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Samrat Roy Choudhury

TitleAssistant Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentPeds Pediatrics, College of Medicine
DivisionPeds Hematology
Address1120 Marshall Street
Mail Slot # 512-1
Little Rock AR 72202
Phone501-364-7531
ORCID ORCID Icon0000-0002-6555-3031 Additional info
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    Other Roles
    Organizer and convenor of Arkansas Children's Monthly Research Seminar Series
    Full Member of Winthrop P Rockefeller Cancer Institute Cancer Biology Program

    Collapse Overview 
    Collapse overview
    Epigenetic alterations, including DNA methylation, histone covalent modifications and super-enhancer regulation of exceptional transcriptional states, have attracted a significant amount of attention for the prevention and treatment of different genetic disorders with cancer at the forefront, mainly due to the inherent reversibility of epigenetic states. Acute myeloid leukemia (AML) is the third most prevalent cancer among the hematological malignancies in the United States, presenting with a diverse array of epigenetic abnormalities including chromosomal alterations or recurrent mutations in the epigenetic modifiers.

    Dr. Choudhury’s laboratory investigates the epigenetic regulatory mechanisms at the enhancers and promoters of the critical oncogenes and tumor suppressors that drive malignant proliferation and invasion during leukemogenesis across the molecular subgroups of AML patients. Using the multi-omics platform, we intend to identify the alterations in DNA-methylation, histone covalent modifications, and accessibility of the transcription factors to the aberrantly expressed genes in and outside the topologically assorted domains of the leukemic blasts. We employ a combination of in vitro and in vivo mouse models to design and target CRISPR or small molecule based perturbation strategies to reverse the dysfunctional epigenetic states and malignant growth.


    Collapse Affiliation 
    Collapse member of
    American Association for Research on Cancer (AACR)
    The American Society of Hematology (ASH)
    WPRCI, UAMS Cancer Biology Group
    Collapse collaborator
    https://uams-triprofiles.uams.edu/profiles/profile/127538

    Collapse Biography 
    Collapse education and training
    University of Arkansas for Medical Sciences, AR, USAResearch Associate11/2020Cancer Epigenetics
    Purdue University, IN, USAPostdoctoral Research Assistant08/2016Cancer Epigenetics
    University of Calcutta, IndiaPh.D.06/2013Biotechnology
    Collapse awards and honors
    2024 - 2026DOD/CDMRP Concept Award (Role: PI), US Department of Defense
    2024 - 2026Marion B. Lyon New Scientist Development Award (Role: PI), Marion B. Lyon Foundation
    2024 - 2025UAMS Teams Science Award (Role: MPI), WPRCI, UAMS
    2023 - 2026DOD/CDMRP Idea Development Award (Role: Co-I)), US Department of Defense
    20225P20GM121293 (Role: Project Leader), NIH/NIGMS
    2021 - 2022Seeds of Science (Role: PI), Envoys

    Collapse Research 
    Collapse research overview
    Acute Myeloid Leukemia is the third most prevalent cancer among the hematological malignancies in the United States, presented with a diverse array of epigenetic abnormalities including chromosomal alterations or recurrent mutations in the epigenetic modifiers.
    The Roy Choudhury laboratory investigates the epigenetic regulatory mechanisms at the enhancers and promoters of the critical oncogenes and tumor suppressors that drive malignant proliferation and invasion during leukemogenesis across the molecular subgroups of AML patients. Using the multi-omics platform, we intend to identify the alterations in DNA-methylation, histone covalent modifications and accessibility of the transcription factors to the aberrantly expressed genes in and outside the topologically assorted domains (TAD) of the leukemic blasts. We employ a combination of in vitro and in vivo mouse models to design and target CRISPR or small molecule based perturbation strategies to reverse the dysfunctional epigenetic states and malignant growth.


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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Kaushal A, Roy Choudhury S. SET-NUP214-induced hypermethylation landscape promotes abnormal overexpression of HOXC cluster genes in acute megakaryoblastic leukemia. Genes Dis. 2025 Mar; 12(2):101320. PMID: 39634129.
      View in: PubMed
    2. Frett B, Stephens KE, Koss B, Melnyk S, Farrar J, Saha D, Roy Choudhury S. Enhancer-activated RET confers protection against oxidative stress to KMT2A-rearranged acute myeloid leukemia. Cancer Sci. 2024 Mar; 115(3):963-973. PMID: 38226414.
      View in: PubMed
    3. Roy Choudhury S, Byrum SD, Alkam D, Ashby C, Zhan F, Tackett AJ, Van Rhee F. Expression of integrin ?-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics. Clin Epigenetics. 2023 02 04; 15(1):18. PMID: 36737807.
      View in: PubMed
    4. Roy Choudhury S, Ashby C, Zhan F, van Rhee F. Epigenetic Deregulation of Telomere-Related Genes in Newly Diagnosed Multiple Myeloma Patients. Cancers (Basel). 2021 Dec 17; 13(24). PMID: 34944968.
      View in: PubMed
    5. Choudhury SR, Ashby C, Tytarenko R, Bauer M, Wang Y, Deshpande S, Den J, Schinke C, Zangari M, Thanendrarajan S, Davies FE, van Rhee F, Morgan GJ, Walker BA. The functional epigenetic landscape of aberrant gene expression in molecular subgroups of newly diagnosed multiple myeloma. J Hematol Oncol. 2020 08 06; 13(1):108. PMID: 32762714.
      View in: PubMed
    6. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 22269475.
      View in: PubMed
    7. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 36899866.
      View in: PubMed
    8. Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 28181538.
      View in: PubMed
    9. Choudhury SR, Ordaz J, Lo CL, Damayanti NP, Zhou F, Irudayaraj J. From the Cover: Zinc oxide Nanoparticles-Induced Reactive Oxygen Species Promotes Multimodal Cyto- and Epigenetic Toxicity. Toxicol Sci. 2017 03 01; 156(1):261-274. PMID: 28115643.
      View in: PubMed
    10. Choudhury SR, Cui Y, Narayanan A, Gilley DP, Huda N, Lo CL, Zhou FC, Yernool D, Irudayaraj J. Optogenetic regulation of site-specific subtelomeric DNA methylation. Oncotarget. 2016 Aug 02; 7(31):50380-50391. PMID: 27391261.
      View in: PubMed
    11. Choudhury SR, Cui Y, Lubecka K, Stefanska B, Irudayaraj J. CRISPR-dCas9 mediated TET1 targeting for selective DNA demethylation at BRCA1 promoter. Oncotarget. 2016 Jul 19; 7(29):46545-46556. PMID: 27356740.
      View in: PubMed
    12. Choudhury SR, Cui Y, Milton JR, Li J, Irudayaraj J. Selective increase in subtelomeric DNA methylation: an epigenetic biomarker for malignant glioma. Clin Epigenetics. 2015; 7:107. PMID: 26451167.
      View in: PubMed
    13. Cui Y, Choudhury SR, Irudayaraj J. Quantitative real-time kinetics of optogenetic proteins CRY2 and CIB1/N using single-molecule tools. Anal Biochem. 2014 Aug 01; 458:58-60. PMID: 24780222.
      View in: PubMed
    14. Roy Choudhury S, Ghosh M, Goswami A. Inhibitory effects of sulfur nanoparticles on membrane lipids of Aspergillus niger: a novel route of fungistasis. Curr Microbiol. 2012 Jul; 65(1):91-7. PMID: 22538469.
      View in: PubMed
    15. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 23546420.
      View in: PubMed
    16. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 21350853.
      View in: PubMed
    17. McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 29797260.
      View in: PubMed
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