 Receptor, trkA
"Receptor, trkA" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.
| Descriptor ID |
D020917
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.660 D12.776.543.750.060.496 D12.776.543.750.750.400.550.550
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| Concept/Terms |
Receptor, trkA- Receptor, trkA
- gp140 c-trk
- c-trk, gp140
- gp140 c trk
- gp140(c-TRK)
- Neurotrophic Tyrosine Kinase Receptor Type 1
- NTRK1 Receptor
- Receptor, NTRK1
- p140-trkA
- p140 trkA
- Proto-Oncogene Protein trk
- Proto Oncogene Protein trk
- trk, Proto-Oncogene Protein
- Receptor, Neurotrophic Tyrosine Kinase Type 1
- trk Proto-Oncogene Protein
- Proto-Oncogene Protein, trk
- trk Proto Oncogene Protein
- trk1 Transforming Tryrosine Kinase
- trkA Receptor
- c-trk Protein
- c trk Protein
- Proto-Oncogene Products c-trk
- Proto Oncogene Products c trk
- c-trk, Proto-Oncogene Products
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Below are MeSH descriptors whose meaning is more general than "Receptor, trkA".
Below are MeSH descriptors whose meaning is more specific than "Receptor, trkA".
This graph shows the total number of publications written about "Receptor, trkA" by people in UAMS Profiles by year, and whether "Receptor, trkA" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 0 | 1 | | 2021 | 2 | 0 | 2 | | 2019 | 0 | 1 | 1 | | 2018 | 1 | 0 | 1 | | 2006 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptor, trkA" by people in Profiles over the past ten years.
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Acharya B, Saha D, Garcia Garcia N, Armstrong D, Jabali B, Hanafi M, Frett B, Ryan KR. Discovery of 9H-pyrimido[4,5-b]indole derivatives as dual RET/TRKA inhibitors. Bioorg Med Chem. 2024 May 15; 106:117749.
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Moccia M, Yang D, Lakkaniga NR, Frett B, McConnell N, Zhang L, Brescia A, Federico G, Zhang L, Salerno P, Santoro M, Li HY, Carlomagno F. Targeted activity of the small molecule kinase inhibitor Pz-1 towards RET and TRK kinases. Sci Rep. 2021 08 09; 11(1):16103.
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Yan W, Zhang L, Lv F, Moccia M, Carlomagno F, Landry C, Santoro M, Gosselet F, Frett B, Li HY. Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation. Eur J Med Chem. 2021 Apr 15; 216:113265.
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Wang H, Diaz AK, Shaw TI, Li Y, Niu M, Cho JH, Paugh BS, Zhang Y, Sifford J, Bai B, Wu Z, Tan H, Zhou S, Hover LD, Tillman HS, Shirinifard A, Thiagarajan S, Sablauer A, Pagala V, High AA, Wang X, Li C, Baker SJ, Peng J. Deep multiomics profiling of brain tumors identifies signaling networks downstream of cancer driver genes. Nat Commun. 2019 08 16; 10(1):3718.
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Yan W, Lakkaniga NR, Carlomagno F, Santoro M, McDonald NQ, Lv F, Gunaganti N, Frett B, Li HY. Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application. J Med Chem. 2019 02 28; 62(4):1731-1760.
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Zhang YP, Brown RE, Zhang PC, Zhao YT, Ju XH, Song C. DHA, EPA and their combination at various ratios differently modulated A?25-35-induced neurotoxicity in SH-SY5Y cells. Prostaglandins Leukot Essent Fatty Acids. 2018 09; 136:85-94.
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