Header Logo
Keywords
Last Name
Institution
Announcement

You can now add alternative names! Click here to add other names that you've published under.

Igor Koturbash

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentEnvironmental Health Sciences, College of Public Health
Address1238 ED III College of Public Health
220 UAMS Campus Dr.
Mail Slot # 820
Little Rock AR 72205
Phone501-526-6638
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R21AT011107     (KOTURBASH, IGOR)Jan 1, 2022 - Jul 31, 2023
    NIH/National Center for Complementary and Integrative Health - Pass Through: University of Mississippi
    In vitro screening of a unique botanical extract collection for herb-drug interaction (HDI) potential
    Role: Principal Investigator
    80NSSC21K0544     (KOTURBASH, IGOR)Jun 1, 2021 - Aug 14, 2024
    National Aeronautics & Space Administration - Pass Through: Louisiana State University
    Integration of in-silico and in-vivo Models for Determining Preclinical Indicators and/or Integrated Biomarkers of Radiation-Induced Vascular Dysfunction
    Role: Principal Investigator
    15JC1V19P00000044     (KOTURBASH, IGOR)Nov 6, 2018 - Sep 30, 2019
    US Department of Justice
    Analysis of hepatotoxicity of the OxyELITE Pro dietary supplement in a mouse model
    Role: Principal Investigator
    7L-CIV02-0942     (KOTURBASH, IGOR)Aug 15, 2017 - Aug 14, 2018
    US Department of Justice
    Analysis of hepatotoxicity of the OxyELITE Pro dietary supplement in a mouse model
    Role: Principal Investigator
    6L-CIV02-0850     (KOTURBASH, IGOR)Aug 15, 2016 - Aug 14, 2017
    US Department of Justice
    Analysis of hepatotoxicity of the OxyELITE Pro dietary supplement in a mouse model
    Role: Principal Investigator
    000500836     (KOTURBASH, IGOR)Jul 1, 2016 - Jun 30, 2017
    NIH/Nat. Inst. for Occupational Safety & Health - Pass Through: University of Alabama at Birmingham
    Effects of wood burning-associated smoke on satellite DNA
    Role: Principal Investigator
    000500836-020     (KOTURBASH, IGOR)Jul 1, 2016 - Jun 30, 2017
    NIH/Nat. Inst. for Occupational Safety & Health - Pass Through: University of Alabama at Birmingham
    Effects of wood burning-associated smoke on satellite DNA
    Role: Principal Investigator
    P20GM109005     (BOERMA, MARJAN)Jun 24, 2015 - May 31, 2025
    NIH
    Center for Studies of Host Response to Cancer Therapy
    Role: Co-Investigator
    HHSF223201400183C     (KOTURBASH, IGOR)Sep 30, 2014 - Jan 15, 2018
    U.S. Food and Drug Administration
    The Diversity Outbred: A Tool to Improve Preclinical Safety Testing and Pharmacog
    Role: Principal Investigator
    NCC 9-58 95     (BOERMA, MARJAN)Sep 1, 2014 - May 31, 2017
    National Space Biomedical Research Institute - Pass Through: Baylor College of Medicine
    Team Leader for the Radiation Effects Team
    Role: Co-Investigator
    U54MD002329     (CORNELL, CAROL ELLEN)Sep 30, 2007 - Apr 30, 2024
    NIH
    Arkansas Center for Health Disparities (ARCHD): An NIMHD COE
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
    List All   |   Timeline
    1. Clement K, Nemec-Bakk AS, Jun SR, Sridharan V, Patel CM, Williams DK, Newhauser WD, Willey JS, Williams J, Boerma M, Chancellor JC, Koturbash I. Long-term effects of combined exposures to simulated microgravity and galactic cosmic radiation on the mouse lung: sex-specific epigenetic reprogramming. Radiat Environ Biophys. 2025 Mar; 64(1):17-27. PMID: 39841235.
      View in: PubMed
    2. Annam SCVAR, Neal WM, Pandey P, Avula B, Katragunta K, Husain I, Khan SI, Koturbash I, Gurley BJ, Khan IA, Chittiboyina AG. A Combined Approach for Rapid Dereplication of Herb-Drug Interaction Causative Agents in Botanical Extracts-A Molecular Networking Strategy To Identify Potential Pregnane X Receptor (PXR) Modulators in Yohimbe. ACS Omega. 2024 Dec 31; 9(52):51394-51407. PMID: 39758619.
      View in: PubMed
    3. Franks AM, Teeter BS, Davis P, Allred M, Landes RD, Koturbash I, Weber J. First-year evaluation of a campus-wide, cross-disciplinary scholarly writing development program supported by a center for biomedical research excellence (COBRE). PLoS One. 2024; 19(10):e0312322. PMID: 39471171.
      View in: PubMed
    4. Roe AL, Krzykwa J, Calder?n AI, Bascoul C, Gurley BJ, Koturbash I, Li AP, Liu Y, Mitchell CA, Oketch-Rabah H, Si L, van Breemen RB, Walker H, Ferguson SS. Developing a Screening Strategy to Identify Hepatotoxicity and Drug Interaction Potential of Botanicals. J Diet Suppl. 2025; 22(1):162-192. PMID: 39450425.
      View in: PubMed
    5. Wallace TC, Koturbash I. DSHEA 1994 - Celebrating 30 Years of Dietary Supplement Regulation in the United States. J Diet Suppl. 2025; 22(1):1-8. PMID: 39449550.
      View in: PubMed
    6. Koturbash I, Yeager RP, Mitchell CA, Ferguson S, Navarro VJ, Paine MF, Roe AL. Botanical-induced toxicity: Liver injury and botanical-drug interactions. A report on a society of Toxicology Annual Meeting symposium. Regul Toxicol Pharmacol. 2024 Nov; 153:105708. PMID: 39304112.
