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Joseph Goellner

TitleResearch Instructor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentInternal Med, College of Medicine
DivisionInternal Med Endo
Address803 Cancer Institute
4104 Outpatient Circle
Mail Slot # 587
Little Rock AR 72205
Phone501-686-5130
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    Collapse Research 
    Collapse research activities and funding
    2P20GM125503     (OBRIEN, CHARLES A)Apr 1, 2023 - Jun 30, 2028
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Principal Investigator
    2P20GM125503-06     (OBRIEN, CHARLES A)Apr 1, 2023 - Jan 31, 2028
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Principal Investigator
    P20GM125503     (OBRIEN, CHARLES A)Apr 1, 2023 - Jan 31, 2028
    NIH/Nat. Inst. of General Medical Sciences
    Center for Musculoskeletal Disease Research (CMDR)
    Role: Co-Investigator
    P01AG013918     (MANOLAGAS, STAVROS C.)Aug 27, 1996 - Apr 30, 2018
    NIH
    Molecular and Cellular Mechanisms of Osteoporosis
    Role: Co-Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Fu Q, Bustamante-Gomez NC, Reyes-Pardo H, Gubrij I, Escalona-Vargas D, Thostenson JD, Palmieri M, Goellner JJ, Nookaew I, Barnes CL, Stambough JB, Ambrogini E, O'Brien CA. Reduced osteoprotegerin expression by osteocytes may contribute to rebound resorption after denosumab discontinuation. JCI Insight. 2023 09 22; 8(18). PMID: 37581932.
      View in: PubMed
    2. Plotkin M, O'Brien CA, Goellner J, Williams J, Carter W, Sharma S, Stone A. A Uromodulin Mutation Drives Autoimmunity and Kidney Mononuclear Phagocyte Endoplasmic Reticulum Stress. Am J Pathol. 2020 12; 190(12):2436-2452. PMID: 32926855.
      View in: PubMed
    3. Cawley KM, Bustamante-Gomez NC, Guha AG, MacLeod RS, Xiong J, Gubrij I, Liu Y, Mulkey R, Palmieri M, Thostenson JD, Goellner JJ, O'Brien CA. Local Production of Osteoprotegerin by Osteoblasts Suppresses Bone Resorption. Cell Rep. 2020 09 08; 32(10):108052. PMID: 32905775.
      View in: PubMed
    4. Xiong J, Cawley K, Piemontese M, Fujiwara Y, Zhao H, Goellner JJ, O'Brien CA. Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss. Nat Commun. 2018 07 25; 9(1):2909. PMID: 30046091.
      View in: PubMed
    5. Fil D, DeLoach A, Yadav S, Alkam D, MacNicol M, Singh A, Compadre CM, Goellner JJ, O'Brien CA, Fahmi T, Basnakian AG, Calingasan NY, Klessner JL, Beal FM, Peters OM, Metterville J, Brown RH, Ling KKY, Rigo F, Ozdinler PH, Kiaei M. Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease. Hum Mol Genet. 2017 02 15; 26(4):686-701. PMID: 28040732.
      View in: PubMed
    6. Xiong J, Piemontese M, Onal M, Campbell J, Goellner JJ, Dusevich V, Bonewald L, Manolagas SC, O'Brien CA. Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone. PLoS One. 2015; 10(9):e0138189. PMID: 26393791.
      View in: PubMed
    7. Onal M, Bishop KA, St John HC, Danielson AL, Riley EM, Piemontese M, Xiong J, Goellner JJ, O'Brien CA, Pike JW. A DNA segment spanning the mouse Tnfsf11 transcription unit and its upstream regulatory domain rescues the pleiotropic biologic phenotype of the RANKL null mouse. J Bone Miner Res. 2015 May; 30(5):855-68. PMID: 25431114.
      View in: PubMed
    8. Lee SM, Goellner JJ, O'Brien CA, Pike JW. A humanized mouse model of hereditary 1,25-dihydroxyvitamin D-resistant rickets without alopecia. Endocrinology. 2014 Nov; 155(11):4137-48. PMID: 25147982.
      View in: PubMed
    9. Lee SM, Bishop KA, Goellner JJ, O'Brien CA, Pike JW. Mouse and human BAC transgenes recapitulate tissue-specific expression of the vitamin D receptor in mice and rescue the VDR-null phenotype. Endocrinology. 2014 Jun; 155(6):2064-76. PMID: 24693968.
      View in: PubMed
    10. Shoshana Bartell, Elena Ambrogini, Li Han, Aaron Warren, Julie Crawford, Srividhya Iyer, Joseph Goellner, Haibo Zhao, Charles O'Brien, Stavros Manolagas, Maria Jose Almeida. Gain or Loss of FoxO Function in Osteoclasts alter Bone Mass in Mice. Journal of Bone and Mineral Research. 2012; S284.
