Angus Macnicol
Title | Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Neurobiology & Developmental Science, College of Medicine |
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Division | Neuro & Devel SFaculty |
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Address | 310 Cancer Institute 4104 Outpatient Circle Mail Slot # 814 Little Rock AR 72205
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Phone | 501-296-1549 |
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ORCID
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vCard | Download vCard |
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Title | Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Physiology and Cell Biology, College of Medicine |
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Title | Professor |
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Institution | University of Arkansas for Medical Sciences |
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Department | Genetics, College of Medicine |
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Division | Genetics Faculty |
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Research 1R01DK139476 (MACNICOL, ANGUS)Sep 18, 2024 - May 31, 2029 NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Molecular mechanisms of pituitary plasticity Role: Principal Investigator |
| 1R01DK139476-01A1 (MACNICOL, ANGUS)Sep 18, 2024 - May 31, 2029 NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Molecular mechanisms of pituitary plasticity Role: Principal Investigator |
| 5R01DK139476 (MACNICOL, ANGUS)Sep 18, 2024 - May 31, 2029 NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Molecular mechanisms of pituitary plasticity Role: Principal Investigator |
| 5R01DK139476-03 (MACNICOL, ANGUS)Sep 18, 2024 - May 31, 2029 NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Molecular mechanisms of pituitary plasticity Role: Principal Investigator |
| 5R01DK139476-04 (MACNICOL, ANGUS)Sep 18, 2024 - May 31, 2029 NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Molecular mechanisms of pituitary plasticity Role: Principal Investigator |
| R01DK139476 (MACNICOL, ANGUS M)Sep 18, 2024 - May 31, 2029 NIH Molecular mechanisms of pituitary plasticity Role: Principal Investigator |
| P20GM152281 (EOFF, ROBERT L)Mar 5, 2024 - Dec 31, 2028 NIH Center for Molecular Interactions in Cancer (CMIC) Role: Co-Investigator |
| R01DK127723 (CHILDS, GWEN V)Jul 17, 2021 - Jun 30, 2025 NIH The Impact of Obesity on Somatotrope Function Role: Co-Principal Investigator |
| R01HD093461 (CHILDS, GWEN V;MACNICOL, ANGUS M ;MACNICOL, MELANIE C)Sep 1, 2018 - Jun 30, 2024 NIH Control of pituitary cell plasticity through regulated mRNA translation Role: Principal Investigator |
| R35GM122601 (RANEY, KEVIN DOUGLAS)May 1, 2017 - Apr 30, 2022 NIH Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids Role: Co-Investigator |
| R01DK113776 (CHILDS, GWEN V)Apr 1, 2017 - Mar 31, 2021 NIH Tropic Roles for Leptin in the Maturation of Somatotropes Role: Co-Principal Investigator |
| R01HD087057 (CHILDS, GWEN V)Aug 15, 2016 - Mar 31, 2021 NIH Post-transcriptional Pathways that Signal Leptin Regulation of Gonadotropes Role: Co-Principal Investigator |
| R01GM117439 (RANEY, KEVIN DOUGLAS)Sep 21, 2015 - Jun 30, 2019 NIH G-quadruplex DNA as a chemical signaling agent Role: Co-Investigator |
| R03HD082793 (CHILDS, GWEN V)Jul 10, 2015 - Jun 30, 2018 NIH Leptin Molecular Regulatory Mechanisms That Prevent Growth hormone Deficiency Role: Co-Principal Investigator |
| abcrp 15 (MACNICOL, ANGUS)Jul 1, 2014 - Jun 30, 2016 Arkansas Breast Cancer Research Program Small Molecule Chemical Screening for Inhibitors of Breast Cancer Tumor-Initiating Cell Self-Renewal Proliferation Role: Principal Investigator |
| abcrp 15 NCE (MACNICOL, ANGUS)Jul 1, 2014 - Jun 30, 2016 Arkansas Breast Cancer Research Program Small Molecule Chemical Screening for Inhibitors of Breast Cancer Tumor-Initiating Cell Self-Renewal Proliferation Role: Principal Investigator |
