 Cyclin-Dependent Kinase Inhibitor p27
"Cyclin-Dependent Kinase Inhibitor p27" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cyclin-dependent kinase inhibitor that coordinates the activation of CYCLIN and CYCLIN-DEPENDENT KINASES during the CELL CYCLE. It interacts with active CYCLIN D complexed to CYCLIN-DEPENDENT KINASE 4 in proliferating cells, while in arrested cells it binds and inhibits CYCLIN E complexed to CYCLIN-DEPENDENT KINASE 2.
| Descriptor ID |
D050760
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| MeSH Number(s) |
D12.644.360.225.600 D12.776.167.187.600 D12.776.476.225.600 D12.776.624.776.355.600
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| Concept/Terms |
Cyclin-Dependent Kinase Inhibitor p27- Cyclin-Dependent Kinase Inhibitor p27
- Cyclin Dependent Kinase Inhibitor p27
- CDKN4 Protein
- p27 CDK Inhibitor
- CDK Inhibitor, p27
- p27 Kip1 Protein
- Kip1 Protein, p27
- CDKN1B Protein
- p27Kip1 Protein
- CDK Inhibitor p27
- p27, CDK Inhibitor
- Cyclin-Dependent Kinase Inhibitor 1B
- Cyclin Dependent Kinase Inhibitor 1B
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Below are MeSH descriptors whose meaning is more general than "Cyclin-Dependent Kinase Inhibitor p27".
Below are MeSH descriptors whose meaning is more specific than "Cyclin-Dependent Kinase Inhibitor p27".
This graph shows the total number of publications written about "Cyclin-Dependent Kinase Inhibitor p27" by people in UAMS Profiles by year, and whether "Cyclin-Dependent Kinase Inhibitor p27" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2020 | 1 | 0 | 1 | | 2015 | 0 | 1 | 1 | | 2011 | 1 | 0 | 1 | | 2009 | 0 | 2 | 2 | | 2008 | 0 | 1 | 1 | | 2007 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 | | 2004 | 0 | 2 | 2 | | 2003 | 0 | 1 | 1 | | 2002 | 0 | 2 | 2 | | 2001 | 0 | 2 | 2 | | 2000 | 0 | 3 | 3 |
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Below are the most recent publications written about "Cyclin-Dependent Kinase Inhibitor p27" by people in Profiles over the past ten years.
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Gu C, Lu T, Wang W, Shao M, Wei R, Guo M, Li R, Qiao L, Hu Y, Zhan F, Seckinger A, Hose D, Yang Y. RFWD2 induces cellular proliferation and selective proteasome inhibitor resistance by mediating P27 ubiquitination in multiple myeloma. Leukemia. 2021 06; 35(6):1803-1807.
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Gao Y, Yang P, Shen H, Yu H, Song X, Zhang L, Zhang P, Cheng H, Xie Z, Hao S, Dong F, Ma S, Ji Q, Bartlow P, Ding Y, Wang L, Liu H, Li Y, Cheng H, Miao W, Yuan W, Yuan Y, Cheng T, Xie XQ. Small-molecule inhibitors targeting INK4 protein p18(INK4C) enhance ex vivo expansion of haematopoietic stem cells. Nat Commun. 2015 Feb 18; 6:6328.
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