 Tandem Mass Spectrometry
"Tandem Mass Spectrometry" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A mass spectrometry technique using two (MS/MS) or more mass analyzers. With two in tandem, the precursor ions are mass-selected by a first mass analyzer, and focused into a collision region where they are then fragmented into product ions which are then characterized by a second mass analyzer. A variety of techniques are used to separate the compounds, ionize them, and introduce them to the first mass analyzer. For example, for in GC-MS/MS, GAS CHROMATOGRAPHY-MASS SPECTROMETRY is involved in separating relatively small compounds by GAS CHROMATOGRAPHY prior to injecting them into an ionization chamber for the mass selection.
| Descriptor ID |
D053719
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| MeSH Number(s) |
E05.196.566.880
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| Concept/Terms |
Tandem Mass Spectrometry- Tandem Mass Spectrometry
- Mass Spectrometry, Tandem
- Mass Spectrometry-Mass Spectrometry
- Mass Spectrometry Mass Spectrometry
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Below are MeSH descriptors whose meaning is more general than "Tandem Mass Spectrometry".
Below are MeSH descriptors whose meaning is more specific than "Tandem Mass Spectrometry".
This graph shows the total number of publications written about "Tandem Mass Spectrometry" by people in UAMS Profiles by year, and whether "Tandem Mass Spectrometry" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
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| 2024 | 2 | 1 | 3 | | 2023 | 2 | 6 | 8 | | 2022 | 1 | 5 | 6 | | 2021 | 2 | 3 | 5 | | 2020 | 2 | 5 | 7 | | 2019 | 1 | 2 | 3 | | 2018 | 1 | 6 | 7 | | 2017 | 0 | 8 | 8 | | 2016 | 1 | 4 | 5 | | 2015 | 0 | 9 | 9 | | 2014 | 2 | 7 | 9 | | 2013 | 0 | 12 | 12 | | 2012 | 1 | 7 | 8 | | 2011 | 6 | 5 | 11 | | 2010 | 2 | 9 | 11 | | 2009 | 3 | 5 | 8 | | 2008 | 2 | 6 | 8 | | 2007 | 1 | 0 | 1 | | 2006 | 1 | 1 | 2 |
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Below are the most recent publications written about "Tandem Mass Spectrometry" by people in Profiles over the past ten years.
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Liu Z, Anderson JD, Rose NR, Baker EH, Dowell AE, Ryan KJ, Acosta EP, Guimbellot JS. Differential distribution of ivacaftor and its metabolites in plasma and human airway epithelia. Pulm Pharmacol Ther. 2024 Sep; 86:102314.
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Lyu W, Yin Z, Xie L, Pasinetti GM, Murrough JW, Marchidan M, Karpman E, Dobbs M, Ferruzzi MG, Simon JE, Wu Q. Method development with high-throughput enhanced matrix removal followed by UHPLC-QqQ-MS/MS for analysis of grape polyphenol metabolites in human urine. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Jul 15; 1242:124189.
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Rose NR, Chalamalla AR, Garcia BA, Krick S, Bergeron J, Sadeghi H, Schellhase DE, Ryan KJ, Dowell AE, Acosta EP, Guimbellot JS. Pharmacokinetic variability of CFTR modulators from standard and alternative regimens. Pulm Pharmacol Ther. 2024 Sep; 86:102301.
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Yu LR, Gao Y, Beger RD. Identification of Proteomic Biomarkers of Acetaminophen-Induced Hepatotoxicity Using Stable Isotope Labeling. Methods Mol Biol. 2024; 2823:225-239.
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Broeckling CD, Beger RD, Cheng LL, Cumeras R, Cuthbertson DJ, Dasari S, Davis WC, Dunn WB, Evans AM, Fern?ndez-Ochoa A, Gika H, Goodacre R, Goodman KD, Gouveia GJ, Hsu PC, Kirwan JA, Kodra D, Kuligowski J, Lan RS, Monge ME, Moussa LW, Nair SG, Reisdorph N, Sherrod SD, Ulmer Holland C, Vuckovic D, Yu LR, Zhang B, Theodoridis G, Mosley JD. Current Practices in LC-MS Untargeted Metabolomics: A Scoping Review on the Use of Pooled Quality Control Samples. Anal Chem. 2023 12 26; 95(51):18645-18654.
