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Melanie Clair Macnicol

TitleAssociate Professor
InstitutionUniversity of Arkansas for Medical Sciences
DepartmentNeurobiology & Developmental Science, College of Medicine
DivisionNeuro & Devel SFaculty
Address660-2 Biomedical Research II
200 South Cedar
Mail Slot # 814
Little Rock AR 72202
Phone501-296-1549
ORCID ORCID Icon0000-0001-6927-2475 Additional info
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    Collapse Research 
    Collapse research activities and funding
    1R01DK139476-01A1     (MACNICOL, ANGUS)Sep 18, 2024 - May 31, 2029
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases
    Molecular mechanisms of pituitary plasticity
    Role: Principal Investigator
    5R01DK139476-03     (MACNICOL, ANGUS)Sep 18, 2024 - May 31, 2029
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases
    Molecular mechanisms of pituitary plasticity
    Role: Principal Investigator
    5R01DK139476-04     (MACNICOL, ANGUS)Sep 18, 2024 - May 31, 2029
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases
    Molecular mechanisms of pituitary plasticity
    Role: Principal Investigator
    R01DK139476     (MACNICOL, MELANIE)Sep 18, 2024 - May 31, 2029
    NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases
    Molecular mechanisms of pituitary plasticity
    Role: Principal Investigator
    R01DK127723     (CHILDS, GWEN V)Jul 17, 2021 - Jun 30, 2025
    NIH
    The Impact of Obesity on Somatotrope Function
    Role: Co-Principal Investigator
    R01HD093461     (CHILDS, GWEN V;MACNICOL, ANGUS M ;MACNICOL, MELANIE C)Sep 1, 2018 - Jun 30, 2024
    NIH
    Control of pituitary cell plasticity through regulated mRNA translation
    Role: Principal Investigator
    R01DK113776     (CHILDS, GWEN V)Apr 1, 2017 - Mar 31, 2021
    NIH
    Tropic Roles for Leptin in the Maturation of Somatotropes
    Role: Co-Principal Investigator
    R01HD087057     (CHILDS, GWEN V)Aug 15, 2016 - Mar 31, 2021
    NIH
    Post-transcriptional Pathways that Signal Leptin Regulation of Gonadotropes
    Role: Co-Investigator
    P30GM110702     (GARCIA-RILL, EDGAR E.)Jun 10, 2014 - Apr 30, 2020
    NIH
    Center for Translational Neuroscience
    Role: Co-Investigator
    P20RR020146     (GARCIA-RILL, EDGAR E.)Sep 16, 2004 - Apr 30, 2014
    NIH
    Center for Translational Neuroscience
    Role: Co-Investigator
    R01HD035688     (MACNICOL, ANGUS M)Dec 15, 1998 - Jun 30, 2014
    NIH
    Maternal gene regulation in early vertebrate development
    Role: Co-Investigator
    F32GM011924     (MACNICOL, MELANIE C)Nov 15, 1988
    NIH/NIGMS
    TEST OF THE RECEPTOR DOMAIN OF CAM KINASE IN VIVO
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions. Don't see publications published under other names? Login to add alternative names.
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    1. Bronson K, Banik J, Lim J, Reddick MM, Hardy L, Childs GV, MacNicol MC, MacNicol AM. Musashi-dependent mRNA translational activation is mediated through association with the Scd6/Like-sm family member, LSM14B. Sci Rep. 2025 Apr 10; 15(1):12363. PMID: 40211036.
      View in: PubMed
    2. Miles TK, Odle AK, Byrum SD, Lagasse AN, Haney AC, Ortega VG, Herdman AK, MacNicol MC, MacNicol AM, Childs GV. Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice. Endocrinology. 2025 Feb 27; 166(4). PMID: 39964842.
      View in: PubMed
    3. Banik J, Moreira ARS, Lim J, Tomlinson S, Hardy LL, Lagasse A, Haney A, Crimmins MR, Boehm U, Odle AK, MacNicol MC, Childs GV, MacNicol AM. The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs. Sci Rep. 2024 03 11; 14(1):5918. PMID: 38467682.
      View in: PubMed
    4. Miles TK, Allensworth-James ML, Odle AK, Silva Moreira AR, Haney AC, LaGasse AN, Gies AJ, Byrum SD, Riojas AM, MacNicol MC, MacNicol AM, Childs GV. Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain. Front Endocrinol (Lausanne). 2023; 14:1332959. PMID: 38720938.
      View in: PubMed
    5. Miles TK, Odle AK, Byrum SD, Lagasse A, Haney A, Ortega VG, Bolen CR, Banik J, Reddick MM, Herdman A, MacNicol MC, MacNicol AM, Childs GV. Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism. Endocrinology. 2023 Dec 23; 165(2). PMID: 38103263.
      View in: PubMed
    6. Moreira ARS, Lim J, Urbaniak A, Banik J, Bronson K, Lagasse A, Hardy L, Haney A, Allensworth M, Miles TK, Gies A, Byrum SD, Wilczynska A, Boehm U, Kharas M, Lengner C, MacNicol MC, Childs GV, MacNicol AM, Odle AK. Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle. Endocrinology. 2023 08 01; 164(9). PMID: 37477898.
