Complement C1r
"Complement C1r" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A 80-kDa subcomponent of complement C1, existing as a SERINE PROTEASE proenzyme in the intact complement C1 complex. When COMPLEMENT C1Q is bound to antibodies, the changed tertiary structure causes autolytic activation of complement C1r which is cleaved into two chains, A (heavy) and B (light, the serine protease), connected by disulfide bonds. The activated C1r serine protease, in turn, activates COMPLEMENT C1S proenzyme by cleaving the Arg426-Ile427 bond. No fragment is released when either C1r or C1s is cleaved.
| Descriptor ID |
D015923
|
| MeSH Number(s) |
D08.811.277.300.280 D12.776.124.486.274.045.280 D12.776.124.486.274.050.280
|
| Concept/Terms |
Complement C1r- Complement C1r
- C1r, Complement
- Complement 1r
- Complement Component 1r
- Component 1r, Complement
- C1r Complement
- Complement, C1r
|
Below are MeSH descriptors whose meaning is more general than "Complement C1r".
Below are MeSH descriptors whose meaning is more specific than "Complement C1r".
This graph shows the total number of publications written about "Complement C1r" by people in UAMS Profiles by year, and whether "Complement C1r" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2019 | 1 | 0 | 1 |
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Below are the most recent publications written about "Complement C1r" by people in Profiles over the past ten years.
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Xavier S, Sahu RK, Bontha SV, Mass V, Taylor RP, Megyesi J, Thielens NM, Portilla D. Complement C1r serine protease contributes to kidney fibrosis. Am J Physiol Renal Physiol. 2019 11 01; 317(5):F1293-F1304.