 Complement C1s
"Complement C1s" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 77-kDa subcomponent of complement C1, encoded by gene C1S, is a SERINE PROTEASE existing as a proenzyme (homodimer) in the intact complement C1 complex. Upon the binding of COMPLEMENT C1Q to antibodies, the activated COMPLEMENT C1R cleaves C1s into two chains, A (heavy) and B (light, the serine protease), linked by disulfide bonds yielding the active C1s. The activated C1s, in turn, cleaves COMPLEMENT C2 and COMPLEMENT C4 to form C4b2a (CLASSICAL C3 CONVERTASE).
| Descriptor ID |
D003173
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| MeSH Number(s) |
D08.811.277.300.290 D12.776.124.486.274.045.290 D12.776.124.486.274.050.290
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| Concept/Terms |
Complement C1s- Complement C1s
- C1s, Complement
- Complement 1s
- C 1 Esterase
- Esterase, C 1
- C1s Complement
- Complement, C1s
- Complement Component 1s
- Component 1s, Complement
- Complement 1 Esterase
- Esterase, Complement 1
- C1 Esterase
- Esterase, C1
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Below are MeSH descriptors whose meaning is more general than "Complement C1s".
Below are MeSH descriptors whose meaning is more specific than "Complement C1s".
This graph shows the total number of publications written about "Complement C1s" by people in UAMS Profiles by year, and whether "Complement C1s" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Complement C1s" by people in Profiles over the past ten years.
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Xavier S, Sahu RK, Bontha SV, Mass V, Taylor RP, Megyesi J, Thielens NM, Portilla D. Complement C1r serine protease contributes to kidney fibrosis. Am J Physiol Renal Physiol. 2019 11 01; 317(5):F1293-F1304.
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