| ABCRP15 (MACNICOL, ANGUS)Jul 1, 2014 - Jun 30, 2016 Arkansas Breast Cancer Research Program Small Molecule Chemical Screening for Inhibitors of Breast Cancer Tumor-Initiating Cell Self-Renewal Proliferation Role: Principal Investigator |
| abcrp15NCE (MACNICOL, ANGUS)Jul 1, 2014 - Jun 30, 2016 Arkansas Breast Cancer Research Program Small Molecule Chemical Screening for Inhibitors of Breast Cancer Tumor-Initiating Cell Self-Renewal Proliferation Role: Principal Investigator |
| RSG (MACNICOL, ANGUS)Mar 1, 2002 - Feb 28, 2006 American Cancer Society, Inc. MRNA translational Control of Cell Cycle Progression Role: Principal Investigator |
| RSG-02-252-01-DDC (MACNICOL, ANGUS)Mar 1, 2002 - Feb 28, 2006 American Cancer Society, Inc. MRNA translational Control of Cell Cycle Progression Role: Principal Investigator |
| RSG-02-252-01-DDC -02 (MACNICOL, ANGUS)Mar 1, 2002 - Feb 28, 2006 American Cancer Society, Inc. MRNA translational Control of Cell Cycle Progression Role: Principal Investigator |
| RSG-02-252-01-DDC -03 (MACNICOL, ANGUS)Mar 1, 2002 - Feb 28, 2006 American Cancer Society, Inc. MRNA translational Control of Cell Cycle Progression Role: Principal Investigator |
| RSG-02-252-01-DDC -04 (MACNICOL, ANGUS)Mar 1, 2002 - Feb 28, 2006 American Cancer Society, Inc. MRNA translational Control of Cell Cycle Progression Role: Principal Investigator |
| R03HD038081 (MACNICOL, ANGUS M)Aug 1, 2000 - Jun 30, 2002 NIH MRNA TRANSLATIONAL REGULATION IN HUMAN OOCYTES Role: Principal Investigator |
| R01HD035688 (MACNICOL, ANGUS M)Dec 15, 1998 - Jun 30, 2014 NIH Maternal gene regulation in early vertebrate development Role: Principal Investigator |
| R01CA070846 (MACNICOL, ANGUS M)Feb 1, 1997 - Dec 31, 2000 NIH RAF-1 REGULATION DURING CELL GROWTH AND DIFFERENTIATION Role: Principal Investigator |
Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications.
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Miles TK, Odle AK, Byrum SD, Lagasse AN, Haney AC, Ortega VG, Herdman AK, MacNicol MC, MacNicol AM, Childs GV. Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice. Endocrinology. 2025 Feb 27; 166(4). PMID: 39964842.
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Banik J, Moreira ARS, Lim J, Tomlinson S, Hardy LL, Lagasse A, Haney A, Crimmins MR, Boehm U, Odle AK, MacNicol MC, Childs GV, MacNicol AM. The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs. Sci Rep. 2024 03 11; 14(1):5918. PMID: 38467682.
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Miles TK, Allensworth-James ML, Odle AK, Silva Moreira AR, Haney AC, LaGasse AN, Gies AJ, Byrum SD, Riojas AM, MacNicol MC, MacNicol AM, Childs GV. Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain. Front Endocrinol (Lausanne). 2023; 14:1332959. PMID: 38720938.
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Miles TK, Odle AK, Byrum SD, Lagasse A, Haney A, Ortega VG, Bolen CR, Banik J, Reddick MM, Herdman A, MacNicol MC, MacNicol AM, Childs GV. Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism. Endocrinology. 2023 Dec 23; 165(2). PMID: 38103263.
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Urbaniak A, Reed MR, Heflin B, Gaydos J, Pi?a-Oviedo S, Jedrzejczyk M, Klejborowska G, Stepczynska N, Chambers TC, Tackett AJ, Rodriguez A, Huczynski A, Eoff RL, MacNicol AM. Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer. Biomed Pharmacother. 2022 Sep; 153:113440. PMID: 36076555.
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Allensworth-James M, Banik J, Odle A, Hardy L, Lagasse A, Moreira ARS, Bird J, Thomas CL, Avaritt N, Kharas MG, Lengner CJ, Byrum SD, MacNicol MC, Childs GV, MacNicol AM. Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi. Endocrinology. 2021 03 01; 162(3). PMID: 33373440.
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Childs GV, Odle AK, MacNicol MC, MacNicol AM. The Importance of Leptin to Reproduction. Endocrinology. 2021 02 01; 162(2). PMID: 33165520.
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MacNicol AM, Odle AK, Childs GV. ELAVL1 Elevates Insights: The Ups and Downs of Regulated mRNA Translation in the Control of Gonadotropin Release. Endocrinology. 2019 10 01; 160(10):2466-2468. PMID: 31504402.
