 Interleukin-12
"Interleukin-12" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A heterodimeric cytokine that plays a role in innate and adaptive immune responses. Interleukin-12 is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by DENDRITIC CELLS; MACROPHAGES and a variety of other immune cells and plays a role in the stimulation of INTERFERON-GAMMA production by T-LYMPHOCYTES and NATURAL KILLER CELLS.
| Descriptor ID |
D018664
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| MeSH Number(s) |
D12.644.276.374.465.512 D12.776.467.374.465.512 D23.529.374.465.512
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| Concept/Terms |
Interleukin-12- Interleukin-12
- Edodekin Alfa
- IL 12
- Natural Killer Cell Stimulatory Factor
- IL-12 p70
- IL12
- Interleukin 12
- Interleukin-12 p70
- Interleukin 12 p70
- p70, Interleukin-12
- Cytotoxic Lymphocyte Maturation Factor
- IL-12
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Below are MeSH descriptors whose meaning is more general than "Interleukin-12".
Below are MeSH descriptors whose meaning is more specific than "Interleukin-12".
This graph shows the total number of publications written about "Interleukin-12" by people in UAMS Profiles by year, and whether "Interleukin-12" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2018 | 1 | 1 | 2 | | 2015 | 1 | 0 | 1 | | 2014 | 0 | 1 | 1 | | 2013 | 1 | 0 | 1 | | 2009 | 0 | 2 | 2 | | 2007 | 2 | 1 | 3 | | 2006 | 0 | 3 | 3 | | 2005 | 2 | 0 | 2 | | 2004 | 1 | 1 | 2 | | 2003 | 0 | 1 | 1 | | 2002 | 1 | 0 | 1 | | 2001 | 1 | 0 | 1 |
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Below are the most recent publications written about "Interleukin-12" by people in Profiles over the past ten years.
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Mehta NK, Rakhra K, Meetze KA, Li B, Momin N, Chang JYH, Wittrup KD, Baeuerle PA, Michaelson JS. CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity. Cancer Immunol Res. 2024 Aug 01; 12(8):1022-1038.
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Scott XO, Chen SH, Hadad R, Yavagal D, Peterson EC, Starke RM, Dietrich WD, Keane RW, de Rivero Vaccari JP. Cohort study on the differential expression of inflammatory and angiogenic factors in thrombi, cerebral and peripheral plasma following acute large vessel occlusion stroke. J Cereb Blood Flow Metab. 2022 10; 42(10):1827-1839.
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Agarwal Y, Milling LE, Chang JYH, Santollani L, Sheen A, Lutz EA, Tabet A, Stinson J, Ni K, Rodrigues KA, Moyer TJ, Melo MB, Irvine DJ, Wittrup KD. Intratumourally injected alum-tethered cytokines elicit potent and safer local and systemic anticancer immunity. Nat Biomed Eng. 2022 02; 6(2):129-143.
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Tait Wojno ED, Hunter CA, Stumhofer JS. The Immunobiology of the Interleukin-12 Family: Room for Discovery. Immunity. 2019 04 16; 50(4):851-870.
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Wang X, Fu Q, Song R, Duan B, Bergquist R, Xu J, Li S, Zhou D, Qin Z. Antinuclear antibodies and interleukin responses in patients with Schistosoma japonicum infection. Parasite Immunol. 2018 Oct; 40(10):e12577.
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Wang X, Che Y, Chen B, Zhang Y, Nakagawa M, Wang X. Evaluation of immune responses induced by a novel human papillomavirus type 16 E7 peptide-based vaccine with Candida skin test reagent as an adjuvant in C57BL/6 mice. Int Immunopharmacol. 2018 Mar; 56:249-260.
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Smith SG, Koppolu BP, Ravindranathan S, Kurtz SL, Yang L, Katz MD, Zaharoff DA. Intravesical chitosan/interleukin-12 immunotherapy induces tumor-specific systemic immunity against murine bladder cancer. Cancer Immunol Immunother. 2015 Jun; 64(6):689-96.
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