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Engelen MPKJ, Kirschner SK, Coyle KS, Argyelan D, Neal G, Dasarathy S, Deutz NEP. Sex related differences in muscle health and metabolism in chronic obstructive pulmonary disease. Clin Nutr. 2023 09; 42(9):1737-1746.
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Assress HA, Ferruzzi MG, Lan RS. Optimization of Mass Spectrometric Parameters in Data Dependent Acquisition for Untargeted Metabolomics on the Basis of Putative Assignments. J Am Soc Mass Spectrom. 2023 Aug 02; 34(8):1621-1631.
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Huynh HH, Kuch K, Orquillas A, Forrest K, Barahona-Carrillo L, Keene D, Henderson VW, Wagner AD, Poston KL, Montine TJ, Lin A, Tian L, MacCoss MJ, Emrick MA, Hoofnagle AN. Metrologically Traceable Quantification of 3 Apolipoprotein E Isoforms in Cerebrospinal Fluid. Clin Chem. 2023 07 05; 69(7):734-745.
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Li J, Sato T, Hern?ndez-Tejero M, Beier JI, Sayed K, Benos PV, Wilkey DW, Humar A, Merchant ML, Duarte-Rojo A, Arteel GE. The plasma degradome reflects later development of NASH fibrosis after liver transplant. Sci Rep. 2023 06 20; 13(1):9965.
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Sethi S, Casal Moura M, Madden B, Debiec H, Nasr SH, Larsen CP, Gross L, Negron V, Singh RD, Nath KA, Storey AJ, Specks U, Fervenza FC, Ronco P, Caza TN. Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a likely antigenic target in membranous nephropathy and nonsteroidal anti-inflammatory drug use. Kidney Int. 2023 08; 104(2):343-352.
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Kasperek MC, Mailing L, Piccolo BD, Moody B, Lan R, Gao X, Hernandez-Saavedra D, Woods JA, Adams SH, Allen JM. Exercise training modifies xenometabolites in gut and circulation of lean and obese adults. Physiol Rep. 2023 03; 11(6):e15638.
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Deutz NEP, Singer P, Wierzchowska-McNew RA, Viana MV, Ben-David IA, Pantet O, Thaden JJ, Ten Have GAM, Engelen MPKJ, Berger MM. Females have a different metabolic response to critical illness, measured by comprehensive amino acid flux analysis. Metabolism. 2023 05; 142:155400.
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Batts TL, Sasaki E, Miller M, Sparago J, Bauer RW, Paulsen D, Boudreaux B, Liu CC, Byrum SD, Johnston AN. Neoplastic signatures: Comparative proteomics of canine hepatobiliary neuroendocrine tumors to normal niche tissue. PLoS One. 2023; 18(1):e0280928.
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Neill HR, Gill CIR, McDonald EJ, McMurray R, McRoberts WC, Loy R, White A, Little R, Muns R, Rosbotham EJ, O'Neill U, Smyth S, Pourshahidi LK. Improving vitamin D content in pork meat by UVB biofortification. Meat Sci. 2023 May; 199:109115.
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Wierzchowska-McNew RA, Engelen MPKJ, Thaden JJ, Ten Have GAM, Deutz NEP. Obesity- and sex-related metabolism of arginine and nitric oxide in adults. Am J Clin Nutr. 2022 12 19; 116(6):1610-1620.
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Chauhan MZ, Chacko JG, Ghaffarieh A, Moulin CM, Pelaez D, Uwaydat SH, Bhattacharya SK. Mitochondrial Triglyceride Dysregulation in Optic Nerves Following Indirect Traumatic Optic Neuropathy. Biomolecules. 2022 12 15; 12(12).
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Clement K, McGill MR, Miousse IR, Young SG, Melnyk S, Koturbash I. Methylsulfonylmethane Serves as a Donor of Methyl Groups for Methylation of DNA in Human Liver HepaRG Cells. J Diet Suppl. 2023; 20(6):950-962.
