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Angus Macnicol

TitleProfessor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentNeurobiology & Developmental Science, College of Medicine
DivisionNeuro & Devel SFaculty
Address310 Cancer Institute
4104 Outpatient Circle
Mail Slot # 814
Little Rock AR 72205
Phone501-296-1549
ORCID ORCID Icon0000-0003-4812-9519 Additional info
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    Other Positions
    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentPhysiology and Cell Biology, College of Medicine

    TitleProfessor
    InstitutionUniversity of Arkansas for Medical Sciences
    DepartmentGenetics, College of Medicine
    DivisionGenetics Faculty


    Collapse Research 
    Collapse research activities and funding
    1R01DK139476-01A1     (MACNICOL, ANGUS)Sep 18, 2024 - May 31, 2029
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases
    Molecular mechanisms of pituitary plasticity
    Role: Principal Investigator
    5R01DK139476-03     (MACNICOL, ANGUS)Sep 18, 2024 - May 31, 2029
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases
    Molecular mechanisms of pituitary plasticity
    Role: Principal Investigator
    5R01DK139476-04     (MACNICOL, ANGUS)Sep 18, 2024 - May 31, 2029
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases
    Molecular mechanisms of pituitary plasticity
    Role: Principal Investigator
    R01DK139476     (MACNICOL, MELANIE)Sep 18, 2024 - May 31, 2029
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases
    Molecular mechanisms of pituitary plasticity
    Role: Principal Investigator
    P20GM152281     (EOFF, ROBERT L)Mar 5, 2024 - Dec 31, 2028
    NIH
    Center for Molecular Interactions in Cancer (CMIC)
    Role: Co-Investigator
    R01DK127723     (CHILDS, GWEN V)Jul 17, 2021 - Jun 30, 2025
    NIH
    The Impact of Obesity on Somatotrope Function
    Role: Co-Principal Investigator
    R01HD093461     (CHILDS, GWEN V;MACNICOL, ANGUS M ;MACNICOL, MELANIE C)Sep 1, 2018 - Jun 30, 2024
    NIH
    Control of pituitary cell plasticity through regulated mRNA translation
    Role: Principal Investigator
    R35GM122601     (RANEY, KEVIN DOUGLAS)May 1, 2017 - Apr 30, 2022
    NIH
    Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids
    Role: Co-Investigator
    R01DK113776     (CHILDS, GWEN V)Apr 1, 2017 - Mar 31, 2021
    NIH
    Tropic Roles for Leptin in the Maturation of Somatotropes
    Role: Co-Principal Investigator
    R01HD087057     (CHILDS, GWEN V)Aug 15, 2016 - Mar 31, 2021
    NIH
    Post-transcriptional Pathways that Signal Leptin Regulation of Gonadotropes
    Role: Co-Principal Investigator
    R01GM117439     (RANEY, KEVIN DOUGLAS)Sep 21, 2015 - Jun 30, 2019
    NIH
    G-quadruplex DNA as a chemical signaling agent
    Role: Co-Investigator
    R03HD082793     (CHILDS, GWEN V)Jul 10, 2015 - Jun 30, 2018
    NIH
    Leptin Molecular Regulatory Mechanisms That Prevent Growth hormone Deficiency
    Role: Co-Principal Investigator
    abcrp 15     (MACNICOL, ANGUS)Jul 1, 2014 - Jun 30, 2016
    Arkansas Breast Cancer Research Program
    Small Molecule Chemical Screening for Inhibitors of Breast Cancer Tumor-Initiating Cell Self-Renewal Proliferation
    Role: Principal Investigator
    abcrp 15 NCE     (MACNICOL, ANGUS)Jul 1, 2014 - Jun 30, 2016
    Arkansas Breast Cancer Research Program
    Small Molecule Chemical Screening for Inhibitors of Breast Cancer Tumor-Initiating Cell Self-Renewal Proliferation
    Role: Principal Investigator
    ABCRP15     (LEE, JEANNETTE Y)Jul 1, 2014 - Jun 30, 2016
    Arkansas Breast Cancer Research Program
    Evaluation of Obesity and Physical Inactivity in the “Spit for the Cure” Participants
    Role: Principal Investigator
    RSG     (MACNICOL, ANGUS)Mar 1, 2002 - Feb 28, 2006
    American Cancer Society, Inc.
