 alpha-Synuclein
"alpha-Synuclein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synuclein that is a major component of LEWY BODIES that plays a role in neurodegeneration and neuroprotection.
| Descriptor ID |
D051844
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| MeSH Number(s) |
D12.776.641.860.500
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| Concept/Terms |
alpha-Synuclein- alpha-Synuclein
- alpha Synuclein
- Non-AB Component of AD Amyloid Protein
- Non AB Component of AD Amyloid Protein
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Below are MeSH descriptors whose meaning is more general than "alpha-Synuclein".
Below are MeSH descriptors whose meaning is more specific than "alpha-Synuclein".
This graph shows the total number of publications written about "alpha-Synuclein" by people in UAMS Profiles by year, and whether "alpha-Synuclein" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2025 | 1 | 0 | 1 | | 2024 | 1 | 0 | 1 | | 2023 | 0 | 1 | 1 | | 2021 | 0 | 1 | 1 | | 2020 | 1 | 0 | 1 | | 2018 | 2 | 0 | 2 | | 2017 | 1 | 0 | 1 | | 2015 | 1 | 0 | 1 | | 2013 | 1 | 0 | 1 | | 2006 | 1 | 0 | 1 |
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Below are the most recent publications written about "alpha-Synuclein" by people in Profiles over the past ten years.
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Winer JR, Plastini MJ, Romero A, Vossler H, Sai I, Channappa D, Abdelnour C, Shahid-Besanti M, Wilson EN, Oh HS, Young CB, Trelle A, Yutsis M, Sha SJ, Ramirez V, Taylor R, Younes K, Wyss-Coray T, Greicius MD, Henderson VW, Wagner AD, Poston KL, Mormino EC. Effects of a-synuclein pathology on synaptic dysfunction and clinical outcomes in normal aging. Alzheimers Dement. 2026 05; 22(5):e71455.
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Rue KL, Herrera S, Shi ZC, Chakraborty I, Tachiki J, Ballesteros J, Andersen JK, Lithgow GJ, Al Isawi WA, Mezei G, Schmidt M, Raptis RG. Coordination of Anle138b to Silver Results in Selective Reduction of a C-Terminal Truncated a-Synuclein Protein and Increased Aggregate Size. ChemMedChem. 2026 Apr 14; 21(7):e202500890.
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Li M, Feng M, Liu T, Duan S, Man X, Yuan X, Wang L, Sun Y, Wei X, Fu Q, Sun B, Lin W. Increased ocular plasma cells induce damaging a-synuclein+ microglia in autoimmune uveitis. Mucosal Immunol. 2025 Jun; 18(3):668-684.
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Lee JY, Castelli V, Sanberg PR, Borlongan CV. Probing Gut Participation in Parkinson's Disease Pathology and Treatment via Stem Cell Therapy. Int J Mol Sci. 2023 Jun 25; 24(13).
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Frey B, AlOkda A, Jackson MP, Riguet N, Duce JA, Lashuel HA. Monitoring alpha-synuclein oligomerization and aggregation using bimolecular fluorescence complementation assays: What you see is not always what you get. J Neurochem. 2021 05; 157(4):872-888.
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Chen Y, Hou Y, Yang J, Du R, Chen C, Chen F, Wang H, Ge R, Chen J. P75 Involved in the Ubiquitination of a-synuclein in Rotenone-based Parkinson's Disease Models. Neuroscience. 2018 09 15; 388:367-373.
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Doherty CPA, Young LM, Karamanos TK, Smith HI, Jackson MP, Radford SE, Brockwell DJ. A peptide-display protein scaffold to facilitate single molecule force studies of aggregation-prone peptides. Protein Sci. 2018 07; 27(7):1205-1217.
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Giffin JC, Richards RC, Craft C, Jahan N, Leggiadro C, Chopin T, Szemerda M, MacKinnon SL, Ewart KV. An extract of the marine alga Alaria esculenta modulates a-synuclein folding and amyloid formation. Neurosci Lett. 2017 03 22; 644:87-93.
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