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Ryan KJ, Guimbellot JS, Dowell AE, Reed-Walker KD, Kerstner-Wood CD, Anderson JD, Liu Z, Acosta EP. Quantitation of cystic fibrosis triple combination therapy, elexacaftor/tezacaftor/ivacaftor, in human plasma and cellular lysate. J Chromatogr B Analyt Technol Biomed Life Sci. 2022 Dec 15; 1213:123518.
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Daily A, Ravishankar P, Harms S, Klimberg VS. Using tears as a non-invasive source for early detection of breast cancer. PLoS One. 2022; 17(4):e0267676.
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Cruthirds CL, Deutz NEP, Harrykissoon R, Zachria AJ, Engelen MPKJ. A low postabsorptive whole body protein balance is associated with markers of poor daily physical functioning in Chronic Obstructive Pulmonary Disease. Clin Nutr. 2022 04; 41(4):885-893.
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Anders NM, Romo CG, Hemingway A, Ahluwalia MS, Rudek MA. Quantitation of terameprocol in human plasma by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2022 Feb 05; 209:114525.
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Christov PP, Richie-Jannetta R, Kingsley PJ, Vemulapalli A, Kim K, Sulikowski GA, Rizzo CJ, Ketkar A, Eoff RL, Rouzer CA, Marnett LJ. Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-M1dG, the Genomic Metabolite of M1dG, and Liquid Chromatography-Tandem Mass Spectrometry Analysis of Its In Vitro Bypass by Human Polymerase ?. Chem Res Toxicol. 2021 12 20; 34(12):2567-2578.
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Krishnan S, Gertz ER, Adams SH, Newman JW, Pedersen TL, Keim NL, Bennett BJ. Effects of a diet based on the Dietary Guidelines on vascular health and TMAO in women with cardiometabolic risk factors. Nutr Metab Cardiovasc Dis. 2022 01; 32(1):210-219.
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Phillips SJ, Oliveto A, Mancino MJ, Hendrickson HP. Development and validation of a rapid liquid chromatography/tandem mass spectrometry method to quantitate gabapentin and buprenorphine in human serum. Rapid Commun Mass Spectrom. 2021 Jul 31; 35(14):e9104.
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Xu Q, Liu Q, Chen Z, Yue Y, Liu Y, Zhao Y, Zhou DX. Histone deacetylases control lysine acetylation of ribosomal proteins in rice. Nucleic Acids Res. 2021 05 07; 49(8):4613-4628.
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Lei MG, Gupta RK, Lee CY. A Rat Model of Orthopedic Implant-Associated Infection for Identification of Staphylococcal Biofilm Proteins. Methods Mol Biol. 2021; 2341:117-125.
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Cross KM, Granados JZ, Ten Have GAM, Thaden JJ, Engelen MPKJ, Lightfoot JT, Deutz NEP. Protein fractional synthesis rates within tissues of high- and low-active mice. PLoS One. 2020; 15(11):e0242926.
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Liu D, Yang S, Kavdia K, Sifford JM, Wu Z, Xie B, Wang Z, Pagala VR, Wang H, Yu K, Dey KK, High AA, Serrano GE, Beach TG, Peng J. Deep Profiling of Microgram-Scale Proteome by Tandem Mass Tag Mass Spectrometry. J Proteome Res. 2021 01 01; 20(1):337-345.
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Kim JH, Lagojda A, Kuehne D, Tshitenge DT, Chaudhuri S, Walker DP, Head G. Determination of Cotton as a Larval Feeding Source for Lepidopteran Moths Using a Derivative from Cotton Metabolites as a Marker by LC-MS/MS Method. J Chem Ecol. 2020 Oct; 46(10):956-966.
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Khalifa OA, Imtiaz F, Ramzan K, Zaki O, Gamal R, Elbaik L, Rihan S, Salam E, Abdul-Mawgoud R, Hassan M, Hassan N, Saleh E, Seoudi D, Moustafa AS. Genotype-phenotype correlation of 33 patients with maple syrup urine disease. Am J Med Genet A. 2020 11; 182(11):2486-2500.
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Granados JZ, Ten Have GAM, Letsinger AC, Thaden JJ, Engelen MPKJ, Lightfoot JT, Deutz NEP. Activated whole-body arginine pathway in high-active mice. PLoS One. 2020; 15(6):e0235095.