    MRNA translational Control of Cell Cycle Progression
    Role: Principal Investigator
    RSG-02-252-01-DDC     (MACNICOL, ANGUS)Mar 1, 2002 - Feb 28, 2006
    American Cancer Society, Inc.
    MRNA translational Control of Cell Cycle Progression
    Role: Principal Investigator
    RSG-02-252-01-DDC -02     (MACNICOL, ANGUS)Mar 1, 2002 - Feb 28, 2006
    American Cancer Society, Inc.
    MRNA translational Control of Cell Cycle Progression
    Role: Principal Investigator
    RSG-02-252-01-DDC -03     (MACNICOL, ANGUS)Mar 1, 2002 - Feb 28, 2006
    American Cancer Society, Inc.
    MRNA translational Control of Cell Cycle Progression
    Role: Principal Investigator
    RSG-02-252-01-DDC -04     (MACNICOL, ANGUS)Mar 1, 2002 - Feb 28, 2006
    American Cancer Society, Inc.
    MRNA translational Control of Cell Cycle Progression
    Role: Principal Investigator
    R03HD038081     (MACNICOL, ANGUS M)Aug 1, 2000 - Jun 30, 2002
    NIH
    MRNA TRANSLATIONAL REGULATION IN HUMAN OOCYTES
    Role: Principal Investigator
    R01HD035688     (MACNICOL, ANGUS M)Dec 15, 1998 - Jun 30, 2014
    NIH
    Maternal gene regulation in early vertebrate development
    Role: Principal Investigator
    R01CA070846     (MACNICOL, ANGUS M)Feb 1, 1997 - Dec 31, 2000
    NIH
    RAF-1 REGULATION DURING CELL GROWTH AND DIFFERENTIATION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Bronson K, Banik J, Lim J, Reddick MM, Hardy L, Childs GV, MacNicol MC, MacNicol AM. Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B. Sci Rep. 2025 Apr 10; 15(1):12363. PMID: 40211036.
      View in: PubMed
    2. Miles TK, Odle AK, Byrum SD, Lagasse AN, Haney AC, Ortega VG, Herdman AK, MacNicol MC, MacNicol AM, Childs GV. Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice. Endocrinology. 2025 Feb 27; 166(4). PMID: 39964842.
      View in: PubMed
    3. Banik J, Moreira ARS, Lim J, Tomlinson S, Hardy LL, Lagasse A, Haney A, Crimmins MR, Boehm U, Odle AK, MacNicol MC, Childs GV, MacNicol AM. The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs. Sci Rep. 2024 03 11; 14(1):5918. PMID: 38467682.
      View in: PubMed
    4. Miles TK, Allensworth-James ML, Odle AK, Silva Moreira AR, Haney AC, LaGasse AN, Gies AJ, Byrum SD, Riojas AM, MacNicol MC, MacNicol AM, Childs GV. Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain. Front Endocrinol (Lausanne). 2023; 14:1332959. PMID: 38720938.
      View in: PubMed
    5. Miles TK, Odle AK, Byrum SD, Lagasse A, Haney A, Ortega VG, Bolen CR, Banik J, Reddick MM, Herdman A, MacNicol MC, MacNicol AM, Childs GV. Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism. Endocrinology. 2023 Dec 23; 165(2). PMID: 38103263.
      View in: PubMed
    6. Moreira ARS, Lim J, Urbaniak A, Banik J, Bronson K, Lagasse A, Hardy L, Haney A, Allensworth M, Miles TK, Gies A, Byrum SD, Wilczynska A, Boehm U, Kharas M, Lengner C, MacNicol MC, Childs GV, MacNicol AM, Odle AK. Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle. Endocrinology. 2023 08 01; 164(9). PMID: 37477898.
      View in: PubMed
    7. Urbaniak A, Reed MR, Heflin B, Gaydos J, Pi?a-Oviedo S, Jedrzejczyk M, Klejborowska G, Stepczynska N, Chambers TC, Tackett AJ, Rodriguez A, Huczynski A, Eoff RL, MacNicol AM. Anti-glioblastoma activity of monensin and its analogs in an organoid model of cancer. Biomed Pharmacother. 2022 Sep; 153:113440. PMID: 36076555.