      View in: PubMed
    7. Gurley BJ, Koturbash I. Phenibut: A drug with one too many "buts". Basic Clin Pharmacol Toxicol. 2024 Oct; 135(4):409-416. PMID: 39197876.
      View in: PubMed
    8. Ewing LE, Skinner CM, McGill MR, Kennon-McGill S, Clement K, Quick CM, Yee EU, Williams DK, Walker LA, ElSohly MA, Gurley BJ, Koturbash I. Human quad liver-on-chip system as a tool toward bridging the gap between animals and humans regarding toxicology and pharmacology of a cannabidiol-rich cannabis extract. Drug Chem Toxicol. 2025 May; 48(3):578-585. PMID: 39155655.
      View in: PubMed
    9. Ewing LE, Harpenau RJ, Skinner CM, Clement K, Quick CM, Yee EU, Williams DK, Walker LA, ElSohly MA, Gurley BJ, Koturbash I. Inter-strain variability in responses to a single administration of the cannabidiol-rich cannabis extract in mice. Food Chem Toxicol. 2024 Oct; 192:114909. PMID: 39128689.
      View in: PubMed
    10. Mattes MD, Koturbash I, Leung CN, Wen S, Jacobson GM. A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy. Nutr Cancer. 2024; 76(6):463-468. PMID: 38591931.
      View in: PubMed
    11. Layman AJ, Alsbrook SM, Koturbash IK, McGill MR. Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements. J Diet Suppl. 2025; 22(1):105-122. PMID: 38562009.
      View in: PubMed
    12. Afshari N, Koturbash I, Boerma M, Newhauser W, Kratz M, Willey J, Williams J, Chancellor J. A Review of Numerical Models of Radiation Injury and Repair Considering Subcellular Targets and the Extracellular Microenvironment. Int J Mol Sci. 2024 Jan 13; 25(2). PMID: 38256089.
      View in: PubMed
    13. Miousse IR, Hale RB, Alsbrook S, Boysen G, Broadnax T, Murry C, Williams C, Park CH, Richards R, Reedy J, Chalbot MC, Kavouras IG, Koturbash I. Climate Change and New Challenges for Rural Communities: Particulate Matter Matters. Sustainability. 2023 Dec 01; 15(23). PMID: 39119507.
      View in: PubMed
    14. Nemec-Bakk AS, Sridharan V, Seawright JW, Nelson GA, Cao M, Singh P, Cheema AK, Singh B, Li Y, Koturbash I, Miousse IR, Ewing LE, Skinner CM, Landes RD, Lowery JD, Mao XW, Singh SP, Boerma M. Effects of proton and oxygen ion irradiation on cardiovascular function and structure in a rabbit model. Life Sci Space Res (Amst). 2023 May; 37:78-87. PMID: 37087182.
      View in: PubMed
    15. Clement K, McGill MR, Miousse IR, Young SG, Melnyk S, Koturbash I. Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells. J Diet Suppl. 2023; 20(6):950-962. PMID: 36469606.
      View in: PubMed
    16. Norton JC, Politis MD, Bimali M, Vyas KS, Bircan E, Nembhard WN, Amick BC, Koturbash I. Analysis of COVID-19 Pandemic on Supplement Usage and Its Combination with Self-Medication within the State of Arkansas. J Diet Suppl. 2023; 20(2):171-198. PMID: 36178162.
      View in: PubMed
    17. Gurley BJ, McGill MR, Koturbash I. Hepatotoxicity due to herbal dietary supplements: Past, present and the future. Food Chem Toxicol. 2022 Nov; 169:113445. PMID: 36183923.
      View in: PubMed
    18. Ewing LE, Pathak R, Landes RD, Skinner CM, Binz R, Young SG, Riklon S, Stahr S, Su J, Boerma M, McElfish PA, Hauer-Jensen M, Koturbash I. Cytogenetic and epigenetic aberrations in peripheral lymphocytes of northwest Arkansas Marshallese. Int J Radiat Biol. 2023; 99(4):644-655. PMID: 35939319.
      View in: PubMed
    19. Ewing LE, Biju PG, Pathak R, Melnyk S, Hauer-Jensen M, Koturbash I. Methods for induction and assessment of intestinal permeability in rodent models of radiation injury. Methods Cell Biol. 2022; 168:235-247. PMID: 35366985.
      View in: PubMed
    20. Binz RL, Sadhukhan R, Miousse IR, Garg S, Koturbash I, Zhou D, Hauer-Jensen M, Pathak R. Dietary Methionine Deficiency Enhances Genetic Instability in Murine Immune Cells. Int J Mol Sci. 2021 Feb 27; 22(5). PMID: 33673497.
      View in: PubMed
    21. Boerma M, Koturbash I. Manned space travel: from a race between nations to a race against the environmental stressors beyond earth. J Environ Sci Health C Toxicol Carcinog. 2021; 39(2):109-112. PMID: 33902390.
      View in: PubMed
    22. Kutanzi KR, Ewing LE, Skinner CM, Quick CM, Kennon-McGill S, McGill MR, Walker LA, ElSohly MA, Gurley BJ, Koturbash I. Safety and Molecular-Toxicological Implications of Cannabidiol-Rich Cannabis Extract and Methylsulfonylmethane Co-Administration. Int J Mol Sci. 2020 Oct 21; 21(20). PMID: 33096940.
      View in: PubMed
    23. Ewing LE, Skinner CM, Pathak R, Yee EU, Krager K, Gurley PC, Melnyk S, Boerma M, Hauer-Jensen M, Koturbash I. Dietary Methionine Supplementation Exacerbates Gastrointestinal Toxicity in a Mouse Model of Abdominal Irradiation. Int J Radiat Oncol Biol Phys. 2021 02 01; 109(2):581-593. PMID: 33002540.
      View in: PubMed
    24. Koturbash I, MacKay D. Cannabidiol and Other Cannabinoids: From Toxicology and Pharmacology to the Development of a Regulatory Pathway. J Diet Suppl. 2020; 17(5):487-492. PMID: 32715797.