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Cragle CE, MacNicol MC, Byrum SD, Hardy LL, Mackintosh SG, Richardson WA, Gray NK, Childs GV, Tackett AJ, MacNicol AM. Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation. J Biol Chem. 2019 07 12; 294(28):10969-10986. PMID: 31152063.
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Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 29929987.
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Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 33805020.
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Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 33013715.
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Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 33112825.
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Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 12242027.
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Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 16763568.
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Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 18481998.
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Sonderman KA, Wolf LL, Armstrong LB, Taylor K, Jiang W, Weil BR, Koehlmoos TP, Ricca RL, Weldon CB, Haider AH, Rice-Townsend SE. Testicular atrophy following inguinal hernia repair in children. Pediatr Surg Int. 2018 May; 34(5):553-560. PMID: 24656611.
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Odle AK, Bene? H, Melgar Castillo A, Akhter N, Syed M, Haney A, Allensworth-James M, Hardy L, Winter B, Manoharan R, Syed R, MacNicol MC, MacNicol AM, Childs GV. Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression. Endocrinology. 2018 02 01; 159(2):883-894. PMID: 29228137.
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Odle AK, Akhter N, Syed MM, Allensworth-James ML, Bene? H, Melgar Castillo AI, MacNicol MC, MacNicol AM, Childs GV. Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence. Front Endocrinol (Lausanne). 2017; 8:367. PMID: 29354094.
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MacNicol MC, Cragle CE, McDaniel FK, Hardy LL, Wang Y, Arumugam K, Rahmatallah Y, Glazko GV, Wilczynska A, Childs GV, Zhou D, MacNicol AM. Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2. Sci Rep. 2017 09 14; 7(1):11503. PMID: 28912529.
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Odle AK, Allensworth-James ML, Akhter N, Syed M, Haney AC, MacNicol M, MacNicol AM, Childs GV. A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones. Endocrinology. 2016 Oct; 157(10):3958-3971. PMID: 27571135.
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Byrd AK, Zybailov BL, Maddukuri L, Gao J, Marecki JC, Jaiswal M, Bell MR, Griffin WC, Reed MR, Chib S, Mackintosh SG, MacNicol AM, Baldini G, Eoff RL, Raney KD. Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress. J Biol Chem. 2016 08 19; 291(34):18041-57. PMID: 27369081.
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MacNicol MC, Cragle CE, Arumugam K, Fosso B, Pesole G, MacNicol AM. Functional Integration of mRNA Translational Control Programs. Biomolecules. 2015 Jul 21; 5(3):1580-99. PMID: 26197342.
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MacNicol AM, Hardy LL, Spencer HJ, MacNicol MC. Neural stem and progenitor cell fate transition requires regulation of Musashi1 function. BMC Dev Biol. 2015 Mar 18; 15:15. PMID: 25888190.
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Penthala NR, Bommagani S, Janganati V, MacNicol KB, Cragle CE, Madadi NR, Hardy LL, MacNicol AM, Crooks PA. Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression. Eur J Med Chem. 2014 Oct 06; 85:517-25. PMID: 25117652.
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Rutledge CE, Lau HT, Mangan H, Hardy LL, Sunnotel O, Guo F, MacNicol AM, Walsh CP, Lees-Murdock DJ. Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements. PLoS One. 2014; 9(2):e88385. PMID: 24586322.
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Cragle, C.E., MacNicol, A.M. In Xenopus Development. From oocyte to fertilizable egg - regulated mRNA translation and the control of maternal gene expression. 2013.
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Charlesworth A, Yamamoto TM, Cook JM, Silva KD, Kotter CV, Carter GS, Holt JW, Lavender HF, MacNicol AM, Ying Wang Y, Wilczynska A. Xenopus laevis zygote arrest 2 (zar2) encodes a zinc finger RNA-binding protein that binds to the translational control sequence in the maternal Wee1 mRNA and regulates translation. Dev Biol. 2012 Sep 15; 369(2):177-90. PMID: 22732570.
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Arumugam K, MacNicol MC, Wang Y, Cragle CE, Tackett AJ, Hardy LL, MacNicol AM. Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes. J Biol Chem. 2012 Mar 23; 287(13):10639-10649. PMID: 22215682.
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McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 18246541.
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McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 18395197.
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McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 22730340.
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McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 24644291.