      View in: PubMed
    8. Urbaniak A, Reed MR, Fil D, Moorjani A, Heflin S, Antoszczak M, Sulik M, Huczynski A, Kupsik M, Eoff RL, MacNicol MC, Chambers TC, MacNicol AM. Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models. Biomed Pharmacother. 2021 Sep; 141:111815. PMID: 34130123.
      View in: PubMed
    9. Odle AK, MacNicol MC, Childs GV, MacNicol AM. Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction. Int J Mol Sci. 2021 Mar 24; 22(7). PMID: 33805020.
      View in: PubMed
    10. Allensworth-James M, Banik J, Odle A, Hardy L, Lagasse A, Moreira ARS, Bird J, Thomas CL, Avaritt N, Kharas MG, Lengner CJ, Byrum SD, MacNicol MC, Childs GV, MacNicol AM. Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi. Endocrinology. 2021 03 01; 162(3). PMID: 33373440.
      View in: PubMed
    11. Childs GV, Odle AK, MacNicol MC, MacNicol AM. The Importance of Leptin to Reproduction. Endocrinology. 2021 02 01; 162(2). PMID: 33165520.
      View in: PubMed
    12. Miles TK, Silva Moreira AR, Allensworth-James ML, Odle AK, Haney AC, MacNicol AM, MacNicol MC, Childs GV. Sex differences in somatotrope response to fasting: biphasic responses in male mice. J Endocrinol. 2020 12; 247(3):213-224. PMID: 33112825.
      View in: PubMed
    13. Childs GV, MacNicol AM, MacNicol MC. Molecular Mechanisms of Pituitary Cell Plasticity. Front Endocrinol (Lausanne). 2020; 11:656. PMID: 33013715.
      View in: PubMed
    14. Allensworth-James ML, Odle AK, Lim J, LaGasse AN, Miles TK, Hardy LL, Haney AC, MacNicol MC, MacNicol AM, Childs GV. Metabolic signalling to somatotrophs: Transcriptional and post-transcriptional mediators. J Neuroendocrinol. 2020 11; 32(11):e12883. PMID: 32657474.
      View in: PubMed
    15. MacNicol AM, Odle AK, Childs GV. ELAVL1 Elevates Insights: The Ups and Downs of Regulated mRNA Translation in the Control of Gonadotropin Release. Endocrinology. 2019 10 01; 160(10):2466-2468. PMID: 31504402.
      View in: PubMed
    16. Cragle CE, MacNicol MC, Byrum SD, Hardy LL, Mackintosh SG, Richardson WA, Gray NK, Childs GV, Tackett AJ, MacNicol AM. Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation. J Biol Chem. 2019 07 12; 294(28):10969-10986. PMID: 31152063.
      View in: PubMed
    17. Allensworth-James ML, Odle A, Haney A, MacNicol M, MacNicol A, Childs G. Sex-specific changes in postnatal GH and PRL secretion in somatotrope LEPR-null mice. J Endocrinol. 2018 09; 238(3):221-230. PMID: 29929987.
      View in: PubMed
    18. Odle AK, Bene? H, Melgar Castillo A, Akhter N, Syed M, Haney A, Allensworth-James M, Hardy L, Winter B, Manoharan R, Syed R, MacNicol MC, MacNicol AM, Childs GV. Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression. Endocrinology. 2018 02 01; 159(2):883-894. PMID: 29228137.
      View in: PubMed
    19. Odle AK, Akhter N, Syed MM, Allensworth-James ML, Bene? H, Melgar Castillo AI, MacNicol MC, MacNicol AM, Childs GV. Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence. Front Endocrinol (Lausanne). 2017; 8:367. PMID: 29354094.
      View in: PubMed
    20. MacNicol MC, Cragle CE, McDaniel FK, Hardy LL, Wang Y, Arumugam K, Rahmatallah Y, Glazko GV, Wilczynska A, Childs GV, Zhou D, MacNicol AM. Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2. Sci Rep. 2017 09 14; 7(1):11503. PMID: 28912529.
      View in: PubMed
    21. Odle AK, Allensworth-James ML, Akhter N, Syed M, Haney AC, MacNicol M, MacNicol AM, Childs GV. A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones. Endocrinology. 2016 Oct; 157(10):3958-3971. PMID: 27571135.