      View in: PubMed
    25. Walker LA, Koturbash I, Kingston R, ElSohly MA, Yates CR, Gurley BJ, Khan I. Cannabidiol (CBD) in Dietary Supplements: Perspectives on Science, Safety, and Potential Regulatory Approaches. J Diet Suppl. 2020; 17(5):493-502. PMID: 32543246.
      View in: PubMed
    26. Miousse IR, Tobacyk J, Quick CM, Jamshidi-Parsian A, Skinner CM, Kore R, Melnyk SB, Kutanzi KR, Xia F, Griffin RJ, Koturbash I. Reply to Flugge: the anti-metastatic potential of methionine restriction in melanoma. Carcinogenesis. 2020 05 14; 41(3):390-391. PMID: 31140558.
      View in: PubMed
    27. Skinner CM, Nookaew I, Ewing LE, Wongsurawat T, Jenjaroenpun P, Quick CM, Yee EU, Piccolo BD, ElSohly M, Walker LA, Gurley B, Koturbash I. Potential Probiotic or Trigger of Gut Inflammation - The Janus-Faced Nature of Cannabidiol-Rich Cannabis Extract. J Diet Suppl. 2020; 17(5):543-560. PMID: 32400224.
      View in: PubMed
    28. Miousse IR, Ewing LE, Skinner CM, Pathak R, Garg S, Kutanzi KR, Melnyk S, Hauer-Jensen M, Koturbash I. Methionine dietary supplementation potentiates ionizing radiation-induced gastrointestinal syndrome. Am J Physiol Gastrointest Liver Physiol. 2020 03 01; 318(3):G439-G450. PMID: 31961718.
      View in: PubMed
    29. Ewing LE, McGill MR, Yee EU, Quick CM, Skinner CM, Kennon-McGill S, Clemens M, Vazquez JH, McCullough SS, Williams DK, Kutanzi KR, Walker LA, ElSohly MA, James LP, Gurley BJ, Koturbash I. Paradoxical Patterns of Sinusoidal Obstruction Syndrome-Like Liver Injury in Aged Female CD-1 Mice Triggered by Cannabidiol-Rich Cannabis Extract and Acetaminophen Co-Administration. Molecules. 2019 Jun 17; 24(12). PMID: 31212965.
      View in: PubMed
    30. Miousse IR, Skinner CM, Sridharan V, Seawright JW, Singh P, Landes RD, Cheema AK, Hauer-Jensen M, Boerma M, Koturbash I. Changes in one-carbon metabolism and DNA methylation in the hearts of mice exposed to space environment-relevant doses of oxygen ions (16O). Life Sci Space Res (Amst). 2019 Aug; 22:8-15. PMID: 31421852.
      View in: PubMed
    31. Ewing LE, Skinner CM, Quick CM, Kennon-McGill S, McGill MR, Walker LA, ElSohly MA, Gurley BJ, Koturbash I. Hepatotoxicity of a Cannabidiol-Rich Cannabis Extract in the Mouse Model. Molecules. 2019 Apr 30; 24(9). PMID: 31052254.
      View in: PubMed
    32. Gurley BJ, Miousse IR, Nookaew I, Ewing LE, Skinner CM, Jenjaroenpun P, Wongsurawat T, Kennon-McGill S, Avula B, Bae JY, McGill MR, Ussery D, Khan IA, Koturbash I. Decaffeinated Green Tea Extract Does Not Elicit Hepatotoxic Effects and Modulates the Gut Microbiome in Lean B6C3F1 Mice. Nutrients. 2019 Apr 03; 11(4). PMID: 30987244.
      View in: PubMed
    33. Koturbash I, Griffin RJ. Harnessing epigenetics and metabolism to modulate tissue response to radiotherapy. Int J Radiat Biol. 2019 04; 95(4):379-381. PMID: 30856046.
      View in: PubMed
    34. Seawright JW, Sridharan V, Landes RD, Cao M, Singh P, Koturbash I, Mao XW, Miousse IR, Singh SP, Nelson GA, Hauer-Jensen M, Boerma M. Effects of low-dose oxygen ions and protons on cardiac function and structure in male C57BL/6J mice. Life Sci Space Res (Amst). 2019 Feb; 20:72-84. PMID: 30797436.
      View in: PubMed
    35. Ewing LE, Miousse IR, Pathak R, Skinner CM, Kosanke S, Boerma M, Hauer-Jensen M, Koturbash I. NZO/HlLtJ as a novel model for the studies on the role of metabolic syndrome in acute radiation toxicity. Int J Radiat Biol. 2020 01; 96(1):93-99. PMID: 30561233.
      View in: PubMed
    36. Skinner CM, Miousse IR, Ewing LE, Sridharan V, Cao M, Lin H, Williams DK, Avula B, Haider S, Chittiboyina AG, Khan IA, ElSohly MA, Boerma M, Gurley BJ, Koturbash I. Impact of obesity on the toxicity of a multi-ingredient dietary supplement, OxyELITE Pro? (New Formula), using the novel NZO/HILtJ obese mouse model: Physiological and mechanistic assessments. Food Chem Toxicol. 2018 Dec; 122:21-32. PMID: 30282009.
      View in: PubMed
    37. Miousse IR, Tobacyk J, Quick CM, Jamshidi-Parsian A, Skinner CM, Kore R, Melnyk SB, Kutanzi KR, Xia F, Griffin RJ, Koturbash I. Modulation of dietary methionine intake elicits potent, yet distinct, anticancer effects on primary versus metastatic tumors. Carcinogenesis. 2018 09 21; 39(9):1117-1126. PMID: 29939201.
      View in: PubMed
    38. Koturbash I. 2017 Michael Fry Award Lecture When DNA is Actually Not a Target: Radiation Epigenetics as a Tool to Understand and Control Cellular Response to Ionizing Radiation. Radiat Res. 2018 07; 190(1):5-11. PMID: 29697303.
