 Integrin alpha Chains
"Integrin alpha Chains" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
| Descriptor ID |
D039001
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| MeSH Number(s) |
D12.776.543.750.705.408.100
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| Concept/Terms |
Integrin alpha Chains- Integrin alpha Chains
- alpha Chains, Integrin
- Integrin alpha Subunits
- alpha Integrins
- Integrins, alpha
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Below are MeSH descriptors whose meaning is more general than "Integrin alpha Chains".
Below are MeSH descriptors whose meaning is more specific than "Integrin alpha Chains".
This graph shows the total number of publications written about "Integrin alpha Chains" by people in UAMS Profiles by year, and whether "Integrin alpha Chains" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2024 | 1 | 0 | 1 | | 2019 | 1 | 0 | 1 | | 2016 | 0 | 1 | 1 | | 2001 | 1 | 0 | 1 |
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Below are the most recent publications written about "Integrin alpha Chains" by people in Profiles over the past ten years.
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Blanco T, Nakagawa H, Musayeva A, Krauthammer M, Singh RB, Narimatsu A, Ge H, Shoushtari SI, Dana R. Acquired immunostimulatory phenotype of migratory CD103+ DCs promotes alloimmunity following corneal transplantation. JCI Insight. 2024 Oct 22; 9(20).
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Shields BD, Koss B, Taylor EM, Storey AJ, West KL, Byrum SD, Mackintosh SG, Edmondson R, Mahmoud F, Shalin SC, Tackett AJ. Loss of E-Cadherin Inhibits CD103 Antitumor Activity and Reduces Checkpoint Blockade Responsiveness in Melanoma. Cancer Res. 2019 03 15; 79(6):1113-1123.
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Qualai J, Li LX, Cantero J, Tarrats A, Fern?ndez MA, Sumoy L, Rodolosse A, McSorley SJ, Genesc? M. Expression of CD11c Is Associated with Unconventional Activated T Cell Subsets with High Migratory Potential. PLoS One. 2016; 11(4):e0154253.
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