      View in: PubMed
    22. Byrd AK, Zybailov BL, Maddukuri L, Gao J, Marecki JC, Jaiswal M, Bell MR, Griffin WC, Reed MR, Chib S, Mackintosh SG, MacNicol AM, Baldini G, Eoff RL, Raney KD. Evidence That G-quadruplex DNA Accumulates in the Cytoplasm and Participates in Stress Granule Assembly in Response to Oxidative Stress. J Biol Chem. 2016 08 19; 291(34):18041-57. PMID: 27369081.
      View in: PubMed
    23. MacNicol MC, Cragle CE, Arumugam K, Fosso B, Pesole G, MacNicol AM. Functional Integration of mRNA Translational Control Programs. Biomolecules. 2015 Jul 21; 5(3):1580-99. PMID: 26197342.
      View in: PubMed
    24. MacNicol AM, Hardy LL, Spencer HJ, MacNicol MC. Neural stem and progenitor cell fate transition requires regulation of Musashi1 function. BMC Dev Biol. 2015 Mar 18; 15:15. PMID: 25888190.
      View in: PubMed
    25. Penthala NR, Bommagani S, Janganati V, MacNicol KB, Cragle CE, Madadi NR, Hardy LL, MacNicol AM, Crooks PA. Heck products of parthenolide and melampomagnolide-B as anticancer modulators that modify cell cycle progression. Eur J Med Chem. 2014 Oct 06; 85:517-25. PMID: 25117652.
      View in: PubMed
    26. Cragle C, MacNicol AM. Musashi protein-directed translational activation of target mRNAs is mediated by the poly(A) polymerase, germ line development defective-2. J Biol Chem. 2014 May 16; 289(20):14239-51. PMID: 24644291.
      View in: PubMed
    27. Janganati V, Penthala NR, Cragle CE, MacNicol AM, Crooks PA. Heterocyclic aminoparthenolide derivatives modulate G(2)-M cell cycle progression during Xenopus oocyte maturation. Bioorg Med Chem Lett. 2014 Apr 15; 24(8):1963-7. PMID: 24656611.
      View in: PubMed
    28. Rutledge CE, Lau HT, Mangan H, Hardy LL, Sunnotel O, Guo F, MacNicol AM, Walsh CP, Lees-Murdock DJ. Efficient translation of Dnmt1 requires cytoplasmic polyadenylation and Musashi binding elements. PLoS One. 2014; 9(2):e88385. PMID: 24586322.
      View in: PubMed
    29. Cragle, C.E., MacNicol, A.M. In Xenopus Development. From oocyte to fertilizable egg - regulated mRNA translation and the control of maternal gene expression. 2013.
    30. Arumugam K, Macnicol MC, Macnicol AM. Autoregulation of Musashi1 mRNA translation during Xenopus oocyte maturation. Mol Reprod Dev. 2012 Aug; 79(8):553-63. PMID: 22730340.
      View in: PubMed
    31. Charlesworth A, Yamamoto TM, Cook JM, Silva KD, Kotter CV, Carter GS, Holt JW, Lavender HF, MacNicol AM, Ying Wang Y, Wilczynska A. Xenopus laevis zygote arrest 2 (zar2) encodes a zinc finger RNA-binding protein that binds to the translational control sequence in the maternal Wee1 mRNA and regulates translation. Dev Biol. 2012 Sep 15; 369(2):177-90. PMID: 22732570.
      View in: PubMed
    32. Arumugam K, MacNicol MC, Wang Y, Cragle CE, Tackett AJ, Hardy LL, MacNicol AM. Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes. J Biol Chem. 2012 Mar 23; 287(13):10639-10649. PMID: 22215682.
      View in: PubMed
    33. MacNicol MC, Cragle CE, MacNicol AM. Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation. Cell Cycle. 2011 Jan 01; 10(1):39-44. PMID: 21191181.
      View in: PubMed
    34. MacNicol MC, MacNicol AM. Developmental timing of mRNA translation--integration of distinct regulatory elements. Mol Reprod Dev. 2010 Aug; 77(8):662-9. PMID: 20652998.
      View in: PubMed
    35. Arumugam K, Wang Y, Hardy LL, MacNicol MC, MacNicol AM. Enforcing temporal control of maternal mRNA translation during oocyte cell-cycle progression. EMBO J. 2010 Jan 20; 29(2):387-97. PMID: 19959990.
      View in: PubMed
    36. Prasad CK, Mahadevan M, MacNicol MC, MacNicol AM. Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation. Mol Reprod Dev. 2008 Aug; 75(8):1258-68. PMID: 18246541.