      View in: PubMed
    7. Urbaniak A, Reed MR, Fil D, Moorjani A, Heflin S, Antoszczak M, Sulik M, Huczynski A, Kupsik M, Eoff RL, MacNicol MC, Chambers TC, MacNicol AM. Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models. Biomed Pharmacother. 2021 Sep; 141:111815. PMID: 34130123.
      View in: PubMed
    8. Odle AK, MacNicol MC, Childs GV, MacNicol AM. Post-Transcriptional Regulation of Gnrhr: A Checkpoint for Metabolic Control of Female Reproduction. Int J Mol Sci. 2021 Mar 24; 22(7). PMID: 33805020.
      View in: PubMed
    9. Allensworth-James M, Banik J, Odle A, Hardy L, Lagasse A, Moreira ARS, Bird J, Thomas CL, Avaritt N, Kharas MG, Lengner CJ, Byrum SD, MacNicol MC, Childs GV, MacNicol AM. Control of the Anterior Pituitary Cell Lineage Regulator POU1F1 by the Stem Cell Determinant Musashi. Endocrinology. 2021 03 01; 162(3). PMID: 33373440.
      View in: PubMed
    10. Childs GV, Odle AK, MacNicol MC, MacNicol AM. The Importance of Leptin to Reproduction. Endocrinology. 2021 02 01; 162(2). PMID: 33165520.
      View in: PubMed
    11. Miles TK, Silva Moreira AR, Allensworth-James ML, Odle AK, Haney AC, MacNicol AM, MacNicol MC, Childs GV. Sex differences in somatotrope response to fasting: biphasic responses in male mice. J Endocrinol. 2020 12; 247(3):213-224. PMID: 33112825.
      View in: PubMed
    12. Childs GV, MacNicol AM, MacNicol MC. Molecular Mechanisms of Pituitary Cell Plasticity. Front Endocrinol (Lausanne). 2020; 11:656. PMID: 33013715.
      View in: PubMed
    13. Allensworth-James ML, Odle AK, Lim J, LaGasse AN, Miles TK, Hardy LL, Haney AC, MacNicol MC, MacNicol AM, Childs GV. Metabolic signalling to somatotrophs: Transcriptional and post-transcriptional mediators. J Neuroendocrinol. 2020 11; 32(11):e12883. PMID: 32657474.
      View in: PubMed
    14. Cragle CE, MacNicol MC, Byrum SD, Hardy LL, Mackintosh SG, Richardson WA, Gray NK, Childs GV, Tackett AJ, MacNicol AM. Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation. J Biol Chem. 2019 07 12; 294(28):10969-10986. PMID: 31152063.
      View in: PubMed
    15. Allensworth-James ML, Odle A, Haney A, MacNicol M, MacNicol A, Childs G. Sex-specific changes in postnatal GH and PRL secretion in somatotrope LEPR-null mice. J Endocrinol. 2018 09; 238(3):221-230. PMID: 29929987.
      View in: PubMed
    16. Odle AK, Bene? H, Melgar Castillo A, Akhter N, Syed M, Haney A, Allensworth-James M, Hardy L, Winter B, Manoharan R, Syed R, MacNicol MC, MacNicol AM, Childs GV. Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression. Endocrinology. 2018 02 01; 159(2):883-894. PMID: 29228137.
      View in: PubMed
    17. Odle AK, Akhter N, Syed MM, Allensworth-James ML, Bene? H, Melgar Castillo AI, MacNicol MC, MacNicol AM, Childs GV. Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence. Front Endocrinol (Lausanne). 2017; 8:367. PMID: 29354094.
      View in: PubMed
    18. MacNicol MC, Cragle CE, McDaniel FK, Hardy LL, Wang Y, Arumugam K, Rahmatallah Y, Glazko GV, Wilczynska A, Childs GV, Zhou D, MacNicol AM. Evasion of regulatory phosphorylation by an alternatively spliced isoform of Musashi2. Sci Rep. 2017 09 14; 7(1):11503. PMID: 28912529.
      View in: PubMed
    19. Fil D, DeLoach A, Yadav S, Alkam D, MacNicol M, Singh A, Compadre CM, Goellner JJ, O'Brien CA, Fahmi T, Basnakian AG, Calingasan NY, Klessner JL, Beal FM, Peters OM, Metterville J, Brown RH, Ling KKY, Rigo F, Ozdinler PH, Kiaei M. Mutant Profilin1 transgenic mice recapitulate cardinal features of motor neuron disease. Hum Mol Genet. 2017 02 15; 26(4):686-701. PMID: 28040732.
      View in: PubMed
    20. Odle AK, Allensworth-James ML, Akhter N, Syed M, Haney AC, MacNicol M, MacNicol AM, Childs GV. A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones. Endocrinology. 2016 Oct; 157(10):3958-3971. PMID: 27571135.
