A mitochondrial disorder characterized by focal or generalized seizures, episodes of transient or persistent neurologic dysfunction resembling strokes, and ragged-red fibers on muscle biopsy. Affected individuals tend to be normal at birth through early childhood, then experience growth failure, episodic vomiting, and recurrent cerebral insults resulting in visual loss and hemiparesis. The cortical lesions tend to occur in the parietal and occipital lobes and are not associated with vascular occlusion. VASCULAR HEADACHE is frequently associated and the disorder tends to be familial. (From Joynt, Clinical Neurology, 1992, Ch56, p117)

Descriptor ID	D017241
MeSH Number(s)	C05.651.460.620.520 C10.228.140.163.100.535 C10.228.140.300.275.500 C10.668.491.500.500.500 C14.907.253.329.500 C16.320.565.189.535 C18.452.132.100.535 C18.452.648.189.535 C18.452.660.560.620.520
Concept/Terms	MELAS Syndrome MELAS Syndrome Syndrome, MELAS Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode

Below are MeSH descriptors whose meaning is more general than "MELAS Syndrome".

Below are MeSH descriptors whose meaning is related to "MELAS Syndrome".

Below are MeSH descriptors whose meaning is more specific than "MELAS Syndrome".