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McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 34130123.
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McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 32657474.
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McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 37477898.
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McGoogan KE, Haafiz AB, Gonz?lez Peralta RP. Herpes simplex virus hepatitis in infants: clinical outcomes and correlates of disease severity. J Pediatr. 2011 Oct; 159(4):608-11. PMID: 40211036.
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MacNicol MC, Cragle CE, MacNicol AM. Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation. Cell Cycle. 2011 Jan 01; 10(1):39-44. PMID: 21191181.
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MacNicol MC, MacNicol AM. Developmental timing of mRNA translation--integration of distinct regulatory elements. Mol Reprod Dev. 2010 Aug; 77(8):662-9. PMID: 20652998.
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Arumugam K, Wang Y, Hardy LL, MacNicol MC, MacNicol AM. Enforcing temporal control of maternal mRNA translation during oocyte cell-cycle progression. EMBO J. 2010 Jan 20; 29(2):387-97. PMID: 19959990.
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Sun, L., Hodeify, R., Haun, S., Charlesworth, A., Macnicol A, Ponappan, S., Ponappan, U., Prigent, C., Machaca, K. Role of Ca2+ effectors during Xenopus oocyte maturation. Biology of Reproduction. 2008; 78:726-735.
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Srivastava, T., Charlesworth, A., Macnicol A, MacNicol, M.C. Nerve growth factor-stimulated PC12 cell differentiation is mediated through the cytoplasmic polyadenylation element binding protein (CPEB1). 2008.
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Wang, Y., Charlesworth, A., Byrd, S.M., Gregerson, R., MacNicol, M.C., Macnicol A. A novel 3’ UTR translational control sequence regulates Xenopus Wee1 mRNA translation. Dev. Biol. 2008; 317:454-466.
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Sun L, Hodeify R, Haun S, Charlesworth A, MacNicol AM, Ponnappan S, Ponnappan U, Prigent C, Machaca K. Ca2+ homeostasis regulates Xenopus oocyte maturation. Biol Reprod. 2008 Apr; 78(4):726-35. PMID: 18094360.
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Charlesworth A, Cox LL, MacNicol AM. Cytoplasmic polyadenylation element (CPE)- and CPE-binding protein (CPEB)-independent mechanisms regulate early class maternal mRNA translational activation in Xenopus oocytes. J Biol Chem. 2004 Apr 23; 279(17):17650-9. PMID: 14752101.
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Charlesworth A, Ridge JA, King LA, MacNicol MC, MacNicol AM. A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation. EMBO J. 2002 Jun 03; 21(11):2798-806. PMID: 12032092.
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Wilczysnka, A., MacNicol, M.C., Macnicol A. Transcription-dependent nucleo-cytoplasmic shuttling of the mRNA translational regulator, Musashi-1.
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Arumugam, K., Wang, Y., MacNicol, M.C., Macnicol A. Deciphering the temporal code of Xenopus maternal mRNA translational activation – a CPE/CPEB combinatorial code is not enough.
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Wilczysnka, A., Arumugam, K., MacNicol, M.C., Macnicol A. CPEB protein family self- and hetero-oligomerization.
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Wilczysnka, A., Arumugam, K., MacNicol, M.C., Macnicol A. Cell-type dependent regulation of Musashi function.
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Wilczysnka, A., MacNicol, M.C., Macnicol A. Musashi exerts 5’ cap-dependent translational repression of target mRNAs in neural progenitor cells.
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Srivastava, T., Macnicol A, MacNicol, M.C. Direct and indirect facilitators of mammalian CPEB1-directed mRNA translational repression.
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Charlesworth, A., Holt, J.W., Wang, Y., Lavender, H., Wilczynska, A., Macnicol A. Zar1-like (ZarL) is a novel RNA-binding protein that specifically interacts with the Translational Control Element in Xenopus maternal mRNAs.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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1993 | 1 | 1994 | 1 | 1999 | 1 | 2001 | 1 | 2002 | 1 | 2004 | 1 | 2007 | 1 | 2008 | 3 | 2009 | 1 | 2010 | 1 | 2011 | 13 | 2012 | 2 | 2013 | 1 | 2014 | 2 | 2015 | 2 | 2016 | 2 | 2017 | 1 | 2018 | 13 | 2019 | 2 | 2021 | 2 | 2022 | 1 | 2023 | 1 | 2024 | 2 | 2025 | 1 |
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