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Adams MK, Banks CAS, Thornton JL, Kempf CG, Zhang Y, Miah S, Hao Y, Sardiu ME, Killer M, Hattem GL, Murray A, Katt ML, Florens L, Washburn MP. Differential Complex Formation via Paralogs in the Human Sin3 Protein Interaction Network. Mol Cell Proteomics. 2020 09; 19(9):1468-1484.
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Chua XY, Mensah T, Aballo T, Mackintosh SG, Edmondson RD, Salomon AR. Tandem Mass Tag Approach Utilizing Pervanadate BOOST Channels Delivers Deeper Quantitative Characterization of the Tyrosine Phosphoproteome. Mol Cell Proteomics. 2020 04; 19(4):730-743.
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Peng H, Chang Y, Baker RC, Zhang G. Interference of mycotoxin binders with ELISA, HPLC and LC-MS/MS analysis of aflatoxins in maize and maize gluten. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2020 Mar; 37(3):496-506.
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Boysen G, Shimoni A, Danylesko I, Varda-Bloom N, Nagler A. A simplified method for detection of N-terminal valine adducts in patients receiving treosulfan. Rapid Commun Mass Spectrom. 2019 Nov 15; 33(21):1635-1642.
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Gao J, Byrd AK, Zybailov BL, Marecki JC, Guderyon MJ, Edwards AD, Chib S, West KL, Waldrip ZJ, Mackintosh SG, Gao Z, Putnam AA, Jankowsky E, Raney KD. DEAD-box RNA helicases Dbp2, Ded1 and Mss116 bind to G-quadruplex nucleic acids and destabilize G-quadruplex RNA. Chem Commun (Camb). 2019 Apr 11; 55(31):4467-4470.
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Davidson JA, Pfeifer Z, Frank B, Tong S, Urban TT, Wischmeyer PA, Mourani P, Landeck B, Christians U, Klawitter J. Metabolomic Fingerprinting of Infants Undergoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay. J Am Heart Assoc. 2018 12 18; 7(24):e010711.
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Boysen G. Response to Interpretation of Mass Spectral Data for the Cisplatin 1,2 Intrastrand Guanine-Guanine Adduct. Chem Res Toxicol. 2018 11 19; 31(11):1108.
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Byrum SD, Loughran AJ, Beenken KE, Orr LM, Storey AJ, Mackintosh SG, Edmondson RD, Tackett AJ, Smeltzer MS. Label-Free Proteomic Approach to Characterize Protease-Dependent and -Independent Effects of sarA Inactivation on the Staphylococcus aureus Exoproteome. J Proteome Res. 2018 10 05; 17(10):3384-3395.
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Zhang X, Zhang S, Liu X, Wang Y, Chang J, Zhang X, Mackintosh SG, Tackett AJ, He Y, Lv D, Laberge RM, Campisi J, Wang J, Zheng G, Zhou D. Oxidation resistance 1 is a novel senolytic target. Aging Cell. 2018 08; 17(4):e12780.
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Yu Y, Chandasana H, Sangari T, Seubert C, Derendorf H. Simultaneous Retrodialysis by Calibrator for Rapid In?Vivo Recovery Determination in Target Site Microdialysis. J Pharm Sci. 2018 08; 107(8):2259-2265.
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Le J, Poindexter B, Sullivan JE, Laughon M, Delmore P, Blackford M, Yogev R, James LP, Melloni C, Harper B, Mitchell J, Benjamin DK, Boakye-Agyeman F, Cohen-Wolkowiez M. Comparative Analysis of Ampicillin Plasma and Dried Blood Spot Pharmacokinetics in Neonates. Ther Drug Monit. 2018 02; 40(1):103-108.
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Wongsurawat T, Woo CC, Giannakakis A, Lin XY, Cheow ESH, Lee CN, Richards M, Sze SK, Nookaew I, Kuznetsov VA, Sorokin V. Distinctive molecular signature and activated signaling pathways in aortic smooth muscle cells of patients with myocardial infarction. Atherosclerosis. 2018 04; 271:237-244.