      View in: PubMed
    39. Miousse IR, Ewing LE, Kutanzi KR, Griffin RJ, Koturbash I. DNA Methylation in Radiation-Induced Carcinogenesis: Experimental Evidence and Clinical Perspectives. Crit Rev Oncog. 2018; 23(1-2):1-11. PMID: 29953365.
      View in: PubMed
    40. Koturbash I. LINE-1 in response to exposure to ionizing radiation. Mob Genet Elements. 2017; 7(6):e1393491. PMID: 29209557.
      View in: PubMed
    41. Lin H, Ewing LE, Koturbash I, Gurley BJ, Miousse IR. MicroRNAs as biomarkers for liver injury: Current knowledge, challenges and future prospects. Food Chem Toxicol. 2017 Dec; 110:229-239. PMID: 29042291.
      View in: PubMed
    42. Herceg Z, Ghantous A, Wild CP, Sklias A, Casati L, Duthie SJ, Fry R, Issa JP, Kellermayer R, Koturbash I, Kondo Y, Lepeule J, Lima SCS, Marsit CJ, Rakyan V, Saffery R, Taylor JA, Teschendorff AE, Ushijima T, Vineis P, Walker CL, Waterland RA, Wiemels J, Ambatipudi S, Degli Esposti D, Hernandez-Vargas H. Roadmap for investigating epigenome deregulation and environmental origins of cancer. Int J Cancer. 2018 03 01; 142(5):874-882. PMID: 28836271.
      View in: PubMed
    43. Miousse IR, Pathak R, Garg S, Skinner CM, Melnyk S, Pavliv O, Hendrickson H, Landes RD, Lumen A, Tackett AJ, Deutz NEP, Hauer-Jensen M, Koturbash I. Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology. Genes Nutr. 2017; 12:22. PMID: 28904640.
      View in: PubMed
    44. Miousse IR, Skinner CM, Lin H, Ewing LE, Kosanke SD, Williams DK, Avula B, Khan IA, ElSohly MA, Gurley BJ, Koturbash I. Safety assessment of the dietary supplement OxyELITE? Pro (New Formula) in inbred and outbred mouse strains. Food Chem Toxicol. 2017 Nov; 109(Pt 1):194-209. PMID: 28843594.
      View in: PubMed
    45. Casero D, Gill K, Sridharan V, Koturbash I, Nelson G, Hauer-Jensen M, Boerma M, Braun J, Cheema AK. Space-type radiation induces multimodal responses in the mouse gut microbiome and metabolome. Microbiome. 2017 08 18; 5(1):105. PMID: 28821301.
      View in: PubMed
    46. Seawright JW, Samman Y, Sridharan V, Mao XW, Cao M, Singh P, Melnyk S, Koturbash I, Nelson GA, Hauer-Jensen M, Boerma M. Effects of low-dose rate ?-irradiation combined with simulated microgravity on markers of oxidative stress, DNA methylation potential, and remodeling in the mouse heart. PLoS One. 2017; 12(7):e0180594. PMID: 28678877.
      View in: PubMed
    47. Miousse IR, Chang J, Shao L, Pathak R, Nzabarushimana ?, Kutanzi KR, Landes RD, Tackett AJ, Hauer-Jensen M, Zhou D, Koturbash I. Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation. Int J Mol Sci. 2017 Jul 04; 18(7). PMID: 28677663.
      View in: PubMed
    48. Miousse IR, Tobacyk J, Melnyk S, James SJ, Cheema AK, Boerma M, Hauer-Jensen M, Koturbash I. One-carbon metabolism and ionizing radiation: a multifaceted interaction. Biomol Concepts. 2017 May 24; 8(2):83-92. PMID: 28574375.
      View in: PubMed
    49. Miousse IR, Murphy LA, Lin H, Schisler MR, Sun J, Chalbot MG, Sura R, Johnson K, LeBaron MJ, Kavouras IG, Schnackenberg LK, Beger RD, Rasoulpour RJ, Koturbash I. Dose-response analysis of epigenetic, metabolic, and apical endpoints after short-term exposure to experimental hepatotoxicants. Food Chem Toxicol. 2017 Nov; 109(Pt 1):690-702. PMID: 28495587.
      View in: PubMed
    50. Miousse IR, Kutanzi KR, Koturbash I. Effects of ionizing radiation on DNA methylation: from experimental biology to clinical applications. Int J Radiat Biol. 2017 05; 93(5):457-469. PMID: 28134023.
      View in: PubMed
    51. Koturbash I, Jadavji NM, Kutanzi K, Rodriguez-Juarez R, Kogosov D, Metz GAS, Kovalchuk O. Fractionated low-dose exposure to ionizing radiation leads to DNA damage, epigenetic dysregulation, and behavioral impairment. Environ Epigenet. 2016 Dec; 2(4):dvw025. PMID: 29492301.
      View in: PubMed
    52. Pathak R, Koturbash I, Hauer-Jensen M. Detection of Inter-chromosomal Stable Aberrations by Multiple Fluorescence In Situ Hybridization (mFISH) and Spectral Karyotyping (SKY) in Irradiated Mice. J Vis Exp. 2017 01 11; (119). PMID: 28117817.
      View in: PubMed
    53. Miousse IR, Koturbash I, Chalbot MC, Hauer-Jensen M, Kavouras I, Pathak R. Analysis of the Ambient Particulate Matter-induced Chromosomal Aberrations Using an In Vitro System. J Vis Exp. 2016 12 21; (118). PMID: 28060322.
      View in: PubMed
    54. Kutanzi KR, Lumen A, Koturbash I, Miousse IR. Pediatric Exposures to Ionizing Radiation: Carcinogenic Considerations. Int J Environ Res Public Health. 2016 10 28; 13(11). PMID: 27801855.