      View in: PubMed
    37. MacNicol AM, Wilczynska A, MacNicol MC. Function and regulation of the mammalian Musashi mRNA translational regulator. Biochem Soc Trans. 2008 Jun; 36(Pt 3):528-30. PMID: 18481998.
      View in: PubMed
    38. Wang YY, Charlesworth A, Byrd SM, Gregerson R, MacNicol MC, MacNicol AM. A novel mRNA 3' untranslated region translational control sequence regulates Xenopus Wee1 mRNA translation. Dev Biol. 2008 May 15; 317(2):454-66. PMID: 18395197.
      View in: PubMed
    39. Srivastava, T., Charlesworth, A., Macnicol A, MacNicol, M.C. Nerve growth factor-stimulated PC12 cell differentiation is mediated through the cytoplasmic polyadenylation element binding protein (CPEB1). 2008.
    40. Wang, Y., Charlesworth, A., Byrd, S.M., Gregerson, R., MacNicol, M.C., Macnicol A. A novel 3’ UTR translational control sequence regulates Xenopus Wee1 mRNA translation. Dev. Biol. 2008; 317:454-466.
    41. Sun, L., Hodeify, R., Haun, S., Charlesworth, A., Macnicol A, Ponappan, S., Ponappan, U., Prigent, C., Machaca, K. Role of Ca2+ effectors during Xenopus oocyte maturation. Biology of Reproduction. 2008; 78:726-735.
    42. Sun L, Hodeify R, Haun S, Charlesworth A, MacNicol AM, Ponnappan S, Ponnappan U, Prigent C, Machaca K. Ca2+ homeostasis regulates Xenopus oocyte maturation. Biol Reprod. 2008 Apr; 78(4):726-35. PMID: 18094360.
      View in: PubMed
    43. Charlesworth A, Wilczynska A, Thampi P, Cox LL, MacNicol AM. Musashi regulates the temporal order of mRNA translation during Xenopus oocyte maturation. EMBO J. 2006 Jun 21; 25(12):2792-801. PMID: 16763568.
      View in: PubMed
    44. Charlesworth A, Cox LL, MacNicol AM. Cytoplasmic polyadenylation element (CPE)- and CPE-binding protein (CPEB)-independent mechanisms regulate early class maternal mRNA translational activation in Xenopus oocytes. J Biol Chem. 2004 Apr 23; 279(17):17650-9. PMID: 14752101.
      View in: PubMed
    45. Liu K, Guan Y, MacNicol MC, MacNicol AM, McGehee RE. Early expression of p107 is associated with 3T3-L1 adipocyte differentiation. Mol Cell Endocrinol. 2002 Aug 30; 194(1-2):51-61. PMID: 12242027.
      View in: PubMed
    46. Charlesworth A, Ridge JA, King LA, MacNicol MC, MacNicol AM. A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation. EMBO J. 2002 Jun 03; 21(11):2798-806. PMID: 12032092.
      View in: PubMed
    47. Wilczysnka, A., MacNicol, M.C., Macnicol A. Transcription-dependent nucleo-cytoplasmic shuttling of the mRNA translational regulator, Musashi-1.
    48. Arumugam, K., Wang, Y., MacNicol, M.C., Macnicol A. Deciphering the temporal code of Xenopus maternal mRNA translational activation – a CPE/CPEB combinatorial code is not enough.
    49. Charlesworth, A., Holt, J.W., Wang, Y., Lavender, H., Wilczynska, A., Macnicol A. Zar1-like (ZarL) is a novel RNA-binding protein that specifically interacts with the Translational Control Element in Xenopus maternal mRNAs.
    50. Wilczysnka, A., Arumugam, K., MacNicol, M.C., Macnicol A. CPEB protein family self- and hetero-oligomerization.
    51. Wilczysnka, A., Arumugam, K., MacNicol, M.C., Macnicol A. Cell-type dependent regulation of Musashi function.
    52. Wilczysnka, A., MacNicol, M.C., Macnicol A. Musashi exerts 5’ cap-dependent translational repression of target mRNAs in neural progenitor cells.
    53. Srivastava, T., Macnicol A, MacNicol, M.C. Direct and indirect facilitators of mammalian CPEB1-directed mRNA translational repression.
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