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Kraemer MP, Halder S, Smyth SS, Morris AJ. Measurement of Lysophosphatidic Acid and Sphingosine-1-Phosphate by Liquid Chromatography-Coupled Electrospray Ionization Tandem Mass Spectrometry. Methods Mol Biol. 2018; 1697:31-42.
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Shi P, Liao M, Chuang BC, Griffin R, Shi J, Hyer M, Fallon JK, Smith PC, Li C, Xia CQ. Efflux transporter breast cancer resistance protein dominantly expresses on the membrane of red blood cells, hinders partitioning of its substrates into the cells, and alters drug-drug interaction profiles. Xenobiotica. 2018 Nov; 48(11):1173-1183.
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Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Steinbach WJ. Phosphorylation of Aspergillus fumigatus PkaR impacts growth and cell wall integrity through novel mechanisms. FEBS Lett. 2017 11; 591(22):3730-3744.
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Beck R, Atherton DS, Kloda S, Dye DW, Robinson CA. Quantification of Loperamide by Gas Chromatography Mass Spectrometry. J Anal Toxicol. 2017 Nov 01; 41(9):729-734.
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Chen TY, Ferruzzi MG, Wu QL, Simon JE, Talcott ST, Wang J, Ho L, Todd G, Cooper B, Pasinetti GM, Janle EM. Influence of diabetes on plasma pharmacokinetics and brain bioavailability of grape polyphenols and their phase II metabolites in the Zucker diabetic fatty rat. Mol Nutr Food Res. 2017 10; 61(10).
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Sun J, Jin J, Beger RD, Cerniglia CE, Chen H. Evaluation of metabolism of azo dyes and their effects on Staphylococcus aureus metabolome. J Ind Microbiol Biotechnol. 2017 Oct; 44(10):1471-1481.
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Prins GS, Ye SH, Birch L, Zhang X, Cheong A, Lin H, Calderon-Gierszal E, Groen J, Hu WY, Ho SM, van Breemen RB. Prostate Cancer Risk and DNA Methylation Signatures in Aging Rats following Developmental BPA Exposure: A Dose-Response Analysis. Environ Health Perspect. 2017 07 11; 125(7):077007.
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Lowery CL, Elliott C, Cooper A, Hadden C, Sonon RN, Azadi P, Williams DK, Marsh JD, Woulfe DS, Kilic F. Cigarette Smoking-Associated Alterations in Serotonin/Adrenalin Signaling Pathways of Platelets. J Am Heart Assoc. 2017 May 18; 6(5).
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Tolbert JA, Bai S, Abdel-Rahman SM, August KJ, Weir SJ, Kearns GL, Neville KA. Pharmacokinetics of two 6-mercaptopurine liquid formulations in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2017 Aug; 64(8).
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Shwab EK, Juvvadi PR, Waitt G, Soderblom EJ, Moseley MA, Nicely NI, Asfaw YG, Steinbach WJ. A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus. mBio. 2017 02 07; 8(1).
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Sampson JN, Falk RT, Schairer C, Moore SC, Fuhrman BJ, Dallal CM, Bauer DC, Dorgan JF, Shu XO, Zheng W, Brinton LA, Gail MH, Ziegler RG, Xu X, Hoover RN, Gierach GL. Association of Estrogen Metabolism with Breast Cancer Risk in Different Cohorts of Postmenopausal Women. Cancer Res. 2017 02 15; 77(4):918-925.
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Chu R, Alford SE, Hart K, Kothari A, Mackintosh SG, Kovak MR, Chambers TC. Mitotic arrest-induced phosphorylation of Mcl-1 revisited using two-dimensional gel electrophoresis and phosphoproteomics: nine phosphorylation sites identified. Oncotarget. 2016 Nov 29; 7(48):78958-78970.
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Walker DK, Thaden JJ, Wierzchowska-McNew A, Engelen MPKJ, Deutz NEP. Determination of ?-hydroxy-?-methylbutyrate concentration and enrichment in human plasma using chemical ionization gas chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 01; 1040:233-238.