      View in: PubMed
    55. Koturbash I, Merrifield M, Kovalchuk O. Fractionated exposure to low doses of ionizing radiation results in accumulation of DNA damage in mouse spleen tissue and activation of apoptosis in a p53/Atm-independent manner. Int J Radiat Biol. 2017 02; 93(2):148-155. PMID: 27758128.
      View in: PubMed
    56. Prior S, Miousse IR, Nzabarushimana E, Pathak R, Skinner C, Kutanzi KR, Allen AR, Raber J, Tackett AJ, Hauer-Jensen M, Nelson GA, Koturbash I. Densely ionizing radiation affects DNA methylation of selective LINE-1 elements. Environ Res. 2016 10; 150:470-481. PMID: 27419368.
      View in: PubMed
    57. Boerma M, Sridharan V, Mao XW, Nelson GA, Cheema AK, Koturbash I, Singh SP, Tackett AJ, Hauer-Jensen M. Effects of ionizing radiation on the heart. Mutat Res Rev Mutat Res. 2016 Oct - Dec; 770(Pt B):319-327. PMID: 27919338.
      View in: PubMed
    58. Pathak R, Bachri A, Ghosh SP, Koturbash I, Boerma M, Binz RK, Sawyer JR, Hauer-Jensen M. The Vitamin E Analog Gamma-Tocotrienol (GT3) Suppresses Radiation-Induced Cytogenetic Damage. Pharm Res. 2016 09; 33(9):2117-25. PMID: 27216753.
      View in: PubMed
    59. Koturbash I, Miousse IR, Sridharan V, Nzabarushimana E, Skinner CM, Melnyk SB, Pavliv O, Hauer-Jensen M, Nelson GA, Boerma M. Radiation-induced changes in DNA methylation of repetitive elements in the mouse heart. Mutat Res. 2016 May; 787:43-53. PMID: 26963372.
      View in: PubMed
    60. Pirela SV, Lu X, Miousse I, Sisler JD, Qian Y, Guo N, Koturbash I, Castranova V, Thomas T, Godleski J, Demokritou P. Effects of intratracheally instilled laser printer-emitted engineered nanoparticles in a mouse model: A case study of toxicological implications from nanomaterials released during consumer use. NanoImpact. 2016 Jan; 1:1-8. PMID: 26989787.
      View in: PubMed
    61. Boerma M, Nelson GA, Sridharan V, Mao XW, Koturbash I, Hauer-Jensen M. Space radiation and cardiovascular disease risk. World J Cardiol. 2015 Dec 26; 7(12):882-8. PMID: 26730293.
      View in: PubMed
    62. Ramadan SS, Sridharan V, Koturbash I, Miousse IR, Hauer-Jensen M, Nelson GA, Boerma M. A priming dose of protons alters the early cardiac cellular and molecular response to (56)Fe irradiation. Life Sci Space Res (Amst). 2016 Feb; 8:8-13. PMID: 26948008.
      View in: PubMed
    63. Lu X, Miousse IR, Pirela SV, Moore JK, Melnyk S, Koturbash I, Demokritou P. In vivo epigenetic effects induced by engineered nanomaterials: A case study of copper oxide and laser printer-emitted engineered nanoparticles. Nanotoxicology. 2016; 10(5):629-39. PMID: 26559097.
      View in: PubMed
    64. Koturbash I, Tolleson WH, Guo L, Yu D, Chen S, Hong H, Mattes W, Ning B. microRNAs as pharmacogenomic biomarkers for drug efficacy and drug safety assessment. Biomark Med. 2015; 9(11):1153-76. PMID: 26501795.
      View in: PubMed
    65. Miousse IR, Koturbash I. The Fine LINE: Methylation Drawing the Cancer Landscape. Biomed Res Int. 2015; 2015:131547. PMID: 26448926.
      View in: PubMed
    66. Miousse IR, Chalbot MC, Pathak R, Lu X, Nzabarushimana E, Krager K, Aykin-Burns N, Hauer-Jensen M, Demokritou P, Kavouras IG, Koturbash I. In Vitro Toxicity and Epigenotoxicity of Different Types of Ambient Particulate Matter. Toxicol Sci. 2015 Dec; 148(2):473-87. PMID: 26342214.
      View in: PubMed
    67. Nzabarushimana E, Prior S, Miousse IR, Pathak R, Allen AR, Latendresse J, Olsen RH, Raber J, Hauer-Jensen M, Nelson GA, Koturbash I. Combined exposure to protons and (56)Fe leads to overexpression of Il13 and reactivation of repetitive elements in the mouse lung. Life Sci Space Res (Amst). 2015 Nov; 7:1-8. PMID: 26553631.
      View in: PubMed
    68. Miousse IR, Currie R, Datta K, Ellinger-Ziegelbauer H, French JE, Harrill AH, Koturbash I, Lawton M, Mann D, Meehan RR, Moggs JG, O'Lone R, Rasoulpour RJ, Pera RA, Thompson K. Importance of investigating epigenetic alterations for industry and regulators: An appraisal of current efforts by the Health and Environmental Sciences Institute. Toxicology. 2015 Sep 01; 335:11-9. PMID: 26134581.
      View in: PubMed
    69. Pirela SV, Miousse IR, Lu X, Castranova V, Thomas T, Qian Y, Bello D, Kobzik L, Koturbash I, Demokritou P. Effects of Laser Printer-Emitted Engineered Nanoparticles on Cytotoxicity, Chemokine Expression, Reactive Oxygen Species, DNA Methylation, and DNA Damage: A Comprehensive in Vitro Analysis in Human Small Airway Epithelial Cells, Macrophages, and Lymphoblasts. Environ Health Perspect. 2016 Feb; 124(2):210-9. PMID: 26080392.
