 Receptor, trkB
"Receptor, trkB" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A protein-tyrosine kinase receptor that is specific for BRAIN-DERIVED NEUROTROPHIC FACTOR; NEUROTROPHIN 3; neurotrophin 4 and neurotrophin 5. It is widely expressed in nervous tissue and plays a role in mediating the effects of neurotrophins on growth and differentiation of neuronal cells.
| Descriptor ID |
D020813
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.700 D12.776.543.750.060.498 D12.776.543.750.750.400.550.600
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| Concept/Terms |
Receptor, trkB- Receptor, trkB
- Brain Derived Neurotrophic Factor Receptor
- Neurotrophic Factor, Brain-Derived, Receptor
- Neurotrophic Tyrosine Kinase Receptor Type 2
- Receptor, Neurotrophic Tyrosine Kinase Type 2
- trkB Receptor
- trkB(gp145) Protein
- BDNF Receptor
- Receptor, BDNF
- NTRK2 Receptor
- Receptor, NTRK2
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Below are MeSH descriptors whose meaning is more general than "Receptor, trkB".
Below are MeSH descriptors whose meaning is more specific than "Receptor, trkB".
This graph shows the total number of publications written about "Receptor, trkB" by people in UAMS Profiles by year, and whether "Receptor, trkB" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2021 | 1 | 0 | 1 | | 2018 | 1 | 0 | 1 | | 2016 | 1 | 0 | 1 | | 2005 | 1 | 0 | 1 | | 2002 | 0 | 1 | 1 |
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Below are the most recent publications written about "Receptor, trkB" by people in Profiles over the past ten years.
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Yan W, Zhang L, Lv F, Moccia M, Carlomagno F, Landry C, Santoro M, Gosselet F, Frett B, Li HY. Discovery of pyrazolo-thieno[3,2-d]pyrimidinylamino-phenyl acetamides as type-II pan-tropomyosin receptor kinase (TRK) inhibitors: Design, synthesis, and biological evaluation. Eur J Med Chem. 2021 Apr 15; 216:113265.
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Yan W, Lakkaniga NR, Carlomagno F, Santoro M, McDonald NQ, Lv F, Gunaganti N, Frett B, Li HY. Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application. J Med Chem. 2019 02 28; 62(4):1731-1760.
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Hildebrand ME, Xu J, Dedek A, Li Y, Sengar AS, Beggs S, Lombroso PJ, Salter MW. Potentiation of Synaptic GluN2B NMDAR Currents by Fyn Kinase Is Gated through BDNF-Mediated Disinhibition in Spinal Pain Processing. Cell Rep. 2016 12 06; 17(10):2753-2765.
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