Aging Cell. 2016 10; 15(5):924-39.
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Robakis D, Cortes E, Clark LN, Vonsattel JP, Virmani T, Alcalay RN, Crary JF, Levy OA. The effect of MAPT haplotype on neocortical Lewy body pathology in Parkinson disease. J Neural Transm (Vienna). 2016 06; 123(6):583-8.
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Colgan N, Siow B, O'Callaghan JM, Harrison IF, Wells JA, Holmes HE, Ismail O, Richardson S, Alexander DC, Collins EC, Fisher EM, Johnson R, Schwarz AJ, Ahmed Z, O'Neill MJ, Murray TK, Zhang H, Lythgoe MF. Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease. Neuroimage. 2016 Jan 15; 125:739-744.
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Deng J, Habib A, Obregon DF, Barger SW, Giunta B, Wang YJ, Hou H, Sawmiller D, Tan J. Soluble amyloid precursor protein alpha inhibits tau phosphorylation through modulation of GSK3? signaling pathway. J Neurochem. 2015 Nov; 135(3):630-7.
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