      View in: PubMed
    70. Goodson WH, Lowe L, Carpenter DO, Gilbertson M, Manaf Ali A, Lopez de Cerain Salsamendi A, Lasfar A, Carnero A, Azqueta A, Amedei A, Charles AK, Collins AR, Ward A, Salzberg AC, Colacci A, Olsen AK, Berg A, Barclay BJ, Zhou BP, Blanco-Aparicio C, Baglole CJ, Dong C, Mondello C, Hsu CW, Naus CC, Yedjou C, Curran CS, Laird DW, Koch DC, Carlin DJ, Felsher DW, Roy D, Brown DG, Ratovitski E, Ryan EP, Corsini E, Rojas E, Moon EY, Laconi E, Marongiu F, Al-Mulla F, Chiaradonna F, Darroudi F, Martin FL, Van Schooten FJ, Goldberg GS, Wagemaker G, Nangami GN, Calaf GM, Williams G, Wolf GT, Koppen G, Brunborg G, Lyerly HK, Krishnan H, Ab Hamid H, Yasaei H, Sone H, Kondoh H, Salem HK, Hsu HY, Park HH, Koturbash I, Miousse IR, Scovassi AI, Klaunig JE, Vondr?cek J, Raju J, Roman J, Wise JP, Whitfield JR, Woodrick J, Christopher JA, Ochieng J, Martinez-Leal JF, Weisz J, Kravchenko J, Sun J, Prudhomme KR, Narayanan KB, Cohen-Solal KA, Moorwood K, Gonzalez L, Soucek L, Jian L, D'Abronzo LS, Lin LT, Li L, Gulliver L, McCawley LJ, Memeo L, Vermeulen L, Leyns L, Zhang L, Valverde M, Khatami M, Romano MF, Chapellier M, Williams MA, Wade M, Manjili MH, Lleonart ME, Xia M, Gonzalez MJ, Karamouzis MV, Kirsch-Volders M, Vaccari M, Kuemmerle NB, Singh N, Cruickshanks N, Kleinstreuer N, van Larebeke N, Ahmed N, Ogunkua O, Krishnakumar PK, Vadgama P, Marignani PA, Ghosh PM, Ostrosky-Wegman P, Thompson PA, Dent P, Heneberg P, Darbre P, Sing Leung P, Nangia-Makker P, Cheng QS, Robey RB, Al-Temaimi R, Roy R, Andrade-Vieira R, Sinha RK, Mehta R, Vento R, Di Fiore R, Ponce-Cusi R, Dornetshuber-Fleiss R, Nahta R, Castellino RC, Palorini R, Abd Hamid R, Langie SA, Eltom SE, Brooks SA, Ryeom S, Wise SS, Bay SN, Harris SA, Papagerakis S, Romano S, Pavanello S, Eriksson S, Forte S, Casey SC, Luanpitpong S, Lee TJ, Otsuki T, Chen T, Massfelder T, Sanderson T, Guarnieri T, Hultman T, Dormoy V, Odero-Marah V, Sabbisetti V, Maguer-Satta V, Rathmell WK, Engstr?m W, Decker WK, Bisson WH, Rojanasakul Y, Luqmani Y, Chen Z, Hu Z. Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead. Carcinogenesis. 2015 Jun; 36 Suppl 1:S254-96. PMID: 26106142.
      View in: PubMed
    71. Ochieng J, Nangami GN, Ogunkua O, Miousse IR, Koturbash I, Odero-Marah V, McCawley LJ, Nangia-Makker P, Ahmed N, Luqmani Y, Chen Z, Papagerakis S, Wolf GT, Dong C, Zhou BP, Brown DG, Colacci AM, Hamid RA, Mondello C, Raju J, Ryan EP, Woodrick J, Scovassi AI, Singh N, Vaccari M, Roy R, Forte S, Memeo L, Salem HK, Amedei A, Al-Temaimi R, Al-Mulla F, Bisson WH, Eltom SE. The impact of low-dose carcinogens and environmental disruptors on tissue invasion and metastasis. Carcinogenesis. 2015 Jun; 36 Suppl 1:S128-59. PMID: 26106135.
      View in: PubMed
    72. Miousse IR, Chalbot MC, Lumen A, Ferguson A, Kavouras IG, Koturbash I. Response of transposable elements to environmental stressors. Mutat Res Rev Mutat Res. 2015 Jul-Sep; 765:19-39. PMID: 26281766.
      View in: PubMed
    73. Lu X, Miousse IR, Pirela SV, Melnyk S, Koturbash I, Demokritou P. Short-term exposure to engineered nanomaterials affects cellular epigenome. Nanotoxicology. 2016; 10(2):140-50. PMID: 25938281.
      View in: PubMed
    74. Camacho L, Basavarajappa MS, Chang CW, Han T, Kobets T, Koturbash I, Surratt G, Lewis SM, Vanlandingham MM, Fuscoe JC, Gamboa da Costa G, Pogribny IP, Delclos KB. Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats. Food Chem Toxicol. 2015 Jul; 81:92-103. PMID: 25862956.
      View in: PubMed
    75. Chang J, Feng W, Wang Y, Luo Y, Allen AR, Koturbash I, Turner J, Stewart B, Raber J, Hauer-Jensen M, Zhou D, Shao L. Whole-body proton irradiation causes long-term damage to hematopoietic stem cells in mice. Radiat Res. 2015 Feb; 183(2):240-8. PMID: 25635345.
      View in: PubMed
    76. Kovalchuk IP, Golubov A, Koturbash IV, Kutanzi K, Martin OA, Kovalchuk O. Age-dependent changes in DNA repair in radiation-exposed mice. Radiat Res. 2014 Dec; 182(6):683-94. PMID: 25409128.
      View in: PubMed
    77. Miousse IR, Shao L, Chang J, Feng W, Wang Y, Allen AR, Turner J, Stewart B, Raber J, Zhou D, Koturbash I. Exposure to low-dose (56)Fe-ion radiation induces long-term epigenetic alterations in mouse bone marrow hematopoietic progenitor and stem cells. Radiat Res. 2014 Jul; 182(1):92-101. PMID: 24960414.