    11. Kathleen Bishop, Erin Riley, Seong Min Lee, Joseph Goellner, Charles O'Brien, J Pike. A 220 Kb DNA Segment Spanning the Mouse Tnfsfl1 Transcription Unit and Its Upstream Regulatory Control Region Rescues the Pleiotropic Biologic Phenotype of the RANKL Null Mouse. Journal of Bone and Mineral Research. 2012; S397.
    12. Ambrogini E, Almeida M, Martin-Millan M, Paik JH, Depinho RA, Han L, Goellner J, Weinstein RS, Jilka RL, O'Brien CA, Manolagas SC. FoxO-mediated defense against oxidative stress in osteoblasts is indispensable for skeletal homeostasis in mice. Cell Metab. 2010 Feb 03; 11(2):136-46. PMID: 20142101.
      View in: PubMed
    13. O'Brien CA, Plotkin LI, Galli C, Goellner JJ, Gortazar AR, Allen MR, Robling AG, Bouxsein M, Schipani E, Turner CH, Jilka RL, Weinstein RS, Manolagas SC, Bellido T. Control of bone mass and remodeling by PTH receptor signaling in osteocytes. PLoS One. 2008 Aug 13; 3(8):e2942. PMID: 18698360.
      View in: PubMed
    14. Qin W, Rudolph AE, Bond BR, Rocha R, Blomme EA, Goellner JJ, Funder JW, McMahon EG. Transgenic model of aldosterone-driven cardiac hypertrophy and heart failure. Circ Res. 2003 Jul 11; 93(1):69-76. PMID: 12791709.
      View in: PubMed
    15. Vidensky S, Zhang Y, Hand T, Goellner J, Shaffer A, Isakson P, Andreasson K. Neuronal overexpression of COX-2 results in dominant production of PGE2 and altered fever response. Neuromolecular Med. 2003; 3(1):15 - 28.
    16. Andreasson KI, Savonenko A, Vidensky S, Goellner JJ, Zhang Y, Shaffer A, Kaufmann WE, Worley PF, Isakson P, Markowska AL. Age-dependent cognitive deficits and neuronal apoptosis in cyclooxygenase-2 transgenic mice. J Neurosci. 2001; 21(20):8198 - 8209.
    17. Matsumoto M, Fukuda W, Circolo A, Goellner J, Strauss-Schoenberger J, Wang X, Fujita S, Hidvegi T, Chaplin DD, Colten HR. Abrogation of the alternative complement pathway by targeted deletion of murine factor B. Proc Natl Acad Sci U S A. 1997; 94(16):8720 - 8725.
    18. Shornick LP, De TP, Mariathasan S, Goellner J, Strauss-Schoenberger J, Karr RW, Ferguson TA, Chaplin DD. Mice deficient in IL-1beta manifest impaired contact hypersensitivity to trinitrochlorobenzone. J Exp Med. 1996; 183(4):1427 - 1436.
    19. Molina H, Holers VM, Li B, Fung Y, Mariathasan S, Goellner J, Strauss-Schoenberger J, Karr RW, Chaplin DD. Markedly impaired humoral immune response in mice deficient in complement receptors 1 and 2. Proc Natl Acad Sci U S A. 1996; 93(8):3357 - 3361.
    20. De TP, Goellner J, Ruddle NH, Streeter PR, Fick A, Mariathasan S, Smith SC, Carlson R, Shornick LP, Strauss-Schoenberger J, . Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science. 1994; 264(5159):703 - 707.
    21. Goellner JJ, Strauss-Schoenberge JM, Karr R. Gene targeting scores a knockout in mice. 1993.
    22. Markham RB, Pier GB, Goellner JJ, Mizel SB. In vitro T cell-mediated killing of Pseudomonas aeruginosa. II. The role of macrophages and T cell subsets in T cell killing. J Immunol. 1985; 134(6):4112 - 4117.
    23. Markham RB, Goellner J, Pier GB. In vitro T cell-mediated killing of Pseudomonas aeruginosa. I. Evidence that a lymphokine mediates killing. J Immunol. 1984; 133(2):962 - 968.
    24. Moog F, Goellner JJ. Chick embryo intestine in culture: influence of insulin and other hormones on sucrase, maltase, and alkaline phosphatase. J Pediatr Gastroenterol Nutr. 1982; 1(3):401 - 410.
    25. Wenning Q, Funder JW, Goellner JJ, Rocha R, Friedrich GE, Rudolph AE, Bond BR, Daust HA, Robinson EL, Ghosh S, Nachowiak D, McMahon EG. 11BHSD2 over-expression in cardiomyocytes leds to severe dilated cardiac hypotrophy and fibrosis in transgenic mice.
    26. Markham RB, Goellner JJ. Human T lymphocyte-mediated killing of Pseudomonas aeruginosa in vitro.
    27. Carron CP, Becker D, Duffin T, Goellner J, Knoerzer D, Mehta P, Munie G, Funckes-Shippy C, Swearingen C, Villami C, Welsch D, Zhang K, Hollister B, Dexter D, De Crescenzo G, McWherter C. The highly selective MMP-1 sparing matrix metalloproteinase inhibitor SC-77964 provides broad-spectrum anti-tumor activity.
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