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Gao Y, Cao Z, Yang X, Abdelmegeed MA, Sun J, Chen S, Beger RD, Davis K, Salminen WF, Song BJ, Mendrick DL, Yu LR. Proteomic analysis of acetaminophen-induced hepatotoxicity and identification of heme oxygenase 1 as a potential plasma biomarker of liver injury. Proteomics Clin Appl. 2017 01; 11(1-2).
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Coleman HN, Greenfield WW, Stratton SL, Vaughn R, Kieber A, Moerman-Herzog AM, Spencer HJ, Hitt WC, Quick CM, Hutchins LF, Mackintosh SG, Edmondson RD, Erickson SW, Nakagawa M. Human papillomavirus type 16 viral load is decreased following a therapeutic vaccination. Cancer Immunol Immunother. 2016 May; 65(5):563-73.
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Abraham PE, Wang X, Ranjan P, Nookaew I, Zhang B, Tuskan GA, Hettich RL. Integrating mRNA and Protein Sequencing Enables the Detection and Quantitative Profiling of Natural Protein Sequence Variants of Populus trichocarpa. J Proteome Res. 2015 Dec 04; 14(12):5318-26.
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Krais AM, Speksnijder EN, Melis JP, Singh R, Caldwell A, Gamboa da Costa G, Luijten M, Phillips DH, Arlt VM. Metabolic activation of 2-amino-1-methyl-6-phenylimidazo [4,5-b]pyridine and DNA adduct formation depends on p53: Studies in Trp53(+/+),Trp53(+/-) and Trp53(-/-) mice. Int J Cancer. 2016 Feb 15; 138(4):976-82.
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Oh H, Smith-Warner SA, Tamimi RM, Wang M, Xu X, Hankinson SE, Fuhrman BJ, Ziegler RG, Eliassen AH. Dietary Fat and Fiber Intakes Are Not Associated with Patterns of Urinary Estrogen Metabolites in Premenopausal Women. J Nutr. 2015 Sep; 145(9):2109-16.
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Nanaware-Kharade N, Thakkar S, Gonzalez GA, Peterson EC. A Nanotechnology-Based Platform for Extending the Pharmacokinetic and Binding Properties of Anti-methamphetamine Antibody Fragments. Sci Rep. 2015 Jul 10; 5:12060.
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Fata CR, Seeley EH, Desouki MM, Du L, Gwin K, Hanley KZ, Hecht JL, Jarboe EA, Liang SX, Parkash V, Quick CM, Zheng W, Shyr Y, Caprioli RM, Fadare O. Are clear cell carcinomas of the ovary and endometrium phenotypically identical? A proteomic analysis. Hum Pathol. 2015 Oct; 46(10):1427-36.
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Walker DK, Thaden JJ, Deutz NE. Application of gas chromatography-tandem mass spectrometry (GC/MS/MS) for the analysis of deuterium enrichment of water. J Mass Spectrom. 2015 Jun; 50(6):838-43.
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Camacho L, Basavarajappa MS, Chang CW, Han T, Kobets T, Koturbash I, Surratt G, Lewis SM, Vanlandingham MM, Fuscoe JC, Gamboa da Costa G, Pogribny IP, Delclos KB. Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats. Food Chem Toxicol. 2015 Jul; 81:92-103.
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Gierach GL, Patel DA, Falk RT, Pfeiffer RM, Geller BM, Vacek PM, Weaver DL, Chicoine RE, Shepherd JA, Mahmoudzadeh AP, Wang J, Fan B, Herschorn SD, Xu X, Veenstra T, Fuhrman B, Sherman ME, Brinton LA. Relationship of serum estrogens and metabolites with area and volume mammographic densities. Horm Cancer. 2015 Jun; 6(2-3):107-19.
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Ziegler RG, Fuhrman BJ, Moore SC, Matthews CE. Epidemiologic studies of estrogen metabolism and breast cancer. Steroids. 2015 Jul; 99(Pt A):67-75.
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Gupta PK, Barone G, Gurley BJ, Fifer EK, Hendrickson HP. Hydrastine pharmacokinetics and metabolism after a single oral dose of goldenseal (Hydrastis canadensis) to humans. Drug Metab Dispos. 2015 Apr; 43(4):534-52.
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