      View in: PubMed
    78. Fisher J, Yang X, Harris C, Koturbash I, Lumen A. The hypothalamic-pituitary-thyroid axis in infants and children: protection from radioiodines. J Thyroid Res. 2014; 2014:710178. PMID: 24971190.
      View in: PubMed
    79. Nzabarushimana E, Miousse IR, Shao L, Chang J, Allen AR, Turner J, Stewart B, Raber J, Koturbash I. Long-term epigenetic effects of exposure to low doses of 56Fe in the mouse lung. J Radiat Res. 2014 Jul; 55(4):823-8. PMID: 24585548.
      View in: PubMed
    80. Miousse IR, Chalbot MC, Aykin-Burns N, Wang X, Basnakian A, Kavouras IG, Koturbash I. Epigenetic alterations induced by ambient particulate matter in mouse macrophages. Environ Mol Mutagen. 2014 Jun; 55(5):428-35. PMID: 24535919.
      View in: PubMed
    81. de Conti A, Tryndyak V, Koturbash I, Heidor R, Kuroiwa-Trzmielina J, Ong TP, Beland FA, Moreno FS, Pogribny IP. The chemopreventive activity of the butyric acid prodrug tributyrin in experimental rat hepatocarcinogenesis is associated with p53 acetylation and activation of the p53 apoptotic signaling pathway. Carcinogenesis. 2013 Aug; 34(8):1900-6. PMID: 23568954.
      View in: PubMed
    82. Tryndyak V, de Conti A, Kobets T, Kutanzi K, Koturbash I, Han T, Fuscoe JC, Latendresse JR, Melnyk S, Shymonyak S, Collins L, Ross SA, Rusyn I, Beland FA, Pogribny IP. Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism. FASEB J. 2012 Nov; 26(11):4592-602. PMID: 22872676.
      View in: PubMed
    83. Von Tungeln LS, Doerge DR, Gamboa da Costa G, Matilde Marques M, Witt WM, Koturbash I, Pogribny IP, Beland FA. Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay. Int J Cancer. 2012 Nov 01; 131(9):2008-15. PMID: 22336951.
      View in: PubMed
    84. Koturbash I, Beland FA, Pogribny IP. Role of microRNAs in the regulation of drug metabolizing and transporting genes and the response to environmental toxicants. Expert Opin Drug Metab Toxicol. 2012 May; 8(5):597-606. PMID: 22435483.
      View in: PubMed
    85. Koturbash I, Melnyk S, James SJ, Beland FA, Pogribny IP. Role of epigenetic and miR-22 and miR-29b alterations in the downregulation of Mat1a and Mthfr genes in early preneoplastic livers in rats induced by 2-acetylaminofluorene. Mol Carcinog. 2013 Apr; 52(4):318-27. PMID: 22213190.
      View in: PubMed
    86. Koturbash I, Simpson NE, Beland FA, Pogribny IP. Alterations in histone H4 lysine 20 methylation: implications for cancer detection and prevention. Antioxid Redox Signal. 2012 Jul 15; 17(2):365-74. PMID: 22035019.
      View in: PubMed
    87. Shpyleva SI, Muskhelishvili L, Tryndyak VP, Koturbash I, Tokar EJ, Waalkes MP, Beland FA, Pogribny IP. Chronic administration of 2-acetylaminofluorene alters the cellular iron metabolism in rat liver. Toxicol Sci. 2011 Oct; 123(2):433-40. PMID: 21785164.
      View in: PubMed
    88. Hudson D, Kovalchuk I, Koturbash I, Kolb B, Martin OA, Kovalchuk O. Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals. Aging (Albany NY). 2011 Jun; 3(6):609-20. PMID: 21685513.
      View in: PubMed
    89. Koturbash I, Scherhag A, Sorrentino J, Sexton K, Bodnar W, Swenberg JA, Beland FA, Pardo-Manuel Devillena F, Rusyn I, Pogribny IP. Epigenetic mechanisms of mouse interstrain variability in genotoxicity of the environmental toxicant 1,3-butadiene. Toxicol Sci. 2011 Aug; 122(2):448-56. PMID: 21602187.
      View in: PubMed
    90. Koturbash I, Beland FA, Pogribny IP. Role of epigenetic events in chemical carcinogenesis--a justification for incorporating epigenetic evaluations in cancer risk assessment. Toxicol Mech Methods. 2011 May; 21(4):289-97. PMID: 21495867.
      View in: PubMed
    91. Koturbash I, Scherhag A, Sorrentino J, Sexton K, Bodnar W, Tryndyak V, Latendresse JR, Swenberg JA, Beland FA, Pogribny IP, Rusyn I. Epigenetic alterations in liver of C57BL/6J mice after short-term inhalational exposure to 1,3-butadiene. Environ Health Perspect. 2011 May; 119(5):635-40. PMID: 21147608.
      View in: PubMed
    92. Kutanzi KR, Koturbash I, Kovalchuk O. Reversibility of pre-malignant estrogen-induced epigenetic changes. Cell Cycle. 2010 Aug 01; 9(15):3078-84. PMID: 20699652.
      View in: PubMed
    93. Kutanzi KR, Koturbash I, Bronson RT, Pogribny IP, Kovalchuk O. Imbalance between apoptosis and cell proliferation during early stages of mammary gland carcinogenesis in ACI rats. Mutat Res. 2010 Dec 10; 694(1-2):1-6. PMID: 20659487.
      View in: PubMed
    94. Koturbash I, Zemp FJ, Pogribny I, Kovalchuk O. Small molecules with big effects: the role of the microRNAome in cancer and carcinogenesis. Mutat Res. 2011 Jun 17; 722(2):94-105. PMID: 20472093.
      View in: PubMed
    95. Koturbash I, Zemp F, Kolb B, Kovalchuk O. Sex-specific radiation-induced microRNAome responses in the hippocampus, cerebellum and frontal cortex in a mouse model. Mutat Res. 2011 Jun 17; 722(2):114-8. PMID: 20478395.