      View in: PubMed
    21. Garcia-Rill E, Luster B, Mahaffey S, MacNicol M, Hyde JR, D'Onofrio SM, Phillips C. Pedunculopontine Gamma Band Activity and Development. Brain Sci. 2015 Dec 03; 5(4):546-67. PMID: 26633526.
      View in: PubMed
    22. MacNicol MC, Cragle CE, Arumugam K, Fosso B, Pesole G, MacNicol AM. Functional Integration of mRNA Translational Control Programs. Biomolecules. 2015 Jul 21; 5(3):1580-99. PMID: 26197342.
      View in: PubMed
    23. MacNicol AM, Hardy LL, Spencer HJ, MacNicol MC. Neural stem and progenitor cell fate transition requires regulation of Musashi1 function. BMC Dev Biol. 2015 Mar 18; 15:15. PMID: 25888190.
      View in: PubMed
    24. Hyde J, MacNicol M, Odle A, Garcia-Rill E. The use of three-dimensional printing to produce in vitro slice chambers. J Neurosci Methods. 2014 Dec 30; 238:82-7. PMID: 25251556.
      View in: PubMed
    25. Arumugam K, Macnicol MC, Macnicol AM. Autoregulation of Musashi1 mRNA translation during Xenopus oocyte maturation. Mol Reprod Dev. 2012 Aug; 79(8):553-63. PMID: 22730340.
      View in: PubMed
    26. Arumugam K, MacNicol MC, Wang Y, Cragle CE, Tackett AJ, Hardy LL, MacNicol AM. Ringo/cyclin-dependent kinase and mitogen-activated protein kinase signaling pathways regulate the activity of the cell fate determinant Musashi to promote cell cycle re-entry in Xenopus oocytes. J Biol Chem. 2012 Mar 23; 287(13):10639-10649. PMID: 22215682.
      View in: PubMed
    27. MacNicol MC, Cragle CE, MacNicol AM. Context-dependent regulation of Musashi-mediated mRNA translation and cell cycle regulation. Cell Cycle. 2011 Jan 01; 10(1):39-44. PMID: 21191181.
      View in: PubMed
    28. MacNicol MC, MacNicol AM. Developmental timing of mRNA translation--integration of distinct regulatory elements. Mol Reprod Dev. 2010 Aug; 77(8):662-9. PMID: 20652998.
      View in: PubMed
    29. Arumugam K, Wang Y, Hardy LL, MacNicol MC, MacNicol AM. Enforcing temporal control of maternal mRNA translation during oocyte cell-cycle progression. EMBO J. 2010 Jan 20; 29(2):387-97. PMID: 19959990.
      View in: PubMed
    30. Prasad CK, Mahadevan M, MacNicol MC, MacNicol AM. Mos 3' UTR regulatory differences underlie species-specific temporal patterns of Mos mRNA cytoplasmic polyadenylation and translational recruitment during oocyte maturation. Mol Reprod Dev. 2008 Aug; 75(8):1258-68. PMID: 18246541.
      View in: PubMed
    31. MacNicol AM, Wilczynska A, MacNicol MC. Function and regulation of the mammalian Musashi mRNA translational regulator. Biochem Soc Trans. 2008 Jun; 36(Pt 3):528-30. PMID: 18481998.
      View in: PubMed
    32. Wang YY, Charlesworth A, Byrd SM, Gregerson R, MacNicol MC, MacNicol AM. A novel mRNA 3' untranslated region translational control sequence regulates Xenopus Wee1 mRNA translation. Dev Biol. 2008 May 15; 317(2):454-66. PMID: 18395197.
      View in: PubMed
    33. Wang, Y, Charlesworth, A, Byrd, SM, Gregerson, R, MacNicol M, MacNicol, AM. A novel 3' UTR translational control sequence regulates Xenopus Wee1 mRNA translation. Dev. Biol. 2008; 317:454-466 IF 4.71.
    34. Arumugam, K., Wang, Y., MacNicol M, MacNicol, A. M. Deciphering the temporal code of Xenopus maternal mRNA translational activation - a CPE/CPEB combinatorial code is not enough. EMBO Journal. 2008.
    35. Beggs ML, Nagarajan R, Taylor-Jones JM, Nolen G, Macnicol M, Peterson CA. Alterations in the TGFbeta signaling pathway in myogenic progenitors with age. Aging Cell. 2004 Dec; 3(6):353-61. PMID: 15569352.
      View in: PubMed
    36. Liu K, Guan Y, MacNicol MC, MacNicol AM, McGehee RE. Early expression of p107 is associated with 3T3-L1 adipocyte differentiation. Mol Cell Endocrinol. 2002 Aug 30; 194(1-2):51-61. PMID: 12242027.
      View in: PubMed
    37. Charlesworth A, Ridge JA, King LA, MacNicol MC, MacNicol AM. A novel regulatory element determines the timing of Mos mRNA translation during Xenopus oocyte maturation. EMBO J. 2002 Jun 03; 21(11):2798-806. PMID: 12032092.
      View in: PubMed
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