      View in: PubMed
    96. Filkowski JN, Ilnytskyy Y, Tamminga J, Koturbash I, Golubov A, Bagnyukova T, Pogribny IP, Kovalchuk O. Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression. Carcinogenesis. 2010 Jun; 31(6):1110-5. PMID: 19959559.
      View in: PubMed
    97. Koturbash I, Thomas JE, Kovalchuk O, Kovalchuk I. Heat-killed bacteria induce genome instability in mouse small intestine, liver and spleen tissues. Cell Cycle. 2009 Jun 15; 8(12):1935-9. PMID: 19440049.
      View in: PubMed
    98. Ilnytskyy Y, Koturbash I, Kovalchuk O. Radiation-induced bystander effects in vivo are epigenetically regulated in a tissue-specific manner. Environ Mol Mutagen. 2009 Mar; 50(2):105-13. PMID: 19107897.
      View in: PubMed
    99. Tamminga J, Kathiria P, Koturbash I, Kovalchuk O. DNA damage-induced upregulation of miR-709 in the germline downregulates BORIS to counteract aberrant DNA hypomethylation. Cell Cycle. 2008 Dec; 7(23):3731-6. PMID: 19029807.
      View in: PubMed
    100. Ilnytskyy Y, Zemp FJ, Koturbash I, Kovalchuk O. Altered microRNA expression patterns in irradiated hematopoietic tissues suggest a sex-specific protective mechanism. Biochem Biophys Res Commun. 2008 Dec 05; 377(1):41-5. PMID: 18823940.
      View in: PubMed
    101. Koturbash I, Kutanzi K, Hendrickson K, Rodriguez-Juarez R, Kogosov D, Kovalchuk O. Radiation-induced bystander effects in vivo are sex specific. Mutat Res. 2008 Jul 03; 642(1-2):28-36. PMID: 18508093.
      View in: PubMed
    102. Koturbash I, Zemp FJ, Kutanzi K, Luzhna L, Loree J, Kolb B, Kovalchuk O. Sex-specific microRNAome deregulation in the shielded bystander spleen of cranially exposed mice. Cell Cycle. 2008 Jun 01; 7(11):1658-67. PMID: 18560276.
      View in: PubMed
    103. Tamminga J, Koturbash I, Baker M, Kutanzi K, Kathiria P, Pogribny IP, Sutherland RJ, Kovalchuk O. Paternal cranial irradiation induces distant bystander DNA damage in the germline and leads to epigenetic alterations in the offspring. Cell Cycle. 2008 May 01; 7(9):1238-45. PMID: 18418050.
      View in: PubMed
    104. Koturbash I, Loree J, Kutanzi K, Koganow C, Pogribny I, Kovalchuk O. In vivo bystander effect: cranial X-irradiation leads to elevated DNA damage, altered cellular proliferation and apoptosis, and increased p53 levels in shielded spleen. Int J Radiat Oncol Biol Phys. 2008 Feb 01; 70(2):554-62. PMID: 18207032.
      View in: PubMed
    105. Yauk C, Polyzos A, Rowan-Carroll A, Somers CM, Godschalk RW, Van Schooten FJ, Berndt ML, Pogribny IP, Koturbash I, Williams A, Douglas GR, Kovalchuk O. Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location. Proc Natl Acad Sci U S A. 2008 Jan 15; 105(2):605-10. PMID: 18195365.
      View in: PubMed
    106. Sedelnikova OA, Nakamura A, Kovalchuk O, Koturbash I, Mitchell SA, Marino SA, Brenner DJ, Bonner WM. DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models. Cancer Res. 2007 May 01; 67(9):4295-302. PMID: 17483342.
      View in: PubMed
    107. Koturbash I, Boyko A, Rodriguez-Juarez R, McDonald RJ, Tryndyak VP, Kovalchuk I, Pogribny IP, Kovalchuk O. Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo. Carcinogenesis. 2007 Aug; 28(8):1831-8. PMID: 17347136.
      View in: PubMed
    108. Loree J, Koturbash I, Kutanzi K, Baker M, Pogribny I, Kovalchuk O. Radiation-induced molecular changes in rat mammary tissue: possible implications for radiation-induced carcinogenesis. Int J Radiat Biol. 2006 Nov; 82(11):805-15. PMID: 17148264.
      View in: PubMed
    109. Koturbash I, Baker M, Loree J, Kutanzi K, Hudson D, Pogribny I, Sedelnikova O, Bonner W, Kovalchuk O. Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo. Int J Radiat Oncol Biol Phys. 2006 Oct 01; 66(2):327-30. PMID: 16965987.
      View in: PubMed
    110. Cassie S, Koturbash I, Hudson D, Baker M, Ilnytskyy Y, Rodriguez-Juarez R, Weber E, Kovalchuk O. Novel retinoblastoma binding protein RBBP9 modulates sex-specific radiation responses in vivo. Carcinogenesis. 2006 Mar; 27(3):465-74. PMID: 16272168.
      View in: PubMed
    111. Pogribny I, Koturbash I, Tryndyak V, Hudson D, Stevenson SM, Sedelnikova O, Bonner W, Kovalchuk O. Fractionated low-dose radiation exposure leads to accumulation of DNA damage and profound alterations in DNA and histone methylation in the murine thymus. Mol Cancer Res. 2005 Oct; 3(10):553-61. PMID: 16254189.
      View in: PubMed
    112. Koturbash I, Pogribny I, Kovalchuk O. Stable loss of global DNA methylation in the radiation-target tissue--a possible mechanism contributing to radiation carcinogenesis? Biochem Biophys Res Commun. 2005 Nov 18; 337(2):526-33. PMID: 16202973.
      View in: PubMed
    Koturbash's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (395) concept(s)
    _
    Co-Authors Expand Description
    See all (33) people
    _
    Similar People Expand Description
    See all (34) people
    _
    Same Department Expand Description
    Search Department